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  1. Article ; Online: Martin Silverman, M.D. 1935-2019.

    Colombo, Daria

    The Psychoanalytic quarterly

    2022  Volume 89, Issue 1, Page(s) 153–157

    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207522-2
    ISSN 2167-4086 ; 0033-2828
    ISSN (online) 2167-4086
    ISSN 0033-2828
    DOI 10.1080/00332828.2020.1688554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 386: Show issues Location:
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  2. Article ; Online: Generation of iPSCs from identical twin, one affected by LHON and one unaffected, both carrying a combination of two mitochondrial variants: m.14484 T>C and m.10680G>A.

    Peron, Camille / Cavaliere, Andrea / Fasano, Chiara / Iannielli, Angelo / Spagnolo, Manuela / Legati, Andrea / Nicol Colombo, Maria / Rizzo, Ambra / Sciacca, Francesca L / Carelli, Valerio / Broccoli, Vania / Lamperti, Costanza / Tiranti, Valeria

    Stem cell research

    2024  Volume 77, Page(s) 103406

    Abstract: ... with key mutations being m.3460G > A, m.11778G > A, and m.14484 T > C. Fibroblasts from identical twins ... sharing m.14484 T > C and m.10680G > A variants each with 70 % heteroplasmy, were used to generate iPSC ... unravelling the role of m.10680G > A, which is still debated. ...

    Abstract Leber hereditary optic neuropathy (LHON) is one of the most common mitochondrial illness, causing retinal ganglion cell degeneration and central vision loss. It stems from point mutations in mitochondrial DNA (mtDNA), with key mutations being m.3460G > A, m.11778G > A, and m.14484 T > C. Fibroblasts from identical twins, sharing m.14484 T > C and m.10680G > A variants each with 70 % heteroplasmy, were used to generate iPSC lines. Remarkably, one twin, a LHON patient, displayed symptoms, while the other, a carrier, remained asymptomatic. These iPSCs offer a valuable tool for studying factors influencing disease penetrance and unravelling the role of m.10680G > A, which is still debated.
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2024.103406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Article ; Online: M-LED

    Falchetta, Giacomo / Stevanato, Nicolò / Moner-Girona, Magda / Mazzoni, Davide / Colombo, Emanuela / Hafner, Manfred

    Multi-sectoral Latent Electricity Demand Assessment for Energy Access Planning

    2020  

    Abstract: ... cost assessments. Here we introduce M-LED, Multi-sectoral Latent Electricity Demand, a geospatial data ...

    Abstract Globally about 800 million people live without electricity at home, over two thirds of which are in sub-Saharan Africa. Ending energy poverty is a key development priority because energy plays an enabling role for human wellbeing and economic activities. Planning electricity access infrastructure and allocating resources efficiently requires a careful assessment of the diverse energy needs across space, time, and sectors. However, because of data scarcity, most country or regional-scale electrification planning studies have been based on top-down electricity demand targets. Yet, poorly representing the heterogeneity in the electricity demand can lead to inappropriate energy planning, inaccurate energy system sizing, and misleading cost assessments. Here we introduce M-LED, Multi-sectoral Latent Electricity Demand, a geospatial data processing platform to estimate electricity demand in communities that live in energy poverty. The key novelties of the platform are the multi-sectoral, bottom-up, time-explicit demand evaluation and the assessment of water-energy-agriculture-development interlinkages. We apply the methodology to the country-study of Kenya. Our findings suggest that a bottom-up approach to evaluating energy needs across space, time, and sectors is likely to improve the reliability and accuracy of supply-side electrification modelling and therefore of electrification planning and policy.
    Keywords ddc:330 ; Q4 ; Q41 ; O13 ; Electricity Access ; Energy Demand ; Rural Development ; Bottom-up Modelling ; Sub-Saharan Africa ; Multi-sectoral Approach ; Water-Energy-Food-Environment Nexus
    Subject code 690
    Language English
    Publisher Milano: Fondazione Eni Enrico Mattei (FEEM)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: I’m No Superman

    Arthur Holtzclaw / Jack Ellis / Christopher Colombo

    BMC Medical Education, Vol 21, Iss 1, Pp 1-

    fostering physician resilience through guided group discussion of Scrubs

    2021  Volume 6

    Abstract: Abstract Background Almost half of trainees experience burnout during their career. Despite the Accreditation Council on Graduate Medical Education (ACGME) recommendation that training programs enact well-being curricula, there is no proven method of ... ...

