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  1. Article ; Online: Noteworthy observations in hypertension from 2015.

    Weir, Matthew R / Blantz, Roland C

    Current opinion in nephrology and hypertension

    2016  Volume 25, Issue 1, Page(s) 1–2

    MeSH term(s) Aged ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  2. Article: Making sense of the sensor: mysteries of the macula densa.

    Blantz, R C

    Kidney international

    2006  Volume 70, Issue 5, Page(s) 828–830

    Abstract: Increases in luminal NaCl concentration at the macula densa (MD), the sensing element, activate tubuloglomerular feedback (TGF). MD cell volume increases when increments are isosmotic and shrinks if osmolality increases. This interesting finding ... ...

    Abstract Increases in luminal NaCl concentration at the macula densa (MD), the sensing element, activate tubuloglomerular feedback (TGF). MD cell volume increases when increments are isosmotic and shrinks if osmolality increases. This interesting finding introduces additional complexity to the role of the MD in TGF.
    MeSH term(s) Animals ; Biological Transport/physiology ; Cell Size ; Feedback, Physiological/physiology ; Glomerular Filtration Rate/physiology ; Humans ; Kidney Glomerulus/blood supply ; Kidney Glomerulus/cytology ; Kidney Glomerulus/physiology ; Kidney Tubules, Distal/blood supply ; Kidney Tubules, Distal/cytology ; Kidney Tubules, Distal/physiology ; Osmolar Concentration ; Osmotic Pressure ; Regional Blood Flow/physiology ; Sodium Chloride/analysis ; Sodium Chloride/pharmacokinetics
    Chemical Substances Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2006-09
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/sj.ki.5001739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  3. Article: Why are some people more receptive to angiotension II?

    Blantz, R C

    Kidney international

    1999  Volume 56, Issue 6, Page(s) 2316–2317

    MeSH term(s) Angiotensin II/physiology ; Angiotensin II/therapeutic use ; Animals ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/physiopathology ; Renin-Angiotensin System/physiology
    Chemical Substances Angiotensin II (11128-99-7)
    Language English
    Publishing date 1999-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1046/j.1523-1755.1999.00808.x
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    Zs.A 797: Show issues Location:
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  4. Article: Tubuloglomerular feedback responses of the downstream efferent resistance: unmasking a role for adenosine?

    Blantz, R C / Vallon, V

    Kidney international

    2007  Volume 71, Issue 9, Page(s) 837–839

    Abstract: This Commentary aims to integrate or interrelate the available in vivo data with the in vitro study by Ren and co-workers, which comes to the somewhat surprising conclusion that tubuloglomerular feedback activation vasodilates the efferent arteriole by ... ...

    Abstract This Commentary aims to integrate or interrelate the available in vivo data with the in vitro study by Ren and co-workers, which comes to the somewhat surprising conclusion that tubuloglomerular feedback activation vasodilates the efferent arteriole by an adenosine-dependent mechanism.
    MeSH term(s) Adenosine/physiology ; Animals ; Arterioles/physiology ; Feedback ; Kidney Glomerulus/blood supply ; Kidney Glomerulus/physiology ; Kidney Tubules/blood supply ; Models, Biological ; Rabbits ; Renal Circulation
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/sj.ki.5002199
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    Zs.A 797: Show issues Location:
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  5. Article: Pathophysiology of pre-renal azotemia.

    Blantz, R C

    Kidney international

    1998  Volume 53, Issue 2, Page(s) 512–523

    MeSH term(s) Adolescent ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation ; Male ; Nephrons/physiology ; Renal Artery/physiopathology ; Uremia/physiopathology ; Uremia/surgery ; Urodynamics ; Vasoconstriction/physiology ; Water-Electrolyte Balance
    Language English
    Publishing date 1998-02
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1046/j.1523-1755.2003_t01-1-00784.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Coordination of kidney filtration and tubular reabsorption: considerations on the regulation of metabolic demand for tubular reabsorption.

    Blantz, R C / Deng, A

    Acta physiologica Hungarica

    2007  Volume 94, Issue 1-2, Page(s) 83–94

    Abstract: Kidney blood flow is highly regulated by a combination of myogenic autoregulation, multiple neurohormonal systems and the tubuloglomerular feedback system, the later of which specifically relates tubular reabsorption to the filtered load. Oxygen and ... ...

