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  1. Article ; Online: Pathology and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    Afewerky, Henok Kessete

    Experimental biology and medicine (Maywood, N.J.)

    2020  Volume 245, Issue 15, Page(s) 1299–1307

    Abstract: Impact statement: The current survey of studies outlines the direct and indirect effects of SARS-CoV-2 on the specific body systems and summarizes the SARS-CoV-2 main pathogenicity mechanisms that require attention during patient hospitalization and for ...

    Abstract Impact statement: The current survey of studies outlines the direct and indirect effects of SARS-CoV-2 on the specific body systems and summarizes the SARS-CoV-2 main pathogenicity mechanisms that require attention during patient hospitalization and for further research.
    MeSH term(s) Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Cardiovascular Diseases/etiology ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Gastrointestinal Diseases/etiology ; Humans ; Nervous System Diseases/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Virus Internalization ; Virus Replication
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/1535370220942126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pathology and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

    Afewerky, Henok Kessete

    Exp Biol Med (Maywood)

    Abstract: IMPACT STATEMENT: The current survey of studies outlines the direct and indirect effects of SARS-CoV-2 on the specific body systems and summarizes the SARS-CoV-2 main pathogenicity mechanisms that require attention during patient hospitalization and for ... ...

    Abstract IMPACT STATEMENT: The current survey of studies outlines the direct and indirect effects of SARS-CoV-2 on the specific body systems and summarizes the SARS-CoV-2 main pathogenicity mechanisms that require attention during patient hospitalization and for further research.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #637473
    Database COVID19

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  3. Article ; Online: Pathology and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

    Afewerky, Henok Kessete

    Experimental Biology and Medicine

    2020  Volume 245, Issue 15, Page(s) 1299–1307

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that causes infectious respiratory disease, named as coronavirus disease of 2019 (COVID-19). While extensive studies have provided basic information on clinical ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that causes infectious respiratory disease, named as coronavirus disease of 2019 (COVID-19). While extensive studies have provided basic information on clinical characteristics of COVID-19, the disease pathology is not fully known. The SARS-CoV-2 virus structural studies and biochemical experiments have also indicated that the virus receptor-binding domain (RBD) binds with a high affinity to angiotensin-converting enzyme-2 (ACE-2) receptor from humans; however, the mechanism remains unclear. Hereunder, a summary of relevant findings in the SARS-CoV-2 virus pathology and major pathogenicity mechanisms are discussed. This review of studies provides additional enlightenments on the way forward to prevent further spread or even cure for the SARS-CoV-2 virus-caused COVID-19 disease, either-or should a similar viral plague occur in the future. Impact statement The current survey of studies outlines the direct and indirect effects of SARS-CoV-2 on the specific body systems and summarizes the SARS-CoV-2 main pathogenicity mechanisms that require attention during patient hospitalization and for further research.
    Keywords General Biochemistry, Genetics and Molecular Biology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ISSN 1535-3702
    DOI 10.1177/1535370220942126
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dynamic changes in lysosome-related pathways in APP/PS1 mice with aging.

    Xu, Zhendong / Hu, Jichang / Wei, Zhen / Lei, Yu / Afewerky, Henok Kessete / Gao, Yang / Wan, Lu / Li, Longfei / Lei, Ling / Liu, Yi / Huang, Fang / Yu, Tong / Wang, Jian-Zhi / Li, Hong-Lian / Liu, Rong / Wang, Xiaochuan

    MedComm

    2024  Volume 5, Issue 4, Page(s) e540

    Abstract: Senile plaque, composed of amyloid β protein (Aβ) aggregates, is a critical pathological feature in Alzheimer's disease (AD), leading to cognitive dysfunction. However, how Aβ aggregates exert age-dependent toxicity and temporal cognitive dysfunction in ... ...

    Abstract Senile plaque, composed of amyloid β protein (Aβ) aggregates, is a critical pathological feature in Alzheimer's disease (AD), leading to cognitive dysfunction. However, how Aβ aggregates exert age-dependent toxicity and temporal cognitive dysfunction in APP/PS1 mice remains incompletely understood. In this study, we investigated AD pathogenesis and dynamic alterations in lysosomal pathways within the hippocampus of age-gradient male mice using transcriptome sequencing, molecular biology assays, and histopathological analyses. We observed high levels of β-amyloid precursor protein (APP) protein expression in the hippocampus at an early stage and age-dependent Aβ deposition. Transcriptome sequencing revealed the enrichment of differential genes related to the lysosome pathway. Furthermore, the protein expression of ATP6V0d2 and CTSD associated with lysosomal functions exhibited dynamic changes with age, increasing in the early stage and decreasing later. Similar age-dependent patterns were observed for the endosome function, autophagy pathway, and SGK1/FOXO3a pathway. Nissl and Golgi staining in the hippocampal region showed age-dependent neuronal loss and synaptic damage, respectively. These findings clearly define the age-gradient changes in the autophagy-lysosome system, the endosome/lysosome system, and the SGK1/FOXO3a pathway in the hippocampus of APP/PS1 mice, providing new perspectives and clues for understanding the possible mechanisms of AD, especially the transition from compensatory to decompensated state.
    Language English
    Publishing date 2024-04-10
    Publishing country China
    Document type Journal Article
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1.

