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  1. Article ; Online: Synthetic Data as a Strategy to Resolve Data Privacy and Confidentiality Concerns in the Sport Sciences: Practical Examples and an R Shiny Application.

    Naughton, Mitchell / Weaving, Dan / Scott, Tannath / Compton, Heidi

    International journal of sports physiology and performance

    2023  Volume 18, Issue 10, Page(s) 1213–1218

    Abstract: ... made through Welch t tests and the distributional similarity standardized propensity mean squared error ...

    Abstract Purpose: There has been a proliferation in technologies in the sport performance environment that collect increasingly larger quantities of athlete data. These data have the potential to be personal, sensitive, and revealing and raise privacy and confidentiality concerns. A solution may be the use of synthetic data, which mimic the properties of the original data. The aim of this study was to provide examples of synthetic data generation to demonstrate its practical use and to deploy a freely available web-based R Shiny application to generate synthetic data.
    Methods: Openly available data from 2 previously published studies were obtained, representing typical data sets of (1) field- and gym-based team-sport external and internal load during a preseason period (n = 28) and (2) performance and subjective changes from before to after the posttraining intervention (n = 22). Synthetic data were generated using the synthpop package in R Studio software, and comparisons between the original and synthetic data sets were made through Welch t tests and the distributional similarity standardized propensity mean squared error statistic.
    Results: There were no significant differences between the original and more synthetic data sets across all variables examined in both data sets (P > .05). Further, there was distributional similarity (ie, low standardized propensity mean squared error) between the original observed and synthetic data sets.
    Conclusions: These findings highlight the potential use of synthetic data as a practical solution to privacy and confidentiality issues. Synthetic data can unlock previously inaccessible data sets for exploratory analysis and facilitate multiteam or multicenter collaborations. Interested sport scientists, practitioners, and researchers should consider utilizing the shiny web application (SYNTHETIC DATA-available at https://assetlab.shinyapps.io/SyntheticData/).
    MeSH term(s) Humans ; Privacy ; Confidentiality ; Software ; Sports ; Technology
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ISSN 1555-0273
    ISSN (online) 1555-0273
    DOI 10.1123/ijspp.2023-0007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sleep Duration, Inflammation, and Asthma Control: Important Bedfellows.

    Denton, Eve / Naughton, Matthew T / Hew, Mark

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 4, Page(s) 1211–1212

    MeSH term(s) Humans ; Sleep Duration ; Sleep ; Inflammation ; Asthma/epidemiology ; Sleep Wake Disorders
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.01.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Considering the Impact of Preparticipation Screening Guidelines on Health Equity for Collegiate Athletes.

    Honda, Trenton / Downey, Brian / Kerkhof, Deanna / Le, Hung M / McNaughton, Michael / Corrado, Gianmichel

    European journal of preventive cardiology

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwae135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An Occupation-Based Lifestyle Lecture Intervention as Part of Inpatient Addiction Recovery Treatment: Exploring Occupational Performance, Balance and Personal Recovery.

    Ryan, Deirdre / Naughton, Marie / de Faoite, Meabh / Dowd, Tara / Morrissey, Ann-Marie

    Substance abuse : research and treatment

    2023  Volume 17, Page(s) 11782218231165123

    Abstract: Introduction: Substance use disorders (SUDs) and addictive behaviours are growing problems which negatively impact health and wellbeing. Occupational therapy can support recovery by facilitating engagement in everyday activities that promote health. To ... ...

