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  1. Book ; Online ; E-Book: Diagnostic pathology, neuropathology

    Kleinschmidt-DeMasters, Bette K. / Pekmezci, Melike / Rodríguez, Fausto J. / Tihan, Tarik

    (Diagnostic pathology)

    2022  

    Title variant Neuropathology
    Author's details B. K. Kleinschmidt-DeMasters, Melike Pekmezci, Fausto J. Rodríguez, Tarik Tihan
    Series title Diagnostic pathology
    Keywords Nervous system/Diseases/Diagnosis
    Subject code 616.80475
    Language English
    Size 1 Online-Ressource (xviii, 963, l Seiten), Illustrationen
    Edition Third edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021251271
    ISBN 978-0-323-71331-3 ; 9780323713306 ; 0-323-71331-9 ; 0323713300
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The WHO classification of tumors of the central nervous system-finally here, and welcome!

    Rodriguez, Fausto J

    Brain pathology (Zurich, Switzerland)

    2022  Volume 32, Issue 4, Page(s) e13077

    MeSH term(s) Central Nervous System/pathology ; Central Nervous System Neoplasms/pathology ; Humans ; World Health Organization
    Language English
    Publishing date 2022-06-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.13077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Diagnsotic pathology, neuropathology

    Kleinschmidt-DeMasters, Bette K. / Rodriguez, Fausto J. / Tihan, Tarik

    (Diagnostic pathology)

    2016  

    Author's details B. K. Kleinschmidt-DeMasters, Fausto J. Rodriguez, Tarik Tihan
    Series title Diagnostic pathology
    Language English
    Size XXI, 805 S.,XXXI S., zahlr. Ill.
    Edition 2. ed.
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT018964545
    ISBN 978-0-323-44592-4 ; 0-323-44592-6
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Diagnostic Pathology of Tumors of Peripheral Nerve.

    Belakhoua, Sarra M / Rodriguez, Fausto J

    Neurosurgery

    2021  Volume 88, Issue 3, Page(s) 443–456

    Abstract: Neoplasms of the peripheral nervous system represent a heterogenous group with a wide spectrum of morphological features and biological potential. They range from benign and curable by complete excision (schwannoma and soft tissue perineurioma) to benign ...

    Abstract Neoplasms of the peripheral nervous system represent a heterogenous group with a wide spectrum of morphological features and biological potential. They range from benign and curable by complete excision (schwannoma and soft tissue perineurioma) to benign but potentially aggressive at the local level (plexiform neurofibroma) to the highly malignant (malignant peripheral nerve sheath tumors [MPNST]). In this review, we discuss the diagnostic and pathologic features of common peripheral nerve sheath tumors, particularly those that may be encountered in the intracranial compartment or in the spine and paraspinal region. The discussion will cover schwannoma, neurofibroma, atypical neurofibromatous neoplasms of uncertain biological potential, intraneural and soft tissue perineurioma, hybrid nerve sheath tumors, MPNST, and the recently renamed enigmatic tumor, malignant melanotic nerve sheath tumor, formerly referred to as melanotic schwannoma. We also discuss the diagnostic relevance of these neoplasms to specific genetic and familial syndromes of nerve, including neurofibromatosis 1, neurofibromatosis 2, and schwannomatosis. In addition, we discuss updates in our understanding of the molecular alterations that represent key drivers of these neoplasms, including neurofibromatosis type 1 and type 2, SMARCB1, LZTR1, and PRKAR1A loss, as well as the acquisition of CDKN2A/B mutations and alterations in the polycomb repressor complex members (SUZ12 and EED) in the malignant progression to MPNST. In summary, this review covers practical aspects of pathologic diagnosis with updates relevant to neurosurgical practice.
    MeSH term(s) Animals ; Humans ; Nerve Sheath Neoplasms/diagnostic imaging ; Nerve Sheath Neoplasms/genetics ; Nerve Sheath Neoplasms/pathology ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/genetics ; Neurilemmoma/pathology ; Neurofibroma/diagnostic imaging ; Neurofibroma/genetics ; Neurofibroma/pathology ; Neurofibromatoses/diagnostic imaging ; Neurofibromatoses/genetics ; Neurofibromatoses/pathology ; Peripheral Nerves/diagnostic imaging ; Peripheral Nerves/pathology ; Peripheral Nervous System Neoplasms/diagnostic imaging ; Peripheral Nervous System Neoplasms/genetics ; Peripheral Nervous System Neoplasms/pathology ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Transcription Factors/genetics
    Chemical Substances LZTR1 protein, human ; Transcription Factors
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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    Zs.MO 539: Show issues

