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Article ; Online: Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: A placebo-controlled, double-blind study.

Ratamess, Nicholas A / Bush, Jill A / Stohs, Sidney J / Ellis, Nicole L / Vought, Ira T / O'Grady, Elizabeth A / Kuper, Jeremy D / Hasan, Saif B / Kang, Jie / Faigenbaum, Avery D

Phytotherapy research : PTR

2017

Abstract: The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and ... either 103 mg of p-synephrine (S), 233 mg of caffeine +104 mg of p-synephrine (LC + S), 240 mg of caffeine ... LC), 337 mg of caffeine +46 mg of p-synephrine (HC + S), 325 mg of caffeine (HC), or a placebo ...

Abstract	The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double-blind manner) either 103 mg of p-synephrine (S), 233 mg of caffeine +104 mg of p-synephrine (LC + S), 240 mg of caffeine (LC), 337 mg of caffeine +46 mg of p-synephrine (HC + S), 325 mg of caffeine (HC), or a placebo. The subjects sat quietly for 3 hr while heart rate (HR) and blood pressure were measured. Only HC + S and HC significantly increased mean systolic blood pressure (SBP) during the second hour and tended to increase mean SBP during the third hour. Mean diastolic blood pressure in S was significantly lower than the other trials during the first and second hours, and mean arterial pressure was significantly lower in S compared to the LC, LC + S, HC, and HC + S trials. No differences were observed in HR. Consumption of p-synephrine may acutely reduce diastolic blood pressure and mean arterial pressure and not affect SBP or HR during quiet sitting. The addition of p-synephrine to caffeine did not augment SBP or HR indicating that consumption of up to 104 mg of p-synephrine does not induce cardiovascular stress during quiet sitting.
Language	English
Publishing date	2017-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.5953
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Article ; Online: Acute hematological and mood perception effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine: A placebo-controlled, double-blind study.

Bush, Jill A / Ratamess, Nicholas A / Stohs, Sidney J / Ellis, Nicole L / Vought, Ira T / O'Grady, Elizabeth A / Kuper, Jeremy D / Kang, Jie / Faigenbaum, Avery D

Phytotherapy research : PTR

2018 Volume 32, Issue 8, Page(s) 1593–1607

Abstract: ... to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects ... visited the laboratory on 6 occasions and were given (in randomized double-blind manner) 103-mg p ... synephrine (S), 233-mg caffeine + 104-mg p-synephrine, 240-mg caffeine, 337-mg caffeine + 46-mg p-synephrine ...

Abstract	The purpose of this study was to examine acute hematological and mood perception responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects visited the laboratory on 6 occasions and were given (in randomized double-blind manner) 103-mg p-synephrine (S), 233-mg caffeine + 104-mg p-synephrine, 240-mg caffeine, 337-mg caffeine + 46-mg p-synephrine, 325-mg caffeine, or a placebo (PL). The subjects sat quietly for 3 hr while completing mood state questionnaires every 30 min. Venous blood samples were collected at baseline (pre) and 3 hr (post) to determine immune, lipid, and chemistry panels. Compared with PL, no significant supplement differences were observed during the S trial with the exception of differential time effects seen in hematocrit (decrease in PL, no change in S), triglycerides and very low-density lipoproteins (no changes in PL, significant decreases in S), and iron (no change in PL, significant elevation in S). Supplements containing caffeine showed increased feelings of attention, excitement, energy, and vigor. These data indicate that consumption of 103-mg p-synephrine does not negatively impact acute blood parameters, does not augment the effects of caffeine, or produce stimulant-like perceptual mood effects.
MeSH term(s)	Affect/drug effects ; Blood Chemical Analysis ; Caffeine/pharmacology ; Dietary Supplements ; Double-Blind Method ; Female ; Hematocrit ; Humans ; Iron/blood ; Lipoproteins, VLDL/blood ; Male ; Plant Extracts/pharmacology ; Synephrine/pharmacology ; Triglycerides/blood ; Young Adult
Chemical Substances	Lipoproteins, VLDL ; Plant Extracts ; Triglycerides ; Caffeine (3G6A5W338E) ; Iron (E1UOL152H7) ; Synephrine (PEG5DP7434)
Language	English
Publishing date	2018-04-19
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6090
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Article: Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury.

Gazzieri, David / Trevisani, Marcello / Springer, Jochen / Harrison, Selena / Cottrell, Graeme S / Andre, Eunice / Nicoletti, Paola / Massi, Daniela / Zecchi, Sandra / Nosi, Daniele / Santucci, Marco / Gerard, Norma P / Lucattelli, Monica / Lungarella, Giuseppe / Fischer, Axel / Grady, Eileen F / Bunnett, Nigel W / Geppetti, Pierangelo

Free radical biology & medicine

2007 Volume 43, Issue 4, Page(s) 581–589

Abstract: ... the mechanisms by which EtOH releases substance P (SP) and SP damages the mucosa are unknown. We hypothesized ...