    Abstract Introduction: Substance use disorders (SUDs) and addictive behaviours are growing problems which negatively impact health and wellbeing. Occupational therapy can support recovery by facilitating engagement in everyday activities that promote health. To date, the inclusion of occupational therapy in addiction recovery is limited and the evidence base for occupation-focused interventions is lacking. This study explores the impact of an occupational therapy-led intervention on self-reported occupational performance and occupational balance issues for people living with SUDs within an inpatient addiction service.
    Methodology: A quantitative pre and post-test study was implemented. The Canadian Personal Recovery Outcome Measure (C-PROM) was the sole outcome measure. The C-PROM is a self-report measure which aims to measure personal views of recovery based on rating activity engagement. The cohort of participants were recruited from referrals into 2 inpatient addiction recovery treatment programmes using purposive sampling. Descriptive statistics were run, and a Wilcoxon Signed Rank Test was used to analyse pre and post-test scoring.
    Results: Sixteen participants (9 male and 7 female) completed the intervention and outcome measure. The majority of participants (31.3%, n = 5) were between 45 and 54 years old. 25% of the sample (n = 4) were in the 35 to 44 age bracket while 18.8% (n = 3) were aged 55 to 64. The majority of participants (68.8%, n = 11) reported substance misuse as their main healthcare concern. The mean score on the C-PROM was significantly higher after participants received the intervention when compared with baseline scoring.
    Conclusion: Following engagement with an occupational therapist-led intervention participants reported increased engagement in activities and occupational performance. Participants also reported improved occupational balance and increased awareness of personal recovery needs. Further research is required to explore the effectiveness of this intervention in larger samples and to explore the transferability and sustainability of skills post discharge.
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 1178-2218 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 1178-2218 ; 0889-7077
    DOI 10.1177/11782218231165123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Friction modulation in limbless, three-dimensional gaits and heterogeneous terrains.

    Zhang, Xiaotian / Naughton, Noel / Parthasarathy, Tejaswin / Gazzola, Mattia

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 6076

    Abstract: Motivated by a possible convergence of terrestrial limbless locomotion strategies ultimately determined by interfacial effects, we show how both 3D gait alterations and locomotory adaptations to heterogeneous terrains can be understood through the lens ... ...

    Abstract Motivated by a possible convergence of terrestrial limbless locomotion strategies ultimately determined by interfacial effects, we show how both 3D gait alterations and locomotory adaptations to heterogeneous terrains can be understood through the lens of local friction modulation. Via an effective-friction modeling approach, compounded by 3D simulations, the emergence and disappearance of a range of locomotory behaviors observed in nature is systematically explained in relation to inhabited environments. Our approach also simplifies the treatment of terrain heterogeneity, whereby even solid obstacles may be seen as high friction regions, which we confirm against experiments of snakes 'diffracting' while traversing rows of posts, similar to optical waves. We further this optic analogy by illustrating snake refraction, reflection and lens focusing. We use these insights to engineer surface friction patterns and demonstrate passive snake navigation in complex topographies. Overall, our study outlines a unified view that connects active and passive 3D mechanics with heterogeneous interfacial effects to explain a broad set of biological observations, and potentially inspire engineering design.
    MeSH term(s) Animals ; Behavior, Animal ; Biomechanical Phenomena ; Friction ; Gait ; Lenses ; Locomotion ; Snakes/physiology
    Language English
    Publishing date 2021-10-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-26276-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A collaborative realist review of remote measurement technologies for depression in young people.

    Walsh, Annabel E L / Naughton, Georgia / Sharpe, Thomas / Zajkowska, Zuzanna / Malys, Mantas / van Heerden, Alastair / Mondelli, Valeria

    Nature human behaviour

    2024  Volume 8, Issue 3, Page(s) 480–492

    Abstract: Digital mental health is becoming increasingly common. This includes use of smartphones and wearables to collect data in real time during day-to-day life (remote measurement technologies, RMT). Such data could capture changes relevant to depression for ... ...

    Abstract Digital mental health is becoming increasingly common. This includes use of smartphones and wearables to collect data in real time during day-to-day life (remote measurement technologies, RMT). Such data could capture changes relevant to depression for use in objective screening, symptom management and relapse prevention. This approach may be particularly accessible to young people of today as the smartphone generation. However, there is limited research on how such a complex intervention would work in the real world. We conducted a collaborative realist review of RMT for depression in young people. Here we describe how, why, for whom and in what contexts RMT appear to work or not work for depression in young people and make recommendations for future research and practice. Ethical, data protection and methodological issues need to be resolved and standardized; without this, RMT may be currently best used for self-monitoring and feedback to the healthcare professional where possible, to increase emotional self-awareness, enhance the therapeutic relationship and monitor the effectiveness of other interventions.
    MeSH term(s) Adolescent ; Humans ; Depression/diagnosis ; Depression/therapy ; Digital Health ; Mental Health ; Smartphone
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-023-01793-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Perceived factors informing the pre-acceptability of digital health innovation by aging respiratory patients: a case study from the Republic of Ireland.

