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Article: [Hematologic Diseases and Neurological Complications].

Omori, Naoki / Nagai, Atsushi

Brain and nerve = Shinkei kenkyu no shinpo

2024 Volume 76, Issue 3, Page(s) 221–229

Abstract: Many hematologic diseases can be complicated by neurological symptoms during the disease course. Hematologic diseases can contribute to strokes and neuropathies; thus, neurologists should be aware of them. Recent reports have increased of neurological ... ...

Abstract	Many hematologic diseases can be complicated by neurological symptoms during the disease course. Hematologic diseases can contribute to strokes and neuropathies; thus, neurologists should be aware of them. Recent reports have increased of neurological side effects associated with new anticancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor-T cell therapy. The relationship between hematologic diseases and neurological complications is expected to become more prevalent.
MeSH term(s)	Humans ; Hematologic Diseases/complications ; Hematologic Diseases/therapy ; Nervous System Diseases/complications ; Nervous System Diseases/therapy ; Stroke
Language	Japanese
Publishing date	2024-03-21
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416202592
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Article ; Online: An Appraisal for Providing Charge Transfer (CT) Through Synthetic Porous Frameworks for their Semiconductor Applications.

Shahmirzaee, Mozhgan / Nagai, Atsushi

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2307828

Abstract: In recent years, there has been considerable focus on the development of charge transfer (CT) complex formation as a means to modify the band gaps of organic materials. In particular, CT complexes alternate layers of aromatic molecules with donor (D) and ...

Abstract	In recent years, there has been considerable focus on the development of charge transfer (CT) complex formation as a means to modify the band gaps of organic materials. In particular, CT complexes alternate layers of aromatic molecules with donor (D) and acceptor (A) properties to provide inherent electrical conductivity. In particular, the synthetic porous frameworks as attractive D-A components have been extensively studied in recent years in comparison to existing D-A materials. Therefore, in this work, the synthetic porous frameworks are classified into conjugated microporous polymers (CMPs), covalent organic frameworks (COFs), and metal-organic frameworks (MOFs) and compare high-quality materials for CT in semiconductors. This work updates the overview of the above porous frameworks for CT, starting with their early history regarding their semiconductor applications, and lists CT concepts and selected key developments in their CT complexes and CT composites. In addition, the network formation methods and their functionalization are discussed to provide access to a variety of potential applications. Furthermore, several theoretical investigations, efficiency improvement techniques, and a discussion of the electrical conductivity of the porous frameworks are also highlighted. Finally, a perspective of synthetic porous framework studies on CT performance is provided along with some comparisons.
Language	English
Publishing date	2024-02-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202307828
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Article ; Online: Effect of proactive combination therapy with peritoneal dialysis and hemodialysis on technique survival and mortality.

Nagai, Kei / Ueda, Atsushi

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

2024

Abstract: Purpose: Clinically relevant evidence for the timing of starting combination therapy with peritoneal dialysis and hemodialysis remains scarce. We retrospectively examined whether combination therapy during the induction phase of dialysis prolongs ... ...

Abstract	Purpose: Clinically relevant evidence for the timing of starting combination therapy with peritoneal dialysis and hemodialysis remains scarce. We retrospectively examined whether combination therapy during the induction phase of dialysis prolongs peritoneal dialysis duration. Methods: This retrospective study includes 160 patients who underwent combination therapy from 20 dialysis facilities. Four groups were categorized: combination at peritoneal dialysis induction (n = 12, Proactive combination group), and combination following peritoneal dialysis durations of < 2 years (n = 65), 2-5 years (n = 70), or > 5 years (n = 13). Differences in technique survival of dialysis, mortality, and hospitalization due to cardiovascular events in the groups were observed. Results: The Proactive combination group had the longer mean duration of combination therapy (3.18 years) comparing to that of combination therapy following peritoneal dialysis (1.45 years), but total peritoneal dialysis duration was shorter than in control groups (4.02 years). Of the 160 cases in the entire cohort, there were 8 deaths, 18 ischemic heart disease hospitalizations, and 18 stroke hospitalizations. The Proactive group had lower crude mortality rate (0/12 cases, 0.0%) and crude hospitalization rate for ischemic heart disease (1/11, 8.3%) than the other groups. However, this cohort study did not have enough statistical power to adjust for patients' background, and we were unable to fully examine the differences in such clinical outcomes by the timing of initiation of combination therapy. Conclusion: Use of combination therapy in the induction phase might prolong the duration of combination therapy, but is not necessarily effective for prolonging peritoneal dialysis technique survival.
Language	English
Publishing date	2024-03-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1463555-0
ISSN	1619-0904 ; 1434-7229
ISSN (online)	1619-0904
ISSN	1434-7229
DOI	10.1007/s10047-024-01437-z
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Article ; Online: Differential Glycoform Analysis of MUC1 Derived from Biological Specimens Using an Antibody-Overlay Lectin Microarray.

