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Article ; Online: Frustration-driven C

Ok, Jong Mok / Baek, S-H / Hoch, C / Kremer, R K / Park, S Y / Ji, Sungdae / Büchner, B / Park, J-H / Hyun, S I / Shim, J H / Bang, Yunkyu / Moon, E G / Mazin, I I / Kim, Jun Sung

Nature communications

2017 Volume 8, Issue 1, Page(s) 2167

Abstract: A subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity- ... ...

Abstract	A subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity-coupled layer is magnetically active, rich phase diagrams are expected in FeSCs, but this has not been explored yet. Here, using high-accuracy
Language	English
Publishing date	2017-12-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/s41467-017-02327-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits.

Mok, Calvin / Xiao, Meng A / Wan, Yin C / Zhao, Winnie / Ahmed, Shanzeh M / Luallen, Robert J / Reinke, Aaron W

PLoS pathogens

2023 Volume 19, Issue 3, Page(s) e1011225

Abstract: ... to these four microsporidia species is conserved, with C. elegans strain-specific differences in potential ... immune genes. Together, our results show that phenotypic differences to microsporidia infection amongst C ...

Abstract	Animals are under constant selective pressure from a myriad of diverse pathogens. Microsporidia are ubiquitous animal parasites, but the influence they exert on shaping animal genomes is mostly unknown. Using multiplexed competition assays, we measured the impact of four different species of microsporidia on 22 wild isolates of Caenorhabditis elegans. This resulted in the identification and confirmation of 13 strains with significantly altered population fitness profiles under infection conditions. One of these identified strains, JU1400, is sensitive to an epidermal-infecting species by lacking tolerance to infection. JU1400 is also resistant to an intestinal-infecting species and can specifically recognize and destroy this pathogen. Genetic mapping of JU1400 demonstrates that these two opposing phenotypes are caused by separate loci. Transcriptional analysis reveals the JU1400 sensitivity to epidermal microsporidia infection results in a response pattern that shares similarity to toxin-induced responses. In contrast, we do not observe JU1400 intestinal resistance being regulated at the transcriptional level. The transcriptional response to these four microsporidia species is conserved, with C. elegans strain-specific differences in potential immune genes. Together, our results show that phenotypic differences to microsporidia infection amongst C. elegans are common and that animals can evolve species-specific genetic interactions.
MeSH term(s)	Animals ; Microsporidia/genetics ; Caenorhabditis elegans ; Host-Pathogen Interactions/genetics ; Microsporidiosis/veterinary ; Caenorhabditis elegans Proteins/genetics
Chemical Substances	Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011225
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Article: Corrigendum: Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.

Sakinah, S / Priya, Sivan Padma / Mok, Pooi Ling / Munisvaradass, Rusheni / Teh, Seoh Wei / Sun, Zhong / Alzahrani, Badr / Bakar, Faizal Abu / Chee, Hui-Yee / Hamat, Rukman Awang / He, Guozhong / Xiong, Chenglong / Joseph, Narcisse / Tong, Jia Bei / Wu, Xiaoyun / Maniam, Mahendran / Samrot, Antony V / Higuchi, Akon / Kumar, S Suresh

Frontiers in cell and developmental biology

2022 Volume 9, Page(s) 800659

Abstract: This corrects the article DOI: 10.3389/fcell.2021.637270.]. ...

Abstract	[This corrects the article DOI: 10.3389/fcell.2021.637270.].
Language	English
Publishing date	2022-02-01
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.800659
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Article ; Online: Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.

Koblan, Luke W / Arbab, Mandana / Shen, Max W / Hussmann, Jeffrey A / Anzalone, Andrew V / Doman, Jordan L / Newby, Gregory A / Yang, Dian / Mok, Beverly / Replogle, Joseph M / Xu, Albert / Sisley, Tyler A / Weissman, Jonathan S / Adamson, Britt / Liu, David R

Nature biotechnology

2023 Volume 41, Issue 11, Page(s) 1655

Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/s41587-023-02028-8
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Article ; Online: C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors

Temming, A Robin / Tammes Buirs, Matthias / Bentlage, Arthur E H / Treffers, Louise W / Feringa, Hannah / de Taeye, Steven W / Kuijpers, Taco W / Nagelkerke, Sietse Q / Brasser, Giso / Mok, Juk Yee / van Esch, Wim J E / van den Berg, Timo K / Rispens, Theo / van der Schoot, C Ellen / Vidarsson, Gestur

Frontiers in immunology

2021 Volume 12, Page(s) 594773

Abstract: ... correlate with clinical outcome. Previously, we found C-reactive protein (CRP) levels to be elevated ...

