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  1. Article ; Online: Self-DNA sensing in cigarette smoke-induced vascular inflammation: the role of mitochondrial DNA release in vascular endothelial cells.

    Liu, Wenhao / Higashikuni, Yasutomi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 3, Page(s) 799–802

    MeSH term(s) Humans ; Cigarette Smoking ; DNA, Mitochondrial ; Endothelial Cells ; Inflammation ; Interleukin-6
    Chemical Substances DNA, Mitochondrial ; Interleukin-6
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01545-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Nocturnal blood pressure and left ventricular hypertrophy in patients with diabetes mellitus.

    Higashikuni, Yasutomi / Liu, Wenhao / Sata, Masataka

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 3, Page(s) 819–822

    MeSH term(s) Humans ; Blood Pressure/physiology ; Hypertrophy, Left Ventricular/etiology ; Hypertrophy, Left Ventricular/physiopathology ; Blood Glucose ; Japan ; Hypertension/complications ; Hypertension/physiopathology ; Diabetes Mellitus
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01562-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension.

    Higashikuni, Yasutomi / Liu, Wenhao / Sata, Masataka

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 10, Page(s) 2415–2418

    MeSH term(s) Muscle, Smooth, Vascular/metabolism ; AMP-Activated Protein Kinases/metabolism ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; MAP Kinase Signaling System ; Ponds ; Receptor, Bradykinin B2/metabolism ; Receptors, Bradykinin/metabolism ; Signal Transduction/drug effects
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Antihypertensive Agents ; Receptor, Bradykinin B2 ; Receptors, Bradykinin
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01385-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Optimizing antihypertensive therapy in patients with diabetes mellitus.

    Liu, Wenhao / Higashikuni, Yasutomi / Sata, Masataka

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 46, Issue 3, Page(s) 797–800

    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Hypertension/physiopathology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Diabetes Mellitus
    Chemical Substances Antihypertensive Agents ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2022-12-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01150-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Linking RNA dynamics to heart disease: the lncRNA/miRNA/mRNA axis in myocardial ischemia-reperfusion injury.

    Liu, Wenhao / Higashikuni, Yasutomi / Sata, Masataka

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 6, Page(s) 1067–1069

    MeSH term(s) Apoptosis ; Humans ; MicroRNAs/genetics ; Myocardial Reperfusion Injury/genetics ; Myocytes, Cardiac ; RNA, Long Noncoding/genetics ; RNA, Messenger
    Chemical Substances MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00905-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Give a Leg Up: Screening for Peripheral Artery Disease after Acute Myocardial Infarction.

    Higashikuni, Yasutomi / Liu, Wenhao / Sata, Masataka

    Journal of atherosclerosis and thrombosis

    2021  Volume 29, Issue 7, Page(s) 989–991

    MeSH term(s) Ankle Brachial Index ; Brachial Artery ; Humans ; Leg/blood supply ; Myocardial Infarction/diagnosis ; Peripheral Arterial Disease/diagnosis
    Language English
    Publishing date 2021-12-01
    Publishing country Japan
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications.

    Higashikuni, Yasutomi / Liu, Wenhao / Obana, Takumi / Sata, Masataka

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social and economic activities, as well as public health. In most patients, the symptoms of ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social and economic activities, as well as public health. In most patients, the symptoms of COVID-19 are a high-grade fever and a dry cough, and spontaneously resolve within ten days. However, in severe cases, COVID-19 leads to atypical bilateral interstitial pneumonia, acute respiratory distress syndrome, and systemic thromboembolism, resulting in multiple organ failure with high mortality and morbidity. SARS-CoV-2 has immune evasion mechanisms, including inhibition of interferon signaling and suppression of T cell and B cell responses. SARS-CoV-2 infection directly and indirectly causes dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction, which interact with each other and are exacerbated by cardiovascular risk factors. In this review, we summarize current knowledge on the pathogenic basis of thromboinflammation and endothelial injury in COVID-19. We highlight the distinct contributions of dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction to the pathogenesis of COVID-19. In addition, we discuss potential therapeutic strategies targeting these mechanisms.
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Blood Coagulation ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Humans ; Immunity, Innate ; Platelet Activation ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Thrombosis/etiology
    Chemical Substances Antiviral Agents ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-11-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222112081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells.

    Higashikuni, Yasutomi / Lu, Timothy K

    ACS synthetic biology

    2019  Volume 8, Issue 12, Page(s) 2607–2619

    Abstract: Human diseases are caused by dysregulation of cellular biological programs that are encoded in DNA. Unveiling the endogenous programs and encoding new programs into the genome are key to creating novel diagnostic and therapeutic strategies. CRISPR/Cas9, ... ...

