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Article ; Online: Absence of Atherosclerosis in Chagas' Disease: The Role of Trypanosoma Cruzi Transialidase.

Higuchi, Maria de Lourdes

2021 Volume 115, Issue 6, Page(s) 1061–1062

Title translation	Ausência de Aterosclerose na Doença de Chagas: O Papel da Transialidase do Trypanosoma Cruzi.
MeSH term(s)	Atherosclerosis ; Chagas Disease/complications ; Computed Tomography Angiography ; Coronary Artery Disease ; Humans ; Prevalence ; Trypanosoma cruzi
Language	Portuguese
Publishing date	2021-01-20
Publishing country	Brazil
Document type	Editorial ; Comment
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20201229
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Article: Commentary: Comparison of the Protective Effects of Individual Components of Particulated

Higuchi, Maria de Lourdes

Frontiers in cardiovascular medicine

2018 Volume 5, Page(s) 171

Language	English
Publishing date	2018-12-03
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2018.00171
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Article ; Online: Distinct Microbial Communities in Dilated Cardiomyopathy Explanted Hearts Are Associated With Different Myocardial Rejection Outcomes.

Pereira, Jaqueline de Jesus / Ikegami, Renata Nishiyama / Kawakami, Joyce Tiyeko / Garavelo, Shérrira Menezes / Reis, Marcia Martins / Palomino, Suely Aparecida Pinheiro / Mangini, Sandrigo / Moreno, Camila Rodrigues / de Barros, Samar Freschi / Souza, Aline Rodrigues / Higuchi, Maria de Lourdes

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 732276

Abstract: Background: Idiopathic dilated cardiomyopathy (IDCM) myocardial inflammation may be associated with external triggering factors such as infectious agents. Here, we searched if moderate/severe heart transplantation rejection is related to the presence of ...

Abstract	Background: Idiopathic dilated cardiomyopathy (IDCM) myocardial inflammation may be associated with external triggering factors such as infectious agents. Here, we searched if moderate/severe heart transplantation rejection is related to the presence of myocardial inflammation in IDCM explanted hearts, associated with microbial communities. Method: Receptor myocardial samples from 18 explanted hearts were separated into groups according to post-transplant outcome: persistent moderate rejection (PMR; n = 6), moderate rejection (MR; n = 7) that regressed after pulse therapy, and no rejection (NR; n = 5)/light intensity rejection. Inflammation was quantified through immunohistochemistry (IHC), and infectious agents were evaluated by IHC, molecular biology, Results: NR presented lower numbers of macrophages, as well as B cells (p = 0.0001), and higher HLA class II expression (p ≤ 0.0001). PMR and MR showed higher levels of Conclusions: This initial study investigating on infectious agents and inflammation in the IDCM explanted hearts showed that the association between
MeSH term(s)	Cardiomyopathy, Dilated ; Heart ; Humans ; Microbiota ; Myocardium ; Parvovirus B19, Human
Language	English
Publishing date	2021-11-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.732276
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Article: Morphomolecular Characterization of Serum Nanovesicles From Microbiomes Differentiates Stable and Infarcted Atherosclerotic Patients.

Moreno, Camila Rodrigues / Ramires, José Antonio Franchini / Lotufo, Paulo Andrade / Soeiro, Alexandre Matos / Oliveira, Luanda Mara da Silva / Ikegami, Renata Nishiyama / Kawakami, Joyce Tiyeko / Pereira, Jaqueline de Jesus / Reis, Marcia Martins / Higuchi, Maria de Lourdes

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 694851

Abstract: Microbial communities are considered decisive for maintaining a healthy situation or for determining diseases. Acute myocardial infarction (AMI) is an important complication of atherosclerosis caused by the rupture of atheroma plaques containing ... ...

Abstract	Microbial communities are considered decisive for maintaining a healthy situation or for determining diseases. Acute myocardial infarction (AMI) is an important complication of atherosclerosis caused by the rupture of atheroma plaques containing proinflammatory cytokines, reactive oxygen species, oxidized low-density lipoproteins (oxLDL), damaged proteins, lipids, and DNA, a microenvironment compatible with a pathogenic microbial community. Previously, we found that archaeal DNA-positive infectious microvesicles (iMVs) were detected in vulnerable plaques and in the sera of Chagas disease patients with heart failure. Now, we characterize and quantify the levels of serum microbiome extracellular vesicles through their size and content using morphomolecular techniques to differentiate clinical outcomes in coronary artery disease (CAD). We detected increased numbers of large iMVs (0.8-1.34 nm) with highly negative surface charge that were positive for archaeal DNA,
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.694851
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Article ; Online: SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023.

