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Article ; Online: A tribute to David Triggle.

Moos, Walter H

2015 Volume 98, Issue 2, Page(s) 360–362

Abstract: A gentleman and a scholar" is how many would characterize David Triggle. His insightful, thoughtful approaches to professional pursuits, both personal research and collaborative relationships, stand out by any measure. He has shaped students, colleagues, ...

Abstract	"A gentleman and a scholar" is how many would characterize David Triggle. His insightful, thoughtful approaches to professional pursuits, both personal research and collaborative relationships, stand out by any measure. He has shaped students, colleagues, and whole fields, calcium ion channels and ligands being most representative of the latter. In recent years, he has expanded his contributions to important commentaries on politics and social challenges in the sciences. David is the rare intellect able to do all this and more, as outlined herein.
MeSH term(s)	Calcium Channel Blockers/chemistry ; Calcium Channel Blockers/history ; Calcium Channels/history ; Calcium Channels/physiology ; Chemistry, Pharmaceutical/history ; Chemistry, Pharmaceutical/methods ; History, 20th Century ; History, 21st Century ; Pharmacology/history ; Pharmacology/methods ; Research/history
Chemical Substances	Calcium Channel Blockers ; Calcium Channels
Language	English
Publishing date	2015-11-15
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2015.04.014
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Article ; Online: Are in-person scientific conferences dead or alive?

Dua, Nick / Fyrenius, Mattias / Johnson, Deborah L / Moos, Walter H

FASEB bioAdvances

2021 Volume 3, Issue 6, Page(s) 420–427

Abstract: Given the disruption caused by the COVID-19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, the ... ...

Abstract	Given the disruption caused by the COVID-19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, the importance of wearing face coverings, and travel restrictions, only virtual meetings have been possible during the pandemic. But many are asking: What is the new post-pandemic normal likely to be? Do we still want to have in-person meetings when the restrictions are eased? Assuming we do, when will they be possible again, and under what conditions? Regardless of what the benefits of virtual symposia might be, are they here to stay? These questions, and many more that are being asked around the world today, are the subject of this perspective. Herein, we attempt to provide useful context and insight into where scientific meetings have been, where they are today, where they are going, and how they will get there. Our conclusion is that the pandemic has created an accelerated opportunity to make the world of future scientific conferences better in a "both/and" collaborative in-person/virtual scenario, not the more limited "pick one" choice.
Language	English
Publishing date	2021-02-20
Publishing country	United States
Document type	Journal Article
ISSN	2573-9832
ISSN (online)	2573-9832
DOI	10.1096/fba.2020-00139
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Article ; Online: Correction to

Walter H. Moos

BioResearch Open Access, Vol 6, Iss 1, Pp 46-

Biores Open Access 2016;5:137–145

2017 Volume 46

Abstract: ... Microbiota and Neurological Disorders: A Gut Feeling” by Moos et al. requires a correction. Reference 98 was ...

Abstract	In the 2016 volume of BioResearch Open Access (vol. 5, no. 1; 137–145), the article entitled “Microbiota and Neurological Disorders: A Gut Feeling” by Moos et al. requires a correction. Reference 98 was incorrectly cited in the first paragraph of page 142; this should be reference 194, which was inadvertently omitted from the article. The corrected text and newly added reference are below: The mouth, being an extension of the digestive tract, presents a readily accessible diagnostic site for the early detection of potential unhealthy pathogens resident in the gut. Salivanomics is a rapidly emerging tool in the arsenal of salivary diagnostics.194 Collecting saliva or swabbing the inside cheek of the mouth is noninterventional, making it a highly attractive diagnostic procedure, particularly for infants and young children. It is not unlikely that regular visits to your dentist may soon be as important to your gut as it is to your oral hygiene, white teeth, and a nice smile. 194. Zhang Y, Sun J, Lin CC, et al. The emerging landscape of salivary diagnostics. Periodontol 2000. 2016;70:38–52. The article has been corrected to reflect this change. The authors apologize for this error.
Keywords	Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	Mary Ann Liebert
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Peptides 2020: A Clear Therapeutic Vision.

Angell, Yvonne / Holford, Mandë / Moos, Walter H

Protein and peptide letters

2019 Volume 25, Issue 12, Page(s) 1042–1043

MeSH term(s)	Drug Discovery ; Humans ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/therapeutic use
Chemical Substances	Peptides
Language	English
Publishing date	2019-01-31
Publishing country	Netherlands
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/092986652512190118153004
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Article ; Online: Are in‐person scientific conferences dead or alive?