Abstract	Although neurokinin 1 receptor antagonists prevent ethanol (EtOH)-induced gastric lesions, the mechanisms by which EtOH releases substance P (SP) and SP damages the mucosa are unknown. We hypothesized that EtOH activates transient receptor potential vanilloid 1 (TRPV1) on sensory nerves to release SP, which stimulates epithelial neurokinin 1 receptors to generate damaging reactive oxygen species (ROS). SP release was assayed in the mouse stomach, ROS were detected using dichlorofluorescein diacetate, and neurokinin 1 receptors were localized by immunofluorescence. EtOH-induced SP release was prevented by TRPV1 antagonism. High dose EtOH caused lesions, and TRPV1 or neurokinin 1 receptor antagonism and neurokinin 1 receptor deletion inhibited lesion formation. Coadministration of low, innocuous doses of EtOH and SP caused lesions by a TRPV1-independent but neurokinin 1 receptor-dependent process. EtOH, capsaicin, and SP stimulated generation of ROS by superficial gastric epithelial cells expressing neurokinin 1 receptors by a neurokinin 1 receptor-dependent mechanism. ROS scavengers prevented lesions induced by a high EtOH dose or a low EtOH dose plus SP. Gastric lesions are caused by an initial detrimental effect of EtOH, which is damaging only if associated with TRPV1 activation, SP release from sensory nerves, stimulation of neurokinin 1 receptors on epithelial cells, and ROS generation.
MeSH term(s)	Animals ; Central Nervous System Depressants/toxicity ; Ethanol/toxicity ; Fluorescent Antibody Technique ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Immunohistochemistry ; Male ; Mice ; Neurons/drug effects ; Neurons/metabolism ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Receptors, Neurokinin-1/drug effects ; Receptors, Neurokinin-1/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Substance P/drug effects ; Substance P/secretion ; TRPV Cation Channels/metabolism
Chemical Substances	Central Nervous System Depressants ; Reactive Oxygen Species ; Receptors, Neurokinin-1 ; TRPV Cation Channels ; Substance P (33507-63-0) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2007-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2007.05.018
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Article ; Online: Re: Perinatal outcomes and intrauterine complications following fetal intervention for congenital heart disease: systematic review and meta-analysis of observational studies. E. Araujo Júnior, G. Tonni, M. Chung, R. Ruano and W. P. Martins. Ultrasound Obstet Gynecol 2016; 48: 426-433.

Moon-Grady, A J

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2016 Volume 48, Issue 4, Page(s) 424–425

MeSH term(s)	Heart Defects, Congenital ; Humans ; Parturition ; Ultrasonics ; Ultrasonography
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.17294
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Article: Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.

Scholzen, T E / Steinhoff, M / Bonaccorsi, P / Klein, R / Amadesi, S / Geppetti, P / Lu, B / Gerard, N P / Olerud, J E / Luger, T A / Bunnett, N W / Grady, E F / Armstrong, C A / Ansel, J C

Journal of immunology (Baltimore, Md. : 1950)

2000 Volume 166, Issue 2, Page(s) 1285–1291

Abstract: Sensory nerve-derived neuropeptides such as substance P demonstrate a number of proinflammatory ... neutral endopeptidase (NEP) is the principal proteolytic substance P-degrading enzyme. This study tests the hypothesis ...

Abstract	Sensory nerve-derived neuropeptides such as substance P demonstrate a number of proinflammatory bioactivities, but less is known about their role in inflammatory skin disease. The cell surface metalloprotease neutral endopeptidase (NEP) is the principal proteolytic substance P-degrading enzyme. This study tests the hypothesis that the absence of NEP results in dysregulated inflammatory skin responses. The effector phase of allergic contact dermatitis (ACD) responses was examined in NEP(-/-) knockout and NEP(+/+) wild-type mice and compared with the irritant contact dermatitis response in these animals. NEP was found to be normally immunolocalized in epidermal keratinocytes and dermal blood vessels. The ACD ear swelling response was 2.5-fold higher in animals lacking NEP and was accompanied by a significant increase in plasma extravasation and infiltration of inflammatory leukocytes. The augmented ACD response in NEP(-/-) animals was abrogated by either administration of a neurokinin receptor 1 antagonist or by repeated pretreatment with topical capsaicin. Similar to NEP(-/-) mice, the acute inhibition of NEP in NEP(+/+) animals resulted in an augmented ACD response. In contrast to the ACD responses, little differences were observed in the irritant contact dermatitis response of NEP(-/-) compared with NEP(+/+) animals after epicutaneous application of the skin irritants croton oil or SDS. Thus, these results indicate that NEP and cutaneous neuropeptides have a significant role in the pathogenesis of ACD.
MeSH term(s)	Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/antagonists & inhibitors ; Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Capillary Permeability/genetics ; Capillary Permeability/immunology ; Capsaicin/administration & dosage ; Croton Oil/toxicity ; Dermatitis, Allergic Contact/enzymology ; Dermatitis, Allergic Contact/genetics ; Dermatitis, Allergic Contact/pathology ; Dermatitis, Allergic Contact/prevention & control ; Dermatitis, Irritant/enzymology ; Dermatitis, Irritant/genetics ; Dermatitis, Irritant/pathology ; Dermatitis, Irritant/prevention & control ; Enzyme Inhibitors/administration & dosage ; Female ; Glycopeptides/administration & dosage ; Injections, Intravenous ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neprilysin/antagonists & inhibitors ; Neprilysin/deficiency ; Neprilysin/metabolism ; Neprilysin/physiology ; Neurokinin-1 Receptor Antagonists ; Piperidines/administration & dosage ; Quinuclidines/administration & dosage ; Skin/blood supply ; Skin/enzymology ; Skin/pathology ; Substance P/toxicity
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Enzyme Inhibitors ; Glycopeptides ; Neurokinin-1 Receptor Antagonists ; Piperidines ; Quinuclidines ; SR 140333 (153050-21-6) ; Substance P (33507-63-0) ; Croton Oil (8001-28-3) ; Neprilysin (EC 3.4.24.11) ; Capsaicin (S07O44R1ZM) ; phosphoramidon (T3G94E2LB1)
Language	English
Publishing date	2000-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.166.2.1285
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Article: Observation of a Charmed Baryon Decaying to D;{0}p at a Mass Near 2.94 GeV/c;{2}.