Abstract	Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still unknown. Antibody titers, for example, often do not strictly correlate with clinical outcome. Previously, we found C-reactive protein (CRP) levels to be elevated in thrombocytopenic patients, correlating with thrombocyte counts, and bleeding severity. Functionally, CRP amplified antibody-mediated phagocytosis of thrombocytes by phagocytes. To investigate whether CRP is a general enhancer of IgG-mediated target cell destruction, we extensively studied the effect of CRP on
MeSH term(s)	Adult ; Animals ; C-Reactive Protein/metabolism ; Cells, Cultured ; Cytophagocytosis/immunology ; Cytotoxicity, Immunologic ; Erythrocytes/immunology ; Female ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Male ; Mice ; Middle Aged ; Models, Biological ; Neutrophils/immunology ; Neutrophils/metabolism ; Receptors, Fc/metabolism ; Receptors, IgG/metabolism ; Respiratory Burst/immunology ; Young Adult
Chemical Substances	Immunoglobulin G ; Receptors, Fc ; Receptors, IgG ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.594773
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Article: Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.

Sakinah, S / Priya, Sivan Padma / Mok, Pooi Ling / Munisvaradass, Rusheni / Teh, Seoh Wei / Sun, Zhong / Alzahrani, Badr / Abu Bakar, Faizal / Chee, Hui-Yee / Awang Hamat, Rukman / He, Guozhong / Xiong, Chenglong / Joseph, Narcisse / Tong, Jia Bei / Wu, Xiaoyun / Maniam, Mahendran / Samrot, Antony V / Higuchi, Akon / Kumar, S Suresh

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 637270

Abstract: ... progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved ...

Abstract	Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection. We administered a combination of hematopoietic stem cells and endothelial progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved their liver functions, confirmed by hematology, histopathology, and next-generation sequencing. These stem and progenitor cells can differentiate into target cells and repair the damaged tissues. In addition, the regime can regulate endothelial proliferation and permeability, modulate inflammatory reactions, enhance extracellular matrix production and angiogenesis, and secrete an array of growth factors to create an enhanced milieu for cell reparation. No previous study has been published on the treatment of dengue infection using stem cells combination. In conclusion, dengue-induced liver damage was rescued by administration of stem cell therapy, with less apoptosis and improved repair and regeneration in the dengue mouse model.
Language	English
Publishing date	2021-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.637270
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Article ; Online: Interaction of Influenza A Nucleoprotein with Host hnRNP-C Is Implicated in Viral Replication.

Tang, Yun-Sang / So, Wai-Kin / Ng, Ka-Leung Andy / Mok, Ka-Pun Chris / Shaw, Pang-Chui

International journal of molecular sciences

2022 Volume 23, Issue 21

Abstract: ... the identification of host heterogeneous nuclear ribonucleoprotein C (hnRNP-C) as an interacting partner ... A subtypes and strains. Using biochemical methods, we determined that hnRNP-C interacts with NP via its C ... terminal auxiliary domain. Further, we determined that the hnRNP-C is a negative regulator of influenza ...

Abstract	The host interactome of influenza viral proteins is ever-expanding. In this work, we report the identification of host heterogeneous nuclear ribonucleoprotein C (hnRNP-C) as an interacting partner of influenza A virus nucleoprotein (NP). We confirmed that this interaction exists across different influenza A subtypes and strains. Using biochemical methods, we determined that hnRNP-C interacts with NP via its C-terminal auxiliary domain. Further, we determined that the hnRNP-C is a negative regulator of influenza viral growth. Its interaction with NP is implicated in the promotion of host cell apoptosis during viral infection. It is the first time that the interaction between influenza nucleoprotein and host heterogeneous nuclear ribonucleoprotein C is characterized in detail. Overall, these findings not only characterize the interaction between NP and its host interacting partner hnRNP-C but also clarify the functional significance of this interaction. This work may lead to a new therapeutic target for the development of anti-influenza drugs.
MeSH term(s)	Humans ; Nucleoproteins/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein Group C ; Cell Line ; Virus Replication ; Influenza, Human
Chemical Substances	Nucleoproteins ; Heterogeneous-Nuclear Ribonucleoprotein Group C
Language	English
Publishing date	2022-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232113613
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Article ; Online: High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits.

