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Article: Antimicrobial Resistance of

Kłos, Marta / Jachowicz, Estera / Pomorska-Wesołowska, Monika / Romaniszyn, Dorota / Kandzierski, Grzegorz / Wójkowska-Mach, Jadwiga

Journal of clinical medicine

2022 Volume 11, Issue 14

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2022-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11143927
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Article ; Online: Hospital-acquired Enterobacteriaceae bloodstream infections in children.

Kłos, Marta / Wójkowska-Mach, Jadwiga

Developmental period medicine

2019 Volume 23, Issue 2, Page(s) 131–136

Abstract: Among the different age groups of children, newborns are most exposed to hospital-acquired bloodstream infection (HA-BSI), especially those who are burdened with additional risk factors, such as low birth weight, immaturity or exposition to medical ... ...

Abstract	Among the different age groups of children, newborns are most exposed to hospital-acquired bloodstream infection (HA-BSI), especially those who are burdened with additional risk factors, such as low birth weight, immaturity or exposition to medical procedures. The aim of this study was to analyze the aetiology of HA-BSI among children at high risk, including incidence and drug resistance. The data was obtained from the PubMed database and included medical articles as well as UNICEF and WHO reports published from 2002 to 2017. The study focused on newborns and older children (under 18 years old) with BSI. The main eligibility criteria, apart from age, were Enterobacteriaceae HA-BSI, and the use of invasive medical procedures. It was demonstrated that the main risk factors of infection were age and medical procedures. Due to non-specific symptoms, sepsis is difficult to diagnose, a fact which leads to a high mortality rate in newborns. The existence of such multi-drug resistant strains as Extended-Spectrum β-Lactamases (ESBLs) or Carbapenem-Resistant Enterobacteriaceae (CRE) phenotypes is a grave cause for concern.
MeSH term(s)	Adolescent ; Bacteremia/epidemiology ; Bacteremia/etiology ; Child ; Child, Preschool ; Cross Infection/epidemiology ; Cross Infection/etiology ; Drug Resistance, Bacterial ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/etiology ; Humans ; Incidence ; Infant ; Infant, Newborn ; Pediatrics ; Risk Factors
Language	English
Publishing date	2019-07-02
Publishing country	Poland
Document type	Journal Article ; Review
ISSN	2354-0060
ISSN (online)	2354-0060
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Article ; Online: Conventional versus Reduced-Frequency Follow-Up in Early-Stage Melanoma Survivors: A Systematic Review with Meta-Analysis.

Richter, Karolina / Stefura, Tomasz / Kłos, Nikola / Tempski, Jonasz / Kołodziej-Rzepa, Marta / Kisielewski, Michał / Wojewoda, Tomasz / Wysocki, Wojciech M

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 3, Page(s) 3366–3372

Abstract: To date, there have been multiple studies and clinical guidelines or recommendations for complex management of melanoma patients. The most controversial subjects included the frequency of follow-up. This study provides a coherent and comprehensive ... ...

Abstract	To date, there have been multiple studies and clinical guidelines or recommendations for complex management of melanoma patients. The most controversial subjects included the frequency of follow-up. This study provides a coherent and comprehensive comparison of conventional vs. reduced-frequency follow-up strategies for early-stage melanoma patients. The value of our study consists in the precise analysis of a large collection of articles and the selection of the most valuable works in relation to the topic according to rigorous criteria, which allowed for a thorough study of the topic. The search strategy was implemented using multiple databases. The inclusion criteria were randomized clinical trial or cohort studies that compared the outcomes of a conventional follow-up schedule versus a reduced-frequency follow-up schedule for patients diagnosed with melanoma. In this study, authors analyzed recurrence and 3-year survival. Meta-analysis of outcomes presented by Deckers et al. and Moncrieff et. al. did not reveal a significant difference favoring one of the groups (OR 1.14; 95%CI: 0.65-2.00;
MeSH term(s)	Humans ; Follow-Up Studies ; Cancer Survivors ; Melanoma/therapy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30030256
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Article: Pathogenicity of Virulent Species of Group C Streptococci in Human.

Kłos, Marta / Wójkowska-Mach, Jadwiga

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2017 Volume 2017, Page(s) 9509604

Abstract: Group C streptococci (GCS) are livestock pathogens and they often cause zoonotic diseases in humans. They are Gram-positive, in ... ...

Abstract	Group C streptococci (GCS) are livestock pathogens and they often cause zoonotic diseases in humans. They are Gram-positive, in mostly
Language	English
Publishing date	2017-06-12
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2017/9509604
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Article: ETHICS OF PROFESSIONAL ACTIVITIES OF SOCIAL WORKERS IN THE FIELD OF HEALTH: THE AMERICAN EXPERIENCE.

