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  1. Article ; Online: Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease.

    Michaels, Margret / Madsen, Karen L

    Mucosal immunology

    2023  Volume 16, Issue 1, Page(s) 72–85

    Abstract: The concept of immunometabolism has emerged recently whereby the repolarizing of inflammatory immune cells toward anti-inflammatory profiles by manipulating cellular metabolism represents a new potential therapeutic approach to controlling inflammation. ... ...

    Abstract The concept of immunometabolism has emerged recently whereby the repolarizing of inflammatory immune cells toward anti-inflammatory profiles by manipulating cellular metabolism represents a new potential therapeutic approach to controlling inflammation. Metabolic pathways in immune cells are tightly regulated to maintain immune homeostasis and appropriate functional specificity. Because effector and regulatory immune cell populations have different metabolic requirements, this allows for cellular selectivity when regulating immune responses based on metabolic pathways. Gut microbes have a major role in modulating immune cell metabolic profiles and functional responses through extensive interactions involving metabolic products and crosstalk between gut microbes, intestinal epithelial cells, and mucosal immune cells. Developing strategies to target metabolic pathways in mucosal immune cells through the modulation of gut microbial metabolism has the potential for new therapeutic approaches for human autoimmune and inflammatory diseases, such as inflammatory bowel disease. This review will give an overview of the relationship between metabolic reprogramming and immune responses, how microbial metabolites influence these interactions, and how these pathways could be harnessed in the treatment of inflammatory bowel disease.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Inflammatory Bowel Diseases ; Inflammation ; Epithelial Cells/metabolism ; Homeostasis
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1016/j.mucimm.2022.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6796: Show issues Location:
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  2. Article: Identification of RAPD markers linked to common bacterial blight resistance genes in Phaseolus vulgaris L.

    Bai, Y / Michaels, T E / Pauls, K P

    Genome

    2008  Volume 40, Issue 4, Page(s) 544–551

    Abstract: Seven hundred and fifty-six random primers were screened with bulks of genomic DNA from common bacterial blight (CBB) resistant and susceptible bean plants. The plants were from a breeding population derived from an interspecific cross between Phaseolus ... ...

    Abstract Seven hundred and fifty-six random primers were screened with bulks of genomic DNA from common bacterial blight (CBB) resistant and susceptible bean plants. The plants were from a breeding population derived from an interspecific cross between Phaseolus acutifolius and Phaseolus vulgaris. Four RAPD markers, named R7313, RE416, RE49, and R4865, were found to be significantly associated with CBB resistance in this population. Forty-nine molecular markers segregating in the population were clustered into 8 linkage groups by a MAPMAKER linkage analysis. The largest linkage group was 140 cM long and contained 25 marker loci, including marker R4865. Markers R7313, RE416, and RE49 were clustered on another linkage group. A regression analysis indicated that the markers in these two groups together accounted for 81% of the variation in CBB resistance in the population. The addition of another marker, M56810, which was not individually associated with CBB resistance, increased the total contribution to the trait to 87%.
    Language English
    Publishing date 2008-04-22
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/g97-071
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
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  3. Article ; Online: Racial Disparities Among Clinical High-Risk and First-Episode Psychosis Multisite Research Participants: A Systematic Review.

    Michaels, Timothy I / Simon-Pearson, Laura / Kane, John M / Cornblatt, Barbara

    Psychiatric services (Washington, D.C.)

    2024  , Page(s) appips20230120

    Abstract: Objective: The NIH has mandated equal representation of Black, Indigenous, and people of color (BIPOC) individuals in clinical research, but it is unclear whether such inclusion has been achieved in multisite research studies of individuals at clinical ... ...

