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  1. Article ; Online: Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease.

    Galuška, David / Pácal, Lukáš / Kaňková, Kateřina

    Kidney & blood pressure research

    2021  Volume 46, Issue 2, Page(s) 152–161

    Abstract: Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. ... ...

    Abstract Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes.
    Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.
    MeSH term(s) Animals ; COVID-19/metabolism ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/etiology ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/physiopathology ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/physiopathology ; Humans ; Signal Transduction/drug effects ; Vitamin D/metabolism ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/metabolism ; Vitamin D Deficiency/physiopathology ; Vitamins/metabolism ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000514286
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  2. Article ; Online: National Collaborative on Childhood Obesity Research Efforts to Advance Childhood Obesity Research: Progress and Next Steps.

    Sharfman, Amanda S / Berrigan, David / Galuska, Deborah A / Khan, Laura Kettel / Stowe, Ellen W / Reedy, Jill

    American journal of preventive medicine

    2023  Volume 65, Issue 2, Page(s) 339–344

    MeSH term(s) Child ; Humans ; Pediatric Obesity/epidemiology ; Pediatric Obesity/prevention & control ; Health Promotion
    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2023.02.017
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  3. Article ; Online: Estimated Number of Deaths Prevented Through Increased Physical Activity Among US Adults.

    Saint-Maurice, Pedro F / Graubard, Barry I / Troiano, Richard P / Berrigan, David / Galuska, Deborah A / Fulton, Janet E / Matthews, Charles E

    JAMA internal medicine

    2022  Volume 182, Issue 3, Page(s) 349–352

    MeSH term(s) Adult ; Exercise ; Humans ; Nutrition Surveys ; Risk Factors ; United States/epidemiology
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.7755
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  4. Article ; Online: Erratum: This Article Corrects: "Coronary Disease in Emergency Department Chest Pain with Recent Negative Stress Testing".

    Walker, Jonathan / Galuska, Michael / Vega, David

    The western journal of emergency medicine

    2018  Volume 19, Issue 6, Page(s) 1065

    Abstract: This corrects the article on p. 384 in vol. 11, PMID: 21079714.]. ...

    Abstract [This corrects the article on p. 384 in vol. 11, PMID: 21079714.].
    Language English
    Publishing date 2018-10-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-900X
    ISSN (online) 1936-9018
    ISSN 1936-900X
    DOI 10.5811/westjem.2018.10.41206
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  5. Article ; Online: Changes in High Weight-for-Length among Infants Enrolled in Special Supplemental Nutrition Program for Women, Infants, and Children during 2010-2018.

    Pan, Liping / Blanck, Heidi M / Galuska, Deborah A / Freedman, David S / Lovellette, Grant / Park, Sohyun / Petersen, Ruth

    Childhood obesity (Print)

    2021  Volume 17, Issue 6, Page(s) 408–419

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Child ; Child, Preschool ; Female ; Food Assistance ; Hispanic or Latino ; Humans ; Infant ; Male ; Overweight ; Pediatric Obesity/epidemiology ; Pediatric Obesity/prevention & control ; White People
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2639910-6
    ISSN 2153-2176 ; 2153-2168
    ISSN (online) 2153-2176
    ISSN 2153-2168
    DOI 10.1089/chi.2021.0055
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  6. Article ; Online: This Article Corrects

    Jonathan Walker / Michael Galuska / David Vega

    Western Journal of Emergency Medicine, Vol 19, Iss

    “Coronary Disease in Emergency Department Chest Pain with Recent Negative Stress Testing”

    2018  Volume 6

    Keywords Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher eScholarship Publishing, University of California
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Changes in Obesity Among US Children Aged 2 Through 4 Years Enrolled in WIC During 2010-2016.

    Pan, Liping / Freedman, David S / Park, Sohyun / Galuska, Deborah A / Potter, Anna / Blanck, Heidi M

    JAMA

    2019  Volume 321, Issue 23, Page(s) 2364–2366

    MeSH term(s) Child, Preschool ; Female ; Food Assistance ; Humans ; Male ; Overweight/epidemiology ; Pediatric Obesity/epidemiology ; United States/epidemiology
    Language English
    Publishing date 2019-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.5051
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    Ua VI Zs.88: Show issues Location:
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  8. Article ; Online: Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease.

    Kronimus, Yannick / Albus, Alexandra / Hasenberg, Mike / Walkenfort, Bernd / Seifert, Marc / Budeus, Bettina / Gronewold, Janine / Hermann, Dirk M / Ross, J Alexander / Lochnit, Günter / Galuska, Sebastian P / Marcus, Katrin / Sitek, Barbara / Klotsche, Jens / Mengel, David / Neumann, Sascha / Dodel, Richard

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 19, Issue 12, Page(s) 5563–5572

    Abstract: Introduction: Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ: Methods: nAbs-Aβ: Results: Deglycosylation of nAbs-Aβ42 had a major impact on Aβ: Discussion: N-glycosylation has been identified as a ... ...

    Abstract Introduction: Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ
    Methods: nAbs-Aβ
    Results: Deglycosylation of nAbs-Aβ42 had a major impact on Aβ
    Discussion: N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies. These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides ; Glycosylation ; Autoantibodies ; Biomarkers ; Polysaccharides ; Peptide Fragments
    Chemical Substances Amyloid beta-Peptides ; Autoantibodies ; Biomarkers ; Polysaccharides ; Peptide Fragments
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13124
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    Zs.A 6316: Show issues Location:
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  9. Article ; Online: Genetic risk score is associated with T2DM and diabetes complications risks.