    Byrne, Tara / Murray, Niall / McDonnell-Naughton, Mary / Rowan, Neil J

    Frontiers in public health

    2023  Volume 11, Page(s) 1203937

    Abstract: It is appreciated that digital health is increasing in interest as an important area for efficiently standardizing and developing health services in Ireland, and worldwide. However, digital health is still considered to be in its infancy and there is a ... ...

    Abstract It is appreciated that digital health is increasing in interest as an important area for efficiently standardizing and developing health services in Ireland, and worldwide. However, digital health is still considered to be in its infancy and there is a need to understand important factors that will support the development and uniform uptake of these technologies, which embrace their utility and ensure data trustworthiness. This constituted the first study to identify themes believed to be relevant by respiratory care and digital health experts in the Republic of Ireland to help inform future decision-making among respiratory patients that may potentially facilitate engagement with and appropriate use of digital health innovation (DHI). The study explored and identified expert participant perceptions, beliefs, barriers, and cues to action that would inform content and future deployment of living labs in respiratory care for remote patient monitoring of people with respiratory diseases using DHI. The objective of this case study was to generate and evaluate appropriate data sets to inform the selection and future deployment of an ICT-enabling technology that will empower patients to manage their respiratory systems in real-time in a safe effective manner through remote consultation with health service providers. The co-creation of effective DHI for respiratory care will be informed by multi-actor stakeholder participation, such as through a Quintuple Helix Hub framework combining university-industry-government-healthcare-society engagements. Studies, such as this, will help bridge the interface between top-down digital health policies and bottom-up end-user engagements to ensure safe and effective use of health technology. In addition, it will address the need to reach a consensus on appropriate key performance indicators (KPIs) for effective uptake, implementation, standardization, and regulation of DHI.
    MeSH term(s) Humans ; Ireland ; Delivery of Health Care ; Monitoring, Physiologic ; Aging
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1203937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Defining and quantifying fatigue in the rugby codes.

    Naughton, Mitchell / Scott, Tannath / Weaving, Dan / Solomon, Colin / McLean, Scott

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0282390

    Abstract: The rugby codes (i.e., rugby union, rugby league, rugby sevens [termed 'rugby']) are team-sports that impose multiple complex physical, perceptual, and technical demands on players which leads to substantial player fatigue post-match. In the post-match ... ...

    Abstract The rugby codes (i.e., rugby union, rugby league, rugby sevens [termed 'rugby']) are team-sports that impose multiple complex physical, perceptual, and technical demands on players which leads to substantial player fatigue post-match. In the post-match period, fatigue manifests through multiple domains and negatively influences recovery. There is, however, currently no definition of fatigue contextualised to the unique characteristics of rugby (e.g., locomotor and collision loads). Similarly, the methods and metrics which practitioners consider when quantifying the components of post-match fatigue and subsequent recovery are not known. The aims of this study were to develop a definition of fatigue in rugby, to determine agreement with this common definition of fatigue, and to outline which methods and metrics are considered important and feasible to implement to quantify post-match fatigue. Subject matter experts (SME) undertook a two-round online Delphi questionnaire (round one; n = 42, round two; n = 23). SME responses in round one were analysed to derive a definition of fatigue, which after discussion and agreement by the investigators, obtained 96% agreement in round two. The SME agreed that fatigue in rugby refers to a reduction in performance-related task ability which is underpinned by time-dependent negative changes within and between cognitive, neuromuscular, perceptual, physiological, emotional, and technical/tactical domains. Further, there were 33 items in the neuromuscular performance, cardio-autonomic, or self-report domains achieved consensus for importance and/or feasibility to implement. Highly rated methods and metrics included countermovement jump force/power (neuromuscular performance), heart rate variability (cardio-autonomic measures), and soreness, mood, stress, and sleep quality (self-reported assessments). A monitoring system including highly-rated fatigue monitoring objective and subjective methods and metrics in rugby is presented. Practical recommendations of objective and subjective measures, and broader considerations for testing and analysing the resulting data in relation to monitoring fatigue are provided.
    MeSH term(s) Humans ; Athletic Performance/physiology ; Football/physiology ; Fatigue ; Muscle Fatigue/physiology ; Team Sports
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling.

