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  1. Article ; Online: Adolescent Brain Development and Contextual Influences: A Decade in Review.

    Galván, Adriana

    Journal of research on adolescence : the official journal of the Society for Research on Adolescence

    2021  Volume 31, Issue 4, Page(s) 843–869

    Abstract: Adolescence is a developmental period characterized by substantial psychological, biological, and neurobiological changes. This review discusses the past decade of research on the adolescent brain, as based on the overarching framework that development ... ...

    Abstract Adolescence is a developmental period characterized by substantial psychological, biological, and neurobiological changes. This review discusses the past decade of research on the adolescent brain, as based on the overarching framework that development is a dynamic process both within the individual and between the individual and external inputs. As such, this review focuses on research showing that the development of the brain is influenced by multiple ongoing and dynamic elements. It highlights the implications this body of work on behavioral development and offers areas of opportunity for future research in the coming decade.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Adolescent Development ; Brain/diagnostic imaging ; Humans
    Language English
    Publishing date 2021-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2017369-6
    ISSN 1532-7795 ; 1050-8392
    ISSN (online) 1532-7795
    ISSN 1050-8392
    DOI 10.1111/jora.12687
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  2. Article ; Online: The Need for Sleep in the Adolescent Brain.

    Galván, Adriana

    Trends in cognitive sciences

    2019  Volume 24, Issue 1, Page(s) 79–89

    Abstract: Sleep is a basic need. Mounting evidence suggests this is particularly true during adolescence, a developmental period involving substantial changes in the brain regions supporting cognition, learning, and emotion. Although sleep loss is a normative ... ...

    Abstract Sleep is a basic need. Mounting evidence suggests this is particularly true during adolescence, a developmental period involving substantial changes in the brain regions supporting cognition, learning, and emotion. Although sleep loss is a normative psychosocially and biologically driven developmental process, it occurs alongside behaviors that characterize adolescence, including deepening cognitive sophistication, improved emotion regulation, and intensifying social cognition, calling into question how sleep may impact these developmental milestones. This review synthesizes growing research aimed at addressing this timely question. It presents evidence that neurodevelopmental changes in brain structure, function, and sleep physiology mechanistically link the relationship between sleep and cognitive ability.
    MeSH term(s) Adolescent ; Brain ; Cognition ; Emotions ; Humans ; Learning ; Sleep
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2010989-1
    ISSN 1879-307X ; 1364-6613
    ISSN (online) 1879-307X
    ISSN 1364-6613
    DOI 10.1016/j.tics.2019.11.002
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  3. Article ; Online: Corrigendum to: "Connectivity of the Corticostriatal and Thalamostriatal Systems in Normal and Parkinsonian States: An Update" Neurobiology of Disease 174: 105878.

    Martel, Anne-Caroline / Galvan, Adriana

    Neurobiology of disease

    2023  Volume 177, Page(s) 105985

    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2022.105985
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  4. Article ; Online: Young people need experiences that boost their mental health.

    Fuligni, Andrew J / Galván, Adriana

    Nature

    2022  Volume 610, Issue 7931, Page(s) 253–256

    MeSH term(s) Adolescent ; Humans ; Mental Disorders/prevention & control ; Mental Disorders/psychology ; Mental Health/statistics & numerical data ; Mental Health Services ; Psychology, Adolescent
    Language English
    Publishing date 2022-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-03172-y
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  5. Article ; Online: Adolescence, brain maturation and mental health.

    Galván, Adriana

    Nature neuroscience

    2017  Volume 20, Issue 4, Page(s) 503–504

    MeSH term(s) Adolescent ; Brain ; Connectome ; Humans ; Mental Disorders/psychology ; Mental Health
    Language English
    Publishing date 2017-03-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/nn.4530
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    Zs.A 4891: Show issues Location:
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  6. Article ; Online: Corrigendum to: Dorsolateral prefrontal cortex response to negative tweets relates to executive functioning.

    Tashjian, Sarah M / Galván, Adriana

    Social cognitive and affective neuroscience

    2021  Volume 16, Issue 7, Page(s) 737

    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2236933-8
    ISSN 1749-5024 ; 1749-5016
    ISSN (online) 1749-5024
    ISSN 1749-5016
    DOI 10.1093/scan/nsab039
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  7. Article ; Online: Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes.

    Galvan, Adriana / Wichmann, Thomas

    Journal of neurophysiology

    2023  Volume 129, Issue 5, Page(s) 1010–1020

    Abstract: The spiking activity of basal ganglia neurons can be characterized by summary statistics such as the average firing rate, or by measures of firing patterns, such as burst discharges, or oscillatory fluctuations of firing rates. Many of these features are ...

    Abstract The spiking activity of basal ganglia neurons can be characterized by summary statistics such as the average firing rate, or by measures of firing patterns, such as burst discharges, or oscillatory fluctuations of firing rates. Many of these features are altered by the presence of parkinsonism. This study examined another distinct attribute of firing activity, i.e., the occurrence of repeating sequences of interspike intervals (ISIs). We studied this feature in extracellular electrophysiological recordings that were made in the basal ganglia of rhesus monkeys, before and after they had been rendered parkinsonian by treatment with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurons in both pallidal segments and in the subthalamic nucleus tended to fire in repeating sequences, typically two ISIs long (i.e., involving three spikes). In recordings that were 5,000 interspike intervals long, 20%-40% of spikes participated in one of many sequences with each ISI replicating the sequence pattern with a timing error of ≤1%. Compared with similar analyses in shuffled representations of the same data, sequences were more common in the original representation of ISIs in all of the tested structures. Induction of parkinsonism reduced the proportion of sequence spikes in the external pallidum but increased it in the subthalamic nucleus. We found no relation between the sequence generation and the firing rate of neurons, and, at most, a weak correlation between sequence generation and the incidence of bursts. We conclude that basal ganglia neurons fire in recognizable sequences of ISIs, whose incidence is influenced by the induction of parkinsonism.
    MeSH term(s) Animals ; Basal Ganglia ; Neurons/physiology ; Subthalamic Nucleus ; Globus Pallidus/physiology ; Parkinsonian Disorders ; Action Potentials/physiology
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00265.2022
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  8. Article ; Online: Building and Characterization of an Affordable diOlistic Device for Single-Cell Labeling in Rodent and Non-Human Primate Brain Slices.

