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  1. Article ; Online: Elusive Hepatic Nodules.

    Campani, Claudia / Guido, Maria / Marra, Fabio

    Gastroenterology

    2024  

    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.03.031
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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
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  2. Article ; Online: Intrahepatic splenosis mimicking hepatocellular carcinoma.

    Rosi, Martina / Adotti, Valentina / Citone, Michele / Marra, Fabio

    United European gastroenterology journal

    2024  Volume 12, Issue 3, Page(s) 412–414

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/diagnosis ; Splenosis/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12549
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  3. Article: Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report.

    Mariottini, Alice / Barilaro, Alessandro / Lotti, Antonio / Marra, Fabio / Massacesi, Luca

    Frontiers in neurology

    2024  Volume 15, Page(s) 1363493

    Abstract: Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different ...

    Abstract Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different mechanisms, including idiosyncratic reaction, autoimmune hepatitis or viral reactivation. In patients receiving the humanized anti-CD20 monoclonal antibody (mAb) ocrelizumab, DILI has been rarely reported and was mostly associated with hepatitis B virus (HBV) reactivation. Here we present the case of a woman with highly active relapsing-remitting MS who had experienced two episodes of DILI while receiving different DMTs, and was successfully switched to ofatumumab, a fully human anti-CD20 mAb, after a further event associated with ocrelizumab treatment and unrelated to HBV reactivation. Despite sharing the mechanism of action, differences in structure, pharmacokinetic/pharmacodynamic profile, and use of ancillary drugs (only needed for ocrelizumab) may have accounted for the successful switch. To our knowledge, this is the first report of a successful switch from ocrelizumab to ofatumumab due to DILI. Ofatumumab may therefore represent a valid therapeutic option for patients experiencing DMTs- and ocrelizumab-induced liver injury, providing that HBV reactivation has been ruled out.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1363493
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  4. Article ; Online: An atypical case of palmo-plantar erythrodysesthesia related to cabozantinib.

    Campani, Claudia / Pimpinelli, Nicola / Marra, Fabio

    Italian journal of dermatology and venereology

    2022  Volume 157, Issue 4, Page(s) 372–374

    MeSH term(s) Anilides/adverse effects ; Humans ; Pyridines/adverse effects
    Chemical Substances Anilides ; Pyridines ; cabozantinib (1C39JW444G)
    Language English
    Publishing date 2022-07-29
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.21.07109-7
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Reply.

    Vizzutti, Francesco / Celsa, Ciro / Battaglia, Salvatore / Miraglia, Roberto / Enea, Marco / Marra, Fabio / Colecchia, Antonio / Cammà, Calogero / Schepis, Filippo

    Hepatology (Baltimore, Md.)

    2023  Volume 77, Issue 3, Page(s) E57–E58

    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32784
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Management of a complex transjugular intrahepatic portosystemic shunt dysfunction with endotipsitis through rotational thrombectomy.

    Vizzutti, Francesco / Casamassima, Emanuele / Falcone, Gianmarco / Gabbani, Giacomo / Rosi, Martina / Adotti, Valentina / Marra, Fabio / Fanelli, Fabrizio

    BJR case reports

    2024  Volume 10, Issue 1, Page(s) uaae005

    Abstract: Transjugular intrahepatic portosystemic shunting (TIPS) is an established strategy for the management of complications of portal hypertension. Endoprosthetic infection ("endotipsitis") is a rare but serious and difficult-to-treat complication of TIPS ... ...

    Abstract Transjugular intrahepatic portosystemic shunting (TIPS) is an established strategy for the management of complications of portal hypertension. Endoprosthetic infection ("endotipsitis") is a rare but serious and difficult-to-treat complication of TIPS placement. Here we report the occurrence of an infected thrombus complicating TIPS placement in a patient with extra-hepatic portal vein obstruction, recurrent variceal bleeding and portal biliopathy accompanied by recurrent cholangitis. Infected thrombotic material within TIPS could be removed only by employing rotational thrombectomy. This procedure revealed the presence of a biliary fistula which carried pathogens in the systemic circulation. The multiple episodes of sepsis did no longer recur following exclusion of the biliary fistula. This case highlights the possibility to use rotational thrombectomy for the management of complex cases of TIPS dysfunction.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1093/bjrcr/uaae005
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  7. Article: Damage Control Interventional Radiology in Liver Trauma: A Comprehensive Review.