Nick Dua / Mattias Fyrenius / Deborah L. Johnson / Walter H. Moos

FASEB BioAdvances, Vol 3, Iss 6, Pp 420-

2021 Volume 427

Abstract: Abstract Given the disruption caused by the COVID‐19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, ... ...

Abstract	Abstract Given the disruption caused by the COVID‐19 pandemic, life as we knew it has been turned upside down, but the need for science to go on has never been stronger. In the realm of scientific conferences, with the requirement for social distancing, the importance of wearing face coverings, and travel restrictions, only virtual meetings have been possible during the pandemic. But many are asking: What is the new post‐pandemic normal likely to be? Do we still want to have in‐person meetings when the restrictions are eased? Assuming we do, when will they be possible again, and under what conditions? Regardless of what the benefits of virtual symposia might be, are they here to stay? These questions, and many more that are being asked around the world today, are the subject of this perspective. Herein, we attempt to provide useful context and insight into where scientific meetings have been, where they are today, where they are going, and how they will get there. Our conclusion is that the pandemic has created an accelerated opportunity to make the world of future scientific conferences better in a “both/and” collaborative in‐person/virtual scenario, not the more limited “pick one” choice.
Keywords	conference ; COVID‐19 ; face‐to‐face ; in‐person ; meeting ; scientific communication/interchange ; Biology (General) ; QH301-705.5
Subject code	170
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mitochondrial drugs come of age.

Moos, Walter H / Dykens, James A

Drug development research

2015 Volume 76, Issue 2, Page(s) 57–60

MeSH term(s)	Drug Discovery ; Drug Therapy ; Energy Metabolism/drug effects ; Humans ; Mitochondria/drug effects
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Editorial
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.21243
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Article ; Online: Building on Success: A Bright Future for Peptide Therapeutics.

Angell, Yvonne / Holford, Mandë / Moos, Walter H

Protein and peptide letters

2018 Volume 25, Issue 12, Page(s) 1044–1050

Abstract: The primary aim of this review article is to highlight current exciting and future looking areas of research in peptide science as applied to the discovery and development of novel therapeutics. Among the strengths of peptides as drug candidates are ... ...

Abstract	The primary aim of this review article is to highlight current exciting and future looking areas of research in peptide science as applied to the discovery and development of novel therapeutics. Among the strengths of peptides as drug candidates are their high potency, specificity, and good safety profile. These positive attributes of peptides along with advances in drug delivery technologies have generated renewed interest in the discovery, optimization, and development of peptides as therapeutics. The intent of this review is to demonstrate that peptides have broad applicability in many therapeutic areas by examining some of the most compelling indications and targets for peptide therapeutics. For example, target selection for peptide therapeutics is challenging due to the inherent properties of peptides; therefore, identifying a clear differentiation strategy for a new peptide program over a small molecule or antibody program from the outset is critical for successful navigation of drug development hurdles. In this review, some of the latest techniques that accentuate the advantages and overcome the druggability limitations of peptides will be covered. Emerging technologies for enhancing the pharmacokinetics of peptides to achieve sufficient in vivo half-lives will be described and evaluated, as well as novel technologies for getting peptides across cell membranes to reach intracellular targets and across the blood-brain-barrier to reach central nervous system targets.
MeSH term(s)	Animals ; Cell Membrane/chemistry ; Drug Design ; Drug Discovery/methods ; Humans ; Peptides/chemistry ; Peptides/pharmacokinetics ; Peptides/therapeutic use
Chemical Substances	Peptides
Language	English
Publishing date	2018-11-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/0929866525666181114155542
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Article ; Online: Epilepsy: Mitochondrial connections to the 'Sacred' disease.

Moos, Walter H / Faller, Douglas V / Glavas, Ioannis P / Kanara, Iphigenia / Kodukula, Krishna / Pernokas, Julie / Pernokas, Mark / Pinkert, Carl A / Powers, Whitney R / Sampani, Konstantina / Steliou, Kosta / Vavvas, Demetrios G

Mitochondrion

2023 Volume 72, Page(s) 84–101

Abstract: Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms of epilepsy makes diagnosis challenging. Diagnosis and monitoring of childhood epilepsy add to the need for non-invasive ... ...

