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Article ; Online: Review of systemic chemotherapy in unresectable colorectal peritoneal carcinomatosis.

Nindra, Udit / Shahnam, Adel / Mahon, Kate L

Asia-Pacific journal of clinical oncology

2021 Volume 18, Issue 1, Page(s) 7–12

Abstract: Colorectal cancer remains the third most common malignancy in Australia with the peritoneum being the second most common metastatic site. Colorectal peritoneal carcinomatosis (CPC) can be treated with cytoreductive surgery and hyperthermic ... ...

Abstract	Colorectal cancer remains the third most common malignancy in Australia with the peritoneum being the second most common metastatic site. Colorectal peritoneal carcinomatosis (CPC) can be treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy but this is only limited to a small subset of patients. Those with inoperable disease have a particularly poor prognosis. While the ideal systemic regimen has not been defined, 5-fluorouracil-based chemotherapy regimens appear to provide overall and progression free survival benefits. The role of targeted agents such as bevacizumab (vascular endothelial growth factor inhibitor) or cetuximab (epidermal growth factor inhibitor) in the setting of CPC is still evolving. Currently, retrospective analyses have shown promising results for the use of bevacizumab in addition to systemic chemotherapy but similar results have not been seen with cetuximab or panitumumab. However, there is significant heterogeneity in the trial data, lack of prospective randomized controlled trials and demonstrated treatment variability based on age and tumour characteristics. This review summarises the current literature in regard to treatment in the unresectable CPC setting as well as discussing issues with the current data and highlighting the need for further trials.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Colorectal Neoplasms/drug therapy ; Fluorouracil ; Humans ; Peritoneal Neoplasms/drug therapy ; Retrospective Studies ; Vascular Endothelial Growth Factor A
Chemical Substances	Vascular Endothelial Growth Factor A ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2021-02-19
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2187409-8
ISSN	1743-7563 ; 1743-7555
ISSN (online)	1743-7563
ISSN	1743-7555
DOI	10.1111/ajco.13552
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Article ; Online: Clinical Correlates and Prevalence of Food Selectivity in Children with Autism Spectrum Disorder.

Wenzell, Megan L / Pulver, Stormi L / McMahon, Meara X H / Rubio, Emily Kate / Gillespie, Scott / Berry, Rashelle C / Betancourt, Ivanna / Minter, Bonnie / Schneider, Olivia / Yarasani, Chitra / Rogers, Destinee / Scahill, Lawrence / Volkert, Valerie / Sharp, William G

The Journal of pediatrics

2024 Volume 269, Page(s) 114004

Abstract: Objective: To examine clinical correlates and prevalence of food selectivity (FS) - ie, self-restricted diet, reluctance to try new foods - in children with autism spectrum disorder (ASD) ascertained from a general outpatient autism clinic.: Study ... ...

Abstract	Objective: To examine clinical correlates and prevalence of food selectivity (FS) - ie, self-restricted diet, reluctance to try new foods - in children with autism spectrum disorder (ASD) ascertained from a general outpatient autism clinic. Study design: A multidisciplinary team (pediatric nurse practitioner, psychologist and dietitian) assessed medical and psychosocial histories and dietary habits in 103 children with ASD (mean age = 5.8 ± 2.2 years; range 2-10). Parents rated child mealtime behavior on the Brief Autism Mealtime Behavior Inventory (BAMBI) and disruptive behavior on the Aberrant Behavior Checklist (ABC). Height and weight measurements were collected. Children were classified as FS or no FS based on parent reported intake and mealtime behavior. A 24-hour dietary recall was used to record intake percentages < 80%. Logistic regression and multivariable modeling were used to evaluate clinical correlates with FS. Results: Of 103 children, 45.6% (n = 47) were classified as FS; 54.4% (n = 56) no FS. After adjusting for potential confounders, the odds of FS increased by 1.91 (95% CI: 1.38, 2.64, P < .001) for every half-SD increase in BAMBI total score and by 1.35 (95% CI: 1.05, 1.74, P = .020) for every half-SD increase in ABC Hyperactivity/Noncompliance. No group differences in anthropometrics or nutritional intake were identified. Conclusions: Food selectivity (FS) in children with ASD was strongly associated with greater severity of disruptive mealtime and hyperactivity/noncompliance behaviors. FS was not associated with anthropometrics or nutritional intake.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2024.114004
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Article ; Online: Plasma Lipidomic Profiling Identifies Elevated Triglycerides as Potential Risk Factor in Chemotherapy-Induced Peripheral Neuropathy.

