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Article: Cinacalcet hydrochloride: a viewpoint by Sharon M. Moe.

Moe, Sharon M

2004 Volume 65, Issue 2, Page(s) 282–283

MeSH term(s)	Cinacalcet Hydrochloride ; Humans ; Hyperparathyroidism, Secondary/drug therapy ; Kidney Failure, Chronic/complications ; Naphthalenes/therapeutic use
Chemical Substances	Naphthalenes ; Cinacalcet Hydrochloride (1K860WSG25)
Language	English
Publishing date	2004-11-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.2165/00003495-200565020-00008
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Zs.A 762: Show issues

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Book ; Conference proceedings: 50 years of research and discovery in chronic kidney disease and mineral & bone disorder

Slatopolsky, Eduardo / Moe, Sharon

the central role of phosphate ; [a Phosphate Centric Forum ... was held on 24 - 25 June, 2010 at the Sheraton West Park Hotel, Munich, Germany]

(Kidney international : Supplement ; 121)

2011

Title variant	Fifty years of research and discovery in chronic kidney disease and mineral & bone disorder
Event/congress	Phosphate Centric Forum (2010, München)
Author's details	guest ed. Eduardo Slatopolsky and Sharon Moe
Series title	Kidney international : Supplement ; 121 Kidney international Kidney international ; Supplement
Collection	Kidney international Kidney international ; Supplement
Language	English
Size	S27 S. : Ill., graph. Darst.
Publisher	Nature Publ. Group
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Conference proceedings
HBZ-ID	HT016800656
Database	Catalogue ZB MED Medicine, Health

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Zs A 797 -Suppl.121-	not available for loan	Zeitschriften-Lesesaal

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Article: Renal osteodystrophy: A historical review of its origins and conceptual evolution.

Eknoyan, Garabed / Moe, Sharon M

Bone reports

2022 Volume 17, Page(s) 101641

Abstract: Long considered an inert supporting framework, bone studies went neglected until the 17th century when they began as descriptive microscopic studies of structure which over time progressed into that of chemistry and physiology. It was in the mid-19th ... ...

Abstract	Long considered an inert supporting framework, bone studies went neglected until the 17th century when they began as descriptive microscopic studies of structure which over time progressed into that of chemistry and physiology. It was in the mid-19th century that studies evolved into an inquisitive discipline which matured into the experimental investigation of bone in health and disease in the 20th century, and ultimately that of molecular studies now deciphering the genetic language of bone biology. These fundamental studies were catalyzed by increasing clinical interest in bone disease. The first bone disease to be identified was rickets in 1645. Its subsequent connection to albuminuric patients reported in 1883 later became renal osteodystrophy in 1942, launching studies that elucidated the functions of vitamin D and parathyroid hormone and their role in the altered calcium and phosphate metabolism of the disease. Studies in osteoporosis and renal osteodystrophy have driven most recent progress benefitting from technological advances in imaging and the precision of evaluating bone turnover, mineralization, and volume. This review exposes the progress of bone biology from a passive support structure to a dynamically regulated organ with vital homeostatic functions whose understanding has undergone more revisions and paradigm shifts than that of any other organ.
Language	English
Publishing date	2022-11-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2022.101641
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Article ; Online: Sudden cardiac death in patients undergoing dialysis: More than a single toxin.

Moe, Sharon M

Heart rhythm

2018 Volume 16, Issue 2, Page(s) 318–319

MeSH term(s)	Death, Sudden, Cardiac ; Humans ; Plastics ; Renal Dialysis
Chemical Substances	Plastics
Language	English
Publishing date	2018-09-24
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2018.09.017
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Article ; Online: Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.

Turner, Mandy E / Beck, Laurent / Hill Gallant, Kathleen M / Chen, Yabing / Moe, Orson W / Kuro-O, Makoto / Moe, Sharon M / Aikawa, Elena

Arteriosclerosis, thrombosis, and vascular biology

2024 Volume 44, Issue 3, Page(s) 584–602

Abstract: Hyperphosphatemia is a common feature in patients with impaired kidney function and is associated with increased risk of cardiovascular disease. This phenomenon extends to the general population, whereby elevations of serum phosphate within the normal ... ...

