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  1. Article ; Online: Pathology of TB/COVID-19 Co-Infection: The phantom menace.

    Mousquer, Gabriel Tassi / Peres, Alessandra / Fiegenbaum, Marilu

    Tuberculosis (Edinburgh, Scotland)

    2020  Volume 126, Page(s) 102020

    Abstract: Tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are currently the two main causes of death among infectious diseases. There is an increasing number of studies trying to elucidate the interactions between Mycobacterium tuberculosis and SARS-CoV- ... ...

    Abstract Tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are currently the two main causes of death among infectious diseases. There is an increasing number of studies trying to elucidate the interactions between Mycobacterium tuberculosis and SARS-CoV-2. Some of the first case reports point to a worsening of respiratory symptoms in co-infected TB/COVID-19 individuals. However, data from the cohort studies has shown some conflicting results. This study proposes to conduct a systematic review on the current literature on TB/COVID-19 co-infection cohorts, evaluating clinical and epidemiological data, focusing on its implications to the immune system. From an immunological perspective, the TB/COVID-19 co-infection has the potential to converge in a "perfect storm". The disorders induced by each pathogen to the immunomodulation tend to induce an unbalanced inflammatory response, which can promote the progression and worsening of both diseases. Understanding the nature of the interactions between M. tuberculosis and SARS-CoV-2 will be crucial for the development of therapeutic strategies against co-infection.
    MeSH term(s) Animals ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/therapy ; COVID-19/virology ; Coinfection ; Disease Progression ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/immunology ; Lung/immunology ; Lung/microbiology ; Lung/virology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Prognosis ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Signal Transduction ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/microbiology ; Tuberculosis, Pulmonary/therapy
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2020-11-17
    Publishing country Scotland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2020.102020
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  2. Article: Pathology of TB/COVID-19 Co-Infection: The phantom menace

    Mousquer, Gabriel Tassi Peres Alessandra Fiegenbaum Marilu

    Tuberculosis

    Abstract: Despite the high number of victims of COVID-19, tuberculosis (TB) remains as the leading cause of death among infectious diseases worldwide Since the beginning of the pandemic, there is an increasing number of studies trying to elucidate the interactions ...

    Abstract Despite the high number of victims of COVID-19, tuberculosis (TB) remains as the leading cause of death among infectious diseases worldwide Since the beginning of the pandemic, there is an increasing number of studies trying to elucidate the interactions between Mycobacterium tuberculosis and SARS-CoV-2 The first case reports point to a worsening of respiratory symptoms in co-infected TB/COVID-19 individuals However, data from the cohort studies has shown some conflicting results This study proposes to conduct a systematic review on the current literature on TB/COVID-19 co-infection cohorts, evaluating clinical and epidemiological data, focusing on its implications to the immune system From an immunological perspective, the TB/COVID-19 co-infection has the potential to generate a "perfect storm" The disorders induced by each pathogen to the immune modulation tend to induce an unbalanced inflammatory response, which can promote the progression and worsening of both diseases Understanding the nature of the interactions between M tuberculosis and SARS-CoV-2 will be crucial for the development of therapeutic strategies against co-infection
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #926650
    Database COVID19

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  3. Article ; Online: Pathology of TB/COVID-19 Co-Infection

    Mousquer, Gabriel Tassi / Peres, Alessandra / Fiegenbaum, Marilu

    Tuberculosis

    The phantom menace

    2020  , Page(s) 102020

    Keywords Immunology ; Microbiology (medical) ; Microbiology ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2020.102020
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Macrophage migration inhibitory factor - 794 CATT

    Machado, Felipe Dominguez / Gehlen, Mirela / Caron, Vitória Schmidt / Mousquer, Gabriel Tassi / Bello, Graziele Lima / Anton, Camila / Bernardi, Rafaela Manzoni / Freitas, Alana Ambos / Unis, Gisela / Costa, Elis Regina Dalla / Rossetti, Maria Lucia Rosa / Silva, Denise Rossato

    Infection

    2021  Volume 49, Issue 3, Page(s) 457–461

    Abstract: Purpose: The establishment of candidate genetic determinants associated with tuberculosis (TB) is a challenge, considering the divergent frequencies among populations. The objective of this study was to evaluate the association between MIF - 794 CATT !## ...

    Abstract Purpose: The establishment of candidate genetic determinants associated with tuberculosis (TB) is a challenge, considering the divergent frequencies among populations. The objective of this study was to evaluate the association between MIF - 794 CATT 
    Methods: Case-control study. Patients > 18 years, with pulmonary TB were included. The control group consisted of blood donors and household contacts, not relatives, healthy and > 18 years. MIF - 794 CATT 
    Results: 126 patients and 119 controls were included. The genotype 5/5 was more frequent among cases (15.1%) than in controls (5.9%) (p = 0.019). Cases had more frequently the allele 5 (29.4%) as compared with controls (19.3%) (p = 0.010). Prevalence of 7/X + 8/X genotypes was not different between cases and controls (p = 0.821). There was no difference between patients with alleles 7 and 8 and those with alleles 5 and 6 (p = 0.608).
    Conclusions: The genotype 5/5 and the allele 5 of MIF - 794 CATT
    MeSH term(s) Case-Control Studies ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Intramolecular Oxidoreductases ; Macrophage Migration-Inhibitory Factors/genetics ; Microsatellite Repeats ; Polymorphism, Single Nucleotide ; Tuberculosis/genetics
    Chemical Substances Macrophage Migration-Inhibitory Factors ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1)
    Language English
    Publishing date 2021-01-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-020-01562-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Validation of a quick and low-cost DNA extraction protocol applicable to long-stored blood samples.

    Mousquer, Gabriel Tassi / Maciel, Lila Partichelli / Pompeu Saraiva, Ana Carolina / Dalla Costa, Elis Regina / Rosa Rossetti, Maria Lucia

    Analytical biochemistry

    2018  Volume 561-562, Page(s) 47–51

    MeSH term(s) Blood Specimen Collection/standards ; DNA/blood ; DNA/economics ; DNA/isolation & purification ; Electrophoresis, Agar Gel ; Humans ; Time Factors
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2018-09-11
    Publishing country United States
    Document type Journal Article ; Validation Studies
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2018.09.006
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