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Book: Estructura social e informalidad laboral en Argentina

Groisman, Fernando

(Temas/Sociales)

2016

Author's details	Fernando Groisman
Series title	Temas/Sociales
Keywords	Income distribution ; Labor market ; Minimum wage ; Argentina
Language	Spanish
Size	247 pages, 23 cm
Edition	1a edición
Publisher	Eudeba
Publishing place	Ciudad de Buenos Aires
Document type	Book
Note	Includes bibliographical references
ISBN	9789502325392 ; 9502325397
Database	ECONomics Information System

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Article: Gran Buenos Aires: polarización de ingresos, clase media e informalidad laboral, 1974 - 2010

Groisman, Fernando

Revista CEPAL , No. 109 , p. 85-105

2013 , Issue 109, Page(s) 85–105

Author's details	Fernando Groisman
Keywords	Social structure ; social classes ; middle class ; labour market ; family incomes ; income distribution ; cities ; statistics ; Argentina
Language	Spanish
Publishing place	Santiago
Document type	Article
ZDB-ID	1136582-1
ISSN	0252-0257
Database	ECONomics Information System

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Article ; Online: Genome-wide detection of novel regulatory RNAs in E. coli.

Raghavan, Rahul / Groisman, Eduardo A / Ochman, Howard

Genome research

2011 Volume 21, Issue 9, Page(s) 1487–1497

Abstract: ... sequences in the intergenic regions of E. coli. Half of the newly discovered sRNAs displayed enhanced stability ... in the presence of the RNA-binding protein Hfq, which is vital to the function of many of the known E. coli sRNAs ... only five of the newly discovered E. coli leader sequences were present in the genomes of other enteric ...

Abstract	The intergenic regions in bacterial genomes can contain regulatory leader sequences and small RNAs (sRNAs), which both serve to modulate gene expression. Computational analyses have predicted the presence of hundreds of these noncoding regulatory RNAs in Escherichia coli; however, only about 80 have been experimentally validated. By applying a deep-sequencing approach, we detected and quantified the vast majority of the previously validated regulatory elements and identified 10 new sRNAs and nine new regulatory leader sequences in the intergenic regions of E. coli. Half of the newly discovered sRNAs displayed enhanced stability in the presence of the RNA-binding protein Hfq, which is vital to the function of many of the known E. coli sRNAs. Whereas previous methods have often relied on phylogenetic conservation to identify regulatory leader sequences, only five of the newly discovered E. coli leader sequences were present in the genomes of other enteric species. For those newly identified regulatory elements having orthologs in Salmonella, evolutionary analyses showed that these regions encoded new noncoding elements rather than small, unannotated protein-coding transcripts. In addition to discovering new noncoding regulatory elements, we validated 53 sRNAs that were previously predicted but never detected and showed that the presence, within intergenic regions, of σ(70) promoters and sequences with compensatory mutations that maintain stable RNA secondary structures across related species is a good predictor of novel sRNAs.
MeSH term(s)	Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Genome, Bacterial/genetics ; Genomics ; Magnesium/metabolism ; Open Reading Frames/genetics ; RNA, Untranslated/genetics ; Reproducibility of Results ; Riboswitch/genetics ; Transcription, Genetic ; Transcriptome
Chemical Substances	Escherichia coli Proteins ; PhoP protein, E coli ; RNA, Untranslated ; Riboswitch ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2011-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.119370.110
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Article ; Online: Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species.

Pearce, Victoria H / Groisman, Eduardo A / Townsend, Guy E

Gut microbes

2023 Volume 15, Issue 1, Page(s) 2221484

Abstract: The mammalian gut microbiota is a critical human health determinant with therapeutic potential for remediation of many diseases. The host diet is a key factor governing the gut microbiota composition by altering nutrient availability and supporting the ... ...