Aubert, B / Barate, R / Bona, M / Boutigny, D / Couderc, F / Karyotakis, Y / Lees, J P / Poireau, V / Tisserand, V / Zghiche, A / Grauges, E / Palano, A / Pappagallo, M / Chen, J C / Qi, N D / Rong, G / Wang, P / Zhu, Y S / Eigen, G /

Ofte, I / Stugu, B / Abrams, G S / Battaglia, M / Brown, D N / Button-Schafer, J / Cahn, R N / Charles, E / Day, C T / Gill, M S / Groysman, Y / Jacobsen, R G / Kadyk, J A / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lynch, G / Mir, L M / Oddone, P J / Orimoto, T J / Pripstein, M / Roe, N A / Ronan, M T / Wenzel, W A / Barrett, M / Ford, K E / Harrison, T J / Hart, A J / Hawkes, C M / Morgan, S E / Watson, A T / Goetzen, K / Held, T / Koch, H / Lewandowski, B / Pelizaeus, M / Peters, K / Schroeder, T / Steinke, M / Boyd, J T / Burke, J P / Cottingham, W N / Walker, D / Cuhadar-Donszelmann, T / Fulsom, B G / Hearty, C / Knecht, N S / Mattison, T S / McKenna, J A / Khan, A / Kyberd, P / Saleem, M / Teodorescu, L / Blinov, V E / Bukin, A D / Druzhinin, V P / Golubev, V B / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Yu Todyshev, K / Best, D S / Bondioli, M / Bruinsma, M / Chao, M / Curry, S / Eschrich, I / Kirkby, D / Lankford, A J / Lund, P / Mandelkern, M / Mommsen, R K / Roethel, W / Stoker, D P / Abachi, S / Buchanan, C / Foulkes, S D / Gary, J W / Long, O / Shen, B C / Wang, K / Zhang, L / Hadavand, H K / Hill, E J / Paar, H P / Rahatlou, S / Sharma, V / Berryhill, J W / Campagnari, C / Cunha, A / Dahmes, B / Hong, T M / Kovalskyi, D / Richman, J D / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Nesom, G / Schalk, T / Schumm, B A / Seiden, A / Spradlin, P / Williams, D C / Wilson, M G / Albert, J / Chen, E / Dvoretskii, A / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Ryd, A / Samuel, A / Andreassen, R / Mancinelli, G / Meadows, B T / Sokoloff, M D / Blanc, F / Bloom, P C / Chen, S / Ford, W T / Hirschauer, J F / Kreisel, A / Nauenberg, U / Olivas, A / Ruddick, W O / Smith, J G / Ulmer, K A / Wagner, S R / Zhang, J / Chen, A / Eckhart, E A / Soffer, A / Toki, W H / Wilson, R J / Winklmeier, F / Zeng, Q / Altenburg, D D / Feltresi, E / Hauke, A / Jasper, H / Spaan, B / Brandt, T / Klose, V / Lacker, H M / Mader, W F / Nogowski, R / Petzold, A / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Volk, A / Bernard, D / Bonneaud, G R / Grenier, P / Latour, E / Thiebaux, Ch / Verderi, M / Bard, D J / Clark, P J / Gradl, W / Muheim, F / Playfer, S / Robertson, A I / Xie, Y / Andreotti, M / Bettoni, D / Bozzi, C / Calabrese, R / Cibinetto, G / Luppi, E / Negrini, M / Petrella, A / Piemontese, L / Prencipe, E / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Pacetti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rama, M / Zallo, A / Buzzo, A / Capra, R / Contri, R / Lo Vetere, M / Macri, M M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Brandenburg, G / Chaisanguanthum, K S / Morii, M / Wu, J / Dubitzky, R S / Marks, J / Schenk, S / Uwer, U / Bhimji, W / Bowerman, D A / Dauncey, P D / Egede, U / Flack, R L / Gaillard, J R / Nash, J A / Nikolich, M B / Panduro Vazquez, W / Chai, X / Charles, M J / Mallik, U / Meyer, N T / Ziegler, V / Cochran, J / Crawley, H B / Dong, L / Eyges, V / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Gristan, A V / Fritsch, M / Schott, G / Arnaud, N / Davier, M / Grosdidier, G / Höcker, A / Le Diberder, F / Lepeltier, V / Lutz, A M / Oyanguren, A / Pruvot, S / Rodier, S / Roudeau, P / Schune, M H / Stocchi, A / Wang, W F / Wormser, G / Cheng, C H / Lange, D J / Wright, D M / Chavez, C A / Forster, I J / Fry, J R / Gabathuler, E / Gamet, R / George, K A / Hutchcroft, D E / Payne, D J / Schofield, K C / Touramanis, C / Bevan, A J / Di Lodovico, F / Menges, W / Sacco, R / Brown, C L / Cowan, G / Flaecher, H U / Hopkins, D A / Jackson, P S / McMahon, T R / Ricciardi, S / Salvatore, F / Davis, C L / Allison, J / Barlow, N R / Barlow, R J / Chia, Y M / Edgar, C L / Kelly, M P / Lafferty, G D / Naisbit, M T / Williams, J C / Yi, J I / Chen, C / Hulsbergen, W D / Jawahery, A / Lae, C