Calvin Mok / Meng A Xiao / Yin C Wan / Winnie Zhao / Shanzeh M Ahmed / Robert J Luallen / Aaron W Reinke

PLoS Pathogens, Vol 19, Iss 3, p e

2023 Volume 1011225

Abstract	Animals are under constant selective pressure from a myriad of diverse pathogens. Microsporidia are ubiquitous animal parasites, but the influence they exert on shaping animal genomes is mostly unknown. Using multiplexed competition assays, we measured the impact of four different species of microsporidia on 22 wild isolates of Caenorhabditis elegans. This resulted in the identification and confirmation of 13 strains with significantly altered population fitness profiles under infection conditions. One of these identified strains, JU1400, is sensitive to an epidermal-infecting species by lacking tolerance to infection. JU1400 is also resistant to an intestinal-infecting species and can specifically recognize and destroy this pathogen. Genetic mapping of JU1400 demonstrates that these two opposing phenotypes are caused by separate loci. Transcriptional analysis reveals the JU1400 sensitivity to epidermal microsporidia infection results in a response pattern that shares similarity to toxin-induced responses. In contrast, we do not observe JU1400 intestinal resistance being regulated at the transcriptional level. The transcriptional response to these four microsporidia species is conserved, with C. elegans strain-specific differences in potential immune genes. Together, our results show that phenotypic differences to microsporidia infection amongst C. elegans are common and that animals can evolve species-specific genetic interactions.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock.

Park, Jong Eun / Shin, Tae Gun / Jeong, Daun / Lee, Gun Tak / Ryoo, Seung Mok / Kim, Won Young / Jo, You Hwan / Suh, Gil Joon / Hwang, Sung Yeon

Biomedicines

2022 Volume 10, Issue 9

Abstract: The prognostic value of low vitamin C levels has not been well investigated in patients ... with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients ... day mortality. The patients were categorized into vitamin C deficiency and normal groups based ...

Abstract	The prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospective multicenter trial and institutional sepsis registry between April 2018 and January 2020. The primary outcome was 28-day mortality. The patients were categorized into vitamin C deficiency and normal groups based on a vitamin C cutoff level of 11.4 mmol/L. Multivariable Cox regression analysis was performed to examine the association between vitamin C levels and 28-day mortality. A total of 165 patients was included for analysis and 77 (46.7%) had vitamin C deficiency. There was no significant difference in the 28-day mortality rate between the vitamin C deficiency group and the normal group (23.4% (
Language	English
Publishing date	2022-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10092090
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Article ; Online: Clinical significance of C-reactive protein-to-prealbumin ratio in predicting early recurrence in resectable pancreatic cancer.

Kwon, Chae Hwa / Seo, Hyung Il / Kim, Dong Uk / Han, Sung Yong / Kim, Suk / Lee, Nam Kyung / Hong, Seung Baek / Ahn, Ji Hyun / Park, Young Mok / Noh, Byung Gwan

Korean journal of clinical oncology

2023 Volume 19, Issue 1, Page(s) 11–17

Abstract: ... receiver operating characteristic (ROC) curves.: Results: In our univariate and multivariate analyses, C-reactive protein (CRP ...

Abstract	Purpose: Resectable pancreatic ductal adenocarcinoma (PDAC) has a high risk of recurrence after curative resection; despite this, the preoperative risk factors for predicting early recurrence remain unclear. This study therefore aimed to identify preoperative inflammation and nutrition factors associated with early recurrence of resectable PDAC. Methods: From March 2021 to November 2021, a total of 20 patients who underwent curative resection for PDAC were enrolled in this study. We evaluated the risk factors for early recurrence within 1 year by univariate and multivariate analyses using Cox hazard proportional regression. The cutoff values for predicting recurrence were examined using receiver operating characteristic (ROC) curves. Results: In our univariate and multivariate analyses, C-reactive protein (CRP), CRP-albumin ratio, and CRP-prealbumin ratio, as well as sex and age, were significant independent prognostic factors for early recurrence in PDAC. However, known inflammatory factors (neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios), nutritional factors (albumin, prealbumin, ferritin, vitamin D), and inflammatory-nutritional factors (Glasgow Prognostic Score, modified Glasgow Prognostic Score, albumin-bilirubin) showed no association with early recurrence. In addition, using cutoff values by ROC curve analysis, a high preoperative CRP level of >5 mg/L, as well as high CRP-to-albumin (>5.3) and CRP-to-prealbumin (>1.3) ratios showed no prognostic value. Conclusion: Our results showed that inflammatory and perioperative nutritional factors, especially CRP-to-prealbumin ratio, have significant associations with early recurrence after curative resection in resectable PDAC. Therefore, for such patients, a cautious approach is needed when inflammation and poor nutritional status are present.
Language	English
Publishing date	2023-06-30
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2288-4084
ISSN (online)	2288-4084
DOI	10.14216/kjco.23003
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