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  1. Article ; Online: Glomerular Disease in Liver Disease.

    Sharma, Purva / Airy, Medha

    Clinics in liver disease

    2022  Volume 26, Issue 2, Page(s) 203–212

    Abstract: Glomerular diseases are an important cause of kidney disease in patients with liver disease. Although kidney involvement due to tubular or vascular disease is more common, glomerular diseases became more prevalent as hepatitis infections increased and ... ...

    Abstract Glomerular diseases are an important cause of kidney disease in patients with liver disease. Although kidney involvement due to tubular or vascular disease is more common, glomerular diseases became more prevalent as hepatitis infections increased and then subsequently decreased with the widespread availability of hepatitis A and B vaccines and the development of effective antiviral treatments for hepatitis B and C. In this review, we discuss the common glomerular pathologies that are seen in patients with liver disease and the current treatment options available to them.
    MeSH term(s) Antiviral Agents/therapeutic use ; Female ; Hepatitis B/complications ; Hepatitis B/drug therapy ; Hepatitis B/epidemiology ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology ; Liver Diseases/complications ; Liver Diseases/epidemiology ; Male ; Vascular Diseases/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2022.01.007
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  2. Article: Pulmonary cement emboli complicated by cardiogenic shock following percutaneous kyphoplasty.

    Reddy, Renuka / Sharma, Purva / Avila, Gustavo / Jobanputra, Yash

    Lung India : official organ of Indian Chest Society

    2022  Volume 39, Issue 1, Page(s) 82–83

    Language English
    Publishing date 2022-01-03
    Publishing country India
    Document type Letter
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_233_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recurrent chylous ascites in patient with previous retroperitoneal radiation treatment.

    Sharma, Purva / Chakraborty, Kanishka

    BMJ case reports

    2022  Volume 15, Issue 10

    Abstract: Chylous ascites is the accumulation of lymphatic fluid in the peritoneal cavity due to disruption of lymphatic drainage caused due to obstruction or trauma. We report a man in his 60s who was previously treated for diffuse large B cell lymphoma with ... ...

    Abstract Chylous ascites is the accumulation of lymphatic fluid in the peritoneal cavity due to disruption of lymphatic drainage caused due to obstruction or trauma. We report a man in his 60s who was previously treated for diffuse large B cell lymphoma with radiation to bulky abdominal/mesenteric lymphadenopathy. He was later found to have recurrent chylous ascites several years later, requiring multiple paracentesis. Recurrent lymphoma was ruled out with negative cytology of peritoneal fluid as well as lymph node biopsy with no evidence of malignancy. We believe that the patient had obstruction of lymphatic drainage due to previous radiation therapy causing fibrosis. The patient underwent lymphangiography which did not visualise the central lymphatic duct within the abdomen raising suspicion for obstruction of the ducts secondary to previous radiation.
    MeSH term(s) Male ; Humans ; Chylous Ascites/etiology ; Chylous Ascites/therapy ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/complications ; Drainage/adverse effects ; Paracentesis/adverse effects ; Abdomen
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-248116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Efficacy of Aqueous Extract of Chinese Caterpillar Mushroom Ophiocordyceps sinensis (Ascomycota) Against Simulated Altitude Stress and Subacute Toxicity Studies.

    Sharma, Purva / Tulsawani, Rajkumar

    International journal of medicinal mushrooms

    2022  Volume 24, Issue 11, Page(s) 21–34

    Abstract: Exposure to high altitude severely impacts performance of unacclimatized individuals and contraindications associated with synthetic drugs ascertain the need for development of herbal drugs. Thus, the present study investigated the adaptogenic potential ... ...