K / Roberts, D A / Simi, G / Blaylock, G / Dallapiccola, C / Hertzbach, S S / Li, X / Moore, T B / Saremi, S / Staengle, H / Willocq, S Y / Cowan, R / Koeneke, K / Sciolla, G / Sekula, S J / Spitznagel, M / Taylor, F / Yamamoto, R K / Kim, H / Patel, P M / Potter, C T / Robertson, S H / Lazzaro, A / Lombardo, V / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Reidy, J / Sanders, D A / Summers, D J / Zhao, H W / Brunet, S / Côté, D / Simard, M / Taras, P / Viaud, F B / Nicholson, H / Cavallo, N / De Nardo, G / Del Re, D / Fabozzi, F / Gatto, C / Lista, L / Monorchio, D / Paolucci, P / Piccolo, D / Sciacca, C / Baak, M / Bulten, H / Raven, G / Snoek, H L / Jessop, C P / Losecco, J M / Allmendinger, T / Benelli, G / Gan, K K / Honscheid, K / Hufnagel, D / Jackson, P D / Kagan, H / Kass, R / Pulliam, T / Rahimi, A M / Ter-Antonyan, R / Wong, Q K / Blout, N L / Brau, J / Frey, R / Igonkina, O / Lu, M / Rahmat, R / Sinev, N B / Strom, D / Strube, J / Torrence, E / Galeazzi, F / Gaz, A / Margoni, M / Morandin, M / Pompili, A / Posocco, M / Rotondo, M / Simonetto, F / Stroili, R / Voci, C / Benayoun, M / Chauveau, J / David, P / Del Buono, L / de la Vaissière, Ch / Hamon, O / Hartfiel, B L / John, M J J / Leruste, Ph / Malclès, J / Ocariz, J / Roos, L / Therin, G / Behera, P K / Gladney, L / Panetta, J / Biasini, M / Covarelli, R / Pioppi, M / Angelini, C / Batignani, G / Bettarini, S / Bucci, F / Calderini, G / Carpinelli, M / Cenci, R / Forti, F / Giorgi, M A / Lusiani, A / Marchiori, G / Mazur, M A / Morganti, M / Neri, N / Paoloni, E / Rizzo, G / Walsh, J / Haire, M / Judd, D / Wagoner, D E / Biesiada, J / Danielson, N / Elmer, P / Lau, Y P / Lu, C / Olsen, J / Smith, A J S / Telnov, A V / Bellini, F / Cavoto, G / D'Orazio, A / Di Marco, E / Faccini, R / Ferrarotto, F / Ferroni, F / Gaspero, M / Li Gioi, L / Mazzoni, M A / Morganti, S / Piredda, G / Polci, F / Safai Tehrani, F / Voena, C / Ebert, M / Schröder, H / Waldi, R / Adye, T / De Groot, N / Franek, B / Olaiya, E O / Wilson, F F / Emery, S / Gaidot, A / Ganzhur, S F / Hamel de Monchenault, G / Kozanecki, W / Legendre, M / Mayer, B / Vasseur, G / Yèche, Ch / Zito, M / Park, W / Purohit, M V / Weidemann, A W / Wilson, J R / Allen, M T / Aston, D / Bartoldus, R / Bechtle, P / Berger, N / Boyarski, A M / Claus, R / Coleman, J P / Convery, M R / Cristinziani, M / Dingfelder, J C / Dong, D / Dorfan, J / Dubois-Felsmann, G P / Dujmic, D / Dunwoodie, W / Field, R C / Glanzman, T / Gowdy, S J / Graham, M T / Halyo, V / Hast, C / Hyrn'ova, T / Innes, W R / Kelsey, M H / Kim, P / Kocian, M L / Leith, D W G S / Li, S / Libby, J / Luitz, S / Luth, V / Lynch, H L / Macfarlane, D B / Marsiske, H / Messner, R / Muller, D R / O'grady, C P / Ozcan, V E / Perazzo, A / Perl, M / Ratcliff, B N / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Snyder, A / Stelzer, J / Su, D / Sullivan, M K / Suzuki, K / Swain, S K / Thompson, J M / Va'vra, J / van Bakel, N / Weaver, M / Weinstein, A J R / Wisniewski, W J / Wittgen, M / Wright, D H / Yarritu, A K / Yi, K / Young, C C / Burchat, P R / Edwards, A J / Majewski, S A / Petersen, B A / Roat, C / Wilden, L / Ahmed, S / Alam, M S / Bula, R / Ernst, J A / Jain, V / Pan, B / Saeed, M A / Wappler, F R / Zain, S B / Bugg, W / Krishnamurthy, M / Spanier, S M / Eckmann, R / Ritchie, J L / Satpathy, A / Schilling, C J / Schwitters, R F / Izen, J M / Kitayama, I / Lou, X C / Ye, S / Bianchi, F / Gallo, F / Gamba, D / Bomben, M / Bosisio, L / Cartaro, C / Cossutti, F / Della Ricca, G / Dittongo, S / Grancagnolo, S / Lanceri, L / Vitale, L / Azzolini, V / Martinez-Vidal, F / Banerjee, Sw / Bhuyan, B / Brown, C M / Fortin, D / Hamano, K / Kowalewski, R / Nugent, I M / Roney, J M / Sobie, R J / Back, J J / Harrison, P F / Latham, T E / Mohanty, G B / Band, H R / Chen, X / Cheng, B / Dasu, S / Datta, M / Eichenbaum, A M / Flood, K T / Hollar, J J / Johnson, J R / Kutter, P E / Li, H / Liu, R / Mellado, B / Mihalyi, A / Mohapatra, A K / Pan, Y / Pierini, M / Prepost, R / Tan, P / Wu, S L / Yu, Z / Neal, H

