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  1. Article ; Online: Reducing "COVID-19 Misinformation" While Preserving Free Speech.

    Sage, William M / Yang, Y Tony

    JAMA

    2022  Volume 327, Issue 15, Page(s) 1443–1444

    MeSH term(s) COVID-19 ; Communication ; Human Rights ; Humans ; Social Media ; Speech
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.4231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Editorial: Highlights for Cardiovascular Therapeutics in 2021 - Trained Immunity, Immunometabolism, Gender Differences of Cardiovascular Diseases, and Novel Targets of Cardiovascular Therapeutics.

    Yang, William Y / Nguyen, Bonnie / Wu, Sheng / Yu, Jun / Wang, Hong / Yang, Xiaofeng

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 892288

    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.892288
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  3. Article: CL-705G: a novel chemical Kir6.2-specific K

    Gando, Ivan / Becerra Flores, Manuel / Chen, I-Shan / Yang, Hua-Qian / Nakamura, Tomoe Y / Cardozo, Timothy J / Coetzee, William A

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1197257

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1197257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthesis of medium-ring lactams and macrocyclic peptide mimetics

    Palate, Kleopas Y / Yang, Zhongzhen / Whitwood, Adrian C / Unsworth, William P

    RSC chemical biology

    2022  Volume 3, Issue 3, Page(s) 334–340

    Abstract: A novel conjugate addition/ring expansion (CARE) cascade reaction sequence is reported that enables medium-sized ring and macrocyclic bis-lactams to be prepared from primary amines and cyclic imides. The reactions are simple to perform, generally high ... ...

    Abstract A novel conjugate addition/ring expansion (CARE) cascade reaction sequence is reported that enables medium-sized ring and macrocyclic bis-lactams to be prepared from primary amines and cyclic imides. The reactions are simple to perform, generally high yielding, and very broad in scope, especially with respect to the primary amine component. CARE reactions can also be performed iteratively, enabling β-peptoid-based macrocyclic peptide mimetics to be 'grown'
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article
    ISSN 2633-0679
    ISSN (online) 2633-0679
    DOI 10.1039/d1cb00245g
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  5. Article ; Online: Nuclear Actin Polymerization Regulates Cell Epithelial-Mesenchymal Transition.

    Du, William W / Qadir, Javeria / Du, Kevin Y / Chen, Yu / Wu, Nan / Yang, Burton B

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 28, Page(s) e2300425

    Abstract: Current studies on actin function primarily rely on cytoplasmic actin due to the absence of cellular models specifically expressing nuclear actin. Here, cell models capable of expressing varying levels of nuclear F/G-actin are generated and a significant ...

    Abstract Current studies on actin function primarily rely on cytoplasmic actin due to the absence of cellular models specifically expressing nuclear actin. Here, cell models capable of expressing varying levels of nuclear F/G-actin are generated and a significant role of nuclear actin in the regulation of epithelial-mesenchymal transition (EMT) is uncovered. Through immunoprecipitation and mass spectrometry analyses, distinct binding partners for nuclear F-actin (β-catenin, SMAD2, and SMAD3) and nuclear G-actin (MYBBP1A, NKRF, and MYPOP) are investigated, which respectively modulate EMT-promoting and EMT-repressing transcriptional events. While nuclear F-actin promotes EMT with enhanced cell migration, survival, and elongated mesenchymal morphology, nuclear G-actin represses EMT and related cell activities. Mechanistically, nuclear F-actin enhances β-catenin, SMAD2, and SMAD3 expression and stability in the nuclei, while nuclear G-actin increases MYBBP1A, NKRF, and MYPOP expression and stability in the nuclei. The association between nuclear F/G-actin and N-cadherin/E-cadherin in the cell lines (in vitro), and increased nuclear actin polymerization in the wound healing cells (in vivo) affirm a significant role of nuclear actin in EMT regulation. With evidence of nuclear actin polymerization and EMT during development, and irregularities in disease states such as cancer and fibrosis, targeting nuclear actin dynamics to trigger dysregulated EMT warrants ongoing study.
    Language English
    Publishing date 2023-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202300425
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  6. Article ; Online: The convergence of tumor suppressors on the type I interferon pathway in clear cell renal cell carcinoma and its therapeutic implications.