Abstract	Hyperphosphatemia is a common feature in patients with impaired kidney function and is associated with increased risk of cardiovascular disease. This phenomenon extends to the general population, whereby elevations of serum phosphate within the normal range increase risk; however, the mechanism by which this occurs is multifaceted, and many aspects are poorly understood. Less than 1% of total body phosphate is found in the circulation and extracellular space, and its regulation involves multiple organ cross talk and hormones to coordinate absorption from the small intestine and excretion by the kidneys. For phosphate to be regulated, it must be sensed. While mostly enigmatic, various phosphate sensors have been elucidated in recent years. Phosphate in the circulation can be buffered, either through regulated exchange between extracellular and cellular spaces or through chelation by circulating proteins (ie, fetuin-A) to form calciprotein particles, which in themselves serve a function for bulk mineral transport and signaling. Either through direct signaling or through mediators like hormones, calciprotein particles, or calcifying extracellular vesicles, phosphate can induce various cardiovascular disease pathologies: most notably, ectopic cardiovascular calcification but also left ventricular hypertrophy, as well as bone and kidney diseases, which then propagate phosphate dysregulation further. Therapies targeting phosphate have mostly focused on intestinal binding, of which appreciation and understanding of paracellular transport has greatly advanced the field. However, pharmacotherapies that target cardiovascular consequences of phosphate directly, such as vascular calcification, are still an area of great unmet medical need.
MeSH term(s)	Humans ; Phosphates/metabolism ; Cardiovascular Diseases/metabolism ; Hyperphosphatemia/drug therapy ; Vascular Calcification/etiology ; Hormones/therapeutic use ; Renal Insufficiency, Chronic
Chemical Substances	Phosphates ; Hormones
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.319198
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Article ; Online: Rationale to reduce calcium intake in adult patients with chronic kidney disease.

Moe, Sharon M

Current opinion in nephrology and hypertension

2018 Volume 27, Issue 4, Page(s) 251–257

Abstract: Purpose of review: Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net ... ...

Abstract	Purpose of review: Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation of intestinal absorption and fecal/urinary excretion. Homeostasis and balance are disconnected in patients with chronic kidney disease (CKD). The purpose of this review is to understand how calcium homeostasis and balance are impaired in CKD. Recent findings: Two formal calcium balance studies have found that an oral intake of 800-1000 mg of calcium in adults with CKD leads to neutral calcium balance, whereas amounts greater than that lead to positive calcium balance. In patients with CKD, the main determinant of positive calcium balance is the intake and the lack of urinary calcium excretion. Summary: Calcium balance is different in patients with advanced CKD compared with patients without CKD. Thus, the oral intake of calcium in the form of diet and binders should not exceed 800-1000 mg/day to achieve neutral calcium balance in adult patients with CKD stages 3b/4.
MeSH term(s)	Adult ; Calcium/metabolism ; Calcium/urine ; Calcium, Dietary/administration & dosage ; Dietary Supplements ; Homeostasis ; Humans ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/urine
Chemical Substances	Calcium, Dietary ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-05-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1151092-4
ISSN	1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
ISSN (online)	1473-6543 ; 1535-3842
ISSN	1062-4813 ; 1062-4821
DOI	10.1097/MNH.0000000000000416
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Article: Am I big boned? Bone length scaled reference data for HRpQCT measures of the radial and tibial diaphysis in White adults.

Warden, Stuart J / Fuchs, Robyn K / Liu, Ziyue / Toloday, Katelynn R / Surowiec, Rachel / Moe, Sharon M

Bone reports

2024 Volume 20, Page(s) 101735

Abstract: Cross-sectional size of a long bone shaft influences its mechanical properties. We recently used high-resolution peripheral quantitative computed tomography (HRpQCT) to create reference data for size measures of the radial and tibial diaphyses. However, ... ...

Abstract	Cross-sectional size of a long bone shaft influences its mechanical properties. We recently used high-resolution peripheral quantitative computed tomography (HRpQCT) to create reference data for size measures of the radial and tibial diaphyses. However, data did not take into account the impact of bone length. Human bone exhibits relatively isometric allometry whereby cross-sectional area increases proportionally with bone length. The consequence is that taller than average individuals will generally have larger z-scores for bone size outcomes when length is not considered. The goal of the current work was to develop a means of determining whether an individual's cross-sectional bone size is suitable for their bone length. HRpQCT scans performed at 30 % of bone length proximal from the distal end of the radius and tibia were acquired from 1034 White females (age = 18.0 to 85.3 y) and 392 White males (age = 18.4 to 83.6 y). Positive relationships were confirmed between bone length and cross-sectional areas and estimated mechanical properties. Scaling factors were calculated and used to scale HRpQCT outcomes to bone length. Centile curves were generated for both raw and bone length scaled HRpQCT data using the LMS approach. Excel-based calculators are provided to facilitate calculation of z-scores for both raw and bone length scaled HRpQCT outcomes. The raw z-scores indicate the magnitude that an individual's HRpQCT outcomes differ relative to expected sex- and age-specific values, with the scaled z-scores also considering bone length. The latter enables it to be determined whether an individual or population of interest has normal sized bones for their length, which may have implications for injury risk. In addition to providing a means of expressing HRpQCT bone size outcomes relative to bone length, the current study also provides centile curves for outcomes previously without reference data, including tissue mineral density and moments of inertia.
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2024.101735
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Article ; Online: Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease.