Abstract	The mammalian gut microbiota is a critical human health determinant with therapeutic potential for remediation of many diseases. The host diet is a key factor governing the gut microbiota composition by altering nutrient availability and supporting the expansion of distinct microbial populations. Diets rich in simple sugars modify the abundance of microbial subsets, enriching for microbiotas that elicit pathogenic outcomes. We previously demonstrated that diets rich in fructose and glucose can reduce the fitness and abundance of a human gut symbiont,
MeSH term(s)	Animals ; Humans ; Bacteroides/genetics ; Bacteroides/metabolism ; Dietary Sugars/metabolism ; Gastrointestinal Microbiome/genetics ; Glucose/metabolism ; Fructose/metabolism ; Mammals
Chemical Substances	Dietary Sugars ; Glucose (IY9XDZ35W2) ; Fructose (30237-26-4)
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2023.2221484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Advancing the fitness of gut commensal bacteria.

Groisman, Eduardo A / Han, Weiwei / Krypotou, Emilia

Science (New York, N.Y.)

2023 Volume 382, Issue 6672, Page(s) 766–768

Abstract: Nutrient starvation of beneficial bacteria helps them colonize the human gut. ...

Abstract	Nutrient starvation of beneficial bacteria helps them colonize the human gut.
MeSH term(s)	Humans ; Symbiosis ; Gastrointestinal Microbiome/genetics ; Firmicutes/genetics ; Firmicutes/metabolism ; Bacteroidetes/genetics ; Bacteroidetes/metabolism ; Probiotics/therapeutic use ; Animals ; Mice ; Genetic Fitness ; Genetic Engineering ; Diet ; Intestines/microbiology ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/prevention & control
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adh9165
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Article ; Online: Experiences of adults living with refractory epilepsy and their views and expectations on receiving results from whole genome sequencing.

Addona, Cynthia / Hurlimann, Thierry / Jaitovich-Groisman, Iris / Godard, Beatrice

Epilepsy research

2023 Volume 196, Page(s) 107221

Abstract: ... for epilepsy patients in clinical settings. Furthermore, while acquiring more genetic knowledge (i.e. WGS ...

Abstract	Introduction: Researchers, clinicians and patients are turning to new innovations in research and clinical practice to further their knowledge in the genetic domain and improve diagnostics or treatment. However, with increased knowledge in genetics, societal issues may arise. Being conscious of these issues is crucial in order to implement standardized and efficient testing on a wider scale that is accessible to a greater number of individuals while simultaneously returning test results, including incidental findings, in a timely manner. Methods: Within the framework of a genomics research project, we invited 20 participants who suffer from refractory epilepsy to provide insight on their personal experiences with epilepsy, as well as their thoughts on receiving Whole Genome Sequencing (WGS) results and with whom they would feel comfortable sharing these results with. Results: All participants had their own unique experience with epilepsy, such as how they handled their diagnosis, their struggles following the diagnosis, the healthcare services they received, how they shared their diagnosis with others, and how they managed stigmatization from others. Most participants would be eager to know their WGS results, whether the results be related to epilepsy (n = 19), response to pharmaceutical drugs including AEDs (n = 16), comorbidities (n = 19) and incidental findings (n = 15). Conclusion: Our findings reinforce the need to improve access to genetic testing for epilepsy patients in clinical settings. Furthermore, while acquiring more genetic knowledge (i.e. WGS) about epilepsy can provide answers for the affected population, it also requires the simultaneous involvement of several medical disciplines, with greater emphasis on genetic and psychological counseling.
MeSH term(s)	Humans ; Adult ; Drug Resistant Epilepsy/diagnosis ; Drug Resistant Epilepsy/genetics ; Motivation ; Anxiety ; Emotions ; Whole Genome Sequencing
Language	English
Publishing date	2023-09-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2023.107221
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Article ; Online: DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.

Duprey, Alexandre / Groisman, Eduardo A

PLoS genetics

2020 Volume 16, Issue 10, Page(s) e1009085

Abstract: ... Why, then, do E. coli and Salmonella exhibit different DNA supercoiling when experiencing the same ... to changes in putrescine concentration within the physiological range, whereas activity of the E. coli enzyme ... was not. In vivo, putrescine activated the Salmonella DNA gyrase and spermidine the E. coli enzyme ...