    Abstract Objective: The NIH has mandated equal representation of Black, Indigenous, and people of color (BIPOC) individuals in clinical research, but it is unclear whether such inclusion has been achieved in multisite research studies of individuals at clinical high risk for psychosis or with first-episode psychosis (FEP). An assessment of inclusion rates is important for understanding the social determinants of psychosis and psychosis risk that specifically affect BIPOC individuals.
    Methods: The authors conducted a systematic review of the literature published between 1993 and 2022 of multisite research studies of clinical high risk for psychosis and FEP in North America to determine ethnoracial inclusion rates. Using an online systematic review tool, the authors checked 2,278 studies for eligibility. Twelve studies met all inclusion criteria. Data were extracted, and demographic characteristics, socioeconomic status, study design, and recruitment strategies used by each study were analyzed.
    Results: Most (62%) of the participants in studies of clinical high risk for psychosis were White. Compared with national data, the demographic characteristics of individuals with clinical high risk were representative across most ethnoracial groups. Black participants (43%) made up the largest ethnoracial group in FEP studies and were overrepresented compared with their representation in the U.S. population. FEP studies were more likely to recruit participants from community mental health centers than were the studies of clinical high risk.
    Conclusions: Although these results suggest high representation of BIPOC individuals in psychosis research, opportunities exist for an improved focus on ethnoracial representation. The authors offer recommendations for practices that may increase ethnoracial diversity in future psychosis study samples.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230120
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    Zs.A 416: Show issues Location:
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  4. Article: Genetic diversity and variation in North American orchardgrass (Dactylis glomerata L.) cultivars and breeding lines

    Xie, Wengang / Bushman, B. Shaun / Ma, Yingmei / West, Mark S / Robins, Joseph G / Michaels, Lisa / Jensen, Kevin B / Zhang, Xinquan / Casler, Michael D / Stratton, Samuel D

    Grassland science. 2014 Sept., v. 60, no. 3

    2014  

    Abstract: Orchardgrass (Dactylis glomerata L.) is a high quality forage grass naturalized ...

    Abstract Orchardgrass (Dactylis glomerata L.) is a high quality forage grass naturalized to temperate climates. Used extensively in hay and grazing agriculture, hundreds of orchardgrass cultivars have been released over the past 50 years. However, progress in yield and other agronomic characteristics in orchardgrass cultivars has occurred slowly and often inconsistently. One cause of the slow progress could be a lack of genetic diversity among orchardgrass cultivars, or an over‐abundance of diversity within cultivars. With an emphasis on North American cultivars, this study assessed the genetic diversity within and among 52 orchardgrass cultivars, breeding lines and accessions. Genetic similarity within cultivars ranged from 52 to 71%, similar to values from wild‐land, unselected accessions. Populations from Wisconsin and Missouri breeding efforts that resulted from two cycles of genotypic recurrent selection were included as checks. Neither group of selection populations exhibited more within‐population similarity compared to the wild‐land accessions (ecotypes) and cultivars. Genetic differentiation was detected only for the selection populations and several cultivars and breeding lines that had a tendency to originate from eastern Asian germplasm and have late flowering times. These results indicated an abundance of genetic variation within the orchardgrass cultivars, but a paucity of genetic differentiation among cultivars.
    Keywords Dactylis glomerata ; agronomic traits ; breeding lines ; cultivars ; ecotypes ; flowering ; forage grasses ; forage quality ; genetic variation ; germplasm ; grazing ; hay ; recurrent selection ; Missouri ; Wisconsin
    Language English
    Dates of publication 2014-09
    Size p. 185-193.
    Publishing place Japanese Society of Grassland Science
    Document type Article
    ZDB-ID 2296471-X
    ISSN 1744-697X ; 1744-6961
    ISSN (online) 1744-697X
    ISSN 1744-6961
    DOI 10.1111/grs.12058
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7779: Show issues

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  5. Book: The eighteenth-century origins of angina pectoris

    Michaels, Leon

    predisposing causes, recognition and aftermath

    (Medical history : Supplement ; 21)

    2001  

    Author's details by Leon Michaels
    Series title Medical history : Supplement ; 21
    Medical history
    Medical history ; Supplement
    Collection Medical history
    Medical history ; Supplement
    Keywords Angina pectoris ; Geschichte 1700-1800
    Subject Stenokardie
    Language English
    Size XVII, 219 S. : Ill., graph. Darst.
    Publisher The Wellcome Trust Centre for the History of Medicine at UCL
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013334302
    ISBN 0-85484-073-7 ; 978-0-85484-073-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua II Zs 120 -Suppl.21- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Child maltreatment fatalities among children and adolescents 5-17 years old.