Damrath, John G / Moe, Sharon M / Wallace, Joseph M

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2022 Volume 37, Issue 7, Page(s) 1297–1306

Abstract: Chronic kidney disease (CKD) affects 15% of Americans and greatly increases fracture risk due to elevated parathyroid hormone, cortical porosity, and reduced bone material quality. Calcimimetic drugs are used to lower parathyroid hormone (PTH) in CKD ... ...

Abstract	Chronic kidney disease (CKD) affects 15% of Americans and greatly increases fracture risk due to elevated parathyroid hormone, cortical porosity, and reduced bone material quality. Calcimimetic drugs are used to lower parathyroid hormone (PTH) in CKD patients, but their impact on bone matrix properties remains unknown. We hypothesized that tissue-level bone quality is altered in early CKD and that calcimimetic treatment will prevent these alterations. To test this hypothesis, we treated Cy/+ rats, a model of spontaneous and progressive CKD-mineral and bone disorder (CKD-MBD), with KP-2326, a preclinical analogue of etelcalcetide, early in the CKD disease course. To measure tissue-level bone matrix composition and material properties, we performed colocalized Raman spectroscopy and nanoindentation on new periosteal bone and perilacunar bone using hydrated femur sections. We found that CKD and KP treatment lowered mineral type B carbonate substitution whereas KP treatment increased mineral crystallinity in new periosteal bone. Reduced elastic modulus was lower in CKD but was not different in KP-treated rats versus CTRL. In perilacunar bone, KP treatment lowered type B carbonate substitution, increased crystallinity, and increased mineral-to-matrix ratio in a spatially dependent manner. KP treatment also increased reduced elastic modulus and hardness in a spatially dependent manner. Taken together, these data suggest that KP treatment improves material properties on the tissue level through a combination of lowering carbonate substitution, increasing mineral crystallinity, and increasing relative mineralization of the bone early in CKD. As a result, the mechanical properties were improved, and in some regions, were the same as control animals. Therefore, calcimimetics may help prevent CKD-induced bone deterioration by improving bone quality in new periosteal bone and in bone tissue near osteocyte lacunae. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
MeSH term(s)	Animals ; Bone Matrix ; Chronic Kidney Disease-Mineral and Bone Disorder/drug therapy ; Humans ; Minerals ; Parathyroid Hormone/pharmacology ; Parathyroid Hormone/therapeutic use ; Rats ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy
Chemical Substances	Minerals ; Parathyroid Hormone
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.4574
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Article ; Online: Impact of Race-Free eGFR on Racial Disparity in Receiving Timely Outpatient Nephrology Care: an Observational Study : Racial Disparities in Outpatient Nephrology Care.

Gunderman, David J / Fricker, Gabrielle E / Kondury, Kasyap / Moe, Sharon M / Al-Makki, Akram

Journal of general internal medicine

2023 Volume 38, Issue 16, Page(s) 3648–3650

MeSH term(s)	Humans ; United States ; Nephrology ; Outpatients ; Ethnicity ; Healthcare Disparities ; White
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Observational Study ; Letter
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-023-08350-w
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Article ; Online: Renal Osteodystrophy or Kidney-Induced Osteoporosis?

Moe, Sharon M

Current osteoporosis reports

2017 Volume 15, Issue 3, Page(s) 194–197

Abstract: Purpose of review: Chronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD related causes of fracture.: ...

Abstract	Purpose of review: Chronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD related causes of fracture. Recent findings: The increase in fractures with CKD most likely represents disordered bone quality due to the abnormal bone remodeling from renal osteodystrophy. There is also an increase in fractures with age in patients with CKD, suggesting that patients with CKD also have many fracture risk factors common to patients without known CKD. Osteoporosis is defined by the National Institutes of Health as "A skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Bone strength reflects the integration of two main features: bone quantity and bone quality." Thus, CKD-related fractures can be considered a type of osteoporosis-where the bone quality is additionally impaired above that of age/hormonal-related osteoporosis. Perhaps using the term CKD-induced osteoporosis, similar to steroid-induced osteoporosis, will allow patients with CKD to be studied in trials investigating therapeutic agents. In this series, we will examine how CKD-induced osteoporosis may be diagnosed and treated.
MeSH term(s)	Chronic Kidney Disease-Mineral and Bone Disorder/etiology ; Fractures, Bone/etiology ; Humans ; Osteoporosis/etiology ; Renal Insufficiency, Chronic/complications
Language	English
Publishing date	2017-05-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-017-0364-1
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