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  5. Article ; Online: Plexiform neurofibroma of the liver, with malignant transformation to MPNST, in a pediatric patient without neurofibromatosis type 1.

    Ioannou, Maria / Zhang, Lindy / Schatz, Krista / Rodriguez, Fausto J / Ahlawat, Shivani / Gocke, Christopher D / Rhee, Daniel S / Staedtke, Verena / Pratilas, Christine A

    Neuro-oncology advances

    2023  Volume 5, Issue 1, Page(s) vdad125

    Language English
    Publishing date 2023-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdad125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hybrid Schwannoma-Perineurioma of the Orbit.

    Zhou, Benjamin / Milman, Tatyana / Rodriguez, Fausto J / Turbin, Roger E / Langer, Paul D

    Ophthalmic plastic and reconstructive surgery

    2023  Volume 40, Issue 1, Page(s) e1–e4

    Abstract: A 52-year-old woman presented with a 6-month history of progressive right proptosis associated with intermittent right retrobulbar and facial pain. MRI revealed a heterogeneously enhancing, well-circumscribed, ovoid, soft tissue mass in the intraconal ... ...

    Abstract A 52-year-old woman presented with a 6-month history of progressive right proptosis associated with intermittent right retrobulbar and facial pain. MRI revealed a heterogeneously enhancing, well-circumscribed, ovoid, soft tissue mass in the intraconal space near the right orbital apex displacing the optic nerve medially. Excisional biopsy established the diagnosis of a schwannoma-perineurioma hybrid peripheral nerve sheath tumor (HPNST). This case represents only the second reported occurrence, to our knowledge, of an orbital schwannoma-perineurioma HPNST.
    MeSH term(s) Female ; Humans ; Middle Aged ; Orbit/diagnostic imaging ; Orbit/pathology ; Nerve Sheath Neoplasms/diagnosis ; Neurilemmoma/diagnosis ; Neurilemmoma/pathology ; Exophthalmos ; Orbital Neoplasms/pathology
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632830-1
    ISSN 1537-2677 ; 0740-9303
    ISSN (online) 1537-2677
    ISSN 0740-9303
    DOI 10.1097/IOP.0000000000002484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2159: Show issues Location:
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  7. Article: Effectiveness of Different Neurocognitive Intervention Approaches on Functionality in Healthy Older Adults: A Systematic Review.

    Sáez-Gutiérrez, Susana / Fernandez-Rodriguez, Eduardo J / Sanchez-Gomez, Celia / Garcia-Martin, Alberto / Polo-Ferrero, Luis / Barbero-Iglesias, Fausto J

    Behavioral sciences (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Subtle loss of functionality in healthy older adults is considered one of the most important predictors of cognitive decline. Neurocognitive interventions are increasingly being used, from a preventive maintenance approach to functional capacity. This ... ...

    Abstract Subtle loss of functionality in healthy older adults is considered one of the most important predictors of cognitive decline. Neurocognitive interventions are increasingly being used, from a preventive maintenance approach to functional capacity. This study evaluates the effectiveness of different neurocognitive approaches on the functionality of healthy older adults. In this systematic review (CRD42023473944), an extensive search was conducted for articles published in the last 10 years (2013-2023) in the following databases: Medline, Scopus, and Web of Science. A total of 809 trials were identified, of which 18 were considered to be eligible for inclusion in the review. The data revealed heterogeneity in sample size, measures of functional assessment, neurocognitive interventions used, number of sessions, session duration, and time. Traditional cognitive stimulation is shown to have no significant functional benefit, while other less commonly used neurocognitive interventions, such as those based on everyday cognition, are associated with more significant benefits. Moreover, it is demonstrated that although the Instrumental Activities of Daily Living scale (IADL) is the most used test in similar studies, it is not sensitive enough to detect changes in functionality in healthy elderly individuals, with other tests such as the Timed Instrumental Activities of Daily Living (TIADL) being more advantageous. Therefore, a new guideline is proposed for its use in clinical practice and research, using homogeneous study protocols and neurocognitive interventions that allow for the transfer and generalization of results in daily life.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14020087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Stem cell modeling of nervous system tumors.