    Simpson, Joanne E / Muir, Morwenna T / Lee, Martin / Naughton, Catherine / Gilbert, Nick / Pollard, Steven M / Gammoh, Noor

    Developmental cell

    2023  Volume 59, Issue 2, Page(s) 228–243.e7

    Abstract: Autophagy is a conserved cellular degradation process. While autophagy-related proteins were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the relevance of this during cancer development is unclear. Here, we identify ...

    Abstract Autophagy is a conserved cellular degradation process. While autophagy-related proteins were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the relevance of this during cancer development is unclear. Here, we identify a role for autophagy in regulating platelet-derived growth factor receptor alpha (PDGFRA) signaling and levels. We find that PDGFRA can be targeted for autophagic degradation through the activity of the autophagy cargo receptor p62. As a result, short-term autophagy inhibition leads to elevated levels of PDGFRA but an unexpected defect in PDGFA-mediated signaling due to perturbed receptor trafficking. Defective PDGFRA signaling led to its reduced levels during prolonged autophagy inhibition, suggesting a mechanism of adaptation. Importantly, PDGFA-driven gliomagenesis in mice was disrupted when autophagy was inhibited in a manner dependent on Pten status, thus highlighting a genotype-specific role for autophagy during tumorigenesis. In summary, our data provide a mechanism by which cells require autophagy to drive tumor formation.
    MeSH term(s) Mice ; Animals ; Signal Transduction ; Brain Neoplasms ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Autophagy
    Chemical Substances Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2023.11.023
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  10. Article ; Online: Cell surface β-lactamase recruitment: A facile selection to identify protein-protein interactions.

    Hinmon, Jordan A / King, Jade M / Mayo, Latrina J / Faries, Cierra R / Lockett, Ya'hnis T / Crawford, David W / Beardslee, Patrick C / Hendricks, Alexander / McNaughton, Brian R

    Protein science : a publication of the Protein Society

    2024  Volume 33, Issue 4, Page(s) e4919

    Abstract: Protein-protein interactions (PPIs) are central to many cellular processes, and the identification of novel PPIs is a critical step in the discovery of protein therapeutics. Simple methods to identify naturally existing or laboratory evolved PPIs are ... ...

    Abstract Protein-protein interactions (PPIs) are central to many cellular processes, and the identification of novel PPIs is a critical step in the discovery of protein therapeutics. Simple methods to identify naturally existing or laboratory evolved PPIs are therefore valuable research tools. We have developed a facile selection that links PPI-dependent β-lactamase recruitment on the surface of Escherichia coli with resistance to ampicillin. Bacteria displaying a protein that forms a complex with a specific protein-β-lactamase fusion are protected from ampicillin-dependent cell death. In contrast, bacteria that do not recruit β-lactamase to the cell surface are killed by ampicillin. Given its simplicity and tunability, we anticipate this selection will be a valuable addition to the palette of methods for illuminating and interrogating PPIs.
    MeSH term(s) beta-Lactamases/genetics ; beta-Lactamases/metabolism ; Ampicillin/pharmacology ; Ampicillin/metabolism ; Bacteria/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Cell Membrane/metabolism ; Anti-Bacterial Agents/metabolism
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Ampicillin (7C782967RD) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4919
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