    Corvino, Fabio / Giurazza, Francesco / Marra, Paolo / Ierardi, Anna Maria / Corvino, Antonio / Basile, Antonio / Galia, Massimo / Inzerillo, Agostino / Niola, Raffaella

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: The liver is the second most common solid organ injured in blunt and penetrating abdominal trauma. Non-operative management (NOM) has become the standard of care for liver injuries in stable patients, where transarterial embolization (TAE) represents the ...

    Abstract The liver is the second most common solid organ injured in blunt and penetrating abdominal trauma. Non-operative management (NOM) has become the standard of care for liver injuries in stable patients, where transarterial embolization (TAE) represents the main treatment, increasing success rates and avoiding invasive surgical procedures. In hemodynamically (HD) unstable patients, operative management (OM) is the standard of care. To date, there are no consensus guidelines about the endovascular treatment of patients with HD instability or in ones that responded to initial infusion therapy. A review of the literature was performed for published papers addressing the outcome of using TAE as the primary treatment for HD unstable/transient responder trauma liver patients with hemorrhagic vascular lesions, both as a single treatment and in combination with surgical treatment, focusing additionally on the different definitions used in the literature of unstable and transient responder patients. Our review demonstrated a good outcome in HD unstable/transient responder liver trauma patients treated with TAE but there still remains much debate about the definition of unstable and transient responder patients.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040365
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  8. Article ; Online: Smartphone-Based Cognitive Telerehabilitation: A Usability and Feasibility Study Focusing on Mild Cognitive Impairment.

    Formica, Caterina / Bonanno, Mirjam / Sorbera, Chiara / Quartarone, Angelo / Giambò, Fabio Mauro / Marra, Angela / Calabrò, Rocco Salvatore

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 2

    Abstract: The implementation of cognitive health apps in patients with mild cognitive impairment (MCI) is challenging because of their cognitive, age, and other clinical characteristics. In this project, we aimed to evaluate the usability and feasibility of the ... ...

    Abstract The implementation of cognitive health apps in patients with mild cognitive impairment (MCI) is challenging because of their cognitive, age, and other clinical characteristics. In this project, we aimed to evaluate the usability and feasibility of the Rehastart app tested in MCI patients. Eighteen subjects affected by MCI due to neurodegenerative disorders (including Parkinson's disease, multiple sclerosis, and amnestic/multidomain MCI) and eighteen healthcare professionals were recruited to this study. Patients were registered on the app by clinicians and they were assigned a protocol of specific cognitive exercises. The recruitment was conducted in the period between March and June 2023. The trial testing of the app consisted of three sessions per week for three weeks, with each session lasting about 30 min. After three weeks, the participants as well as medical personnel were invited to rate the usability and feasibility of the Rehastart mobile application. The instruments employed to evaluate the usability and feasibility of the app were the System Usability Scale (SUS), The Intrinsic Motivation Inventory (IMI) and the Client Satisfaction Questionnaire (CSQ). We did not find statistically significant differences on the SUS (
    MeSH term(s) Humans ; Smartphone ; Feasibility Studies ; Telerehabilitation ; Cognitive Dysfunction ; Parkinson Disease ; Cognition
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24020525
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  9. Article ; Online: NAIF: A novel artificial intelligence-based tool for accurate diagnosis of stage F3/F4 liver fibrosis in the general adult population, validated with three external datasets.

    Hassoun, Samir / Bruckmann, Chiara / Ciardullo, Stefano / Perseghin, Gianluca / Marra, Fabio / Curto, Armando / Arena, Umberto / Broccolo, Francesco / Di Gaudio, Francesca

    International journal of medical informatics

    2024  Volume 185, Page(s) 105373

    Abstract: Objective: The purpose of this study was to determine the effectiveness of a new AI-based tool called NAIF (NAFLD-AI-Fibrosis) in identifying individuals from the general population with advanced liver fibrosis (stage F3/F4). We compared NAIF's ... ...