    Hubacek, Jaroslav A / Dlouha, Lucie / Adamkova, Vera / Dlouha, Dana / Pacal, Lukas / Kankova, Katerina / Galuska, David / Lanska, Vera / Veleba, Jiri / Pelikanova, Terezie

    Gene

    2022  Volume 849, Page(s) 146921

    Abstract: Background: Type 2 diabetes mellitus (T2DM) is a prototypical complex disease with polygenic architecture playing an important role in determining susceptibility to develop the disease (and its complications) in subjects exposed to modifiable lifestyle ... ...

    Abstract Background: Type 2 diabetes mellitus (T2DM) is a prototypical complex disease with polygenic architecture playing an important role in determining susceptibility to develop the disease (and its complications) in subjects exposed to modifiable lifestyle factors. A current challenge is to quantify the degree of the individual's genetic risk using genetic risk scores (GRS) capturing the results of genome-wide association studies while incorporating possible ethnicity- or population-specific differences.
    Methods: This study included three groups of T2DM (T2DM-I, N = 1,032; T2DM-II, N = 353; and T2DM-III, N = 399) patients and 2,481 diabetes-free subjects. The status of the microvascular and macrovascular diabetes complications were known for the T2DM-I patients. Overall, 21 single nucleotide polymorphisms (SNPs) were analyzed, and selected subsets were used to determine the GRS (both weighted - wGRS and unweighted - uGRS) for T2DM risk predictions (6 SNPs) and for predicting the risks of complications (7 SNPs).
    Results: The strongest T2DM markers (P < 0.0001) were within the genes for TCF7L2 (transcription factor 7-like 2), FTO (fat mass and obesity associated protein) and ARAP1 (ankyrin repeat and PH domain 1). The T2DM-I subjects with uGRS values greater (Odds Ratio, 95 % Confidence Interval) than six had at least twice (2.00, 1.72-2.32) the risk of T2DM development (P < 0.0001), and these results were confirmed in the independent groups (T2DM-II 1.82, 1.45-2.27; T2DM-III 2.63, 2.11-3.27). The wGRS (>0.6) further improved (P < 0.000001) the risk estimations for all three T2DM groups. The uGRS was also a significant predictor of neuropathy (P < 0.0001), nephropathy (P < 0.005) and leg ischemia (P < 0.0005).
    Conclusions: If carefully selected and specified, GRS, both weighted and unweighted, could be significant predictors of T2DM development, as well as the diabetes complications development.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Genome-Wide Association Study ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Genetic Predisposition to Disease ; T Cell Transcription Factor 1/genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; Diabetes Complications
    Chemical Substances Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; T Cell Transcription Factor 1 ; FTO protein, human (EC 1.14.11.33)
    Language English
    Publishing date 2022-09-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2022.146921
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    Zs.A 1357: Show issues Location:
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  10. Article ; Online: Supporting Active Living Through Community Plans: The Association of Planning Documents With Design Standards and Features.

    Peterson, Erin L / Carlson, Susan A / Schmid, Thomas L / Brown, David R / Galuska, Deborah A

    American journal of health promotion : AJHP

    2018  Volume 33, Issue 2, Page(s) 191–198

    Abstract: Purpose: The purpose of this study was to examine the association between the presence of supportive community planning documents in US municipalities with design standards and requirements supportive of active living.: Design: Cross-sectional study ... ...

    Abstract Purpose: The purpose of this study was to examine the association between the presence of supportive community planning documents in US municipalities with design standards and requirements supportive of active living.
    Design: Cross-sectional study using data from the 2014 National Survey of Community-Based Policy and Environmental Supports for Healthy Eating and Active Living.
    Setting: Nationally representative sample of US municipalities.
    Participants: Respondents are 2005 local officials.
    Measures: Assessed: (1) The presence of design standards and feature requirements and (2) the association between planning documents and design standards and feature requirements supportive of active living in policies for development.
    Analysis: Using logistic regression, significant trends were identified in the presence of design standards and feature requirements by plan and number of supportive objectives present.
    Results: Prevalence of design standards ranged from 19% (developer dedicated right-of-way for bicycle infrastructure development) to 50% (traffic-calming features in areas with high pedestrian and bicycle volume). Features required in policies for development ranged from 14% (short/medium pedestrian-scale block sizes) to 44% (minimum sidewalk widths of 5 feet) of municipalities. As the number of objectives in municipal plans increased, there was a significant and positive trend ( P < .05) in the prevalence of each design standard and requirement.
    Conclusions: Municipal planning documents containing objectives supportive of physical activity are associated with design standards and feature requirements supportive of activity-friendly communities.
    MeSH term(s) City Planning/organization & administration ; Community Participation/methods ; Cross-Sectional Studies ; Environment Design ; Exercise ; Health Promotion/organization & administration ; Humans ; Policy ; Residence Characteristics ; Socioeconomic Factors ; Transportation ; United States
    Language English
    Publishing date 2018-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645160-3
    ISSN 2168-6602 ; 0890-1171
    ISSN (online) 2168-6602
    ISSN 0890-1171
    DOI 10.1177/0890117118779011
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