    Abstract Human diseases are caused by dysregulation of cellular biological programs that are encoded in DNA. Unveiling the endogenous programs and encoding new programs into the genome are key to creating novel diagnostic and therapeutic strategies. CRISPR/Cas9, originally identified in bacteria, has revolutionized genome editing in mammalian cells. Recent advances in CRISPR technologies have provided new programmable platforms for modifying cell function and behavior. CRISPR-based transcriptional regulators and modified gRNAs have enabled multiplexed regulation and visualization of genome dynamics with spatiotemporal precision. Using these toolkits, genome-scale screening platforms can identify key genetic elements or combinations thereof that modulate phenotypes in mammalian cells. In addition, imaging platforms for multiplexed genomic labeling have been created to study the conformation and dynamics of chromatin in living cells, which are essential for genome function. Furthermore, CRISPR-based computation and memory platforms have been built in living mammalian cells by using DNA as a data processing and storage medium to regulate and monitor cellular behaviors. The conditional regulation of CRISPR-based parts has enabled the design of complex multilayered biological programs. CRISPR-based memory platforms can continuously record biological events as mutations in defined DNA loci. By making use of base editors, CRISPR-based computation and memory platforms have been interconnected to perform logic operations based on past events. These technologies open up new avenues for understanding biological phenomena and designing mammalian cells as living machines for biomedical applications.
    MeSH term(s) Animals ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Gene Editing ; Genetic Testing ; Genome ; Humans ; Mammals/genetics ; Phenotype ; Transcription, Genetic
    Language English
    Publishing date 2019-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.9b00297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19

    Yasutomi Higashikuni / Wenhao Liu / Takumi Obana / Masataka Sata

    International Journal of Molecular Sciences, Vol 22, Iss 12081, p

    Current Findings and Therapeutic Implications

    2021  Volume 12081

    Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social and economic activities, as well as public health. In most patients, the symptoms of ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social and economic activities, as well as public health. In most patients, the symptoms of COVID-19 are a high-grade fever and a dry cough, and spontaneously resolve within ten days. However, in severe cases, COVID-19 leads to atypical bilateral interstitial pneumonia, acute respiratory distress syndrome, and systemic thromboembolism, resulting in multiple organ failure with high mortality and morbidity. SARS-CoV-2 has immune evasion mechanisms, including inhibition of interferon signaling and suppression of T cell and B cell responses. SARS-CoV-2 infection directly and indirectly causes dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction, which interact with each other and are exacerbated by cardiovascular risk factors. In this review, we summarize current knowledge on the pathogenic basis of thromboinflammation and endothelial injury in COVID-19. We highlight the distinct contributions of dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction to the pathogenesis of COVID-19. In addition, we discuss potential therapeutic strategies targeting these mechanisms.
    Keywords COVID-19 ; endothelial injury ; inflammation ; platelet activation ; SARS-CoV-2 ; therapeutics ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Clinical valve thrombosis and arterial embolism in a cancer patient after transcatheter aortic valve replacement.

    Sawano, Shinnosuke / Miura, Mizuki / Higashikuni, Yasutomi / Saigusa, Hiroyuki / Kodera, Satoshi / Takeda, Norifumi / Hatano, Masaru / Ando, Jiro / Ono, Minoru / Komuro, Issei

    Oxford medical case reports

    2023  Volume 2023, Issue 11, Page(s) omad125

    Abstract: The number of cancer patients with severe aortic stenosis and atrial fibrillation (AF) is increasing in the aging population. Transcatheter aortic valve replacement (TAVR) is an established treatment option for severe aortic stenosis with high surgical ... ...

    Abstract The number of cancer patients with severe aortic stenosis and atrial fibrillation (AF) is increasing in the aging population. Transcatheter aortic valve replacement (TAVR) is an established treatment option for severe aortic stenosis with high surgical risk, including individuals with cancer. Antithrombotic therapy should be considered for post-TAVR or AF patients. However, antithrombotic management in cancer patients remains challenging due to the increased risk of both thromboembolism and bleeding. We present a case of clinical valve thrombosis and arterial embolism after transcatheter aortic valve replacement in an elderly patient with a history of metastatic pancreatic cancer and permanent atrial fibrillation under treatment of single antiplatelet therapy. Warfarin treatment after successful surgical thrombectomy to the occluded arteries improved clinical valve thrombosis, although the long-term outcome remains unclear. This case demonstrates that novel management algorithms for thromboembolism and bleeding in elderly cancer patients with AF and valvular heart disease are urgently needed.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omad125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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