    Michaels, Nichole L / Letson, Megan M

    Child abuse & neglect

    2021  Volume 117, Page(s) 105032

    Abstract: Background: Child maltreatment-related fatalities occur among children of all ages. However, few published studies have examined child abuse and neglect deaths among older children and adolescents.: Objective: To epidemiologically describe child ... ...

    Abstract Background: Child maltreatment-related fatalities occur among children of all ages. However, few published studies have examined child abuse and neglect deaths among older children and adolescents.
    Objective: To epidemiologically describe child maltreatment-related fatalities among children in the United States 5-17 years old.
    Participants and setting: Ten years of data from the United States National Violent Death Reporting System (2006-2015) were analyzed to examine child maltreatment deaths among children 5-17 years of age.
    Methods: Child fatalities attributed to homicide or undetermined causes were reviewed by the study team to identify deaths related to child abuse and/or neglect, injury mechanisms, relationships between perpetrators and victims, victim and perpetrator characteristics, and circumstances surrounding the deaths.
    Results: The study team identified 285 abuse- and/or neglect-related fatalities during the study period. The mean age of the victims was 9.2 years and 54.4 % of victims were male. Suspected perpetrators were most frequently mothers (28.1 %) and fathers (26.3 %). The most common injury mechanism was firearms (20.7 %). A significantly greater percentage of deaths among children 11-17 years were attributable to firearms (31.6 %), compared to deaths among children 5-10 years. Among younger children 5-10 years, blunt force trauma was the most frequent injury mechanism (22.6 %).
    Conclusions: Older children and adolescents are frequently excluded from child maltreatment research. Although child maltreatment deaths are less common among older children compared to younger children, these fatalities have unique characteristics that should be considered when developing prevention strategies.
    MeSH term(s) Adolescent ; Cause of Death ; Child ; Child Abuse ; Child, Preschool ; Female ; Homicide ; Humans ; Male ; Mothers ; Suicide ; United States/epidemiology
    Language English
    Publishing date 2021-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2021.105032
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1437: Show issues Location:
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  7. Article ; Online: Lessons From COVID-19 for Protecting Workers in the Next Pandemic.

    Michaels, David / Wagner, Gregory R / Ryan, Lillian

    JAMA

    2023  Volume 330, Issue 1, Page(s) 23–24

    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Health Personnel/statistics & numerical data ; Mental Health ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; SARS-CoV-2 ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Diseases/prevention & control ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.8229
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  8. Article: Mapping quantitative trait loci for a common bean (Phaseolus vulgaris L.) ideotype.

    Beattie, Aaron D / Larsen, Jamie / Michaels, Tom E / Pauls, K Peter

    Genome

    2003  Volume 46, Issue 3, Page(s) 411–422

    Abstract: ... previously defined for a bean (Phaseolus vulgaris L.) ideotype. The QTLs were mapped to seven LGs ...

    Abstract Breeding a model plant that encompasses individual traits thought to enhance yield potential, known as ideotype breeding, has traditionally focused on phenotypic selection of plants with desirable morphological traits. Broadening this breeding method to the molecular level through the use of molecular markers would avoid the environmental interactions associated with phenotypic selection. A population of 110 F5 recombinant inbred lines (RILs), derived from the cross between WO3391 and 'OAC Speedvale', was used to develop a genetic linkage map consisting of 105 random amplified polymorphic DNA (RAPD), simple sequence repeat (SSR), and sequence-tagged site (STS) markers. The map has a total length of 641 cM distributed across 8 linkage groups (LGs). Five of them were aligned on the core linkage map of bean. Twenty-one quantitative trait loci (QTLs) were identified over three environments for eight agronomic and architectural traits previously defined for a bean (Phaseolus vulgaris L.) ideotype. The QTLs were mapped to seven LGs with several regions containing QTLs for multiple traits. At least one QTL was located for each trait and a maximum of four were associated with lodging. Total explained phenotypic variance ranged from 10.6% for hypocotyl diameter to 45.4% for maturity. Some of the QTLs identified will be useful for early generation selection of tall, upright, high-yielding lines in a breeding program.
    MeSH term(s) Analysis of Variance ; Canada ; Chromosome Mapping ; Crosses, Genetic ; Phaseolus/genetics ; Phenotype ; Quantitative Trait Loci/genetics ; Random Amplified Polymorphic DNA Technique ; Sequence Tagged Sites
    Language English
    Publishing date 2003-06
    Publishing country Canada
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/g03-015
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    Zs.A 1266: Show issues Location:
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  9. Article: Pulsed Dye Laser for Treatment of Basal Cell Carcinoma.