    Abstract Exposure to high altitude severely impacts performance of unacclimatized individuals and contraindications associated with synthetic drugs ascertain the need for development of herbal drugs. Thus, the present study investigated the adaptogenic potential of Ophiocordyceps sinensis aqueous extract (CSAQ) using simulated altitude stress models such as severe hypoxia (SH) in hermetic vessel, cold restraint (CR) at 4°C, and hypobaric hypoxia (HBH) at 7,620 meter, ~ 282 mm Hg. To further address safety limits of extract, subacute toxicity studies were conducted in rats orally administered with CSAQ (0, 100, 500 and 1000 mg/kg) in a single dose/day for 28 days. Results revealed that animals administered with CSAQ increased convulsion time and core body temperature during SH and CR stress. CSAQ modulated thermogenic response by upregulating uncoupling protein 1 and maintaining metabolic homeostasis. Further, CSAQ improved antioxidant status (glutathione and 2,3-diposhphoglycerate), attenuated pro-inflammatory cytokine NF-κB, and augmented hypoxia inducible factor and nuclear erythroid 2 related factor 2 in HBH exposed animals. Toxicity studies revealed no observed adverse effect level with 1000 mg/kg extract in body weight gain, organ/body weight ratio, hematological variables, biochemical parameters and histoarchitecture of vital organs. In conclusion, CSAQ initiated dose dependent adaptive response and exhibited high safety margins, which strongly suggests the therapeutic potential of CSAQ in mitigating high altitude maladies.
    MeSH term(s) Rats ; Animals ; Altitude ; Cordyceps ; Hypoxia/drug therapy ; Body Weight ; China
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108803-2
    ISSN 1940-4344 ; 1521-9437
    ISSN (online) 1940-4344
    ISSN 1521-9437
    DOI 10.1615/IntJMedMushrooms.2022045194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7482: Show issues

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  5. Article ; Online: Burkitt lymphoma: interpreting FISH testing for

    Sharma, Purva / Singal, Sakshi / Costello, Patrick / Krishnan, Koyamangalath

    BMJ case reports

    2022  Volume 15, Issue 2

    Abstract: Burkitt lymphoma is a highly aggressive B cell non-Hodgkin's lymphoma characterised by translocation ... ...

    Abstract Burkitt lymphoma is a highly aggressive B cell non-Hodgkin's lymphoma characterised by translocation of
    MeSH term(s) Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/genetics ; Gene Rearrangement ; Genes, myc/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Translocation, Genetic
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-246687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient.

    Sharma, Purva / Chakraborty, Kanishka

    BMJ case reports

    2021  Volume 14, Issue 5

    Abstract: COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous ... ...

    Abstract COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hodgkin's lymphoma, who was diagnosed with COVID-19 infection prior to initiating chemotherapy. Two months after resolution of symptoms and testing negative for COVID-19, she presented with multiple acute thromboembolic complications of the infection, including bilateral jugular venous thrombosis, right atrial clot and arterial emboli in the brain resulting in cerebrovascular injury. These were thought to be delayed manifestations of the systemic coagulopathy secondary to infection. Also, some of these thromboembolic phenomena occurred while the patient was on anticoagulation, which emphasises the extensive hyperinflammatory state caused by the virus. This case highlights the importance of thromboprophylaxis especially in high-risk patients with this infection.
    MeSH term(s) Adult ; Anticoagulants/therapeutic use ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/etiology ; COVID-19 ; Female ; Humans ; SARS-CoV-2 ; Venous Thromboembolism
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-242921
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  7. Article ; Online: The Case | A benign reason behind a malignant finding.

    Bharati, Joyita / Bijol, Vanesa / Salvatore, Steven / Jhaveri, Kenar D / Sharma, Purva

    Kidney international

    2022  Volume 103, Issue 2, Page(s) 433–434

    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.08.016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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  8. Article ; Online: Atypical Anti-Glomerular Basement Membrane Disease.

    Bharati, Joyita / Yang, Yihe / Sharma, Purva / Jhaveri, Kenar D

    Kidney international reports

    2023  Volume 8, Issue 6, Page(s) 1151–1161

    Abstract: Atypical anti-glomerular basement membrane (anti-GBM) disease is characterized by linear immunoglobulin G (IgG) deposition along the GBM without circulating IgG anti-GBM antibodies. Compared to classic anti-GBM disease, atypical anti-GBM disease tends to ...