Marin-Neto, José Antonio / Rassi, Anis / Oliveira, Gláucia Maria Moraes / Correia, Luís Claudio Lemos / Ramos Júnior, Alberto Novaes / Luquetti, Alejandro Ostermayer / Hasslocher-Moreno, Alejandro Marcel / Sousa, Andréa Silvestre de / Paola, Angelo Amato Vincenzo de / Sousa, Antônio Carlos Sobral / Ribeiro, Antonio Luiz Pinho / Correia Filho, Dalmo / Souza, Dilma do Socorro Moraes de / Cunha-Neto, Edecio / Ramires, Felix Jose Alvarez / Bacal, Fernando / Nunes, Maria do Carmo Pereira / Martinelli Filho, Martino / Scanavacca, Maurício Ibrahim /

Saraiva, Roberto Magalhães / Oliveira Júnior, Wilson Alves de / Lorga-Filho, Adalberto Menezes / Guimarães, Adriana de Jesus Benevides de Almeida / Braga, Adriana Lopes Latado / Oliveira, Adriana Sarmento de / Sarabanda, Alvaro Valentim Lima / Pinto, Ana Yecê das Neves / Carmo, Andre Assis Lopes do / Schmidt, Andre / Costa, Andréa Rodrigues da / Ianni, Barbara Maria / Markman Filho, Brivaldo / Rochitte, Carlos Eduardo / Macêdo, Carolina Thé / Mady, Charles / Chevillard, Christophe / Virgens, Cláudio Marcelo Bittencourt das / Castro, Cleudson Nery de / Britto, Constança Felicia De Paoli de Carvalho / Pisani, Cristiano / Rassi, Daniela do Carmo / Sobral Filho, Dário Celestino / Almeida, Dirceu Rodrigues de / Bocchi, Edimar Alcides / Mesquita, Evandro Tinoco / Mendes, Fernanda de Souza Nogueira Sardinha / Gondim, Francisca Tatiana Pereira / Silva, Gilberto Marcelo Sperandio da / Peixoto, Giselle de Lima / Lima, Gustavo Glotz de / Veloso, Henrique Horta / Moreira, Henrique Turin / Lopes, Hugo Bellotti / Pinto, Ibraim Masciarelli Francisco / Ferreira, João Marcos Bemfica Barbosa / Nunes, João Paulo Silva / Barreto-Filho, José Augusto Soares / Saraiva, José Francisco Kerr / Lannes-Vieira, Joseli / Oliveira, Joselina Luzia Menezes / Armaganijan, Luciana Vidal / Martins, Luiz Cláudio / Sangenis, Luiz Henrique Conde / Barbosa, Marco Paulo Tomaz / Almeida-Santos, Marcos Antonio / Simões, Marcos Vinicius / Yasuda, Maria Aparecida Shikanai / Moreira, Maria da Consolação Vieira / Higuchi, Maria de Lourdes / Monteiro, Maria Rita de Cassia Costa / Mediano, Mauro Felippe Felix / Lima, Mayara Maia / Oliveira, Maykon Tavares de / Romano, Minna Moreira Dias / Araujo, Nadjar Nitz Silva Lociks de / Medeiros, Paulo de Tarso Jorge / Alves, Renato Vieira / Teixeira, Ricardo Alkmim / Pedrosa, Roberto Coury / Aras Junior, Roque / Torres, Rosalia Morais / Povoa, Rui Manoel Dos Santos / Rassi, Sergio Gabriel / Alves, Silvia Marinho Martins / Tavares, Suelene Brito do Nascimento / Palmeira, Swamy Lima / Silva Júnior, Telêmaco Luiz da / Rodrigues, Thiago da Rocha / Madrini Junior, Vagner / Brant, Veruska Maia da Costa / Dutra, Walderez Ornelas / Dias, João Carlos Pinto

Arquivos brasileiros de cardiologia

2023 Volume 120, Issue 6, Page(s) e20230269

Title translation	Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023.
MeSH term(s)	Humans ; Chagas Disease/complications ; Chagas Disease/diagnosis ; Chagas Disease/therapy ; Cardiomyopathies/diagnosis ; Cardiomyopathies/therapy ; Chagas Cardiomyopathy/diagnosis ; Chagas Cardiomyopathy/therapy
Language	Portuguese
Publishing date	2023-06-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20230269
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Article ; Online: Infectious agents is a risk factor for myxomatous mitral valve degeneration: A case control study.

