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  1. Book ; Thesis: Untersuchungen zu mitogenen und anti-apoptotischen Wirkungen des Wachstumsfaktors PDGF hinsichtlich ihrer Beteiligung an der adipogenen Konversion von 3T3-L1-Präadipocyten

    Staiger, Harald

    1998  

    Author's details vorgelegt von Harald Staiger
    Language German
    Size 114 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 1998
    HBZ-ID HT008957469
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    98 D 2612 order for loan Magazin

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  2. Article: Deutsches Zentrum für Diabetesforschung – Maßgeschneiderte Vorbeugung des Typ-2-Diabetes

    Staiger, Harald

    Diabetologie und Stoffwechsel

    2016  Volume 11, Issue 04, Page(s) 266–267

    Language German
    Publishing date 2016-08-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0036-1580376
    Database Thieme publisher's database

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  3. Article ; Online: Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.

    Stirm, Laura / Huypens, Peter / Sass, Steffen / Batra, Richa / Fritsche, Louise / Brucker, Sara / Abele, Harald / Hennige, Anita M / Theis, Fabian / Beckers, Johannes / Hrabě de Angelis, Martin / Fritsche, Andreas / Häring, Hans-Ulrich / Staiger, Harald

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6793

    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-11273-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Circulating FGF21 Levels in Human Health and Metabolic Disease.

    Keuper, Michaela / Häring, Hans-Ulrich / Staiger, Harald

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

    2019  Volume 128, Issue 11, Page(s) 752–770

    Abstract: Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor ... ...

    Abstract Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor isoforms (FGFR1c and FGFR3c) and the co-factor beta-Klotho (KLB) to trigger downstream signaling pathways. Although targeting FGF21 signaling in humans by analogues and receptor agonists results in beneficial effects, e. g., improvements in plasma lipids and decreased body weight, it failed to recapitulate the improvements in glucose handling shown for many mouse models. FGF21's role and metabolic effects in mice and its therapeutic potential have extensively been reviewed elsewhere. In this review we focus on circulating FGF21 levels in humans and their associations with disease and clinical parameters, focusing primarily on obesity and obesity-associated diseases such as type-2 diabetes. We provide a comprehensive overview on human circulating FGF21 levels under normal physiology and metabolic disease. We discuss the emerging field of inactivating FGF21 in human blood by fibroblast activation protein (FAP) and its potential clinical implications.
    MeSH term(s) Biomarkers/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Endopeptidases/metabolism ; Fibroblast Growth Factors/blood ; Humans ; Membrane Proteins/metabolism ; Metabolic Diseases/blood ; Metabolic Diseases/diagnosis ; Obesity/blood ; Obesity/diagnosis
    Chemical Substances Biomarkers ; FGF21 protein, human ; Membrane Proteins ; Fibroblast Growth Factors (62031-54-3) ; Endopeptidases (EC 3.4.-) ; fibroblast activation protein alpha (EC 3.4.21.-)
    Language English
    Publishing date 2019-05-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-0879-2968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Author Correction

    Laura Stirm / Peter Huypens / Steffen Sass / Richa Batra / Louise Fritsche / Sara Brucker / Harald Abele / Anita M. Hennige / Fabian Theis / Johannes Beckers / Martin Hrabě de Angelis / Andreas Fritsche / Hans-Ulrich Häring / Harald Staiger

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin

    2022  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Vaterschaft und Depression: familiärer Umgang mit einer depressiven Erkrankung aus Sicht von Vätern – eine qualitative Untersuchung.

    Götzl, Christian / Staiger, Tobias / Stiawa, Maja / Beschoner, Petra / Gündel, Harald / Becker, Thomas / Kilian, Reinhold / Krumm, Silvia

    Psychiatrische Praxis

    2021  Volume 49, Issue 8, Page(s) 411–418

    Abstract: Objective: Investigation of the experiences of depressed fathers in dealing with their depressive disorder in the family.: Methods: 17 semi-structured narrative interviews were conducted and analyzed following a Grounded Theory Approach.: Results: ...

    Title translation Fatherhood and Depression: Dealing with Depression in the Family from the Fathers' Perspective - A Qualitative Study.
    Abstract Objective: Investigation of the experiences of depressed fathers in dealing with their depressive disorder in the family.
    Methods: 17 semi-structured narrative interviews were conducted and analyzed following a Grounded Theory Approach.
    Results: Fathers describe individual coping strategies in dealing with their depressive disorder that aim at independently coping from their family (self-management, [non])disclosure of the disorder).
    Conclusion: Fathers should be supported in (the decision-making process of) disclosing their illness to the family and developing coping strategies that take family needs further into account.
    MeSH term(s) Male ; Humans ; Fathers ; Depression ; Germany ; Qualitative Research ; Adaptation, Psychological
    Language German
    Publishing date 2021-11-26
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1667-9363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 971: Show issues Location:
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  7. Book ; Online ; Thesis: Placental and humoral alterations in gestational diabetes

    Stirm, Laura [Verfasser] / Staiger, Harald [Akademischer Betreuer]

    2018  

    Author's details Laura Stirm ; Betreuer: Harald Staiger
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  8. Article: Circulating FGF21 Levels in Human Health and Metabolic Disease

    Keuper, Michaela / Häring, Hans-Ulrich / Staiger, Harald

    Experimental and Clinical Endocrinology & Diabetes

    2019  Volume 128, Issue 11, Page(s) 752–770

    Abstract: Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor ... ...