    Abstract Objective: The purpose of this study was to determine the effectiveness of a new AI-based tool called NAIF (NAFLD-AI-Fibrosis) in identifying individuals from the general population with advanced liver fibrosis (stage F3/F4). We compared NAIF's performance to two existing risk score calculators, aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (Fib4).
    Methods: To set up the algorithm for diagnosing severe liver fibrosis (defined as Fibroscan® values E ≥ 9.7 KPa), we used 19 blood biochemistry parameters and two demographic parameters in a group of 5,962 individuals from the NHANES population (2017-2020 pre-pandemic, public database). We then assessed the algorithm's performance by comparing its accuracy, precision, sensitivity, specificity, and F1 score values to those of APRI and Fib4 scoring systems.
    Results: In a kept-out sub dataset of the NHANES population, NAIF achieved a predictive precision of 72 %, a sensitivity of 61 %, and a specificity of 77 % in correctly identifying adults (aged 18-79 years) with severe liver fibrosis. Additionally, NAIF performed well when tested with two external datasets of Italian patients with a Fibroscan® score E ≥ 9.7 kPa, and with an external dataset of patients with diagnosis of severe liver fibrosis through biopsy.
    Conclusions: The results of our study suggest that NAIF, using routinely available parameters, outperforms in sensitivity existing scoring methods (Fib4 and APRI) in diagnosing severe liver fibrosis, even when tested with external validation datasets. NAIF uses routinely available parameters, making it a promising tool for identifying individuals with advanced liver fibrosis from the general population. Word count abstract: 236.
    MeSH term(s) Adult ; Humans ; Artificial Intelligence ; Nutrition Surveys ; Platelet Count ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2024.105373
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  10. Article ; Online: Pseudoaneurysms embolization with glue via percutaneous direct puncture: a multicenter experience on 54 patients.

    Giurazza, Francesco / Ierardi, Annamaria / Marra, Paolo / Lucatelli, Pierleone / Corvino, Fabio / Pane, Francesco / Sironi, Sandro / Carrafiello, Gianpaolo / Loffroy, Romaric / Niola, Raffaella

    CVIR endovascular

    2024  Volume 7, Issue 1, Page(s) 11

    Abstract: Background: This retrospective multicentric study aims to report on technical safety and effectiveness of pseudoaneurysms embolization with glue (N-butyl cyanoacrylate) adopting a percutaneous direct puncture approach.: Results: Fifty-four patients ... ...

    Abstract Background: This retrospective multicentric study aims to report on technical safety and effectiveness of pseudoaneurysms embolization with glue (N-butyl cyanoacrylate) adopting a percutaneous direct puncture approach.
    Results: Fifty-four patients data were collected from five centers. All patients at the time of treatment presented with unruptured PAs and were hemodynamically stable. True aneurysms and lesions treated with embolics other than glue were excluded. Pseudoaneurysms diagnosis was based on CT and anamnestic data; initial investigation with digital-subtracted arteriography was acquired in all cases; then, percutaneous embolizations were performed in the angio-suite (ultrasound, fluoroscopy, ConeBeam CT guidance) or in CT. Technical success was considered as complete pseudoaneurysm embolization at final imaging with sole percutaneous strategy, without need for additional endovascular embolization. Clinical success was intended as pseudoaneurysm resolution within one week follow-up with stabilization or restored clinical conditions. Pseudoaneurysms origins were traumatic (57.4%), inflammatory (24.1%) or spontaneous (18.5%); 39 patients (72.2%) were symptomatic, presenting with pain and/or pulsatile mass. Mean lesions diameter was 19.3 mm (range: 7-30); pseudoaneurysms were located in abdomen (48.1%), limbs (42.6%) and thorax (9.3%). Coagulation function was impaired in 16.6% and 48.1% was under antiplatelets/anticoagulation therapy. In 16.6% the percutaneous approach followed previous treatments failure. The image-guidance modality for percutaneous puncture was most often ultrasound combined with fluoroscopy (38%). Clinical success was obtained in all patients while technical success occurred in 94.4% because 3 patients required an additional endovascular embolization. Complications were registered in 14.8%, all of low grade without clinical sequelae neither prolonged recovery (7 non target embolizations, 1 post-embolization syndrome).
    Conclusions: In this study, pseudoaneurysms embolization with glue via percutaneous direct puncture was safe and effective with a low rate of minor complications.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2520-8934
    ISSN (online) 2520-8934
    DOI 10.1186/s42155-024-00426-w
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