Tiveron, Marcos Gradim / Pomerantzeff, Pablo Maria Alberto / de Lourdes Higuchi, Maria / Reis, Marcia Martins / de Jesus Pereira, Jaqueline / Kawakami, Joyce Tieko / Ikegami, Renata Nishiyama / de Almeida Brandao, Carlos Manuel / Jatene, Fabio Biscegli

BMC infectious diseases

2017 Volume 17, Issue 1, Page(s) 297

Abstract: Background: The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze ...

Abstract	Background: The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze the effect of Mycoplasma pneumoniae (Mp), Chlamydophila pneumoniae (Cp) and Borrelia burgdorferi (Bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve degeneration etiopathogenesis. Methods: An immunohistochemical test was performed to detect the inflammatory cells (CD20, CD45, CD68) and Mp, Bb and MMP9 antigens in two groups. The in situ hybridization was performed to detect Chlamydophila pneumoniae and the bacteria study was performed using transmission electron microscopy. Group 1 (n = 20), surgical specimen composed by myxomatous mitral valve degeneration, and group 2 (n = 20), autopsy specimen composed by normal mitral valve. The data were analyzed using SigmaStat version 20 (SPSS Inc., Chicago, IL, USA). The groups were compared using Student's t test, Mann-Whitney test. A correlation analysis was performed using Spearman's correlation test. P values lower than 0.05 were considered statistically significant. Results: By immunohistochemistry, there was a higher inflammatory cells/mm2 for CD20 and CD45 in group 1, and CD68 in group 2. Higher number of Mp and Cp antigens was observed in group 1 and more Bb antigens was detected in group 2. The group 1 exhibited a positive correlation between the Bb and MVD percentage, between CD45 and Mp, and between MMP9 with Mp. These correlations were not observed in the group 2. Electron microscopy revealed the presence of structures compatible with microorganisms that feature Borrelia and Mycoplasma characteristics. Conclusions: The presence of infectious agents, inflammatory cells and collagenases in mitral valves appear to contribute to the pathogenesis of MVD. Mycoplasma pneumoniae was strongly related with myxomatous mitral valve degeneration. Despite of low percentage of Borrelia burgdorferi in MD group, this agent was correlated with myxomatous degeneration and this may occour due synergistic actions between these infectious agents likely contribute to collagen degradation.
MeSH term(s)	Aged ; Borrelia burgdorferi/pathogenicity ; Case-Control Studies ; Chicago ; Chlamydophila pneumoniae/genetics ; Chlamydophila pneumoniae/pathogenicity ; Collagen/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Matrix Metalloproteinase 9/metabolism ; Microscopy, Electron, Transmission ; Middle Aged ; Mitral Valve/microbiology ; Mitral Valve/pathology ; Mitral Valve Insufficiency/pathology ; Mycoplasma pneumoniae/pathogenicity ; Myocarditis/microbiology ; Myocarditis/pathology ; Risk Factors
Chemical Substances	Collagen (9007-34-5) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2017-04-21
Publishing country	England
Document type	Journal Article ; Observational Study
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-017-2387-8
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Article ; Online: Archaea Symbiont of

Higuchi, Maria de Lourdes / Kawakami, Joyce T / Ikegami, Renata N / Reis, Marcia M / Pereira, Jaqueline de Jesus / Ianni, Barbara M / Buck, Paula / Oliveira, Luanda Mara da Silva / Santos, Marilia H H / Hajjar, Ludhmila A / Bocchi, Edimar A

Frontiers in cellular and infection microbiology

2018 Volume 8, Page(s) 412

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antigens, Bacterial/blood ; Archaea/physiology ; Biomarkers ; Chagas Disease/blood ; Chagas Disease/immunology ; Collagenases ; Exosomes ; Female ; Flow Cytometry ; Heart Failure/blood ; Heart Failure/immunology ; Humans ; Male ; Metalloproteases ; Microscopy, Electron, Transmission ; Middle Aged ; Trypanosoma cruzi/immunology ; Trypanosoma cruzi/microbiology
Chemical Substances	Antigens, Bacterial ; Biomarkers ; AMZ1 protein, human (EC 3.4.-) ; Metalloproteases (EC 3.4.-) ; Collagenases (EC 3.4.24.-)
Language	English
Publishing date	2018-11-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2018.00412
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Article ; Online: Pentoxifylline reduces inflammation and prevents myocardial perfusion derangements in experimental chronic Chagas' cardiomyopathy.