Matsuda, Atsushi / Boottanun, Patcharaporn / Koizumi, Sachiko / Nagai, Misugi / Kuno, Atsushi

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2763, Page(s) 223–236

Abstract: The association between altered glycosylation of MUC1 and various disease events has sparked significant interest. However, analytical technologies to investigate the disease-related glycoforms of endogenous MUC1 in blood and tissue specimens are limited. ...

Abstract	The association between altered glycosylation of MUC1 and various disease events has sparked significant interest. However, analytical technologies to investigate the disease-related glycoforms of endogenous MUC1 in blood and tissue specimens are limited. Therefore, we devised a reliable technique for differential analysis of endogenous MUC1 glycoforms based on an antibody-assisted lectin microarray. Its highly sensitive detection aids in analyzing soluble MUC1 from relatively small amounts of serum via a simple enrichment process. Micro-/macro-dissection of the MUC1-positive region is combined with glycoform analysis of the membrane-tethered MUC1. Thus, we have optimized the protocol for sample qualification using immunohistochemistry, sample pretreatment for tissue sections, protein extraction, purification via immunoprecipitation, and the antibody-overlay lectin microarray, which are sequentially essential for differential glycoform analysis of endogenous MUC1.
MeSH term(s)	Lectins/metabolism ; Mucin-1/metabolism ; Antibodies ; Microarray Analysis/methods ; Immunohistochemistry
Chemical Substances	Lectins ; Mucin-1 ; Antibodies
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3670-1_19
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Article ; Online: Recent advancements of covalent organic frameworks (COFs) as proton conductors under anhydrous conditions for fuel cell applications.

Joseph, Vellaichamy / Nagai, Atsushi

RSC advances

2023 Volume 13, Issue 43, Page(s) 30401–30419

Abstract: Recent electrochemical energy conversion devices require more advanced proton conductors for their broad applications, especially, proton exchange membrane fuel cell (PEMFC) construction. Covalent organic frameworks (COFs) are an emerging class of ... ...

Abstract	Recent electrochemical energy conversion devices require more advanced proton conductors for their broad applications, especially, proton exchange membrane fuel cell (PEMFC) construction. Covalent organic frameworks (COFs) are an emerging class of organic porous crystalline materials that are composed of organic linkers and connected by strong covalent bonds. The unique characteristics including well-ordered and tailorable pore channels, permanent porosity, high degree of crystallinity, excellent chemical and thermal stability, enable COFs to be the potential proton conductors in fuel cell devices. Generally, proton conduction of COFs is dependent on the amount of water (extent of humidity). So, the constructed fuel cells accompanied complex water management system which requires large radiators and airflow for their operation at around 80 °C to avoid overheating and efficiency roll-off. To overcome such limitations, heavy-duty fuel cells require robust proton exchange membranes with stable proton conduction at elevated temperatures. Thus, proton conducting COFs under anhydrous conditions are in high demand. This review summarizes the recent progress in emerging COFs that exhibit proton conduction under anhydrous conditions, which may be prospective candidates for solid electrolytes in fuel cells.
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article ; Review
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra04855a
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Article ; Online: Impact of collaboration between general practitioners and nephrologists on renal function: an experience in the Hitachi area.

Nagai, Kei / Ueda, Atsushi

Clinical and experimental nephrology

2022 Volume 26, Issue 10, Page(s) 1039–1041

MeSH term(s)	General Practitioners ; Humans ; Kidney/physiology ; Kidney Failure, Chronic ; Nephrologists ; Nephrology
Language	English
Publishing date	2022-05-13
Publishing country	Japan
Document type	Letter
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-022-02237-6
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Article ; Online: Distinctive nail pattern following androgen replacement therapy.

Miyata, Ippei / Nagai, Atsushi

IJU case reports

2022 Volume 5, Issue 6, Page(s) 515–516

Abstract: Introduction: A distinctive nail pattern in a patient undergoing androgen replacement therapy is presented hereby.: Case presentation: A 47-year-old male patient noticed a peculiar "washboard-like" pattern on his fingernails. He had been undergoing ... ...

Abstract	Introduction: A distinctive nail pattern in a patient undergoing androgen replacement therapy is presented hereby. Case presentation: A 47-year-old male patient noticed a peculiar "washboard-like" pattern on his fingernails. He had been undergoing androgen replacement therapy for late onset hypogonadism syndrome. The patient realized his nails were growing faster after his therapy was altered from a tri-weekly basis to a bi-weekly basis. Conclusion: This phenomenon is likely to be attributed to the androgen replacement therapy, as the spacing between the ridges were widening in concordance with the strengthening of the therapy.
Language	English
Publishing date	2022-08-29
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12530
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Article: Erectile dysfunction.

Nagai, Atsushi

Nihon rinsho. Japanese journal of clinical medicine

2018 Volume 75, Issue 4, Page(s) 584–587

Abstract: Aging is the biggest risk factor of erectile dysfunction (ED). Seventy-one percent of Japanese men aged 70 to 79 years reported suffering from ED. Blood vessels and nerves related to erection are damaged by various risk factors as well as histological ... ...