Physical review letters

2007 Volume 98, Issue 1, Page(s) 12001

Abstract: A search for charmed baryons decaying to D(0)p reveals two states: the Lambdac(2880)+ baryon and ...

Abstract	A search for charmed baryons decaying to D(0)p reveals two states: the Lambdac(2880)+ baryon and a previously unobserved state at a mass of [2939.8+/-1.3(stat)+/-1.0(syst)] MeV/c2 and with an intrinsic width of [17.5+/-5.2(stat)+/-5.9(syst)] MeV. Consistent and significant signals are observed for the K(-)pi(+) and K(-)pi(+)pi(-)pi(+) decay modes of the D0 in 287 fb(-1) annihilation data recorded by the BABAR detector at a center-of-mass energy of 10.58 GeV. There is no evidence in the D+p spectrum of doubly charged partners. The mass and intrinsic width of the Lambdac(2880)+ baryon and relative yield of the two baryons are also measured.
Language	English
Publishing date	2007-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.98.012001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Complex infectious disease issues in the intensive care unit

O'Grady, Naomi P.

(Infectious disease clinics of North America ; volume 31, number 3 (September 2017))

2017

Author's details	editors Naomi P. O'Grady, Sameer S. Kadri
Series title	Infectious disease clinics of North America ; volume 31, number 3 (September 2017)
Collection
Language	English
Size	xiv Seiten, Seite 398-591, Illustrationen
Publisher	Elsevier
Publishing place	Philadelphia, Pennsylvania
Publishing country	United States
Document type	Book
HBZ-ID	HT019469486
ISBN	978-0-323-54556-3 ; 0-323-54556-4
Database	Catalogue ZB MED Medicine, Health

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Se 1187 -31,3-	verfügbar in Königswinter	Königswinter

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Article ; Online: Can P-H sigma-bond complexes be prepared? A computational study by DFT and AIM methods.

Burchell, Richard P L / Sirsch, Peter / Clark, Natascha L N / McGrady, G Sean

Dalton transactions (Cambridge, England : 2003)

2010 Volume 39, Issue 13, Page(s) 3170–3173

Abstract: ... included in this study exhibit closely similar Mn-H-P geometries, in spite of a wide range of substituents ... coordinate than corresponding silanes, with strong Mn-P and Mn-H bonding and a weak P-H interaction. ...

