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  1. Article ; Online: Predicting ophthalmic clinic non-attendance using machine learning: Development and validation of models using nationwide data.

    Breeze, Finley / Hossain, Ruhella R / Mayo, Michael / McKelvie, James

    Clinical & experimental ophthalmology

    2023  Volume 51, Issue 8, Page(s) 764–774

    Abstract: ... SD 0.072). XGBoost performed better than logistic regression (mean AUROC = 0.756, p = 0.002 ... on the complete nationwide dataset (mean AUROC = 0.754, p = 0.04).: Conclusion: Machine learning algorithms ...

    Abstract Background: Ophthalmic clinic non-attendance in New Zealand is associated with poorer health outcomes, marked inequities and costs NZD$30 million per annum. Initiatives to improve attendance typically involve expensive and ineffective brute-force strategies. The aim was to develop machine learning models to accurately predict ophthalmic clinic non-attendance.
    Methods: This multicentre, retrospective observational study developed and validated predictive models of clinic non-attendance. Attendance data for 3.1 million appointments from all New Zealand government-funded ophthalmology clinics from 2009 to 2018 were aggregated for analysis. Repeated ten-fold cross validation was used to train and optimise XGBoost and logistic regression models on several demographic and clinic-related variables. Models developed using the entire training set were compared with those restricted to regional subsets of the data.
    Results: In the testing data set from 2019, there were 407 574 appointments (median [range] age, 66 [0-105] years; 210 365 [51.6%] female) with a non-attendance rate of 5.7% (n = 23 309 missed appointments), XGBoost models trained on each region's data achieved the highest mean AUROC of 0.764 (SD 0.058) and mean AUPRC of 0.157 (SD 0.072). XGBoost performed better than logistic regression (mean AUROC = 0.756, p = 0.002). Training individual XGBoost models for each region led to better performance than training a single model on the complete nationwide dataset (mean AUROC = 0.754, p = 0.04).
    Conclusion: Machine learning algorithms can predict ophthalmic clinic non-attendance with relatively basic demographic and clinic data. These findings suggest further research examining implementation of such algorithms in scheduling systems or public health interventions may be useful.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Retrospective Studies ; Appointments and Schedules ; Ambulatory Care Facilities ; Machine Learning ; Algorithms
    Language English
    Publishing date 2023-10-27
    Publishing country Australia
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patient-reported quality of life and eligibility for cataract surgery: assessing the relationship between ethnicity and 'Impact on Life' questionnaire scores in New Zealand.

    Wang, Nancy / Hunt, Lyn / McKelvie, James

    The New Zealand medical journal

    2022  Volume 135, Issue 1553, Page(s) 19–26

    Abstract: ... 22.8/36 vs 22.4/36) despite statistical significance for the difference (p=0.001). Māori and Pacific ...

    Abstract Aims: The 'Impact on Life' (IoL) questionnaire is a patient reported quality-of-life assessment tool used to prioritise cataract surgery in New Zealand (NZ). This study evaluated the association between ethnicity and IoL questionnaire responses.
    Methods: This is a retrospective cohort study of patients prioritised for public-funded cataract surgery between November 2014 and March 2019 in New Zealand. Data were extracted from the New Zealand Ministry of Health National Prioritisation Web Service database. Ethnic, demographic and IoL data for all patients who were prioritised for surgery were analysed after controlling for age, gender, visual acuity and cataract type.
    Results: Of the 58,648 prioritisation events, over the four-and-a-half-year period, 46,352 prioritisation events had documented scores for the IoL questionnaire. The study population had a mean age of 74.4 years and had a female preponderance (74%). The average IoL score was 22.5/36 (SD 7.8). After controlling for age, gender, visual acuity (VA) and cataract type, there was only a marginal difference between Māori and non-Māori IoL scores (22.8/36 vs 22.4/36) despite statistical significance for the difference (p=0.001). Māori and Pacific people presented at a younger age (68.5 years and 66.7 years, respectively) with worse visual acuity than other ethnic groups (mean range 70.1-76.7 years). Mean IoL scores were 23.0/36 for Māori and Pacific people and 22.4/36 for other ethnic groups.
    Conclusions: Māori and Pacific people present younger with worse VA and more advanced cataracts at time of surgical prioritisation when compared with other ethnic groups. Despite these differences, after controlling for confounding factors, the mean IoL score did not differ to a level that was clinically significant between different ethnic groups in New Zealand at time of prioritisation for cataract surgery. These results suggest that there are no meaningful ethnic specific differences in patient reported quality of life for patients with cataract in New Zealand after controlling for other factors. Alternatively, the IoL tool may lack the sensitivity to detect meaningful ethnic disparities that may exist for quality of life in this cohort of patients.
    MeSH term(s) Aged ; Cataract/epidemiology ; Ethnicity ; Female ; Humans ; New Zealand/epidemiology ; Patient Reported Outcome Measures ; Quality of Life ; Retrospective Studies ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: International health experiences in postgraduate medical education: A meta-analysis of their effect on graduates' clinical practice among underserved populationsExpériences internationales de soins de santé en formation médicale post-doctorale : une méta-analyse des effets sur la pratique clinique des diplômés au sein des populations mal desservies.