Abstract	Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms of epilepsy makes diagnosis challenging. Diagnosis and monitoring of childhood epilepsy add to the need for non-invasive biomarkers, especially when evaluating antiseizure medications. Although underlying mechanisms of epileptogenesis are not fully understood, evidence for mitochondrial involvement is substantial. Seizures affect 35%-60% of patients diagnosed with mitochondrial diseases. Mitochondrial dysfunction is pathophysiological in various epilepsies, including those of non-mitochondrial origin. Decreased ATP production caused by malfunctioning brain cell mitochondria leads to altered neuronal bioenergetics, metabolism and neurological complications, including seizures. Iron-dependent lipid peroxidation initiates ferroptosis, a cell death pathway that aligns with altered mitochondrial bioenergetics, metabolism and morphology found in neurodegenerative diseases (NDDs). Studies in mouse genetic models with seizure phenotypes where the function of an essential selenoprotein (GPX4) is targeted suggest roles for ferroptosis in epilepsy. GPX4 is pivotal in NDDs, where selenium protects interneurons from ferroptosis. Selenium is an essential central nervous system micronutrient and trace element. Low serum concentrations of selenium and other trace elements and minerals, including iron, are noted in diagnosing childhood epilepsy. Selenium supplements alleviate intractable seizures in children with reduced GPX activity. Copper and cuproptosis, like iron and ferroptosis, link to mitochondria and NDDs. Connecting these mechanistic pathways to selenoproteins provides new insights into treating seizures, pointing to using medicines including prodrugs of lipoic acid to treat epilepsy and to potential alternative therapeutic approaches including transcranial magnetic stimulation (transcranial), photobiomodulation and vagus nerve stimulation.
MeSH term(s)	Animals ; Mice ; Selenium/metabolism ; Mitochondria/metabolism ; Epilepsy/metabolism ; Seizures/metabolism ; Iron/metabolism
Chemical Substances	Selenium (H6241UJ22B) ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-08-13
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2023.08.002
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Book: Drug discovery technologies

Moos, Walter H. / Clark, Colin R.

(Ellis Horwood series in pharmaceutical technology)

1990

Title variant	Drug discovery technologies / Colin R. Clark and Walter H. Moos
Author's details	ed.: C. R. Clark
Series title	Ellis Horwood series in pharmaceutical technology
Keywords	Drug Design ; Chemistry, Pharmaceutical ; Arzneimittelentwicklung ; Arzneimittel ; Chemische Synthese
Subject	Arzneimittel ; Drug Development ; Synthese ; Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge
Language	English
Size	XV, 283 S. : graph. Darst.
Publisher	Horwood u.a.
Publishing place	Chichester
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT003534855
ISBN	0-7458-0625-2 ; 0-470-21604-2 ; 978-0-7458-0625-9 ; 978-0-470-21604-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury.

Moos, Walter H / Faller, Douglas V / Glavas, Ioannis P / Harpp, David N / Kamperi, Natalia / Kanara, Iphigenia / Kodukula, Krishna / Mavrakis, Anastasios N / Pernokas, Julie / Pernokas, Mark / Pinkert, Carl A / Powers, Whitney R / Sampani, Konstantina / Steliou, Kosta / Tamvakopoulos, Constantin / Vavvas, Demetrios G / Zamboni, Robert J / Chen, Xiaohong

Biochemical pharmacology

2022 Volume 203, Page(s) 115168

Abstract: Pathological deterioration of mitochondrial function is increasingly linked with multiple degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic diseases, including those of genetic origin. Several of these diseases ... ...

Abstract	Pathological deterioration of mitochondrial function is increasingly linked with multiple degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic diseases, including those of genetic origin. Several of these diseases are rare, typically defined in the United States as an illness affecting fewer than 200,000 people in the U.S. population, or about one in 1600 individuals. Vision impairment due to mitochondrial dysfunction in the eye is a prominent feature evident in numerous primary mitochondrial diseases and is common to the pathophysiology of many of the familiar ophthalmic disorders, including age-related macular degeneration, diabetic retinopathy, glaucoma and retinopathy of prematurity - a collection of syndromes, diseases and disorders with significant unmet medical needs. Focusing on metabolic mitochondrial pathway mechanisms, including the possible roles of cuproptosis and ferroptosis in retinal mitochondrial dysfunction, we shed light on the potential of α-lipoyl-L-carnitine in treating eye diseases. α-Lipoyl-L-carnitine is a bioavailable mitochondria-targeting lipoic acid prodrug that has shown potential in protecting against retinal degeneration and photoreceptor cell loss in ophthalmic indications.
MeSH term(s)	Carnitine/metabolism ; Humans ; Infant, Newborn ; Mitochondria/metabolism ; Photoreceptor Cells/metabolism ; Photoreceptor Cells/pathology ; Retina/metabolism ; Retinal Degeneration/drug therapy ; Retinal Degeneration/metabolism ; Retinal Degeneration/prevention & control
Chemical Substances	Carnitine (S7UI8SM58A)
Language	English
Publishing date	2022-07-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2022.115168
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