    Langbein, Lauren E / El Hajjar, Rayan / Kim, William Y / Yang, Haifeng

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 5, Page(s) C1417–C1429

    Abstract: In clear cell renal cell carcinoma (ccRCC), the von Hippel-Lindau tumor suppressor gene/hypoxia inducible factor (VHL/HIF) axis lays the groundwork for tumorigenesis and is the target of many therapeutic agents. HIF activation alone, however, is largely ... ...

    Abstract In clear cell renal cell carcinoma (ccRCC), the von Hippel-Lindau tumor suppressor gene/hypoxia inducible factor (VHL/HIF) axis lays the groundwork for tumorigenesis and is the target of many therapeutic agents. HIF activation alone, however, is largely insufficient for kidney tumor development, and secondary mutations in
    MeSH term(s) Humans ; Carcinoma, Renal Cell/drug therapy ; Von Hippel-Lindau Tumor Suppressor Protein/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Interferon Type I/therapeutic use ; Gene Expression Regulation, Neoplastic ; Kidney Neoplasms/drug therapy ; Cell Transformation, Neoplastic/genetics
    Chemical Substances Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; Interferon Type I
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00255.2022
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article: Predicting the Efficacy of SBRT for Lung Cancer with

    Chen, Kuifei / Hou, Liqiao / Chen, Meng / Li, Shuling / Shi, Yangyang / Raynor, William Y / Yang, Haihua

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Purpose: to develop a radiogenomic model on the basis of : Methods: A total of 123 patients with lung cancer who had undergone : Results: A total of 2042 radiomics features were extracted. Five radiomic features were related to the PFS ... ...

    Abstract Purpose: to develop a radiogenomic model on the basis of
    Methods: A total of 123 patients with lung cancer who had undergone
    Results: A total of 2042 radiomics features were extracted. Five radiomic features were related to the PFS stratification of lung-cancer patients with SBRT. T-stage and overall stages (TNM) were independent factors for predicting PFS stratification. AUCs under the ROC curve of the radiomics, clinical EGFR, and radiogenomic models were 0.84, 0.67, and 0.86, respectively. The calibration curve shows that the predicted value of the radiogenomic model was in good agreement with the actual value. The decision and influence curve showed that the model had high clinical application values. After Bootstrap validation, the mean AUC of the radiogenomic model was 0.850(95%CI 0.849-0.851).
    Conclusions: The radiogenomic model based on
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040884
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  8. Article ; Online: Huntington's Disease: Genome-wide Neuroprotection Screening Goes Viral.

    Lee, C Y Daniel / Yang, X William

    Neuron

    2020  Volume 106, Issue 1, Page(s) 4–6

    Abstract: Forward genetic screen, typically performed in invertebrates or mammalian cell lines, has been instrumental in discovering genes essential for neural function. In this issue of Neuron, Wertz et al. (2020) demonstrate the first viral-mediated, genome-wide ...

    Abstract Forward genetic screen, typically performed in invertebrates or mammalian cell lines, has been instrumental in discovering genes essential for neural function. In this issue of Neuron, Wertz et al. (2020) demonstrate the first viral-mediated, genome-wide screen to identify neuroprotective genes in wild-type and Huntington's disease (HD) mouse brains.
    MeSH term(s) Animals ; Cell Death ; Cell Survival ; Huntington Disease ; Mice ; Neurons ; Neuroprotection
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.03.020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  9. Article ; Online: Correction to: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.

    Sharma, Vinay Kumar / Yang, Xuyu / Kim, Soo-Kyung / Mafi, Amirhossein / Saiz-Sanchez, Daniel / Villanueva-Anguita, Patricia / Xiao, Lan / Inoue, Asuka / Goddard, William A / Loh, Y Peng / Toulabi, Leila

    Cellular and molecular life sciences : CMLS

    2023  Volume 80, Issue 3, Page(s) 65

    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-023-04711-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Electrochemical studies of tris(cyclopentadienyl)thorium and uranium complexes in the +2, +3, and +4 oxidation states.

    Wedal, Justin C / Barlow, Jeffrey M / Ziller, Joseph W / Yang, Jenny Y / Evans, William J

    Chemical science

    2021  Volume 12, Issue 24, Page(s) 8501–8511

    Abstract: Electrochemical measurements on tris(cyclopentadienyl)thorium and uranium compounds in the +2, +3, and +4 oxidation states are reported with ... ...

    Abstract Electrochemical measurements on tris(cyclopentadienyl)thorium and uranium compounds in the +2, +3, and +4 oxidation states are reported with C
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc01906f
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