    Zhang, Bing / Li, Lanfang / Tang, Xiaomei / Zeng, Jinyu / Song, Yige / Hou, Zhenye / Ma, Tian / Afewerky, Henok Kessete / Li, Hao / Lu, Youming / He, Aodi / Li, Xinyan

    Molecular neurobiology

    2023  Volume 60, Issue 12, Page(s) 7285–7296

    Abstract: The inhibitory neurons in the brain play an essential role in neural network firing patterns by releasing γ-aminobutyric acid (GABA) as the neurotransmitter. In the mouse brain, based on the protein molecular markers, inhibitory neurons are usually to be ...

    Abstract The inhibitory neurons in the brain play an essential role in neural network firing patterns by releasing γ-aminobutyric acid (GABA) as the neurotransmitter. In the mouse brain, based on the protein molecular markers, inhibitory neurons are usually to be divided into three non-overlapping groups: parvalbumin (PV), neuropeptide somatostatin (SST), and vasoactive intestinal peptide (VIP)-expressing neurons. Each neuronal group exhibited unique properties in molecule, electrophysiology, circuitry, and function. Calbindin 1 (Calb1), a ubiquitous calcium-binding protein, often acts as a "divider" in excitatory neuronal classification. Based on Calb1 expression, the excitatory neurons from the same brain region can be classified into two subgroups with distinct properties. Besides excitatory neurons, Calb1 also expresses in part of inhibitory neurons. But, to date, little research focused on the intersectional relationship between inhibitory neuronal subtypes and Calb1. In this study, we genetically targeted Calb1-expression (Calb1
    MeSH term(s) Animals ; Mice ; Brain ; Calbindin 1 ; Mice, Transgenic ; Neural Networks, Computer ; Neurons ; Parvalbumins
    Chemical Substances Calbindin 1 ; Parvalbumins ; Calb1 protein, mouse
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03542-1
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  6. Article ; Online: Serum interleukin-30 level in patients with psoriasis and its correlation with psoriasis severity: a case-control study.

    Omar, Nergez Sabah / Long, Xinxin / Xian, Jiayi / Afewerky, Henok Kessete / Hussain, Saeed Ghulam / Peng, Xuebiao

    The Journal of international medical research

    2021  Volume 49, Issue 4, Page(s) 3000605211004039

    Abstract: Objectives: To examine the serum levels of interleukin (IL)-30 in patients with psoriasis and evaluate the correlations with the Psoriasis Area and Severity Index (PASI).: Methods: Serum was collected from 26 patients with psoriasis and 26 healthy ... ...

    Abstract Objectives: To examine the serum levels of interleukin (IL)-30 in patients with psoriasis and evaluate the correlations with the Psoriasis Area and Severity Index (PASI).
    Methods: Serum was collected from 26 patients with psoriasis and 26 healthy controls in a case-control setting, and the level of IL-30 was determined using an enzyme-linked immunosorbent assay. Statistical analysis of the IL-30 levels among groups and further correlation analyses of IL-30 levels with PASI scores were performed.
    Results: A significant increase in the level of IL-30 in patients with psoriasis compared with healthy controls was observed. In addition, a positive correlation between the IL-30 concentration and PASI scores was found in patients with psoriasis.
    Conclusion: IL-30 is presumably involved in the proliferation of epidermal cells during the development of psoriasis. Further studies with a larger number of participants are required to comprehensively elucidate the biological roles of IL-30 in the pathogenesis of psoriasis.
    MeSH term(s) Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interleukins/blood ; Psoriasis/diagnosis ; Severity of Illness Index
    Chemical Substances Interleukins ; MYDGF protein, human
    Language English
    Publishing date 2021-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605211004039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease.