Tanaka, Denise Mayumi / Fabricio, Camila Godoy / Marin-Neto, José A / de Barros Filho, Antônio Carlos Leite / de Oliveira, Luciano Fonseca Lemos / Mejia, Jorge / Almeida, Rafael Ribeiro / de Souza Vieira, Raquel / Lopes, Carla Duque / Batah, Sabrina Setembre / Moreira, Henrique Turin / de Lourdes Higuchi, Maria / Neto, Edecio Cunha / Fabro, Alexandre Todorovic / Nekolla, Stephan G / Romano, Minna Moreira Dias / Simões, Marcus Vinícius

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2023 Volume 30, Issue 6, Page(s) 2327–2337

Abstract: Background: Myocardial perfusion defect (MPD) is common in chronic Chagas cardiomyopathy (CCC) and is associated with inflammation and development of left ventricular systolic dysfunction. We tested the hypothesis that pentoxifylline (PTX) could reduce ... ...

Abstract	Background: Myocardial perfusion defect (MPD) is common in chronic Chagas cardiomyopathy (CCC) and is associated with inflammation and development of left ventricular systolic dysfunction. We tested the hypothesis that pentoxifylline (PTX) could reduce inflammation and prevent the development of MPD in a model of CCC in hamsters. Methods and results: We investigated with echocardiogram and rest myocardial perfusion scintigraphy at baseline (6-months after T. cruzi infection/saline) and post-treatment (after additional 2-months of PTX/saline administration), female Syrian hamsters assigned to 3 groups: T. cruzi-infected animals treated with PTX (CH + PTX) or saline (CH + SLN); and uninfected control animals (CO). At the baseline, all groups showed similar left ventricular ejection fraction (LVEF) and MPD areas. At post-treatment evaluation, there was a significant increase of MPD in CH + SLN group (0.8 ± 1.6 to 9.4 ± 9.7%), but not in CH + PTX (1.9 ± 3.0% to 2.7 ± 2.7%) that exhibited MPD area similar to CO (0.0 ± 0.0% to 0.0 ± 0.0%). The LVEF decreased in both infected groups. Histological analysis showed a reduced inflammatory infiltrate in CH + PTX group (395.7 ± 88.3 cell/mm Conclusions: The prolonged use of PTX is associated with positive effects, including prevention of MPD development and reduction of inflammation in the chronic hamster model of CCC.
MeSH term(s)	Cricetinae ; Animals ; Female ; Chagas Cardiomyopathy/diagnostic imaging ; Pentoxifylline/pharmacology ; Pentoxifylline/therapeutic use ; Stroke Volume ; Ventricular Function, Left ; Tomography, X-Ray Computed ; Chagas Disease ; Inflammation ; Perfusion
Chemical Substances	Pentoxifylline (SD6QCT3TSU)
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-023-03270-y
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Zs.A 4121: Show issues

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Article ; Online: Advanced Therapies for Ventricular Arrhythmias in Patients With Chagasic Cardiomyopathy: JACC State-of-the-Art Review.

Romero, Jorge / Velasco, Alejandro / Pisani, Cristiano F / Alviz, Isabella / Briceno, David / Díaz, Juan Carlos / Della Rocca, Domenico Giovanni / Natale, Andrea / de Lourdes Higuchi, Maria / Scanavacca, Mauricio / Di Biase, Luigi

Journal of the American College of Cardiology

2021 Volume 77, Issue 9, Page(s) 1225–1242

Abstract: Chagas disease is caused by infection from the protozoan parasite Trypanosoma cruzi. Although it is endemic to Latin America, global migration has led to an increased incidence of Chagas in Europe, Asia, Australia, and North America. Following acute ... ...