    Abstract Atypical anti-glomerular basement membrane (anti-GBM) disease is characterized by linear immunoglobulin G (IgG) deposition along the GBM without circulating IgG anti-GBM antibodies. Compared to classic anti-GBM disease, atypical anti-GBM disease tends to be milder with a more indolent course in certain cases. Moreover, pathologic disease pattern is much more heterogenous in atypical anti-GBM disease than in the classic type, which is uniformly characterized by diffuse crescentic and necrotizing glomerulonephritis. Although there is no single well-established target antigen in atypical anti-GBM disease, the target antigen (within the GBM) and the autoantibody type are hypothesized to be different from the classic type. Some patients have the same antigen as the Goodpasture antigen that are detected only by a highly sensitive technique (biosensor analysis). Some cases of atypical anti-GBM disease have autoantibodies of a different subclass restriction like IgG4, or of monoclonal nature. Antibodies targeting antigen/epitope structure other than the Goodpasture antigen can be detected using modified assays in some cases. Patients with IgA- and IgM-mediated anti-GBM disease are known to have negative circulating antibodies because conventional assays do not detect these classes of antibodies. A significant proportion of cases with atypical anti-GBM disease do not have any identifiable antibodies despite extensive evaluation. Nevertheless, extensive evaluation of atypical autoantibodies using modified assays and sensitive techniques should be attempted, if feasible. This review summarizes the recent literature on atypical anti-GBM disease.
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.03.010
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  9. Article ; Online: Management of Hepatitis C Virus and Hepatitis B Virus Infection in the Setting of Kidney Disease.

    Sharma, Purva / Sawtell, Rani / Wang, Qiyu / Sise, Meghan E

    Advances in kidney disease and health

    2023  Volume 30, Issue 4, Page(s) 343–355

    Abstract: Treatment of chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infection poses unique challenges in patients with kidney disease. Direct-acting antivirals have been a major breakthrough in eradicating HCV infection, and several pangenotypic ... ...

    Abstract Treatment of chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infection poses unique challenges in patients with kidney disease. Direct-acting antivirals have been a major breakthrough in eradicating HCV infection, and several pangenotypic regimens are available for patients with chronic kidney disease or end-stage kidney disease requiring dialysis with high cure rates and no need for dose adjustment. Direct-acting antiviral therapy alone can treat HCV-associated cryoglobulinemic glomerulonephritis; concurrent antiviral and immunosuppressive therapy is needed for cases of severe, organ-threatening manifestations of cryoglobulinemia. Immunosuppression may be needed for HBV-associated kidney disease (polyarteritis nodosa or membranous nephropathy) when there is evidence of severe immune-mediated injury while weighing the risk of potential viral activation. Most HBV antiviral agents need to be dose-adjusted in patients with chronic kidney disease or end-stage kidney disease requiring dialysis, and drug-drug interactions need to be carefully evaluated in patients with kidney transplants. Considerations for accepting HCV- and HBV-infected donors for kidney transplantation are discussed.
    MeSH term(s) Humans ; Hepatitis B virus ; Hepacivirus ; Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/complications ; Hepatitis B/complications ; Hepatitis C/complications ; Renal Insufficiency, Chronic/complications ; Kidney Failure, Chronic/complications
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 3156601-7
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2023.04.003
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  10. Article ; Online: Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis

    Purva Sharma / Rajkumar Tulsawani

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 16

    Abstract: Abstract Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing ... ...

    Abstract Abstract Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprotective mechanism using rat hypobaric hypoxia test model. Rats exposed to hypobaric hypoxia showed deranged spatial memory in morris water maze test with hippocampal damage and vasogenic cerebral edema. All these changes were prevented with GLAQ treatment. Blood and biochemical analysis revealed activation of hypoxic ventilatory response, red blood cells induction, reversal of electrolyte and redox imbalance, and restoration of cellular bioenergetic losses in GLAQ treated animals. Notably, GLAQ treatment ameliorated levels of neurotransmitters (catecholamines, serotonin, glutamate), prevented glucocorticoid and α-synuclein surge, improved neuroplasticity by upregulating CREB/p-CREB/BDNF expression via ERK1/ERK2 induction. Further, restoration of nuclear factor erythroid 2-related factor with stabilization of hypoxia inducible factors and inflammatory markers were evidenced in GLAQ treated rats which was additionally established in gene reporter array using an alternative HT22 cell test model. Conclusively, our studies provide novel insights into systemic to molecular level protective mechanism by GLAQ in combating hypobaric hypoxia induced oxidative stress and memory impairment.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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