    Afewerky, Henok Kessete / Li, Hao / Zhang, Tongmei / Li, Xinyan / Mahaman, Yacoubou Abdoul Razak / Duan, Limin / Qin, Pengwei / Zheng, Jiequn / Pei, Lei / Lu, Youming

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 1537

    Abstract: The third isoform of the ... ...

    Abstract The third isoform of the Na
    MeSH term(s) Sodium-Calcium Exchanger
    Chemical Substances Sodium-Calcium Exchanger
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-05568-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The emerging role of exosomes in Alzheimer's disease.

    Zhang, Tongmei / Ma, Sehui / Lv, Junkai / Wang, Xinyuan / Afewerky, Henok Kessete / Li, Hao / Lu, Youming

    Ageing research reviews

    2021  Volume 68, Page(s) 101321

    Abstract: Alzheimer's disease (AD), manifested by memory loss and a decline in cognitive functions, is the most prevalent neurodegenerative disease accounting for 60-80 % of dementia cases. But, to-date, there is no effective treatment available to slow or stop ... ...

    Abstract Alzheimer's disease (AD), manifested by memory loss and a decline in cognitive functions, is the most prevalent neurodegenerative disease accounting for 60-80 % of dementia cases. But, to-date, there is no effective treatment available to slow or stop the progression of AD. Exosomes are small extracellular vesicles that carry constituents, such as functional messenger RNAs, non-coding RNAs, proteins, lipids, DNA, and other bioactive substances of their source cells. In the brain, exosomes are likely to be sourced by almost all cell types and involve in cell communication to regulate cellular functions. The yet, accumulated evidence on the roles of exosomes and their constituents in the AD pathological process suggests their significance as additional biomarkers and therapeutic targets for AD. This review summarizes the current reported research findings on exosomes roles in the pathogenesis, diagnosis, and treatment of AD.
    MeSH term(s) Alzheimer Disease ; Biomarkers ; Exosomes ; Extracellular Vesicles ; Humans ; Neurodegenerative Diseases
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-03-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2021.101321
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  9. Article ; Online: Serum interleukin-30 level in patients with psoriasis and its correlation with psoriasis severity

    Nergez Sabah Omar / Xinxin Long / Jiayi Xian / Henok Kessete Afewerky / Saeed Ghulam Hussain / Xuebiao Peng

    Journal of International Medical Research, Vol

    a case-control study

    2021  Volume 49

    Abstract: Objectives To examine the serum levels of interleukin (IL)-30 in patients with psoriasis and evaluate the correlations with the Psoriasis Area and Severity Index (PASI). Methods Serum was collected from 26 patients with psoriasis and 26 healthy controls ... ...

    Abstract Objectives To examine the serum levels of interleukin (IL)-30 in patients with psoriasis and evaluate the correlations with the Psoriasis Area and Severity Index (PASI). Methods Serum was collected from 26 patients with psoriasis and 26 healthy controls in a case–control setting, and the level of IL-30 was determined using an enzyme-linked immunosorbent assay. Statistical analysis of the IL-30 levels among groups and further correlation analyses of IL-30 levels with PASI scores were performed. Results A significant increase in the level of IL-30 in patients with psoriasis compared with healthy controls was observed. In addition, a positive correlation between the IL-30 concentration and PASI scores was found in patients with psoriasis. Conclusion IL-30 is presumably involved in the proliferation of epidermal cells during the development of psoriasis. Further studies with a larger number of participants are required to comprehensively elucidate the biological roles of IL-30 in the pathogenesis of psoriasis.
    Keywords Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Critical review of the

    Afewerky, Henok Kessete / Ayodeji, Ayeni Emmanuel / Tiamiyu, Bashir Bolaji / Orege, Joshua Iseoluwa / Okeke, Emmanuel Sunday / Oyejobi, Aanuoluwapo Opeyemi / Bate, Petuel Ndip Ndip / Adeyemi, Sherif Babatunde

    Bulletin of the National Research Centre

    2021  Volume 45, Issue 1, Page(s) 176

    Abstract: Background: Withania somnifera: Methodology: Scientific articles and publications were scooped and sourced from high-impact factor journals and filtered with relevant keywords on : Results: This critical review covers the : Conclusion: W. ... ...

    Abstract Background: Withania somnifera
    Methodology: Scientific articles and publications were scooped and sourced from high-impact factor journals and filtered with relevant keywords on
    Results: This critical review covers the
    Conclusion: W. somnifera
    Language English
    Publishing date 2021-10-21
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2522-8307
    ISSN (online) 2522-8307
    DOI 10.1186/s42269-021-00635-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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