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Article ; Online: Accuracy and precision of simpler and lower-cost technologies to measure the initial lean angle, step length and step velocity for forward lean releases.

Carbonneau, Evelyne / Léonard, Guillaume / Lalanne, Kevin / da Silva, Rubens A / Smeesters, Cécile

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

2022 Volume 67, Page(s) 102699

Abstract: Current technologies to measure the maximum forward lean angle, step length and velocity in a clinical setting are neither simple nor cheap. Therefore, the purpose of this study was to determine the accuracy and precision of four live and one post- ... ...

Abstract	Current technologies to measure the maximum forward lean angle, step length and velocity in a clinical setting are neither simple nor cheap. Therefore, the purpose of this study was to determine the accuracy and precision of four live and one post-processing measurement methods compared to the 3D motion analysis gold standard. Twelve healthy younger adults recovered balance, after being released from six randomly ordered forward initial lean angles, using four different live measurement methods: LabVIEW, load cell, inclinometer and protractor. The initial lean angle, step length and velocity were also calculated in post-processing using 2D video analysis and 3D motion analysis. The LabVIEW method was the most accurate and precise, followed by the protractor, inclinometer and load cell methods. The load cell method was the most complex, followed by the LabVIEW, inclinometer and protractor methods. The LabVIEW method was the most expensive, followed by the load cell, inclinometer and protractor methods. Video analysis was sufficiently accurate and precise, equal in complexity and much less expensive than the gold standard. Simpler and lower-cost technologies to measure the initial lean angle, step length and velocity are sufficiently accurate and precise (live: protractor, post-processing: video analysis) to potentially use in a clinical setting.
Language	English
Publishing date	2022-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1073161-1
ISSN	1873-5711 ; 1050-6411
ISSN (online)	1873-5711
ISSN	1050-6411
DOI	10.1016/j.jelekin.2022.102699
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Article: Complete Response to Immunotherapy in a Patient with

Mathias-Machado, Maria Cecilia / Peixoto, Renata D / Ashton-Prolla, Patricia / Da Silva, Leonard Medeiros / Dienstmann, Rodrigo

Case reports in oncology

2023 Volume 16, Issue 1, Page(s) 504–510

Abstract: MUTYH-associated polyposis syndrome is an uncommon, autosomal recessive colorectal polyposis syndrome caused by biallelic inactivation ... ...

Abstract	MUTYH-associated polyposis syndrome is an uncommon, autosomal recessive colorectal polyposis syndrome caused by biallelic inactivation of
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000530965
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Article: Crossing the Andes: Challenges and opportunities for digital pathology in Latin America.

Coudry, Renata A / Assis, Emilio A C P / Frassetto, Fernando Pereira / Jansen, Angela Marie / da Silva, Leonard Medeiros / Parra-Medina, Rafael / Saieg, Mauro

Journal of pathology informatics

2024 Volume 15, Page(s) 100369

Abstract: The most widely accepted and used type of digital pathology (DP) is whole-slide imaging (WSI). The USFDA granted two WSI system approvals for primary diagnosis, the first in 2017. In Latin America, DP has the potential to reshape healthcare by enhancing ... ...

Abstract	The most widely accepted and used type of digital pathology (DP) is whole-slide imaging (WSI). The USFDA granted two WSI system approvals for primary diagnosis, the first in 2017. In Latin America, DP has the potential to reshape healthcare by enhancing diagnostic capabilities through artificial intelligence (AI) and standardizing pathology reports. Yet, we must tackle regulatory hurdles, training, resource availability, and unique challenges to the region. Collectively addressing these hurdles can enable the region to harness DP's advantages-enhancing disease diagnosis, medical research, and healthcare accessibility for its population. Americas Health Foundation assembled a panel of Latin American pathologists who are experts in DP to assess the hurdles to implementing it into pathologists' workflows in the region and provide recommendations for overcoming them. Some key steps recommended include creating a Latin American Society of Digital Pathology to provide continuing education, developing AI models trained on the Latin American population, establishing national regulatory frameworks for protecting the data, and standardizing formats for DP images to ensure that pathologists can collaborate and validate specimens across the various DP platforms.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2579241-6
ISSN	2153-3539 ; 2229-5089
ISSN (online)	2153-3539
ISSN	2229-5089
DOI	10.1016/j.jpi.2024.100369
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Article ; Online: The influence of experimental low back pain on neural networks involved in the control of lumbar erector spinae muscles.

Rohel, Antoine / Desmons, Mikaël / Léonard, Guillaume / Desgagnés, Amélie / da Silva, Rubens / Simoneau, Martin / Mercier, Catherine / Massé-Alarie, Hugo

Journal of neurophysiology

2022 Volume 127, Issue 6, Page(s) 1593–1605

Abstract: Low back pain (LBP) often modifies spine motor control, but the neural origin of these motor control changes remains largely unexplored. This study aimed to determine the impact of experimental low back pain on the excitability of cortical, subcortical, ... ...

