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Article ; Online: Outcomes of delayed chest closure after congenital heart surgery in neonates.

Kanakis, Meletios / Samanidis, George / Kolovou, Kyriaki / Katsaridis, Sotirios / Sait, Athina Maria / Kourelis, Georgios / Giannopoulos, Nicholas / Bobos, Dimitrios

La Pediatria medica e chirurgica : Medical and surgical pediatrics

2024 Volume 46, Issue 1

Abstract: We present the outcomes of delayed chest closure in neonates who underwent congenital heart surgery under cardiopulmonary bypass. Eighty-one consecutive neonatal patients (age ≤ 28 days) with congenital heart diseases who underwent heart operations and ... ...

Abstract	We present the outcomes of delayed chest closure in neonates who underwent congenital heart surgery under cardiopulmonary bypass. Eighty-one consecutive neonatal patients (age ≤ 28 days) with congenital heart diseases who underwent heart operations and after surgery, chest remained open in the intensive care unit until DCC. Correction of transposition of the great arteries pathology was the most common surgical procedure (48.1% of patients). Median sternal closure time from surgery was 3 (2-4) days. Median age of neonates was 9 (5-12) days. In addition, in 4 cases (4.9%) there was secretion from the surgical site after DCC and after taking cultures, in 2 (2.4%) of the cases a pathogen was identified. Multivariable linear regression analysis (adjusted to gender and CPB) showed that only the age-predicted the sternum closure time (β=-0.09, 95%CI: - 0.16 to -0.02, p=0.02). In-hospital mortality was 6 (7.4%) patients. Although the DCC in neonates who underwent CHD surgical correction was related to a high mortality rate, only the age of neonates predicted the sternum closure time in the ICU.
MeSH term(s)	Infant, Newborn ; Humans ; Transposition of Great Vessels ; Time Factors ; Heart Defects, Congenital/surgery ; Cardiac Surgical Procedures/methods ; Cardiopulmonary Bypass
Language	English
Publishing date	2024-02-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605942-9
ISSN	2420-7748 ; 0391-5387
ISSN (online)	2420-7748
ISSN	0391-5387
DOI	10.4081/pmc.2024.328
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Article ; Online: Outcomes after repair of complete atrioventricular canal with a modified single-patch technique: a retrospective study.

Samanidis, George / Kostopanagiotou, Konstantinos / Kanakis, Meletios / Kourelis, Georgios / Kolovou, Kyriaki / Vagenakis, Georgios / Bobos, Dimitrios / Giannopoulos, Nicholas

Journal of Yeungnam medical science

2023 Volume 40, Issue 2, Page(s) 187–192

Abstract: Background: This study aimed to present the short- and midterm outcomes after complete atrioventricular canal defect (CAVC) repair using a single-patch technique.: Methods: This study included 30 children who underwent surgical correction of the CAVC ...

Abstract	Background: This study aimed to present the short- and midterm outcomes after complete atrioventricular canal defect (CAVC) repair using a single-patch technique. Methods: This study included 30 children who underwent surgical correction of the CAVC using a single-patch technique. Results: The median age of the patients was 5.7 months (interquartile range [IQR], 5.0-7.5 months), and 23 patients (76.7%) had type A CAVC. Fourteen patients (46.7%) were female and 17 (56.7%) had been diagnosed with Down syndrome. The in-hospital mortality rate was 0%. No deaths were observed during a median follow-up of 4 years (IQR, 3.5-5.0 years). Patients without Down syndrome were associated with late moderate mitral regurgitation (MR) (p=0.02). Late MR less than moderate degree was observed in 96.6%, 78.5%, and 50% of patients after 2, 4, and 5 years of follow-up, respectively, while late tricuspid valve regurgitation less than moderate degree was observed in 96.7%, 85.9%, and 59.0% of patients after 2, 4, and 6 years of follow-up, respectively. After a median follow-up of 4 years, only one patient had required surgical repair of a left ventricular outflow tract obstruction, which occurred 26 months after the first operation. Multivariable logistic regression analysis adjusted for the type of CAVC, sex, Down syndrome, age, and weight revealed that the absence of Down syndrome was a risk factor for late moderate MR (MR-2) (odds ratio, 0.05; 95% confidence interval, 0.006-0.50; p=0.01). Conclusion: A single-patch technique for CAVC surgical repair is a safe method with acceptable short- and midterm results.
Language	English
Publishing date	2023-02-01
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2799-8010
ISSN (online)	2799-8010
DOI	10.12701/jyms.2022.00759
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Article ; Online: Evolocumab use in Greece is associated with early and sustainable reductions in low-density cholesterol (LDL-C) and high persistence to therapy: Results from the Greek cohort analysis of the observational HEYMANS study.