    Dawe, Russell / McKelvie, Mark

    Canadian medical education journal

    2020  Volume 11, Issue 4, Page(s) e70–e79

    Abstract: ... underserved populations (OR = 2.12; CI = 95%; P = 0.03). The certainty of the evidence was low due to limitations in study ...

    Abstract Background: International health experiences (IHEs) are popular among medical learners and provide a valuable learning experience. IHE participants have demonstrated an increased intention to care for underserved populations in the future, but what is its actual impact on practice? This study evaluates the effect of postgraduate IHE participation on the future careers of clinicians regarding their work among underserved populations.
    Methods: We conducted a systematic review and meta-analysis of peer-reviewed articles comparing the populations served by physicians who had participated in an IHE with those of physicians who had not participated in an IHE.
    Results: 764 titles were scanned, 28 articles were reviewed, with an eventual 3 studies of fair-good or good quality identified. These addressed physicians' service to domestic underserved populations, and also addressed future service in a low- or middle-income country (LMIC). Meta-analysis demonstrated a statistically-significant increase in service by IHE graduates to domestic underserved populations (OR = 2.12; CI = 95%; P = 0.03). The certainty of the evidence was low due to limitations in study design (non-randomised studies) and inconsistency in effects.
    Conclusion: Participation in an IHE may cause an increase in care for domestic underserved populations in future clinical practice, though further research from high quality randomised trials is needed to increase the certainty of the effect. Further study is needed to establish whether there is a similar effect with increased future service in a LMIC setting.
    Language English
    Publishing date 2020-08-06
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2689512-2
    ISSN 1923-1202
    ISSN 1923-1202
    DOI 10.36834/cmej.56940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Delayed Bacterial Endotheliitis and Endophthalmitis 11 Years after Cataract Surgery.

    Poon, Elisabeth / Poon, Alexander / McKelvie, Penelope / Levitz, Lewis / Zamir, Ehud

    Case reports in ophthalmology

    2023  Volume 14, Issue 1, Page(s) 376–381

    Abstract: Infective endophthalmitis is an uncommon complication following intraocular surgery. Chronic endophthalmitis may present some time after intraocular surgery, making the diagnosis challenging. ...

    Abstract Infective endophthalmitis is an uncommon complication following intraocular surgery. Chronic endophthalmitis may present some time after intraocular surgery, making the diagnosis challenging.
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2577666-6
    ISSN 1663-2699
    ISSN 1663-2699
    DOI 10.1159/000531501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Re: concomitant adult onset xanthogranuloma and IgG4-related orbital disease: A rare occurrence.

    McNab, Alan A / McKelvie, Penny

    Orbit (Amsterdam, Netherlands)

    2020  Volume 40, Issue 1, Page(s) 85–86

    MeSH term(s) Adult ; Granuloma ; Humans ; Immunoglobulin G ; Orbital Diseases/diagnosis ; Xanthomatosis
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2020-10-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603157-2
    ISSN 1744-5108 ; 0167-6830
    ISSN (online) 1744-5108
    ISSN 0167-6830
    DOI 10.1080/01676830.2020.1832124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Isolated esophageal IgG4-related disease presenting with progressive dysphagia and weight loss in a middle-aged man.

    Poole, Hannah / Fehily, Sasha / McKelvie, Penelope / Miller, Ashley / Lust, Mark / Holmes, Jacinta Alison

    Clinical journal of gastroenterology

    2022  Volume 15, Issue 3, Page(s) 526–530

    Abstract: Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized immune-mediated condition that results in inflammation, stricturing and mass formation. It causes a wide spectrum of disease and clinical presentations depending on the organ ... ...