    Abstract Kidney blood flow is highly regulated by a combination of myogenic autoregulation, multiple neurohormonal systems and the tubuloglomerular feedback system, the later of which specifically relates tubular reabsorption to the filtered load. Oxygen and substrate requirements of the kidney are dictated by both supply of oxygen and substrates and metabolic demands of the kidney. The tubuloglomerular feedback system utilizes mediators which are intimately linked to cellular metabolism, ATP and adenosine. This system based upon communication transfer between the macular densa and the afferent arteriole stabilizes kidney function and is not static but temporally adapts or resets to new external physiologic conditions. Such temporal adaptation occurs via modulators such as nitric oxide (NO), primarily derived from NOS-1, angiotensin II and COX-2 products. These hormonal influences also exert capacities to modulate cellular demands for oxygen, particularly NO which decreases oxygen consumption via multiple mechanisms. The several mechanisms whereby NO and other hormonal systems and transporter activity can regulate and produce changes in kidney metabolic demands are discussed. Modulators which influence temporal adaptation and resetting of TGF are also significant contributors to the regulation of cellular oxygen consumption in the kidney. These systems may act in concert to preserve the coordination of filtered load and tubular reabsorption and the metabolic demands of kidney function, thereby determining the ischemic threshold for kidney function.
    MeSH term(s) Absorption ; Animals ; Citrulline/analogs & derivatives ; Citrulline/pharmacology ; Feedback ; Glomerular Filtration Rate ; Kidney/blood supply ; Kidney/physiology ; Kidney Glomerulus/physiology ; Kidney Tubules/physiology ; Nitric Oxide Synthase Type I/physiology ; Signal Transduction ; Sodium/metabolism ; Thiourea/analogs & derivatives ; Thiourea/pharmacology
    Chemical Substances Citrulline (29VT07BGDA) ; Sodium (9NEZ333N27) ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; Thiourea (GYV9AM2QAG) ; S-methylthiocitrulline (M790X706JV)
    Language English
    Publishing date 2007-03
    Publishing country Hungary
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 802801-1
    ISSN 1588-2683 ; 0231-424X ; 0001-6756
    ISSN (online) 1588-2683
    ISSN 0231-424X ; 0001-6756
    DOI 10.1556/APhysiol.94.2007.1-2.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.361: Show issues Location:
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  7. Article: Acetaminophen: acute and chronic effects on renal function.

    Blantz, R C

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    1996  Volume 28, Issue 1 Suppl 1, Page(s) S3–6

    Abstract: Acetaminophen (APAP) is normally metabolized in the liver and kidney by P450 enzymes. No toxicity is observed with therapeutic doses of APAP. However, after ingestion of large quantities of APAP (>2,000 mg/kg), highly reactive quinones, metabolites of ... ...

    Abstract Acetaminophen (APAP) is normally metabolized in the liver and kidney by P450 enzymes. No toxicity is observed with therapeutic doses of APAP. However, after ingestion of large quantities of APAP (>2,000 mg/kg), highly reactive quinones, metabolites of APAP, are generated; these react with glutathione and sulfhydryl groups on critical proteins, resulting in cellular dysfunction and hepatic and renal toxicity. The P450 metabolizing enzymes differ somewhat in character between the liver and kidney. Factors that enhance renal toxicity include chronic liver disease, possibly gender, concurrent renal insults, and conditions that alter the activity of P450-metabolizing enzyme systems. Acute renal toxicity is characterized by cellular injury primarily confined to the proximal tubule and significant reductions in glomerular filtration rate. However, there is little evidence that chronic administration of APAP contributes to chronic renal disease and analgesic nephropathy. The only report on this subject suggests that combination therapy with aspirin is required for medullary damage in rats. No evidence exists for the development of chronic analgesic nephropathy with APAP alone. Epidemiologic studies in healthy individuals have failed to demonstrate a significant correlation between APAP use and chronic renal disease and classic analgesic nephropathy. Therefore, large doses of APAP can produce both renal and hepatic failure, but little evidence exists for production of classic analgesic nephropathy with the use of APAP alone.
    MeSH term(s) Acetaminophen/adverse effects ; Acetaminophen/pharmacokinetics ; Acetaminophen/toxicity ; Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/pharmacokinetics ; Analgesics, Non-Narcotic/toxicity ; Animals ; Humans ; Kidney/drug effects ; Kidney/physiology ; Kidney Failure, Chronic/chemically induced
    Chemical Substances Analgesics, Non-Narcotic ; Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 1996-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1016/s0272-6386(96)90561-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  8. Article: Are the oxygen costs of kidney function highly regulated?

    Blantz, Roland C / Weir, Matthew R

    Current opinion in nephrology and hypertension

    2004  Volume 13, Issue 1, Page(s) 67–71

    MeSH term(s) Angiotensin II/physiology ; Animals ; Humans ; Kidney/metabolism ; Kidney/physiology ; Nitric Oxide/physiology ; Oxygen Consumption/physiology
    Chemical Substances Angiotensin II (11128-99-7) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2004-06-28
    Publishing country England
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1151092-4
    ISSN 1535-3842 ; 1062-4821 ; 1062-4813
    ISSN (online) 1535-3842
    ISSN 1062-4821 ; 1062-4813
    DOI 10.1097/00041552-200401000-00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The clinical utilization of albuminuria as a surrogate measure of cardiovascular disease burden and risk for events: are we there yet?

    Weir, Matthew R / Blantz, Roland C

    Current opinion in nephrology and hypertension

    2004  Volume 14, Issue 1, Page(s) 39–41

    MeSH term(s) Albuminuria/etiology ; Albuminuria/prevention & control ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/physiopathology ; Humans ; Risk Factors
    Language English
    Publishing date 2004-11-10
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 1151092-4
    ISSN 1535-3842 ; 1062-4821 ; 1062-4813
    ISSN (online) 1535-3842
    ISSN 1062-4821 ; 1062-4813
    DOI 10.1097/00041552-200501000-00007
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  10. Article: Filtration, reabsorption and oxygen in the kidney.

    Blantz, R C

    Advances in experimental medicine and biology

    1994  Volume 361, Page(s) 579–584

    MeSH term(s) Glomerular Filtration Rate/physiology ; Humans ; Kidney/blood supply ; Kidney/physiology ; Kidney Glomerulus/physiology ; Kidney Tubules/physiology ; Oxygen Consumption/physiology
    Language English
    Publishing date 1994
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4615-1875-4_105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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