Klos, Liliia Y / Shkoliar, Mariana V / Stavkova, Sofiya Н / Kozak, Marta Y / Khudoba, Oleksandra V / Yatsyshyn, Uliana V / Flaherty, Maureen

Wiadomosci lekarskie (Warsaw, Poland : 1960)

2022 Volume 75, Issue 8 pt 1, Page(s) 1888–1894

Abstract: Objective: The aim: Coverage of the American experience of successful application of professional ethics of social workers in the field of health to solve complex ethical dilemmas in the activity of a social worker.: Patients and methods: Materials ... ...

Abstract	Objective: The aim: Coverage of the American experience of successful application of professional ethics of social workers in the field of health to solve complex ethical dilemmas in the activity of a social worker. Patients and methods: Materials and methods: The methodological basis of the study was the use of an axiological approach in identifying the values and ethics of the professional activity of social workers, a competence approach in determining the competence of a social work specialist in the field of health in matters of professional ethics, an interdisciplinary approach in integrating the ethical competence of a social work specialist in the practice of solving ethical dilemmas in the field of health, including in the process of work of an interdisciplinary team of specialists. Conclusion: Conclusions: The content and specifics of the practical application of the Code of Professional Ethics of the National Association of Social Workers of the USA in social work in the field of health were studied. It was determined that many situations in the practice of social work do not have simple answers when solving complex ethical issues in the field of health. Social workers, in addition to the values, principles and standards of the Code, in making decisions about professional actions in the field of health, must take into account their own beliefs and those of the client. The mechanism for the adjustment of difficult ethical choice cases in the practice of a social worker in the field of health is described.
MeSH term(s)	Decision Making ; Ethics, Professional ; Humans ; Morals ; Social Work ; Social Workers ; United States
Language	English
Publishing date	2022-04-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	414731-5
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
DOI	10.36740/WLek202208112
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Article ; Online: Epidemiology, Drug Resistance, and Virulence of

Kłos, Marta / Pomorska-Wesołowska, Monika / Romaniszyn, Dorota / Chmielarczyk, Agnieszka / Wójkowska-Mach, Jadwiga

Polish journal of microbiology

2019 Volume 68, Issue 4, Page(s) 541–548

Abstract: Analysis of the epidemiology of : Analysis of the epidemiology ... ...

Abstract	Analysis of the epidemiology of Analysis of the epidemiology of
MeSH term(s)	Adolescent ; Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Child ; Drug Resistance, Bacterial ; Eye Infections/epidemiology ; Eye Infections/microbiology ; Female ; Humans ; Microbial Sensitivity Tests ; Middle Aged ; Poland/epidemiology ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/classification ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Virulence Factors
Language	English
Publishing date	2019-12-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2234080-4
ISSN	2544-4646 ; 1733-1331
ISSN (online)	2544-4646
ISSN	1733-1331
DOI	10.33073/pjm-2019-056
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Article ; Online: Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells

Kamila Puchałowicz / Maciej Tarnowski / Marta Tkacz / Dariusz Chlubek / Patrycja Kłos / Violetta Dziedziejko

International Journal of Molecular Sciences, Vol 21, Iss 4425, p

2020 Volume 4425

Abstract: A new approach to improve the effectiveness of acute myeloid leukemia (AML) treatment is to use the properties of purinergic signaling molecules secreted into the bone marrow milieu in response to leukemic cell growth. Therefore, our study aimed to ... ...

Abstract	A new approach to improve the effectiveness of acute myeloid leukemia (AML) treatment is to use the properties of purinergic signaling molecules secreted into the bone marrow milieu in response to leukemic cell growth. Therefore, our study aimed to evaluate the effects of extracellular adenine nucleotides and adenosine on the growth and death parameters in the leukemic THP-1 cell line. Cells were exposed to ATP, ADP, AMP, adenosine and nonhydrolyzable analogues of ATP and ADP (ATPγS and ADPβS) in a 1–1000 μM broad concentration range. The basal mRNA expression of the P1 and P2 receptors was evaluated by real-time PCR. Changes in the processes of cell growth and death were assessed by flow cytometry analysis of proliferation, cell cycle and apoptosis. Chemotaxis toward stromal cell-derived factor-1 (SDF-1) was performed using the modified Boyden chamber assay, and chemokine receptor type 4 (CXCR4) surface expression was quantified by flow cytometry. We indicated several antileukemic actions. High micromolar concentrations (100–1000 μM) of extracellular adenine nucleotides and adenosine inhibit the growth of cells by arresting the cell cycle and/or inducing apoptosis. ATP is characterized by the highest potency and widest range of effects, and is responsible for the cell cycle arrest and the apoptosis induction. Compared to ATP, the effect of ADP is slightly weaker. Adenosine mostly has a cytotoxic effect, with the induction of apoptosis. The last studied nucleotide, AMP, demonstrated only a weak cytotoxic effect without affecting the cell cycle. In addition, cell migration towards SDF-1 was inhibited by low micromolar concentrations (10 μM). One of the reasons for this action of ATPγS and adenosine was a reduction in CXCR4 surface expression, but this only partially explains the mechanism of antimigratory action. In summary, extracellular adenine nucleotides and adenosine inhibit THP-1 cell growth, cause death of cells and modulate the functioning of the SDF-1/CXCR4 axis. Thus, they negatively affect the processes that are responsible for the progression of AML and the difficulties in AML treatment.
Keywords	acute myeloid leukemia ; apoptosis ; cell cycle ; chemoresistance ; cytotoxicity ; extracellular nucleotides ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells.