Abstract	Low back pain (LBP) often modifies spine motor control, but the neural origin of these motor control changes remains largely unexplored. This study aimed to determine the impact of experimental low back pain on the excitability of cortical, subcortical, and spinal networks involved in the control of back muscles. Thirty healthy subjects were recruited and allocated to pain (capsaicin and heat) or control (heat) groups. Corticospinal excitability (motor-evoked potential; MEP) and intracortical networks were assessed by single- and paired-pulse transcranial magnetic stimulation, respectively. Electrical vestibular stimulation was applied to assess vestibulospinal excitability (vestibular MEP; VMEP) and the stretch reflex for excitability of the spinal or supraspinal loop (R1 and R2, respectively). Evoked back motor responses were measured before, during, and after pain induction. Nonparametric rank-based ANOVA determined if pain modulated motor neural networks. A decrease of R1 amplitude was present after the pain disappearance (
MeSH term(s)	Back Muscles ; Electromyography ; Evoked Potentials, Motor/physiology ; Humans ; Low Back Pain ; Muscle, Skeletal ; Neural Networks, Computer ; Pyramidal Tracts/physiology ; Transcranial Magnetic Stimulation
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00030.2022
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Article: Effect of Barrel-to-Barrel Variation on Color and Phenolic Composition of a Red Wine.

Pfahl, Leonard / Catarino, Sofia / Fontes, Natacha / Graça, António / Ricardo-da-Silva, Jorge

Foods (Basel, Switzerland)

2021 Volume 10, Issue 7

Abstract: Tangible variation of sensory characteristics is often observed in wine aged in similar barrels. Barrel-to-barrel variation in barrel-aged wines was investigated in respect of the most important phenolic compounds of oenological interest. A red wine was ... ...

Abstract	Tangible variation of sensory characteristics is often observed in wine aged in similar barrels. Barrel-to-barrel variation in barrel-aged wines was investigated in respect of the most important phenolic compounds of oenological interest. A red wine was aged in 49 medium-toasted oak (
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10071669
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Article ; Online: NMR and multivariate methods: Identification of chemical markers in extracts of pedra-ume-caá and their antiglycation, antioxidant, and enzymatic inhibition activities.

Oliveira, Edinilze S C / Pontes, Flávia L D / Acho, Leonard D R / da Silva, Bárbara Janaína P / do Rosário, Alessandro S / Chaves, Francisco Célio M / Campos, Francinete R / Bezerra, Jaqueline de A / Lima, Emerson S / Machado, Marcos B

Phytochemical analysis : PCA

2024 Volume 35, Issue 3, Page(s) 552–566

Abstract: Introduction: In Brazil, the plant group popularly known as "pedra-ume-caá" is used in folk medicine for the treatment of diabetes, and its raw material is commonly sold.: Objective: The aim of the study was to apply a method for chemical ... ...

Abstract	Introduction: In Brazil, the plant group popularly known as "pedra-ume-caá" is used in folk medicine for the treatment of diabetes, and its raw material is commonly sold. Objective: The aim of the study was to apply a method for chemical identification of extracts of dry pedra-ume-caá leaves using HPLC-high-resolution mass spectrometry (HRMS) and NMR and develop a multivariate model with NMR data to authenticate commercial samples. In addition, to evaluate the biological activities of the extracts. Materials and methods: Dry extracts of Myrcia multiflora, Myrcia amazonica, Myrcia guianensis, Myrcia sylvatica, Eugenia punicifolia leaves, and 15 commercial samples (sold in Manaus and Belém, Brazil) were prepared by infusion. All the extracts were analysed using HPLC-high-resolution mass spectrometry (HRMS), NMR, principal component analysis (PCA), and hierarchical cluster analysis (HCA). The antidiabetic effect of extracts was evaluated according to enzymatic inhibition. Their content of total phenols, cell viability, and antioxidant and antiglycation activities were also determined. Results: HPLC-HRMS and NMR analysis of these extracts permitted the identification of 17 compounds. Conclusion: This study revealed the chemical markers of matrices, and it was possible to differentiate the materials marketed as pedra-ume-caá. Moreover, this study corroborates the potential of these species for treating diabetes.
MeSH term(s)	Antioxidants/chemistry ; Plant Extracts/chemistry ; Myrtaceae/chemistry ; Magnetic Resonance Spectroscopy ; Diabetes Mellitus ; Plant Leaves/chemistry
Chemical Substances	Antioxidants ; Plant Extracts
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3312
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Article: Claudin 18.2 as a New Biomarker in Gastric Cancer-What Should We Know?

