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  1. Article ; Online: Autopsy Histopathologic Cardiac Findings in 2 Adolescents Following the Second COVID-19 Vaccine Dose.

    Paddock, Christopher D / Reagan-Steiner, Sarah / Su, John R / Oster, Matthew E / Martines, Roosecelis B / Bhatnagar, Julu / Shimabukuro, Tom T

    Archives of pathology & laboratory medicine

    2022  Volume 146, Issue 8, Page(s) 921–923

    MeSH term(s) Adolescent ; Autopsy ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Cause of Death ; Humans ; Myocardium/pathology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2022-0084-LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Difficulties in Differentiating Coronaviruses from Subcellular Structures in Human Tissues by Electron Microscopy.

    Bullock, Hannah A / Goldsmith, Cynthia S / Zaki, Sherif R / Martines, Roosecelis B / Miller, Sara E

    Emerging infectious diseases

    2021  Volume 27, Issue 4, Page(s) 1023–1031

    Abstract: Efforts to combat the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have placed a renewed focus on the use of transmission electron microscopy for identifying coronavirus in tissues. In ... ...

    Abstract Efforts to combat the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have placed a renewed focus on the use of transmission electron microscopy for identifying coronavirus in tissues. In attempts to attribute pathology of COVID-19 patients directly to tissue damage caused by SARS-CoV-2, investigators have inaccurately reported subcellular structures, including coated vesicles, multivesicular bodies, and vesiculating rough endoplasmic reticulum, as coronavirus particles. We describe morphologic features of coronavirus that distinguish it from subcellular structures, including particle size range (60-140 nm), intracellular particle location within membrane-bound vacuoles, and a nucleocapsid appearing in cross section as dense dots (6-12 nm) within the particles. In addition, although the characteristic spikes of coronaviruses may be visible on the virus surface, especially on extracellular particles, they are less evident in thin sections than in negative stain preparations.
    MeSH term(s) Biopsy/methods ; COVID-19/pathology ; COVID-19/virology ; Cellular Structures/classification ; Cellular Structures/ultrastructure ; Humans ; Microscopy, Electron/methods ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/ultrastructure
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2704.204337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electron microscopy of SARS-CoV-2: a challenging task.

    Goldsmith, Cynthia S / Miller, Sara E / Martines, Roosecelis B / Bullock, Hannah A / Zaki, Sherif R

    Lancet (London, England)

    2020  Volume 395, Issue 10238, Page(s) e99

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Endothelial Cells ; Humans ; Microscopy, Electron ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31188-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Zika Virus: Pathology From the Pandemic.

    Ritter, Jana M / Martines, Roosecelis B / Zaki, Sherif R

    Archives of pathology & laboratory medicine

    2017  Volume 141, Issue 1, Page(s) 49–59

    Abstract: Context: -As the number of Zika virus (ZIKV) infections continues to grow, so, too, does the spectrum of recognized clinical disease, in both adult and congenital infections. Defining the tissue pathology associated with the various disease ... ...

    Abstract Context: -As the number of Zika virus (ZIKV) infections continues to grow, so, too, does the spectrum of recognized clinical disease, in both adult and congenital infections. Defining the tissue pathology associated with the various disease manifestations provides insight into pathogenesis and diagnosis, and potentially future prevention and treatment, of ZIKV infections.
    Objective: -To summarize the syndromes and pathology associated with ZIKV infection, the implications of pathologic findings in the pathogenesis of ZIKV disease, and the use of pathology specimens for diagnosis of ZIKV infection.
    Data sources: -The major sources of information for this review were published articles obtained from PubMed and pathologic findings from cases submitted to the Infectious Diseases Pathology Branch at the Centers for Disease Control and Prevention.
    Conclusions: -Pathologic findings associated with ZIKV infection are characteristic but not specific. In congenital Zika syndrome, tissue pathology is due to direct viral infection of neural structures, whereas in Guillain-Barré syndrome, pathology is likely due to a postviral, aberrant host-directed immune response. Both fetal and placental pathology specimens are useful for ZIKV diagnosis by molecular and immunohistochemical assays; however, the implications of ZIKV detection in placentas from second- and third-trimester normal live births are unclear, as the potential postnatal effects of late gestational exposure remain to be seen.
    MeSH term(s) Congenital Abnormalities/pathology ; Congenital Abnormalities/virology ; Female ; Fetus/pathology ; Fetus/virology ; Humans ; Pandemics ; Placenta/pathology ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology ; Zika Virus/physiology ; Zika Virus Infection/epidemiology ; Zika Virus Infection/pathology ; Zika Virus Infection/virology
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2016-0397-SA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pathology and Monkeypox virus Localization in Tissues From Immunocompromised Patients With Severe or Fatal Mpox.

    Ritter, Jana M / Martines, Roosecelis B / Bhatnagar, Julu / Rao, Agam K / Villalba, Julian A / Silva-Flannery, Luciana / Lee, Elizabeth / Bullock, Hannah A / Hutson, Christina L / Cederroth, Terra / Harris, Cynthia K / Hord, Kristin / Xu, Ya / Brown, Cameron A / Guccione, Jack P / Miller, Matthew / Paddock, Christopher D / Reagan-Steiner, Sarah

    The Journal of infectious diseases

    2024  Volume 229, Issue Supplement_2, Page(s) S219–S228

    Abstract: Background: Pathology and Monkeypox virus (MPXV) tissue tropism in severe and fatal human mpox is not thoroughly described but can help elucidate the disease pathogenesis and the role of coinfections in immunocompromised patients.: Methods: We ... ...