    Abstract Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor isoforms (FGFR1c and FGFR3c) and the co-factor beta-Klotho (KLB) to trigger downstream signaling pathways. Although targeting FGF21 signaling in humans by analogues and receptor agonists results in beneficial effects, e. g., improvements in plasma lipids and decreased body weight, it failed to recapitulate the improvements in glucose handling shown for many mouse models. FGF21’s role and metabolic effects in mice and its therapeutic potential have extensively been reviewed elsewhere. In this review we focus on circulating FGF21 levels in humans and their associations with disease and clinical parameters, focusing primarily on obesity and obesity-associated diseases such as type-2 diabetes. We provide a comprehensive overview on human circulating FGF21 levels under normal physiology and metabolic disease. We discuss the emerging field of inactivating FGF21 in human blood by fibroblast activation protein (FAP) and its potential clinical implications.
    Keywords hepatokine ; metabolic disease ; obesity ; diabetes
    Language English
    Publishing date 2019-05-20
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-0879-2968
    Database Thieme publisher's database

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  9. Article: Vaterschaft und Depression

    Götzl, Christian / Staiger, Tobias / Stiawa, Maja / Beschoner, Petra / Gündel, Harald / Becker, Thomas / Kilian, Reinhold / Krumm, Silvia

    Psychiatrische Praxis

    Familiärer Umgang mit einer depressiven Erkrankung aus Sicht von Vätern - Eine qualitative Untersuchung

    2022  Volume 49, Issue 8, Page(s) 411–418

    Abstract: Ziel der Studie: Untersuchung von Erfahrungen depressiv erkrankter Väter zum Umgang mit der Erkrankung in der Familie. Methoden: 17 teilstrukturierte Interviews wurden entlang der Grounded Theory Methodology durchgeführt und analysiert. Ergebnisse: Väter ...

    Title translation Fatherhood and depression: Dealing with depression in the family from the fathers' perspective - A qualitative study
    Abstract Ziel der Studie: Untersuchung von Erfahrungen depressiv erkrankter Väter zum Umgang mit der Erkrankung in der Familie. Methoden: 17 teilstrukturierte Interviews wurden entlang der Grounded Theory Methodology durchgeführt und analysiert. Ergebnisse: Väter beschrieben überwiegend Strategien im Umgang mit ihrer depressiven Erkrankung, die eine Bewältigung unabhängig von der Familie vorsehen (Selbstmanagement, [Nicht-]Sprechen über die Erkrankung). Schlussfolgerung: Väter brauchen Unterstützung in der (Entscheidung zur) Offenlegung ihrer Erkrankung gegenüber der Familie sowie für die Entwicklung von Bewältigungsstrategien, die die Bedarfe der Familie stärker berücksichtigen. (c) Thieme. All rights reserved.
    Keywords Bewältigungsverhalten ; Coping Behavior ; Depression (Emotion) ; Depressive Stimmung ; Einstellungen zur Geschlechtsrolle ; Familienbeziehungen ; Family Relations ; Fathers ; Major Depression ; Masculinity ; Männlichkeit ; Selbstkontrolltechniken ; Self-Management ; Sex Role Attitudes ; Väter
    Language German
    Document type Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1667-9363
    Database PSYNDEX

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  10. Article ; Online: Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals.

    Böhm, Anja / Keuper, Michaela / Meile, Tobias / Zdichavsky, Marty / Fritsche, Andreas / Häring, Hans-Ulrich / de Angelis, Martin Hrabě / Staiger, Harald / Franko, Andras

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 12407

    Abstract: Among obese subjects, metabolically healthy (MHO) and unhealthy obese (MUHO) subjects exist, the latter being characterized by whole-body insulin resistance, hepatic steatosis, and subclinical inflammation. Insulin resistance and obesity are known to ... ...

    Abstract Among obese subjects, metabolically healthy (MHO) and unhealthy obese (MUHO) subjects exist, the latter being characterized by whole-body insulin resistance, hepatic steatosis, and subclinical inflammation. Insulin resistance and obesity are known to associate with alterations in mitochondrial density, morphology, and function. Therefore, we assessed mitochondrial function in human subcutaneous preadipocytes as well as in differentiated adipocytes derived from well-matched donors. Primary subcutaneous preadipocytes from 4 insulin-resistant (MUHO) versus 4 insulin-sensitive (MHO), non-diabetic, morbidly obese Caucasians (BMI > 40 kg/m
    MeSH term(s) Adipocytes/pathology ; Adult ; Body Mass Index ; Cell Respiration ; Female ; Glycolysis ; Health ; Humans ; Male ; Middle Aged ; Mitochondria/metabolism ; Obesity/metabolism ; Obesity/pathology ; Phenotype
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-69016-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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