Abstract	Aging is the biggest risk factor of erectile dysfunction (ED). Seventy-one percent of Japanese men aged 70 to 79 years reported suffering from ED. Blood vessels and nerves related to erection are damaged by various risk factors as well as histological change in a corpus cavernosum penis, decreased testosterone level, and various complexed factors. Phosphodiesterase 5 inhibitors are the first-line choice for both on-demand and chronic treat- ment of ED. Late-onset hypogonadism (LOH) is diagnosed when declining testosterone con- centrations in the aging male cause ED and the metabolic syndrome (MetS). Testosterone replacement therapy for these patients has beneficial effect on ED and MetS and improves quality of sexual life.
MeSH term(s)	Aged ; Erectile Dysfunction ; Humans ; Male
Language	Japanese
Publishing date	2018-12-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article ; Online: The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications.

Sheikh, Abdullah Md / Yano, Shozo / Tabassum, Shatera / Nagai, Atsushi

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between the vascular system and ... ...

Abstract	Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between the vascular system and degenerative diseases, shedding light on the underlying mechanisms and profound implications for disease progression and management. The pivotal role of the vascular system in maintaining tissue homeostasis is highlighted, as it serves as the conduit for oxygen, nutrients, and immune cells to vital organs and tissues. Due to the vital role of the vascular system in maintaining homeostasis, its dysfunction, characterized by impaired blood flow, endothelial dysfunction, and vascular inflammation, emerges as a common denominator of degenerative diseases across multiple systems. In the nervous system, we explored the influence of vascular factors on neurodegenerative diseases such as Alzheimer's and Parkinson's, emphasizing the critical role of cerebral blood flow regulation and the blood-brain barrier. Within the kidney system, the intricate relationship between vascular health and chronic kidney disease is scrutinized, unraveling the mechanisms by which hypertension and other vascular factors contribute to renal dysfunction. Throughout this review, we emphasize the clinical significance of understanding vascular involvement in degenerative diseases and potential therapeutic interventions targeting vascular health, highlighting emerging treatments and prevention strategies. In conclusion, a profound appreciation of the role of the vascular system in degenerative diseases is essential for advancing our understanding of degenerative disease pathogenesis and developing innovative approaches for prevention and treatment. This review provides a comprehensive foundation for researchers, clinicians, and policymakers seeking to address the intricate relationship between vascular health and degenerative diseases in pursuit of improved patient outcomes and enhanced public health.
MeSH term(s)	Humans ; Blood-Brain Barrier/pathology ; Neurodegenerative Diseases/pathology ; Cerebrovascular Circulation ; Biological Transport ; Homeostasis
Language	English
Publishing date	2024-02-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042169
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Article ; Online: Sustainability of peritoneal dialysis and renal function with proactive combination therapy.

Nagai, Kei / Ueda, Atsushi

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

2022 Volume 26, Issue 4, Page(s) 335–339

Abstract: Most combined peritoneal dialysis and hemodialysis therapies are used to compensate for the lack of dialysis volume and efficiency in pre-started peritoneal dialysis patients. The aim was to determine the effects on both peritoneal dialysis and residual ... ...

Abstract	Most combined peritoneal dialysis and hemodialysis therapies are used to compensate for the lack of dialysis volume and efficiency in pre-started peritoneal dialysis patients. The aim was to determine the effects on both peritoneal dialysis and residual renal function when proactively combined therapy is started at dialysis induction. This report was based on observation of 10 patients who initiated dialysis therapy with a combination of peritoneal and hemodialysis at induction, and the control group consisted of 24 patients with peritoneal monotherapy in a single dialysis center. The technical survival of peritoneal dialysis therapy and urinary volume and creatinine clearance as residual renal function were assessed. Technical survival of peritoneal dialysis during the 5-year observation period was much better in patients who started with proactive combination therapy than with peritoneal dialysis monotherapy. Between induction and 24 months later, median urinary volume (interquartile value) changed from 1500 (1100-1583) to 800 (545-1875) mL/day and from 1600 (1300-2150) to 1480 (115-1885) mL/day for peritoneal alone and for combination therapy, respectively. Creatinine clearance values changed from 7.0 (6.0-8.7) to 2.0 (1.0-3.0) mL/min for peritoneal alone and from 6.0 (4.0-7.3) to 3.0 (0.5-4.0) mL/min for combination therapy. Though some possible confounding factors, including selection bias, cannot be ruled out, this investigation suggests the benefit of proactive combination dialysis therapy on the sustainability of peritoneal dialysis and residual renal function.
MeSH term(s)	Humans ; Creatinine ; Peritoneal Dialysis ; Renal Dialysis ; Peritoneum ; Kidney/physiology ; Kidney Failure, Chronic/therapy
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2022-12-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1463555-0
ISSN	1619-0904 ; 1434-7229
ISSN (online)	1619-0904
ISSN	1434-7229
DOI	10.1007/s10047-022-01375-8
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