Mathias-Machado, Maria Cecília / de Jesus, Victor Hugo Fonseca / Jácome, Alexandre / Donadio, Mauro Daniel / Aruquipa, Marcelo Porfirio Sunagua / Fogacci, João / Cunha, Renato Guerino / da Silva, Leonard Medeiros / Peixoto, Renata D'Alpino

Cancers

2024 Volume 16, Issue 3

Abstract: Gastric cancer (GC) remains a formidable global health challenge, ranking among the top-five causes of cancer-related deaths worldwide. The majority of patients face advanced stages at diagnosis, with a mere 6% five-year survival rate. First-line ... ...

Abstract	Gastric cancer (GC) remains a formidable global health challenge, ranking among the top-five causes of cancer-related deaths worldwide. The majority of patients face advanced stages at diagnosis, with a mere 6% five-year survival rate. First-line treatment for metastatic GC typically involves a fluoropyrimidine and platinum agent combination; yet, predictive molecular markers have proven elusive. This review navigates the evolving landscape of GC biomarkers, with a specific focus on Claudin 18.2 (CLDN18.2) as an emerging and promising target. Recent phase III trials have unveiled the efficacy of Zolbetuximab, a CLDN18.2-targeting antibody, in combination with oxaliplatin-based chemotherapy for CLDN18.2-positive metastatic GC. As this novel therapeutic avenue unfolds, understanding the nuanced decision making regarding the selection of anti-CLDN18.2 therapies over other targeted agents in metastatic GC becomes crucial. This manuscript reviews the evolving role of CLDN18.2 as a biomarker in GC and explores the current status of CLDN18.2-targeting agents in clinical development. The aim is to provide concise insights into the potential of CLDN18.2 as a therapeutic target and guide future clinical decisions in the management of metastatic GC.
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030679
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Article ; Online: Potential Movement Corridors and High Road-Kill Likelihood do not Spatially Coincide for Felids in Brazil: Implications for Road Mitigation.

Cerqueira, Rafaela Cobucci / Leonard, Paul B / da Silva, Lucas Gonçalves / Bager, Alex / Clevenger, Anthony P / Jaeger, Jochen A G / Grilo, Clara

Environmental management

2021 Volume 67, Issue 2, Page(s) 412–423

Abstract: The negative effects of roads on wildlife populations are a growing concern. Movement corridors and road-kill data are typically used to prioritize road segments for mitigation measures. Some research suggests that locations where animals move across ... ...

Abstract	The negative effects of roads on wildlife populations are a growing concern. Movement corridors and road-kill data are typically used to prioritize road segments for mitigation measures. Some research suggests that locations where animals move across roads following corridors coincide with locations where they are often killed by vehicles. Other research indicates that corridors and road-kill rarely occur in the same locations. We compared movement corridor and road mortality models as means of prioritizing road segments for mitigation for five species of felids in Brazil: tiger cats (Leopardus tigrinus and Leopardus guttulus were analyzed together), ocelot (Leopardus pardalis), jaguarundi (Herpailurus yagouaroundi), and puma (Puma concolor). We used occurrence data for each species and applied circuit theory to identify potential movement corridors crossed by roads. We used road-kill records for each species and applied maximum entropy to determine where mortality was most likely to occur on roads. Our findings suggest that movement corridors and high road mortality are not spatially associated. We suggest that differences in the behavioral state of the individuals in the species occurrence and road-kill data may explain these results. We recommend that the road segments for which the results from the two methods agree (~5300 km for all studied species combined at 95th percentile) should be high-priority candidates for mitigation together with road segments identified by at least one method in areas where felids occur in low population densities or are threatened by isolation effects.
MeSH term(s)	Animals ; Animals, Wild ; Brazil ; Cats ; Felidae ; Population Density ; Puma
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-020-01411-4
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Article ; Online: Exercise oscillatory breathing in heart failure with reduced ejection fraction: clinical implication.

da Luz Goulart, Cássia / Agostoni, Piergiuseppe / Salvioni, Elisabetta / Kaminsky, Leonard A / Myers, Jonathan / Arena, Ross / Borghi-Silva, Audrey

European journal of preventive cardiology

2022 Volume 29, Issue 12, Page(s) 1692–1698

Abstract: Aim: The aim of the study is (i) to evaluate the impact of exercise oscillatory ventilation (EOV) in patients with heart failure (HF) with reduced left ventricular ejection fraction (HFrEF) during cardiopulmonary exercise testing (CPET) compared with no ...