    Abstract Background: Pathology and Monkeypox virus (MPXV) tissue tropism in severe and fatal human mpox is not thoroughly described but can help elucidate the disease pathogenesis and the role of coinfections in immunocompromised patients.
    Methods: We analyzed biopsy and autopsy tissues from 22 patients with severe or fatal outcomes to characterize pathology and viral antigen and DNA distribution in tissues by immunohistochemistry and in situ hybridization. Tissue-based testing for coinfections was also performed.
    Results: Mucocutaneous lesions showed necrotizing and proliferative epithelial changes. Deceased patients with autopsy tissues evaluated had digestive tract lesions, and half had systemic tissue necrosis with thrombotic vasculopathy in lymphoid tissues, lung, or other solid organs. Half also had bronchopneumonia, and one-third had acute lung injury. All cases had MPXV antigen and DNA detected in tissues. Coinfections were identified in 5 of 16 (31%) biopsy and 4 of 6 (67%) autopsy cases.
    Conclusions: Severe mpox in immunocompromised patients is characterized by extensive viral infection of tissues and viremic dissemination that can progress despite available therapeutics. Digestive tract and lung involvement are common and associated with prominent histopathological and clinical manifestations. Coinfections may complicate mpox diagnosis and treatment. Significant viral DNA (likely correlating to infectious virus) in tissues necessitates enhanced biosafety measures in healthcare and autopsy settings.
    MeSH term(s) Humans ; Coinfection ; Monkeypox virus ; Mpox (monkeypox) ; Immunocompromised Host ; Antigens, Viral ; DNA, Viral
    Chemical Substances Antigens, Viral ; DNA, Viral
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad574
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  7. Article ; Online: Electron microscopy of SARS-CoV-2

    Goldsmith, Cynthia S / Miller, Sara E / Martines, Roosecelis B / Bullock, Hannah A / Zaki, Sherif R

    The Lancet

    a challenging task

    2020  Volume 395, Issue 10238, Page(s) e99

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31188-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Notes from the Field: Severe Bartonella quintana Infections Among Persons Experiencing Unsheltered Homelessness - New York City, January 2020-December 2022.

    Rich, Shannan N / Beeson, Amy / Seifu, Leah / Mitchell, Kara / Wroblewski, Danielle / Juretschko, Stefan / Keller, Marina / Gnanaprakasam, Rachel / Agladze, Mariam / Kodama, Rich / Kupferman, Tania / Bhatnagar, Julu / Martines, Roosecelis B / Reagan-Steiner, Sarah / Slavinski, Sally / Kuehnert, Matthew J / Bergeron-Parent, Camille / Corvese, Gabriella / Marx, Grace E /
    Ackelsberg, Joel

    MMWR. Morbidity and mortality weekly report

    2023  Volume 72, Issue 42, Page(s) 1147–1148

    MeSH term(s) Humans ; Trench Fever ; New York City/epidemiology ; Ill-Housed Persons
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7242a3
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  9. Article ; Online: Melioidosis in Cynomolgus Macaques (

    Taetzsch, Sara J / Swaney, Erin M / Gee, Jay E / Hidalgo, Pablo M / Broussard, Kelly R / Martines, Roosecelis B / Blaney, David D / Galland, G Gale / Gulvik, Christopher A / Marston, Chung K / Liu, Lindy / Elrod, Mindy G / DeLeon-Carnes, Marlene / Tyler, Ronald D / Bower, William A / Bhatnager, Julu / Brown, Clive M / Pieracci, Emily G / Weiner, Zachary P

    Comparative medicine

    2023  Volume 72, Issue 6, Page(s) 394–402

    Abstract: Melioidosis, a potentially fatal infectious disease of humans and animals, including nonhuman primates (NHPs), is caused by the high-consequence ... ...

    Abstract Melioidosis, a potentially fatal infectious disease of humans and animals, including nonhuman primates (NHPs), is caused by the high-consequence pathogen
    MeSH term(s) Humans ; United States ; Animals ; Melioidosis/diagnosis ; Melioidosis/epidemiology ; Melioidosis/veterinary ; Macaca fascicularis ; Abscess ; Cambodia ; Burkholderia pseudomallei
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2006425-1
    ISSN 2769-819X ; 0023-6764 ; 1532-0820
    ISSN (online) 2769-819X
    ISSN 0023-6764 ; 1532-0820
    DOI 10.30802/AALAS-CM-22-000024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intersecting Paths of Emerging and Reemerging Infectious Diseases.

    Wilson, Tais M / Paddock, Christopher D / Reagan-Steiner, Sarah / Bhatnagar, Julu / Martines, Roosecelis B / Wiens, Andrea L / Madsen, Michael / Komatsu, Kenneth K / Venkat, Heather / Zaki, Sherif R

    Emerging infectious diseases

    2021  Volume 27, Issue 5, Page(s) 1517–1519

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shares common clinicopathologic features with other severe pulmonary illnesses. Hantavirus pulmonary syndrome was diagnosed in 2 patients in Arizona, USA, suspected of dying from infection with ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shares common clinicopathologic features with other severe pulmonary illnesses. Hantavirus pulmonary syndrome was diagnosed in 2 patients in Arizona, USA, suspected of dying from infection with SARS-CoV-2. Differential diagnoses and possible co-infections should be considered for cases of respiratory distress during the SARS-CoV-2 pandemic.
    MeSH term(s) Arizona ; COVID-19 ; Communicable Diseases, Emerging/epidemiology ; Hantavirus Pulmonary Syndrome ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2705.204779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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