Puchałowicz, Kamila / Tarnowski, Maciej / Tkacz, Marta / Chlubek, Dariusz / Kłos, Patrycja / Dziedziejko, Violetta

International journal of molecular sciences

2020 Volume 21, Issue 12

Abstract	A new approach to improve the effectiveness of acute myeloid leukemia (AML) treatment is to use the properties of purinergic signaling molecules secreted into the bone marrow milieu in response to leukemic cell growth. Therefore, our study aimed to evaluate the effects of extracellular adenine nucleotides and adenosine on the growth and death parameters in the leukemic THP-1 cell line. Cells were exposed to ATP, ADP, AMP, adenosine and nonhydrolyzable analogues of ATP and ADP (ATPγS and ADPβS) in a 1-1000 μM broad concentration range. The basal mRNA expression of the P1 and P2 receptors was evaluated by real-time PCR. Changes in the processes of cell growth and death were assessed by flow cytometry analysis of proliferation, cell cycle and apoptosis. Chemotaxis toward stromal cell-derived factor-1 (SDF-1) was performed using the modified Boyden chamber assay, and chemokine receptor type 4 (CXCR4) surface expression was quantified by flow cytometry. We indicated several antileukemic actions. High micromolar concentrations (100-1000 μM) of extracellular adenine nucleotides and adenosine inhibit the growth of cells by arresting the cell cycle and/or inducing apoptosis. ATP is characterized by the highest potency and widest range of effects, and is responsible for the cell cycle arrest and the apoptosis induction. Compared to ATP, the effect of ADP is slightly weaker. Adenosine mostly has a cytotoxic effect, with the induction of apoptosis. The last studied nucleotide, AMP, demonstrated only a weak cytotoxic effect without affecting the cell cycle. In addition, cell migration towards SDF-1 was inhibited by low micromolar concentrations (10 μM). One of the reasons for this action of ATPγS and adenosine was a reduction in CXCR4 surface expression, but this only partially explains the mechanism of antimigratory action. In summary, extracellular adenine nucleotides and adenosine inhibit THP-1 cell growth, cause death of cells and modulate the functioning of the SDF-1/CXCR4 axis. Thus, they negatively affect the processes that are responsible for the progression of AML and the difficulties in AML treatment.
MeSH term(s)	Adenosine/pharmacology ; Adenosine Diphosphate/analogs & derivatives ; Adenosine Diphosphate/pharmacology ; Adenosine Monophosphate/pharmacology ; Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/pharmacology ; Affinity Labels ; Apoptosis ; Cell Cycle ; Cell Movement ; Cell Proliferation ; Extracellular Matrix/metabolism ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Thionucleotides/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Affinity Labels ; Thionucleotides ; adenosine 5'-O-(2-thiodiphosphate) (35094-45-2) ; adenosine 5'-O-(3-thiotriphosphate) (35094-46-3) ; Adenosine Monophosphate (415SHH325A) ; Adenosine Diphosphate (61D2G4IYVH) ; Adenosine Triphosphate (8L70Q75FXE) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2020-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21124425
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Article ; Online: Combining diaries and accelerometers to explain change in physical activity during a lifestyle intervention for adults with pre-diabetes: A PREVIEW sub-study.