Abstract	A series of complexes of general formula [CpMn(CO)(2)(eta(2)-HPR(1)R(2).BCl(3))] has been studied by DFT calculations and topological analyses of the charge density thus derived. The 21 complexes included in this study exhibit closely similar Mn-H-P geometries, in spite of a wide range of substituents (R(1); R(2)) at the phosphorus atom. Topological analysis of the electron density suggests that these are genuine sigma-bond complexes, albeit at a later stage on the oxidative addition reaction coordinate than corresponding silanes, with strong Mn-P and Mn-H bonding and a weak P-H interaction.
Language	English
Publishing date	2010-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/b922191n
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Article: Acute hematological and mood perception effects of bitter orange extract (p‐synephrine) consumed alone and in combination with caffeine: A placebo‐controlled, double‐blind study

Bush, Jill A / Avery D. Faigenbaum / Elizabeth A. O'Grady / Ira T. Vought / Jeremy D. Kuper / Jie Kang / Nicholas A. Ratamess / Nicole L. Ellis / Sidney J. Stohs

Phytotherapy research. 2018 Aug., v. 32, no. 8

2018

Abstract: ... to supplementation with p‐synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects ... visited the laboratory on 6 occasions and were given (in randomized double‐blind manner) 103‐mg p ... synephrine (S), 233‐mg caffeine + 104‐mg p‐synephrine, 240‐mg caffeine, 337‐mg caffeine + 46‐mg p‐synephrine ...

Abstract	The purpose of this study was to examine acute hematological and mood perception responses to supplementation with p‐synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects visited the laboratory on 6 occasions and were given (in randomized double‐blind manner) 103‐mg p‐synephrine (S), 233‐mg caffeine + 104‐mg p‐synephrine, 240‐mg caffeine, 337‐mg caffeine + 46‐mg p‐synephrine, 325‐mg caffeine, or a placebo (PL). The subjects sat quietly for 3 hr while completing mood state questionnaires every 30 min. Venous blood samples were collected at baseline (pre) and 3 hr (post) to determine immune, lipid, and chemistry panels. Compared with PL, no significant supplement differences were observed during the S trial with the exception of differential time effects seen in hematocrit (decrease in PL, no change in S), triglycerides and very low‐density lipoproteins (no changes in PL, significant decreases in S), and iron (no change in PL, significant elevation in S). Supplements containing caffeine showed increased feelings of attention, excitement, energy, and vigor. These data indicate that consumption of 103‐mg p‐synephrine does not negatively impact acute blood parameters, does not augment the effects of caffeine, or produce stimulant‐like perceptual mood effects.
Keywords	blood composition ; blood sampling ; caffeine ; chemistry ; Citrus aurantium ; emotions ; energy ; hematocrit ; iron ; low density lipoprotein ; placebos ; questionnaires ; triacylglycerols ; vigor
Language	English
Dates of publication	2018-08
Size	p. 1593-1607.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6090
Database	NAL-Catalogue (AGRICOLA)

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Article: Evidence for B+-->J/psip(-)Lambda; and search for B0-->J/psip(-)p.

Aubert, B / Barate, R / Boutigny, D / Gaillard, J-M / Hicheur, A / Karyotakis, Y / Lees, J P / Robbe, P / Tisserand, V / Zghiche, A / Palano, A / Pompili, A / Chen, J C / Qi, N D / Rong, G / Wang, P / Zhu, Y S / Eigen, G / Ofte, I /