Abstract	Chagas disease is caused by infection from the protozoan parasite Trypanosoma cruzi. Although it is endemic to Latin America, global migration has led to an increased incidence of Chagas in Europe, Asia, Australia, and North America. Following acute infection, up to 30% of patients will develop chronic Chagas disease, with most patients developing Chagasic cardiomyopathy. Chronic Chagas cardiomyopathy is highly arrhythmogenic, with estimated annual rates of appropriate implantable cardioverter-defibrillator therapies and electrical storm of 25% and 9.1%, respectively. Managing arrhythmias in patients with Chagasic cardiomyopathy is a major challenge for the clinical electrophysiologist, requiring intimate knowledge of cardiac anatomy, advanced training, and expertise. Endocardial-epicardial mapping and ablation strategy is needed to treat arrhythmias in this patient population, owing to the suboptimal long-term success rate of endocardial mapping and ablation alone. We also describe innovative approaches to improve acute and long-term clinical outcomes in patients with refractory ventricular arrhythmias following catheter ablation, such as bilateral cervicothoracic sympathectomy and bilateral renal denervation, among others.
MeSH term(s)	Autonomic Denervation/methods ; Autonomic Denervation/trends ; Catheter Ablation/methods ; Catheter Ablation/trends ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/epidemiology ; Chagas Cardiomyopathy/therapy ; Defibrillators, Implantable/trends ; Epicardial Mapping/methods ; Epicardial Mapping/trends ; Humans ; Kidney/innervation ; Kidney/physiology ; Review Literature as Topic ; Tachycardia, Ventricular/diagnostic imaging ; Tachycardia, Ventricular/epidemiology ; Tachycardia, Ventricular/therapy ; Treatment Outcome
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.12.056
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Article ; Online: Biomechanical Properties and Microstructural Analysis of the Human Nonaneurysmal Aorta as a Function of Age, Gender and Location: An Autopsy Study.

Ninomiya, Otavio Henrique / Tavares Monteiro, José Augusto / Higuchi, Maria de Lourdes / Puech-Leão, Pedro / de Luccia, Nelson / Raghavan, Madhavan Lakshmi / da Silva, Erasmo Simão

Journal of vascular research

2015 Volume 52, Issue 4, Page(s) 257–264

Abstract: Introduction: The biomechanical failure properties and histological composition of the human nonaneurysmal aorta were studied.: Methods: Twenty-six human aortas were harvested from fresh cadavers at autopsy. A total of 153 circumferentially oriented ... ...

Abstract	Introduction: The biomechanical failure properties and histological composition of the human nonaneurysmal aorta were studied. Methods: Twenty-six human aortas were harvested from fresh cadavers at autopsy. A total of 153 circumferentially oriented strips were obtained from the aortas for biomechanical and histological studies. Results: The failure load (6.18 ± 2.03 vs. 4.85 ± 2.04 N; p = 0.001), failure tension (19.88 ± 9.05 vs. 14.53 ± 7 N/cm; p = 0.001), failure strain (0.66 ± 0.31 vs. 0.49 ± 0.25; p = 0.003) and amount of elastic fibers (19.39 ± 15.57 vs. 14.06 ± 9.5%; p = 0.011) were all significantly higher for the thoracic than the abdominal aorta. There was a significant negative correlation between age and failure load (R = -0.35; p < 0.0001), failure stress (R = -0.63; p < 0.0001), failure tension (R = -0.52; p < 0.0001) and failure strain (R = -0.8; p < 0.0001). Male aortas had a higher failure load and failure tension than female aortas. Conclusion: The thoracic aorta has a higher strength and elasticity than the abdominal aorta. The elderly have weaker and stiffer aortas than the young. Male aortas are stronger than female aortas.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging/pathology ; Aorta, Abdominal/pathology ; Aorta, Abdominal/physiopathology ; Aorta, Thoracic/pathology ; Aorta, Thoracic/physiopathology ; Autopsy ; Biomechanical Phenomena ; Elastic Tissue/pathology ; Elastic Tissue/physiopathology ; Elasticity ; Female ; Humans ; Male ; Middle Aged ; Sex Factors ; Stress, Mechanical ; Vascular Stiffness
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	1105259-4
ISSN	1423-0135 ; 1018-1172
ISSN (online)	1423-0135
ISSN	1018-1172
DOI	10.1159/000442979
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