Vlachopoulos, C / Massia, D / Kochiadakis, G / Kolovou, G / Patsilinakos, S / Bridges, I / Sibartie, M / Dhalwani, N N / Liberopoulos, E / Ray, K K

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2023 Volume 74, Page(s) 74–76

MeSH term(s)	Humans ; Cholesterol, LDL ; Greece/epidemiology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Anticholesteremic Agents/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Proprotein Convertase 9 ; Treatment Outcome
Chemical Substances	evolocumab (LKC0U3A8NJ) ; Cholesterol, LDL ; Antibodies, Monoclonal, Humanized ; Anticholesteremic Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Proprotein Convertase 9 (EC 3.4.21.-)
Language	English
Publishing date	2023-09-18
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2023.09.003
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Article: Preoperative surgical planning for biventricular repair of double outlet right ventricle by using a 3D heart model.

Kanakis, Meletios / Kostolny, Martin / Samanidis, George / Kolovou, Kyriaki / Chatziantoniou, Anastasios / Giannopoulos, Nicholas / Kourtidou, Soultana / Petsios, Konstantinos / Vrachliotis, Thomas / Bobos, Dimitrios

Quantitative imaging in medicine and surgery

2023 Volume 14, Issue 2, Page(s) 2107–2113

Language	English
Publishing date	2023-12-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-1191
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Article ; Online: Assessing the activity of different plant-derived molecules and potential biological nitrification inhibitors on a range of soil ammonia- and nitrite-oxidizing strains.

Kolovou, Maria / Panagiotou, Dimitra / Süße, Lars / Loiseleur, Olivier / Williams, Simon / Karpouzas, Dimitrios G / Papadopoulou, Evangelia S

Applied and environmental microbiology

2023 Volume 89, Issue 11, Page(s) e0138023

Abstract: Importance: Synthetic nitrification inhibitors are routinely used with nitrogen fertilizers to reduce nitrogen losses from agroecosystems, despite having drawbacks like poor efficiency, cost, and entry into the food chain. Plant-derived BNIs constitute ... ...

Abstract	Importance: Synthetic nitrification inhibitors are routinely used with nitrogen fertilizers to reduce nitrogen losses from agroecosystems, despite having drawbacks like poor efficiency, cost, and entry into the food chain. Plant-derived BNIs constitute a more environmentally conducive alternative. Knowledge on the activity of BNIs to soil nitrifiers is largely based on bioassays with a single
MeSH term(s)	Bacteria ; Soil ; Ammonia ; Nitrites/pharmacology ; Nitrification ; Nitrogen/pharmacology ; Soil Microbiology ; Oxidation-Reduction ; Archaea
Chemical Substances	Soil ; Ammonia (7664-41-7) ; Nitrites ; Nitrogen (N762921K75)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.01380-23
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Article ; Online: Correction to: Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia.

Ben-Omran, Tawfeg / Masana, Luis / Kolovou, Genovefa / Ariceta, Gema / Nóvoa, F Javier / Lund, Allan M / Bogsrud, Martin P / Araujo, María / Hussein, Osamah / Ibarretxe, Daiana / Sanchez-Hernández, Rosa M / Santos, Raul D

Advances in therapy

2024 Volume 41, Issue 4, Page(s) 1765–1769

Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Published Erratum
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-023-02739-z
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Article ; Online: Executive summary of the Hellenic Atherosclerosis Society guidelines for the diagnosis and treatment of dyslipidemias - 2023.

Katsiki, N / Filippatos, Td / Vlachopoulos, C / Panagiotakos, D / Milionis, H / Tselepis, A / Garoufi, A / Rallidis, L / Richter, D / Nomikos, T / Kolovou, G / Kypreos, K / Chrysohoou, C / Tziomalos, K / Skoumas, I / Koutagiar, I / Attilakos, A / Papagianni, M / Boutari, C /

Kotsis, V / Pitsavos, C / Elisaf, M / Tsioufis, K / Liberopoulos, E

Atherosclerosis plus

2024 Volume 55, Page(s) 74–92

Abstract: Atherosclerotic cardiovascular disease (ASCVD) remains the main cause of death worldwide, and thus its prevention, early diagnosis and treatment is of paramount importance. Dyslipidemia represents a major ASCVD risk factor that should be adequately ... ...

Abstract	Atherosclerotic cardiovascular disease (ASCVD) remains the main cause of death worldwide, and thus its prevention, early diagnosis and treatment is of paramount importance. Dyslipidemia represents a major ASCVD risk factor that should be adequately managed at different clinical settings. 2023 guidelines of the Hellenic Atherosclerosis Society focus on the assessment of ASCVD risk, laboratory evaluation of dyslipidemias, new and emerging lipid-lowering drugs, as well as diagnosis and treatment of lipid disorders in women, the elderly and in patients with familial hypercholesterolemia, acute coronary syndromes, heart failure, stroke, chronic kidney disease, diabetes, autoimmune diseases, and non-alcoholic fatty liver disease. Statin intolerance is also discussed.
Language	English
Publishing date	2024-02-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2667-0895
ISSN (online)	2667-0895
DOI	10.1016/j.athplu.2024.01.004
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Article ; Online: The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C).