    Heffernan, Kate S / Galvan, Adriana

    Current protocols

    2023  Volume 3, Issue 4, Page(s) e760

    Abstract: In the brain, cell morphology often reflects function and thus provides a first glance into cell-specific changes in health and disease. Studying the morphology of individual cells, including neurons and glia, is essential to fully understand brain ... ...

    Abstract In the brain, cell morphology often reflects function and thus provides a first glance into cell-specific changes in health and disease. Studying the morphology of individual cells, including neurons and glia, is essential to fully understand brain connectivity and changes in disease states. Many recent morphological studies of brain cells have relied on transgenic animals and viral vectors to label individual cells. However, transgenic animals are not always available, and in non-human primate (NHP) models, viral transduction poses several practical and financial challenges, limiting the number of researchers that can thoroughly investigate cell morphology in NHP or other non-transgenic animals. The diOlistic system for delivering fluorescent lipophilic dye-coated gold or tungsten particles into brain tissue has been used to label single cells, but the currently available systems are expensive, have limited applications, and are rare in laboratories. Investigations of cell morphology without transgenic or viral approaches rely on immunohistochemical markers that may not reveal structural detail, such as in astrocytes. To overcome these practical limitations to expand our understanding of cell morphology across species with an emphasis on astrocytes, we constructed a low-cost ballistic method to deliver dye-coated gold or tungsten particles into NHP and rodent brain slices. We have optimized the tissue processing parameters to achieve penetration of DiI-coated particles, allowing for the complete reconstruction of individual cells within a brain slice. While we report on astrocytes in rodent and NHP brain slices, this protocol can be adapted and implemented across species and tissue types to evaluate cell morphology. © 2023 Wiley Periodicals LLC. Basic Protocol 1: Building the diOlistic device Basic Protocol 2: Preparation of dye "bullet" carriers Basic Protocol 3: Perfusion, brain sectioning, and diOlistic labeling Alternate Protocol: Immunohistochemical labeling of sections prior to diOlistic bombardment.
    MeSH term(s) Animals ; Rodentia/metabolism ; Staining and Labeling ; Tungsten/chemistry ; Brain ; Fluorescent Dyes/metabolism ; Primates/metabolism ; Animals, Genetically Modified ; Gold
    Chemical Substances Tungsten (V9306CXO6G) ; Fluorescent Dyes ; Gold (7440-57-5)
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.760
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  9. Article ; Online: Frontopolar Cortex Response to Positive Feedback Relates to Nonincentivized Task Persistence.

    Tashjian, Sarah M / Galván, Adriana

    Cerebral cortex (New York, N.Y. : 1991)

    2021  Volume 32, Issue 11, Page(s) 2293–2309

    Abstract: When individuals make decisions whether to persist at a task, their decision-making is informed by whether success is pending or accomplished. If pending, the brain facilitates behavioral persistence; if the goal is accomplished or no longer desired, the ...

    Abstract When individuals make decisions whether to persist at a task, their decision-making is informed by whether success is pending or accomplished. If pending, the brain facilitates behavioral persistence; if the goal is accomplished or no longer desired, the brain enables switching away from the current task. Feedback, which is known to differentially engage reward neurocircuitry, may modulate goal-directed behavior such as task persistence. However, prior studies are confounded by offering external incentives for persistence. This study tested whether neural response to feedback differed as a function of nonincentivized task persistence in 99 human participants ages 13-30 (60 females). Individuals who persisted engaged the frontopolar cortex (FPC) to a greater extent during receipt of task-relevant positive feedback compared with negative feedback. For individuals who quit, task-irrelevant monetary reward engaged the FPC to a greater extent compared with positive feedback. FPC activation in response to positive feedback is identified as a key contributor to task persistence.
    MeSH term(s) Adolescent ; Adult ; Attention ; Brain/physiology ; Brain Mapping ; Feedback ; Female ; Humans ; Reward ; Young Adult
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhab317
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  10. Article ; Online: Applications of chemogenetics in non-human primates.

    Raper, Jessica / Galvan, Adriana

    Current opinion in pharmacology

    2022  Volume 64, Page(s) 102204

    Abstract: Due to its low invasiveness and controllability, chemogenetic approaches offer a highly attractive option to modulate neuronal activity in basic research and future clinical applications. Chemogenetics have revolutionized neuroscience research by ... ...

    Abstract Due to its low invasiveness and controllability, chemogenetic approaches offer a highly attractive option to modulate neuronal activity in basic research and future clinical applications. Chemogenetics have revolutionized neuroscience research by facilitating manipulations of selective brain circuits. To date, however, the large majority of these studies have been conducted in rodent models, while the wide application of chemogenetics in nonhuman primates (NHPs) is yet to occur. Still, important progress has been achieved in the use of chemogenetics in NHP studies in the last few years. Here we review the studies that have been published using chemogenetics in NHPs and discuss the current limitations of the technique to its more widespread use in NHPs and possible ways to overcome them.
    MeSH term(s) Animals ; Humans ; Neurons/physiology ; Primates
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102204
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