    Abstract Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized immune-mediated condition that results in inflammation, stricturing and mass formation. It causes a wide spectrum of disease and clinical presentations depending on the organ system involved. Isolated esophageal IgG4-RD is rare and diagnosis can be difficult. It is highly responsive to corticosteroids, and early identification and instigation of management is key.We describe the case of a 47-year-old man who presented with a food bolus obstruction on a background of progressive dysphagia and weight loss. Imaging and gastroscopy demonstrated diffuse esophageal thickening with a benign appearing stricture. Following non-specific histologic findings on biopsy and a non-diagnostic endoscopic ultrasound guided fine needle aspiration, he underwent video-assisted thoracoscopic surgery with esophageal core biopsy. This confirmed the diagnosis of IgG4-RD. Initial treatment was with corticosteroids. However, due to recurrence of symptoms upon weaning of corticosteroids, azathioprine maintenance therapy was instituted. Azathioprine has previously been used in systemic cases of IgG4-RD but has not been reported for isolated esophageal disease.This case highlights the difficulties in the diagnosis and treatment of esophageal IgG4-RD and the need to consider it as a differential diagnosis when histology reveals esophagitis with lymphoplasmacytic infiltration.
    MeSH term(s) Azathioprine/therapeutic use ; Deglutition Disorders/etiology ; Humans ; Immunoglobulin G4-Related Disease ; Male ; Middle Aged ; Weight Loss
    Chemical Substances Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2022-04-06
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-022-01623-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Validation of Mahajan's formula for scaling ocular higher-order aberrations by pupil size.

    Wallace, Henry B / Misra, Stuti L / McKelvie, James

    Indian journal of ophthalmology

    2020  Volume 68, Issue 6, Page(s) 1067–1072

    Abstract: ... Holm-Bonferroni correction (P > 0.05). Mean differences between the scaled and measured Zernike ...

    Abstract Purpose: Zernike polynomials for describing ocular higher order aberrations are affected by pupil aperture. The current study aimed to validate Mahajan's formula for scaling Zernike polynomials by pupil size.
    Methods: Higher order aberrations for 3 intraocular lens models (AcrySof IQ IOL SN60WF, Technis ZA9003, Adapt Advanced Optics) were measured using the Zywave aberrometer and a purpose-built physical model eye. Zernike coefficients were mathematically scaled from a 5 mm to a 3 mm pupil diameter (5:3 mm), from a 5 mm to a 2 mm pupil diameter (5:2 mm), and from a 3 mm to a 2 mm pupil diameter (3:2 mm). Agreement between the scaled coefficients and the measured coefficients at the same pupil aperture was assessed using the Bland-Altman method in R statistical software.
    Results: No statistically significant mean difference (MD) occurred between the scaled and measured Zernike coefficients for 21 of 23 analyses after Holm-Bonferroni correction (P > 0.05). Mean differences between the scaled and measured Zernike coefficients were clinically insignificant for all aberrations up to the fourth order, and within 0.10 μm. Oblique secondary astigmatism (Z
    Conclusion: A formula for the scaling of higher order aberrations by pupil size is validated as accurate. Pupil scaling enables accurate comparison of individual higher order aberrations in clinical research for situations involving different pupil sizes.
    MeSH term(s) Astigmatism ; Humans ; Models, Theoretical ; Pupil ; Refraction, Ocular
    Language English
    Publishing date 2020-05-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_773_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: International health experiences in postgraduate medical education

    Russell Dawe / Mark McKelvie

    Canadian Medical Education Journal, Vol 11, Iss

    A meta-analysis of their effect on graduates’ clinical practice among underserved populations

    2020  Volume 4

    Abstract: ... underserved populations (OR = 2.12; CI = 95%; P = 0.03). The certainty of the evidence was low due to limitations in study ...