Mavrogeni, Sophie I / Kolovou, Genovefa / Tsirimpis, Vasileios / Kafetzis, Dimitrios / Tsolas, Georgios / Fotis, Lampros

Rheumatology international

2021 Volume 41, Issue 6, Page(s) 1037–1044

Abstract: Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually ...

Abstract	Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C will need intensive care unit. Myocarditis and coronary artery ectasia/aneurysm are included between the main cardiovascular complications in MIS-C. Therefore, close clinical assessment is need it both at diagnosis and during follow-up. Echocardiography is the cornerstone modality for myocardial function and coronary artery evaluation in the acute phase. Cardiovascular magnetic resonance (CMR) detects diffuse myocardial inflammation including oedema/fibrosis, myocardial perfusion and coronary arteries anatomy during the convalescence and in adolescents, where echocardiography may provide inadequate images. Brain involvement in MIS-C is less frequent compared to cardiovascular disease. However, it is not unusual and should be monitored by clinical evaluation and brain magnetic resonance (MRI), as we still do not know its effect in brain development. Brain MRI in MIS-C shows T2-hyperintense lesions associated with restricted diffusion and bilateral thalamic lesions. To conclude, MIS-C is a multisystem disease affecting many vital organs, such as heart and brain. Clinical awareness, application of innovative, high technology imaging modalities and advanced treatment protocols including supportive and anti-inflammatory medication will help physicians to prevent the dreadful complications of MIS-C.
MeSH term(s)	Adolescent ; Brain/diagnostic imaging ; COVID-19/diagnosis ; COVID-19/physiopathology ; Child ; Child, Preschool ; Coronary Angiography ; Echocardiography ; Electrocardiography ; Heart/diagnostic imaging ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging ; Neuroimaging ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/physiopathology
Language	English
Publishing date	2021-04-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-04845-z
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Article ; Online: Pharmacogenetics and Statin Treatment: Reality or Theory?

Bousoula, Eleni / Kolovou, Vana / Perrea, Despoina / Kolovou, Genovefa

Current vascular pharmacology

2014 Volume 13, Issue 5, Page(s) 616–623

Abstract: Pharmacogenetics investigates heritable genetic polymorphisms that can effect responses to drug therapy. The main application of pharmacogenetics is genotype-guided dosing of medications and genotype-selection of treatment with the highest efficacy and ... ...

Abstract	Pharmacogenetics investigates heritable genetic polymorphisms that can effect responses to drug therapy. The main application of pharmacogenetics is genotype-guided dosing of medications and genotype-selection of treatment with the highest efficacy and lowest risk of adverse effects. Cardiovascular disease (CVD) is the leading cause of mortality and morbidity globally. Dyslipidemia is one of the classical risk factors for developing CVD. 3-hydroxy-3-methylglutaryl-coenzyme (HMGCoA) reductase inhibitors called statins are the cornerstones in dyslipidemia treatment. However, there is a broad variation in individual responses to statin treatment. This variation may not only be due to environmental factors such as adherence to treatment, diet and exercise but also due to genetic factors. Many studies have focused on various genetic polymorphisms of genes that are involved in cholesterol metabolism, trying to define their contribution to a potential genotype-guided treatment against dyslipidemia.
MeSH term(s)	Animals ; Cardiovascular Diseases/etiology ; Cholesterol/metabolism ; Dyslipidemias/drug therapy ; Dyslipidemias/genetics ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Pharmacogenetics ; Polymorphism, Genetic ; Risk Factors ; Treatment Outcome
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2014-10-17
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2192362-0
ISSN	1875-6212 ; 1570-1611
ISSN (online)	1875-6212
ISSN	1570-1611
DOI	10.2174/1570161113666150130165651
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Article: Cardiac Disease in Rheumatoid Arthritis - Can Cardiovascular Magnetic Resonance Imaging Depict the Janus Duality?

Mavrogeni, Sophie I / Markousis-Mavrogenis, George / Kolovou, Genovefa D

The Journal of rheumatology

2018 Volume 45, Issue 8, Page(s) 1073–1074

MeSH term(s)	Arthritis, Rheumatoid ; Fibrosis ; Heart Diseases ; Humans ; Inflammation ; Magnetic Resonance Imaging
Language	English
Publishing date	2018-08-01
Publishing country	Canada
Document type	Editorial ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.180242
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