    Baran, Kelsey L / Cheung, Tiffany C / Csank, George A / Michaels, Basil M

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 3, Page(s) e4850

    Abstract: Basal cell carcinoma (BCC) is the most common malignancy worldwide. The incidence of BCC is increasing up to 10% per year worldwide. Surgical excision and Mohs surgery are the gold standard treatment modalities. However, patients may not be candidates ... ...

    Abstract Basal cell carcinoma (BCC) is the most common malignancy worldwide. The incidence of BCC is increasing up to 10% per year worldwide. Surgical excision and Mohs surgery are the gold standard treatment modalities. However, patients may not be candidates for surgery. Pulsed dye laser (PDL) is a novel technique for treating BCC.
    Methods: Patients with biopsy-proven BCC underwent two treatments with PDL at 6-week intervals at Berkshire Cosmetic and Reconstructive Surgery Center. Patients returned 6 weeks after the second treatment for evaluation for response to treatment. Follow-up examinations were conducted at 6, 12, and 18 months after treatment with PDL.
    Results: Twenty patients with 21 biopsy-proven BCCs were treated with PDL at Berkshire Cosmetic and Reconstructive Surgery Center between 2019 and 2021. Nineteen BCCs had a complete response after two treatments, for a clearance rate of 90%. Two of the 21 lesions did not respond for an incomplete response rate of 10%.
    Conclusion: PDL is an effective nonsurgical treatment option in the management of BCC.
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004850
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
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  10. Article: An epidemiological study of unintentional pediatric firearm fatalities in the USA, 2009-2018.

    Vaishnav, Arti / Smith, Gary A / Badeti, Jaahnavi / Michaels, Nichole L

    Injury epidemiology

    2023  Volume 10, Issue 1, Page(s) 25

    Abstract: Background: Firearm injuries are the leading cause of mortality among children and adolescents 1-19 years old in the USA. Many prior studies on this topic lack detailed information about the circumstances of the firearm fatalities and include decedents ... ...

    Abstract Background: Firearm injuries are the leading cause of mortality among children and adolescents 1-19 years old in the USA. Many prior studies on this topic lack detailed information about the circumstances of the firearm fatalities and include decedents and shooters of all ages. This study characterizes firearm fatalities in the USA in which children < 15 years old unintentionally killed themselves or another child.
    Methods: Ten years of data from the National Violent Death Reporting System were analyzed. Unintentional firearm fatalities among children were reviewed to identify characteristics of decedents and the children who inflicted the deaths, their relationship, and circumstances of the deaths. There were 279 firearm fatalities during the study period involving children < 15 years old who unintentionally killed themselves or another child < 15 years old.
    Results: Most victims were male (81.4%), and 40.9% were 2-4 years old. Most incidents (64.0%) occurred at the victim's residence, and in 80.9% of cases the firearm owner was a relative of the shooter. In the < 5-year age group, 80.3% of injuries were self-inflicted, and in the 10-14-year age group, 32.3% of shooters were a friend of the victim.
    Conclusion: This study highlights that children in the USA are shooting themselves and each other in their own homes, and often accessing firearms owned by family members. These findings can be used to guide prevention efforts, such as child access prevention laws, to reduce the number of pediatric firearm fatalities in the future.
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2764253-7
    ISSN 2197-1714
    ISSN 2197-1714
    DOI 10.1186/s40621-023-00438-5
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