    Abstract Abstract Background Almost half of trainees experience burnout during their career. Despite the Accreditation Council on Graduate Medical Education (ACGME) recommendation that training programs enact well-being curricula, there is no proven method of addressing this difficult topic. Methods We created a curriculum addressing physician resiliency and well-being, designed for an Internal Medicine Residency Program. This curriculum utilized episodes from a medical television series, Scrubs, to facilitate a monthly, 1-h faculty guided discussion group. We collected informal feedback and abbreviated Maslach Burnout Inventories (aMBI) monthly and conducted a formal focus group after 6 months to gauge its effectiveness. Results The curriculum was successfully conducted for 12 months with each session averaging 18–20 residents. Residents reported high satisfaction, stating it was more enjoyable and helpful than traditional resiliency training. 19 of 24 residents (79 %) completed a baseline aMBI, and 17 of 20 residents (85 %) who attended the most recent session completed the 6-month follow-up, showing a non-significant 1-point improvement in all subsets of the aMBI. Conclusions This novel, low-cost, easily implemented curriculum addressed resiliency and burn-out in an Internal Medicine Residency. It was extremely well received and can easily be expanded to other training programs or to providers outside of training.
    Keywords Physician wellbeing ; Burnout ; GME ; Curriculum ; Media in education ; Special aspects of education ; LC8-6691 ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Extracellular vesicles from PBDE-47 treated M(LPS) THP-1 macrophages modulate the expression of markers of epithelial integrity, EMT, inflammation and muco-secretion in ALI culture of airway epithelium.

    Albano, Giusy Daniela / Longo, Valeria / Montalbano, Angela Marina / Aloi, Noemi / Barone, Rosario / Cibella, Fabio / Profita, Mirella / Colombo, Paolo

    Life sciences

    2023  Volume 322, Page(s) 121616

    Abstract: ... lung epithelial cells.: Main methods: sEVs from M(LPS) THP-1 macrophage-like cells after PBDE-47 ...

    Abstract Aims: The lung epithelial cells form a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli. These cells interact with several other cellular components, of which macrophages are some of the most relevant. We analysed the effects of the PBDE-47 on the microRNA cargo of THP-1 macrophage like derived small Extracellular Vesicles (sEVs) and the effects on A549 lung epithelial cells.
    Main methods: sEVs from M(LPS) THP-1 macrophage-like cells after PBDE-47 treatment (sEVs
    Key findings: sEVs
    Significance: PBDE-47 treated macrophages secrete sEVs with altered microRNA cargo that affect the mRNA expression of TJs, adhesion molecules, cytokines and EMT markers damaging the normal function of the lung epithelium, potentially contributing to the development of lung diseases.
    MeSH term(s) Humans ; Lipopolysaccharides/pharmacology ; MicroRNAs/metabolism ; Macrophages/metabolism ; Epithelium/metabolism ; Extracellular Vesicles/metabolism ; Lung/metabolism ; Inflammation/metabolism
    Chemical Substances pentabromodiphenyl ether (7REL09ZX35) ; 2,2',4,4'-tetrabromodiphenyl ether (0N97R5X10X) ; Lipopolysaccharides ; MicroRNAs
    Language English
    Publishing date 2023-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.368: Show issues Location:
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  6. Article ; Online: The rationale for the use of colchicine in COVID-19: comments on the letter by Cumhur Cure M et al.

    Piantoni, Silvia / Colombo, Enrico / Airò, Paolo / Tincani, Angela / Brucato, Antonio / Franceschini, Franco / Andreoli, Laura / Furloni, Roberto / Scarsi, Mirko

    Clinical rheumatology

    2020  Volume 39, Issue 8, Page(s) 2489–2490

    MeSH term(s) Betacoronavirus ; COVID-19 ; Colchicine ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Colchicine (SML2Y3J35T)
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-05232-y
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    Zs.A 1740: Show issues Location:
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  7. Article ; Online: Reply to M.L. Friedlander et al.