    Furnari, Frank B / Anastasaki, Corina / Bian, Shan / Fine, Howard A / Koga, Tomoyuki / Le, Lu Q / Rodriguez, Fausto J / Gutmann, David H

    Disease models & mechanisms

    2024  Volume 17, Issue 2

    Abstract: Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective therapies for these cancers. Although human nervous system ... ...

    Abstract Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective therapies for these cancers. Although human nervous system tumor cells and genetically engineered mouse models have served as excellent platforms for drug discovery and preclinical testing, they have limitations with respect to accurately recapitulating important aspects of the pathobiology of spontaneously arising human tumors. For this reason, attention has turned to the deployment of human stem cell engineering involving human embryonic or induced pluripotent stem cells, in which genetic alterations associated with nervous system cancers can be introduced. These stem cells can be used to create self-assembling three-dimensional cerebral organoids that preserve key features of the developing human brain. Moreover, stem cell-engineered lines are amenable to xenotransplantation into mice as a platform to investigate the tumor cell of origin, discover cancer evolutionary trajectories and identify therapeutic vulnerabilities. In this article, we review the current state of human stem cell models of nervous system tumors, discuss their advantages and disadvantages, and provide consensus recommendations for future research.
    MeSH term(s) Child ; Humans ; Animals ; Mice ; Cell Differentiation ; Induced Pluripotent Stem Cells/pathology ; Brain Neoplasms/pathology ; Brain/pathology ; Mutation
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Orbital SOX10-mutant schwannoma with plexiform growth: Expanding the histopathological spectrum of a new molecular group.

    Wali, Ansar A / Yang, Robin / Merbs, Shannath L / Rodriguez, Fausto J / Eberhart, Charles G / Lucas, Calixto-Hope G

    Journal of neuropathology and experimental neurology

    2023  Volume 82, Issue 11, Page(s) 963–965

    MeSH term(s) Humans ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/genetics ; Neurilemmoma/pathology ; SOXE Transcription Factors/genetics
    Chemical Substances SOXE Transcription Factors ; SOX10 protein, human
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Letter
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlad080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: N for nucleus in neurofibromin: new role for an old tumor suppressor?

    Rodriguez, Fausto J

    Journal of neurochemistry

    2016  Volume 136, Issue 1, Page(s) 11–12

    Abstract: This Editorial highlights a study by Koliou X et al. in the current issue of Journal of Neurochemistry, in which the authors demonstrate that neurofibromin is transported to the nucleus in a cell cycle-dependent manner in astrocytic cells. During mitosis ...

    Abstract This Editorial highlights a study by Koliou X et al. in the current issue of Journal of Neurochemistry, in which the authors demonstrate that neurofibromin is transported to the nucleus in a cell cycle-dependent manner in astrocytic cells. During mitosis in their model, neurofibromin localizes in particular to the mitotic spindle where it binds to tubulin through a C-terminal domain phosphorylated at Ser 2808 (left). Depletion of neurofibromin leads to non-aligned chromosomes during metaphase, or abnormal congression (right), a process that may affect tumorigenesis in neoplasms with neurofibromin loss through chromosome instability and aneuploidy. Read the full article 'Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression' on page 78.
    MeSH term(s) Active Transport, Cell Nucleus/physiology ; Cell Nucleus/metabolism ; Chromosomes/metabolism ; Humans ; Neurofibromin 1/metabolism ; Spindle Apparatus/metabolism
    Chemical Substances Neurofibromin 1
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.13435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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