    Abstract Background: International health experiences (IHEs) are popular among medical learners and provide a valuable learning experience. IHE participants have demonstrated an increased intention to care for underserved populations in the future, but what is its actual impact on practice? This study evaluates the effect of postgraduate IHE participation on the future careers of clinicians regarding their work among underserved populations. Methods: We conducted a systematic review and meta-analysis of peer-reviewed articles comparing the populations served by physicians who had participated in an IHE with those of physicians who had not participated in an IHE. Results: 764 titles were scanned, 28 articles were reviewed, with an eventual 3 studies of fair-good or good quality identified. These addressed physicians’ service to domestic underserved populations, and also addressed future service in a low- or middle-income country (LMIC). Meta-analysis demonstrated a statistically-significant increase in service by IHE graduates to domestic underserved populations (OR = 2.12; CI = 95%; P = 0.03). The certainty of the evidence was low due to limitations in study design (non-randomised studies) and inconsistency in effects. Conclusion: Participation in an IHE may cause an increase in care for domestic underserved populations in future clinical practice, though further research from high quality randomised trials is needed to increase the certainty of the effect. Further study is needed to establish whether there is a similar effect with increased future service in a LMIC setting
    Keywords Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Canadian Medical Education Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Quantifying Improvement in V˙ o2peak and Exercise Thresholds in Cardiovascular Disease Using Reliable Change Indices.

    Faricier, Robin / Keltz, Randi R / Hartley, Tim / McKelvie, Robert S / Suskin, Neville G / Prior, Peter L / Keir, Daniel A

    Journal of cardiopulmonary rehabilitation and prevention

    2023  Volume 44, Issue 2, Page(s) 121–130

    Abstract: ... in V˙ o2 at θ LT ( P = .78), RCP ( P = .08), or V˙ o2peak ( P = .74) and each variable exhibited ...

    Abstract Purpose: Improving aerobic fitness through exercise training is recommended for the treatment of cardiovascular disease (CVD). However, strong justifications for the criteria of assessing improvement in key parameters of aerobic function including estimated lactate threshold (θ LT ), respiratory compensation point (RCP), and peak oxygen uptake (V˙ o2peak ) at the individual level are not established. We applied reliable change index (RCI) statistics to determine minimal meaningful change (MMC RCI ) cutoffs of θ LT , RCP, and V˙ o2peak for individual patients with CVD.
    Methods: Sixty-six stable patients post-cardiac event performed three exhaustive treadmill-based incremental exercise tests (modified Bruce) ∼1 wk apart (T1-T3). Breath-by-breath gas exchange and ventilatory variables were measured by metabolic cart and used to identify θ LT , RCP, and V˙ o2peak . Using test-retest reliability and mean difference scores to estimate error and test practice/exposure, respectively, MMC RCI values were calculated for V˙ o2 (mL·min -1. kg -1 ) at θ LT , RCP, and V˙ o2peak .
    Results: There were no significant between-trial differences in V˙ o2 at θ LT ( P = .78), RCP ( P = .08), or V˙ o2peak ( P = .74) and each variable exhibited excellent test-retest variability (intraclass correlation: 0.97, 0.98, and 0.99; coefficient of variation: 6.5, 5.4, and 4.9% for θ LT , RCP, and V˙ o2peak , respectively). Derived from comparing T1-T2, T1-T3, and T2-T3, the MMC RCI for θ LT were 3.91, 3.56, and 2.64 mL·min -1. kg -1

    4.01, 2.80, and 2.79 mL·min -1. kg -1 for RCP; and 3.61, 3.83, and 2.81 mL·min -1. kg -1 for V˙ o2peak . For each variable, MMC RCI scores were lowest for T2-T3 comparisons.
    Conclusion: These MMC RCI scores may be used to establish cutoff criteria for determining meaningful changes for interventions designed to improve aerobic function in individuals with CVD.
    MeSH term(s) Humans ; Cardiovascular Diseases ; Reproducibility of Results ; Oxygen Consumption ; Exercise Test ; Exercise
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2272063-7
    ISSN 1932-751X ; 1932-7501
    ISSN (online) 1932-751X
    ISSN 1932-7501
    DOI 10.1097/HCR.0000000000000837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pembrolizumab associated sarcoid-like lymphadenopathy mimicking progressive disease in Hodgkin lymphoma.

    Chau, Bruce Tsz Chun / McKelvie, Penelope / Bazargan, Ali / Mohamed, Muhajir

    Pathology

    2020  Volume 53, Issue 5, Page(s) 675–678

    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/pharmacology ; Disease Progression ; Hodgkin Disease/diagnosis ; Hodgkin Disease/pathology ; Humans ; Lymph Nodes/pathology ; Lymphadenopathy/diagnosis ; Lymphadenopathy/drug therapy ; Lymphadenopathy/pathology ; Male ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2020.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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