Abstract	DNA supercoiling is essential for all living cells because it controls all processes involving DNA. In bacteria, global DNA supercoiling results from the opposing activities of topoisomerase I, which relaxes DNA, and DNA gyrase, which compacts DNA. These enzymes are widely conserved, sharing >91% amino acid identity between the closely related species Escherichia coli and Salmonella enterica serovar Typhimurium. Why, then, do E. coli and Salmonella exhibit different DNA supercoiling when experiencing the same conditions? We now report that this surprising difference reflects disparate activation of their DNA gyrases by the polyamine spermidine and its precursor putrescine. In vitro, Salmonella DNA gyrase activity was sensitive to changes in putrescine concentration within the physiological range, whereas activity of the E. coli enzyme was not. In vivo, putrescine activated the Salmonella DNA gyrase and spermidine the E. coli enzyme. High extracellular Mg2+ decreased DNA supercoiling exclusively in Salmonella by reducing the putrescine concentration. Our results establish the basis for the differences in global DNA supercoiling between E. coli and Salmonella, define a signal transduction pathway regulating DNA supercoiling, and identify potential targets for antibacterial agents.
MeSH term(s)	DNA Gyrase/drug effects ; DNA Gyrase/genetics ; DNA Topoisomerases, Type I/drug effects ; DNA Topoisomerases, Type I/genetics ; DNA, Superhelical/drug effects ; DNA, Superhelical/genetics ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Magnesium/pharmacology ; Putrescine/pharmacology ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/enzymology ; Salmonella typhimurium/genetics ; Spermidine/biosynthesis
Chemical Substances	DNA, Superhelical ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; DNA Gyrase (EC 5.99.1.3) ; Magnesium (I38ZP9992A) ; Spermidine (U87FK77H25) ; Putrescine (V10TVZ52E4)
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1009085
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between multiple sclerosis and urinary levels of toxic metals and organophosphates: A cross-sectional study in Israel.

Armon-Omer, Ayelet / Mansor, Tarek / Edelstein, Michael / Bukovetzky, Elena / Groisman, Luda / Rorman, Efrat / Nov, Adi Sharabi / Shahien, Radi

Multiple sclerosis and related disorders

2024 Volume 83, Page(s) 105445

Abstract: Background: Multiple sclerosis (MS) is a multifactorial disease of uncertain etiology damaging myelin sheaths around axons of the central nervous system. Myelin protects the axon from potentially harmful exogenous factors. The aetiological role of ... ...

Abstract	Background: Multiple sclerosis (MS) is a multifactorial disease of uncertain etiology damaging myelin sheaths around axons of the central nervous system. Myelin protects the axon from potentially harmful exogenous factors. The aetiological role of environmental exposure metals and organophosphates is unclear. Objective: Identify whether urinary levels of metals and organophosphates differed in MS patients and controls. Methods: We recruited MS patients from Ziv Medical Centre and healthy controls. MS patients were evaluated according to Expanded Disability Status Scale into mild and moderate-severe conditions. Each participant provided a urine sample and completed epidemiological questionnaires. The levels of six metal (Aluminum, Cadmium, Chromium, Lead, Mercury, Nickel) and one metalloid (Arsenic) and common organophosphates pesticide metabolites (6 dialkylphosphates, DAP) were measured in urine using inductively coupled plasma-mass spectrometry and gas-chromatography mass-spectrometry. We compared cases with controls in terms of urinary levels of these compounds using Mann-Whitney and Kruskall-Wallis tests. Results: Urinary cadmium and mercury levels were higher in the 49 MS patients than the 37 controls (p < 0.01). Cadmium levels were higher in moderate-severe MS patients (n = 24) than mild MS patients (n = 25) (p = 0.003). Conclusion: Urinary cadmium and mercury levels were higher among MS patients than controls. Cadmium levels correlated with disease severity. Further studies are needed to explore potential causal pathways between these compounds and MS pathogenesis.
MeSH term(s)	Humans ; Cadmium ; Cross-Sectional Studies ; Organophosphates ; Multiple Sclerosis/epidemiology ; Israel ; Mercury
Chemical Substances	Cadmium (00BH33GNGH) ; Organophosphates ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2024-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2024.105445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparing process-based models with the inventory approach to predict CH4 emission of livestock enteric fermentation