Stugu, B / Abrams, G S / Borgland, A W / Breon, A B / Brown, D N / Button-Shafer, J / Cahn, R N / Charles, E / Day, C T / Gill, M S / Gritsan, A V / Groysman, Y / Jacobsen, R G / Kadel, R W / Kadyk, J / Kerth, L T / Kolomensky, Yu G / Kral, J F / Kukartsev, G / LeClerc, C / Levi, M E / Lynch, G / Mir, L M / Oddone, P J / Orimoto, T J / Pripstein, M / Roe, N A / Romosan, A / Ronan, M T / Shelkov, V G / Telnov, A V / Wenzel, W A / Harrison, T J / Hawkes, C M / Knowles, D J / Penny, R C / Watson, A T / Watson, N K / Deppermann, T / Goetzen, K / Koch, H / Lewandowski, B / Pelizaeus, M / Peters, K / Schmuecker, H / Steinke, M / Barlow, N R / Bhimji, W / Boyd, J T / Chevalier, N / Cottingham, W N / Mackay, C / Wilson, F F / Hearty, C / Mattison, T S / McKenna, J A / Thiessen, D / Kyberd, P / McKemey, A K / Blinov, V E / Bukin, A D / Golubev, V B / Ivanchenko, V N / Kravchenko, E A / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Yushkov, A N / Best, D / Chao, M / Kirkby, D / Lankford, A J / Mandelkern, M / McMahon, S / Mommsen, R K / Roethel, W / Stoker, D P / Buchanan, C / Hadavand, H K / Hill, E J / MacFarlane, D B / Paar, H P / Rahatlou, Sh / Schwanke, U / Sharma, V / Berryhill, J W / Campagnari, C / Dahmes, B / Kuznetsova, N / Levy, S L / Long, O / Lu, A / Mazur, M A / Richman, J D / Verkerke, W / Beringer, J / Eisner, A M / Heusch, C A / Lockman, W S / Schalk, T / Schmitz, R E / Schumm, B A / Seiden, A / Turri, M / Walkowiak, W / Williams, D C / Wilson, M G / Albert, J / Chen, E / Dorsten, M P / Dubois-Felsmann, G P / Dvoretskii, A / Hitlin, D G / Narsky, I / Porter, F C / Ryd, A / Samuel, A / Yang, S / Jayatilleke, S / Mancinelli, G / Meadows, B T / Sokoloff, M D / Barillari, T / Blanc, F / Bloom, P / Clark, P J / Ford, W T / Nauenberg, U / Olivas, A / Rankin, P / Roy, J / Smith, J G / van Hoek, W C / Zhang, L / Harton, J L / Hu, T / Soffer, A / Toki, W H / Wilson, R J / Zhang, J / Altenburg, D / Brandt, T / Brose, J / Colberg, T / Dickopp, M / Dubitzky, R S / Hauke, A / Lacker, H M / Maly, E / Müller-Pfefferkorn, R / Nogowski, R / Otto, S / Schubert, K R / Schwierz, R / Spaan, B / Wilden, L / Bernard, D / Bonneaud, G R / Brochard, F / Cohen-Tanugi, J / Thiebaux, Ch / Vasileiadis, G / Verderi, M / Khan, A / Lavin, D / Muheim, F / Playfer, S / Swain, J E / Tinslay, J / Bozzi, C / Piemontese, L / Sarti, A / Treadwell, E / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Falciai, D / Finocchiaro, G / Patteri, P / Peruzzi, I M / Piccolo, M / Zallo, A / Buzzo, A / Contri, R / Crosetti, G / Lo Vetere, M / Macri, M / Monge, M R / Passaggio, S / Pastore, F C / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Bailey, S / Morii, M / Grenier, G J / Lee, S-J / Mallik, U / Cochran, J / Crawley, H B / Lamsa, J / Meyer, W T / Prell, S / Rosenberg, E I / Yi, J / Davier, M / Grosdidier, G / Höcker, A / Laplace, S / Le Diberder, F / Lepeltier, V / Lutz, A M / Petersen, T C / Plaszczynski, S / Schune, M H / Tantot, L / Wormser, G / Bionta, R M / Brigljević, V / Cheng, C H / Lange, D J / Wright, D M / Bevan, A J / Fry, J R / Gabathuler, E / Gamet, R / Kay, M / Payne, D J / Sloane, R J / Touramanis, C / Aspinwall, M L / Bowerman, D A / Dauncey, P D / Egede, U / Eschrich, I / Morton, G W / Nash, J A / Sanders, P / Taylor, G P / Back, J J / Bellodi, G / Harrison, P F / Shorthouse, H W / Strother, P / Vidal, P B / Cowan, G / Flaecher, H U / George, S / Green, M G / Kurup, A / Marker, C E / McMahon, T R / Ricciardi, S / Salvatore, F / Vaitsas, G / Winter, M A / Brown, D / Davis, C L / Allison, J / Barlow, R J / Forti, A C / Hart, P A / Jackson, F / Lafferty, G D / Lyon, A J / Weatherall, J H / Williams, J C / Farbin, A / Jawahery, A / Kovalskyi, D / Lae, C K / Lillard, V / Roberts, D A / Blaylock, G / Dallapiccola, C / Flood, K T / Hertzbach, S S / Kofler, R / Koptchev, V B / Moore, T B / Staengle, H / Willocq, S / Cowan, R / Sciolla, G / Taylor, F / Yamamoto, R K / Mangeol, D J J / Milek, M / Patel, P M / Lazzaro, A / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Reidy, J / Sanders, D A / Summers, D J / Zhao, H W / Hast, C / Taras, P / Nicholson, H / Cartaro, C / Cavallo, N / De Nardo, G / Fabozzi, F / Gatto, C / Lista, L / Paolucci, P / Piccolo, D / Sciacca, C / Baak, M A / Raven, G / LoSecco, J M / Gabriel, T A / Brau, B / Pulliam, T / Brau, J / Frey, R / Iwasaki, M / Potter, C T / Sinev, N B / Strom, D / Torrence, E / Colecchia, F / Dorigo, A / Galeazzi, F / Margoni, M / Morandin, M / Posocco, M / Rotondo, M / Simonetto, F / Stroili, R / Tiozzo, G / Voci, C / Benayoun, M / Briand, H / Chauveau, J / David, P / de la Vaissière, Ch / Del Buono, L / Hamon, O / Leruste, Ph / Ocariz, J / Pivk, M / Roos, L / Stark, J / T'Jampens, S / Manfredi, P F / Re, V / Gladney, L / Guo, Q H / Panetta, J / Angelini, C / Batignani, G / Bettarini, S / Bondioli, M / Bucci, F / Calderini, G / Carpinelli, M / Forti, F / Giorgi, M A / Lusiani, A / Marchiori, G / Martinez-Vidal, F / Morganti, M / Neri, N / Paoloni, E / Rama, M / Rizzo, G / Sandrelli, F / Walsh, J / Haire, M / Judd, D / Paick, K / Wagoner, D E / Danielson, N / Elmer, P / Lu, C / Miftakov, V / Olsen, J / Smith, A J S / Varnes, E W / Bellini, F / Cavoto, G / del Re, D / Faccini, R / Ferrarotto, F / Ferroni, F / Gaspero, M / Leonardi, E / Mazzoni, M A / Morganti, S / Pierini, M / Piredda, G / Safai Tehrani, F / Serra, M / Voena, C / Christ, S / Wagner, G / Waldi, R / Adye, T / De Groot, N / Franek, B / Geddes, N I / Gopal, G P / Olaiya, E O / Xella, S M / Aleksan, R / Emery, S / Gaidot, A / Ganzhur, S F / Giraud, P-F / Hamel de Monchenault, G / Kozanecki, W / Langer, M / London, G W / Mayer, B / Schott, G / Vasseur, G / Yeche, Ch / Zito, M / Purohit, M V / Weidemann, A W / Yumiceva, F X / Aston, D / Bartoldus, R / Berger, N / Boyarski, A M / Buchmueller, O L / Convery, M R / Coupal, D P / Dong, D / Dorfan, J / Dujmic, D / Dunwoodie, W / Field, R C / Glanzman, T / Gowdy, S J / Grauges-Pous, E / Hadig, T / Halyo, V / Hryn'ova, T / Innes, W R / Jessop, C P / Kelsey, M H / Kim, P / Kocian, M L / Langenegger, U / Leith, D W G S / Luitz, S / Luth, V / Lynch, H L / Marsiske, H / Menke, S / Messner, R / Muller, D R / O'Grady, C P / Ozcan, V E / Perazzo, A / Perl, M / Petrak, S / Ratcliff, B N / Robertson, S H / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Simi, G / Snyder, A / Soha, A / Stelzer, J / Su, D / Sullivan, M K / Tanaka, H A / Va'vra, J / Wagner, S R / Weaver, M / Weinstein, A J R / Wisniewski, W J / Wright, D H / Young, C C / Burchat, P R / Meyer, T I / Roat, C / Ahmed, S / Ernst, J A / Bugg, W / Krishnamurthy, M / Spanier, S M / Eckmann, R / Kim, H / Ritchie, J L / Schwitters, R F / Izen, J M / Kitayama, I / Lou, X C / Ye, S / Bianchi, F / Bona, M / Gallo, F / Gamba, D / Borean, C / Bosisio, L / Della Ricca, G / Dittongo, S / Grancagnolo, S / Lanceri, L / Poropat, P / Vitale, L / Vuagnin, G / Panvini, R S / Banerjee, Sw / Brown, C M / Fortin, D / Jackson, P D / Kowalewski, R / Roney, J M / Band, H R / Dasu, S / Datta, M / Eichenbaum, A M / Hu, H / Johnson, J R / Liu, R / Di Lodovico, F / Mohapatra, A K / Pan, Y / Prepost, R / Sekula, S J / von Wimmersperg-Toeller, J H / Wu, J / Wu, S L / Yu, Z / Neal, H

Physical review letters

2003 Volume 90, Issue 23, Page(s) 231801

Abstract: We have performed a search for the decays B+-->J/psip(-)Lambda; and search for B0-->J/psip(-)p ...

Abstract	We have performed a search for the decays B+-->J/psip(-)Lambda; and search for B0-->J/psip(-)p. in a data set of (88.9+/-1.0) x 10(6) Upsilon(4S) decays collected by the BABAR experiment at the PEP-II e(+)e(-) storage ring at the Stanford Linear Accelerator Center. Four charged B candidates have been observed with an expected background of 0.21+/-0.14 events. The corresponding branching fraction is (12(+9)(-6)) x 10(-6), where statistical and systematic uncertainties have been combined. The result can be interpreted as a 90% confidence level (C.L.) upper limit of 26 x 10(-6). We also find one B0 candidate, with an expected background of 0.64+/-0.17 events, implying a 90% C.L. upper limit of 1.9 x 10(-6).
Language	English
Publishing date	2003-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.90.231801
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