Abstract	Aim: The aim of the study is (i) to evaluate the impact of exercise oscillatory ventilation (EOV) in patients with heart failure (HF) with reduced left ventricular ejection fraction (HFrEF) during cardiopulmonary exercise testing (CPET) compared with no EOV (N-EOV); (ii) to identify the influence of EOV persistence (P-EOV) and EOV disappearance (D-EOV) during CPET on the outcomes of mortality and hospitalization in HFrEF patients; and (iii) to identify further predictors of mortality and hospitalization in patients with P-EOV. Methods and results: Three hundred and fifteen stable HFrEF patients underwent CPET and were followed for 35 months. We identified 202 patients N-EOV and 113 patients with EOV. Patients with EOV presented more symptoms [New York Heart Association (NYHA) III: 35% vs. N-EOV 20%, P < 0.05], worse cardiac function (LVEF: 28 ± 6 vs. N-EOV 39 ± 1, P < 0.05), higher minute ventilation/carbon dioxide production (V̇E/V̇CO2 slope: 41 ± 11 vs. N-EOV 37 ± 8, P < 0.05) and a higher rate of deaths (26% vs. N-EOV 6%, P < 0.05) and hospitalization (29% vs. N-EOV 9%, P < 0.05). Patients with P-EOV had more severe HFrEF (NYHA IV: 23% vs. D-EOV: 9%, P < 0.05), had worse cardiac function (LVEF: 24 ± 5 vs. D-EOV: 34 ± 3, P < 0.05) and had lower peak oxygen consumption (V̇O2) (12.0 ± 3.0 vs. D-EOV: 13.3 ± 3.0 mLO2 kg-1.min-1, P < 0.05). Among P-EOV, other independent predictors of mortality were V̇E/V̇CO2 slope ≥36 and V̇O2 peak ≤12 mLO2 kg-1 min-1; a V̇E/V̇CO2 slope≥34 was a significant predictor of hospitalization. Kaplan-Meier survival analysis showed that HFrEF patients with P-EOV had a higher risk of mortality and higher risk of hospitalization (P < 0.05) than patients with D-EOV and N-EOV. Conclusion: In HFrEF patients, EOV persistence during exercise had a strong prognostic role. In P-EOV patients, V̇E/V̇CO2 ≥36 and V̇O2 peak ≤12 mLO2 kg-1 min-1 had a further additive negative prognostic role.
MeSH term(s)	Exercise Test/methods ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Oxygen Consumption ; Prognosis ; Pulmonary Ventilation ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwac116
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Article ; Online: Objectifying the Role of the Depressor Anguli Oris Muscle Using High-Resolution Ultrasound: A Prospective Study.

Kehrer, Andreas / Ruewe, Marc / Klebuc, Michael / Platz Batista da Silva, Natascha / Lonic, Daniel / Heidkrueger, Paul / Knoedler, Samuel / Jung, Ernst-Michael / Prantl, Lukas / Knoedler, Leonard

Plastic and reconstructive surgery

2023 Volume 152, Issue 4, Page(s) 866–870

Abstract: Background: In the setting of facial palsy, synkinesis of the depressor anguli oris (DAO) muscle is a common pathology, impairing dynamic and resting facial symmetry.In this prospective study, the authors used high-resolution ultrasound (HRUS) to ... ...

Abstract	Background: In the setting of facial palsy, synkinesis of the depressor anguli oris (DAO) muscle is a common pathology, impairing dynamic and resting facial symmetry.In this prospective study, the authors used high-resolution ultrasound (HRUS) to evaluate the morphologic features of DAO and to quantify bilateral differences in DAO cross-sectional diameter (CSD) in individuals with unilateral synkinesis. Methods: From June of 2020 to May of 2021, 30 patients (19 women, 11 men) with clinically diagnosed unilateral synkinesis underwent evaluation with HRUS. DAO CSD was measured bilaterally, 1 cm inferior to the modiolus, in both the resting and smiling positions. Results: The Sunnybrook Facial Grading System Synkinesis Score was 6.20 ± 2.48 (range, 0 to 10). DAO CSD at rest measured 2.41 ± 0.67 mm (range, 1.40 to 4.00 mm) on the control side and 2.66 ± 0.98 mm (range, 1.60 to 5.10 mm) on the affected side. On the control side, DAO CSD was reduced by -0.19 ± 0.43 mm (range, -1.10 to 1.12 mm) during smiling. In contrast, the synkinetic DAO CSD increased by 0.64 ± 0.38 mm (range, 0.00 to 1.59 mm) ( P < 0.001) with animation. The pattern of increased CSD in synkinetic DAO muscles and decreased or unchanged CSD on the control side during smiling was identified in 70% of patients. Conclusions: HRUS demonstrates increased CSD in synkinetic DAO muscles during active smiling. The opposite is true for DAO muscles on the control side, which exhibit decreased CSD with animation. HRUS can be performed preoperatively to objectify DAO dysfunction and guide targeted therapy. Clinical question/level of evidence: Diagnostic, IV.
MeSH term(s)	Male ; Humans ; Female ; Prospective Studies ; Facial Muscles/diagnostic imaging ; Synkinesis ; Facial Paralysis/surgery ; Smiling/physiology
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010287
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