Jianan Zhang / Lan Chen / Yizhao Chen / Pavel Groisman

Environmental Research Letters, Vol 18, Iss 3, p

2023 Volume 035002

Abstract: ... predicted from PcMs is lower than IvtMs and the variation between PcMs is substantially higher, i.e. 0.34 ... model strategies undertaken, i.e. the demand-oriented strategy for IvtMs and the resource-demand co ...

Abstract	Livestock production is the largest anthropogenic methane (CH _4 ) source globally over the decades. Enteric fermentation of ruminants is responsible for the majority of global livestock CH _4 emissions. Both inventory-based models (IvtMs) and process-based models (PcMs) are extensively used to assess the livestock CH _4 emission dynamics. However, the model performance and the associated uncertainty have not been well quantified and understood, which greatly hamper our credibility of the regional and global CH _4 emission predictions. In this study, we compared the CH _4 emissions of livestock enteric fermentation (CH _4,ef ) predicted by multiple IvtMs and PcMs across Inner Mongolia, a region dominated by typical temperate grasslands that are widely used for animal husbandry. Twenty predictions from five IvtMs, and ten predations from five PcMs were explicitly calculated and compared for the reference year of 2006. The CH _4,ef predicted from PcMs is lower than IvtMs and the variation between PcMs is substantially higher, i.e. 0.34 ± 0.36 g CH _4 /m ^2 yr and 0.78 ± 0.14 g CH _4 /m ^2 yr for PcMs and IvtMs, respectively. Different model strategies undertaken, i.e. the demand-oriented strategy for IvtMs and the resource-demand co-determined one for PcMs, cause the different predictions of CH _4,ef between the two model groups. Using the results from IvtMs as the baseline scalar, we identified and benchmarked the performance of individual PcMs in the study region. The quantitative information provided can facilitate the understanding of key principles and processes of CH _4,ef estimations, which will contribute to the future model development of global CH _4 emission.
Keywords	livestock ; CH4 ; emission factors ; process-based models ; inventory-based models ; enteric fermentation ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
Subject code	660
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis.

Bruna, Roberto E / Kendra, Christopher G / Groisman, Eduardo A / Pontes, Mauricio H

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 11

Abstract: Phosphorus (P) is an essential component of core biological molecules. In bacteria, P is acquired mainly as inorganic orthophosphate (Pi) and assimilated into adenosine triphosphate (ATP) in the cytoplasm. Although P is essential, excess cytosolic Pi ... ...

Abstract	Phosphorus (P) is an essential component of core biological molecules. In bacteria, P is acquired mainly as inorganic orthophosphate (Pi) and assimilated into adenosine triphosphate (ATP) in the cytoplasm. Although P is essential, excess cytosolic Pi hinders growth. We now report that bacteria limit Pi uptake to avoid disruption of Mg
MeSH term(s)	Adenosine Triphosphate/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biological Transport ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Cytoplasm/metabolism ; Gene Expression Regulation, Bacterial ; Homeostasis ; Magnesium/metabolism ; Microbial Viability ; Mutation ; Phosphates/metabolism ; Phosphates/toxicity ; Protein Biosynthesis ; Salmonella typhimurium/genetics ; Salmonella typhimurium/growth & development ; Salmonella typhimurium/metabolism
Chemical Substances	Bacterial Proteins ; Cation Transport Proteins ; Phosphates ; Adenosine Triphosphate (8L70Q75FXE) ; MgtC protein, Salmonella typhimurium (EC 3.6.1.-) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2021370118
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