    Colombo, Nicoletta

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2013  Volume 31, Issue 18, Page(s) 2363

    MeSH term(s) Doxorubicin/analogs & derivatives ; Epothilones/therapeutic use ; Fallopian Tube Neoplasms/drug therapy ; Female ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Neoplasms, Glandular and Epithelial/drug therapy ; Ovarian Neoplasms/drug therapy ; Peritoneal Neoplasms/drug therapy ; Polyethylene Glycols/therapeutic use
    Chemical Substances Epothilones ; Polyethylene Glycols (30IQX730WE) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2013-06-20
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2012.48.3750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  8. Article ; Online: Extracellular vesicles from PBDE-47 treated M(LPS) THP-1 macrophages modulate the expression of markers of epithelial integrity, EMT, inflammation and muco-secretion in ALI culture of airway epithelium

    Albano, Giusy Daniela / Longo, Valeria / Montalbano, Angela Marina / Aloi, Noemi / Barone, Rosario / Cibella, Fabio / Profita, Mirella / Colombo, Paolo

    Life Sciences. 2023 June, v. 322 p.121616-

    2023  

    Abstract: ... lung epithelial cells. sEVs from M(LPS) THP-1 macrophage-like cells after PBDE-47 treatment ...

    Abstract The lung epithelial cells form a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli. These cells interact with several other cellular components, of which macrophages are some of the most relevant. We analysed the effects of the PBDE-47 on the microRNA cargo of THP-1 macrophage like derived small Extracellular Vesicles (sEVs) and the effects on A549 lung epithelial cells. sEVs from M(LPS) THP-1 macrophage-like cells after PBDE-47 treatment (sEVsᴾᴮᴰᴱ⁺ᴸᴾS) were characterized by nanoparticle tracking analysis and their microRNA cargo studied by qPCR. Confocal microscopy was applied to study sEVs cellular uptake by A549 cells. The expression of tight junctions (TJs), adhesion molecules, inflammation markers and mucus production in A549 cultured in air liquid interface (ALI) conditions were studied by Real Time PCR and confocal microscopy. sEVsᴾᴮᴰᴱ⁺ᴸᴾS microRNA cargo analysis showed that the PBDE-47 modulated the expression of the miR-15a-5p, miR29a-3p, miR-143-3p and miR-122-5p. Furthermore, ALI cultured A549 cells incubated with sEVsᴾᴮᴰᴱ⁺ᴸᴾS showed that zonula occludens-1 (p ≤ 0.04), claudin (p ≤ 0.02), E-cadherin (p ≤ 0.006) and Vimentin (p ≤ 0.0008) mRNAs were increased in A549 cells after sEVsᴾᴮᴰᴱ⁺ᴸᴾS treatment. Indeed, Interleukin (IL)-8 (p ≤ 0.008) and mucin (MUC5AC and MUC5B) (p ≤ 0.03 and p ≤ 0.0001) mRNA expression were up- and down-regulated, respectively. PBDE-47 treated macrophages secrete sEVs with altered microRNA cargo that affect the mRNA expression of TJs, adhesion molecules, cytokines and EMT markers damaging the normal function of the lung epithelium, potentially contributing to the development of lung diseases.
    Keywords adhesion ; cadherins ; confocal microscopy ; epithelium ; gene expression ; inflammation ; interleukins ; liquid-air interface ; lungs ; macrophages ; microRNA ; mucins ; mucus ; nanoparticles ; quantitative polymerase chain reaction ; vimentin ; ALI ; AMs ; DAMPs ; DMSO ; ECs ; EGF like ; EMT ; IL-13 ; IL-17 ; IL-1b ; IL-6 ; IL-8 ; LPS ; MUC5AC ; MUC5B ; NTA ; PBDE-47 ; PMA ; sEVs ; sEVsDMSO+LPS ; sEVsPBDE+LPS ; TJ ; TNF-a ; YAP1 ; ZO-1 ; Epithelial cells ; Cell-cell communication ; Airway diseases
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121616
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 73/732: Show issues

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  9. Article: The rationale for the use of colchicine in COVID-19: comments on the letter by Cumhur Cure M et al

    Piantoni, Silvia / Colombo, Enrico / Airò, Paolo / Tincani, Angela / Brucato, Antonio / Franceschini, Franco / Andreoli, Laura / Furloni, Roberto / Scarsi, Mirko

    Clin Rheumatol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610104
    Database COVID19

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  10. Article: The sample of M&A

    Colombo, Massimo G / Garrone, Paola

    Mergers & acquisitions : the innovation impact , p. 89-103

    descriptive statistics

    2006  , Page(s) 89–103

    Author's details Massimo G. Colombo and Paola Garrone
    Keywords 50
    Language English
    Publisher Elgar
    Publishing place Cheltenham [u.a.]
    Document type Article
    Database ECONomics Information System

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