Klos, Leon / Stratton, Gareth / Mackintosh, Kelly A / McNarry, Melitta A / Fogelholm, Mikael / Drummen, Mathijs / Macdonald, Ian / Martinez, J Alfredo / Navas-Carretero, Santiago / Handjieva-Darlenska, Teodora / Bogdanov, Georgi / Gant, Nicholas / Poppitt, Sally D / Silvestre, Marta P / Brand-Miller, Jennie / Muirhead, Roslyn / Schlicht, Wolfgang / Huttunen-Lenz, Maija / Brodie, Shannon /

Jalo, Elli / Westerterp-Plantenga, Margriet / Adam, Tanja / Siig Vestentoft, Pia / Tikkanen, Heikki / Quist, Jonas S / Raben, Anne / Swindell, Nils

PloS one

2024 Volume 19, Issue 3, Page(s) e0300646

Abstract: Self-report and device-based measures of physical activity (PA) both have unique strengths and limitations; combining these measures should provide complementary and comprehensive insights to PA behaviours. Therefore, we aim to 1) identify PA clusters ... ...

Abstract	Self-report and device-based measures of physical activity (PA) both have unique strengths and limitations; combining these measures should provide complementary and comprehensive insights to PA behaviours. Therefore, we aim to 1) identify PA clusters and clusters of change in PA based on self-reported daily activities and 2) assess differences in device-based PA between clusters in a lifestyle intervention, the PREVIEW diabetes prevention study. In total, 232 participants with overweight and prediabetes (147 women; 55.9 ± 9.5yrs; BMI ≥25 kg·m-2; impaired fasting glucose and/or impaired glucose tolerance) were clustered using a partitioning around medoids algorithm based on self-reported daily activities before a lifestyle intervention and their changes after 6 and 12 months. Device-assessed PA levels (PAL), sedentary time (SED), light PA (LPA), and moderate-to-vigorous PA (MVPA) were assessed using ActiSleep+ accelerometers and compared between clusters using (multivariate) analyses of covariance. At baseline, the self-reported "walking and housework" cluster had significantly higher PAL, MVPA and LPA, and less SED than the "inactive" cluster. LPA was higher only among the "cycling" cluster. There was no difference in the device-based measures between the "social-sports" and "inactive" clusters. Looking at the changes after 6 months, the "increased walking" cluster showed the greatest increase in PAL while the "increased cycling" cluster accumulated the highest amount of LPA. The "increased housework" and "increased supervised sports" reported least favourable changes in device-based PA. After 12 months, there was only minor change in activities between the "increased walking and cycling", "no change" and "increased supervised sports" clusters, with no significant differences in device-based measures. Combining self-report and device-based measures provides better insights into the behaviours that change during an intervention. Walking and cycling may be suitable activities to increase PA in adults with prediabetes.
MeSH term(s)	Adult ; Humans ; Female ; Prediabetic State/therapy ; Exercise ; Life Style ; Walking ; Accelerometry
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300646
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Article: Does Hospitalization Change the Perception of COVID-19 Vaccines among Unvaccinated Patients?

Zarębska-Michaluk, Dorota / Rzymski, Piotr / Moniuszko-Malinowska, Anna / Brzdęk, Michał / Martonik, Diana / Rorat, Marta / Wielgat, Jakub / Kłos, Krzysztof / Musierowicz, Witold / Wasilewski, Piotr / Mazur, Włodzimierz / Oczko-Grzesik, Barbara / Bociąga-Jasik, Monika / Kowalska, Justyna / Flisiak, Robert

Vaccines

2022 Volume 10, Issue 3

Abstract: The COVID-19 vaccination has been the subject of unprecedented misinformation, false news, and public concerns. This study presents a unique analysis comprising persons who were not vaccinated and became ill. It investigates reasons for not vaccinating ... ...

Abstract	The COVID-19 vaccination has been the subject of unprecedented misinformation, false news, and public concerns. This study presents a unique analysis comprising persons who were not vaccinated and became ill. It investigates reasons for not vaccinating and evaluates how the personal experience of COVID-19 affected further attitudes and decisions related to health. The study included 730 consecutive unvaccinated patients hospitalized in 12 centers in Poland during the autumn 2021 pandemic wave. The most frequent reason behind the refusal to receive the vaccine was concern over the adverse effects, disbelief that the vaccine was sufficiently tested, and one's conviction that COVID-19 will not affect a patient. Online information, friends, spouse, children/grandchildren, and other family members were most often the source of discouragement from vaccination. Most individuals regretted their decision not to receive a vaccine (66.0%), declared to promote COVID-19 vaccination after discharge (64.0%), and to receive a COVID-19 vaccine in the time recommended for convalescents (69.5%). Individuals expressing no regrets of vaccine refusal more frequently revealed conspiracy beliefs. The study shows that personal experience with severe COVID-19 can influence the perception of vaccination, but approximately one-third of unvaccinated hospitalized patients still appear to express vaccine hesitancy.
Language	English
Publishing date	2022-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10030476
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