Yeung, Nicole / Li, Tiffany / Lin, Hui-Ming / Timmins, Hannah C / Goldstein, David / Harrison, Michelle / Friedlander, Michael / Mahon, Kate L / Giles, Corey / Meikle, Peter J / Park, Susanna B / Horvath, Lisa G

JCO precision oncology

2024 Volume 8, Page(s) e2300690

Abstract: Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of cytotoxic cancer treatment, often necessitating dose reduction (DR) or chemotherapy discontinuation (CD). Studies on peripheral neuropathy related to ... ...

Abstract	Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of cytotoxic cancer treatment, often necessitating dose reduction (DR) or chemotherapy discontinuation (CD). Studies on peripheral neuropathy related to chemotherapy, obesity, and diabetes have implicated lipid metabolism. This study examined the association between circulating lipids and CIPN. Methods: Lipidomic analysis was performed on plasma samples from 137 patients receiving taxane-based treatment. CIPN was graded using Total Neuropathy Score-clinical version (TNSc) and patient-reported outcome measure European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN (EORTC-QLQ-CIPN20). Results: A significant proportion of elevated baseline lipids were associated with high-grade CIPN defined by TNSc and EORTC-QLQ-CIPN20 including triacylglycerols (TGs). Multivariable Cox regression on lipid species, adjusting for BMI, age, and diabetes, showed several elevated baseline TG associated with shorter time to DR/CD. Latent class analysis identified two baseline lipid profiles with differences in risk of CIPN (hazard ratio, 2.80 [95% CI, 1.50 to 5.23]; Conclusion: Elevated baseline plasma TG is associated with an increased risk of CIPN development and warrants further validation in other cohorts. Ultimately, this may enable therapeutic intervention.
MeSH term(s)	Humans ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/blood ; Female ; Male ; Lipidomics ; Middle Aged ; Triglycerides/blood ; Risk Factors ; Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Adult ; Taxoids/adverse effects ; Taxoids/therapeutic use ; Bridged-Ring Compounds
Chemical Substances	Triglycerides ; Antineoplastic Agents ; Taxoids ; taxane (1605-68-1) ; Bridged-Ring Compounds
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.23.00690
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Article ; Online: Early Subacute White Matter Hyperintensities and Recovery of Language After Stroke.

Vadinova, Veronika / Sihvonen, Aleksi J / Garden, Kimberley L / Ziraldo, Laura / Roxbury, Tracy / O'Brien, Kate / Copland, David A / McMahon, Katie L / Brownsett, Sonia L E

Neurorehabilitation and neural repair

2023 Volume 37, Issue 4, Page(s) 218–227

Abstract: Background: White matter hyperintensities (WMH) are considered to contribute to diminished brain reserve, negatively impacting on stroke recovery. While WMH identified in the chronic phase after stroke have been associated with post-stroke aphasia, the ... ...

Abstract	Background: White matter hyperintensities (WMH) are considered to contribute to diminished brain reserve, negatively impacting on stroke recovery. While WMH identified in the chronic phase after stroke have been associated with post-stroke aphasia, the contribution of premorbid WMH to the early recovery of language across production and comprehension has not been investigated. Objective: To investigate the relationship between premorbid WMH severity and longitudinal comprehension and production outcomes in aphasia, after controlling for stroke lesion variables. Methods: Longitudinal behavioral data from individuals with a left-hemisphere stroke were included at the early subacute (n = 37) and chronic (n = 28) stage. Spoken language comprehension and production abilities were assessed at both timepoints using word and sentence-level tasks. Magnetic resonance imaging (MRI) was performed at the early subacute stage to derive stroke lesion variables (volume and proportion damage to critical regions) and WMH severity rating. Results: The presence of severe WMH explained an additional 18% and 25% variance in early subacute ( Conclusions: Subacute clinical MRI can be used to improve prognoses of recovery of aphasia after stroke. We demonstrate that severe early subacute WMH add to the prediction of impaired longitudinal language recovery in comprehension, but not production. This emphasizes the need to consider different domains of language when investigating novel neurobiological predictors of aphasia recovery.
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; White Matter/pathology ; Stroke/complications ; Stroke/diagnostic imaging ; Stroke/pathology ; Aphasia/etiology ; Aphasia/complications ; Language ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491637-x
ISSN	1552-6844 ; 1545-9683 ; 0888-4390
ISSN (online)	1552-6844
ISSN	1545-9683 ; 0888-4390
DOI	10.1177/15459683231168384
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Article ; Online: Chronic aphasias after left-hemisphere resective surgery.

de Zubicaray, Greig I / Brownsett, Sonia L E / Copland, David A / Drummond, Kate / Jeffree, Rosalind L / Olson, Sarah / Murton, Emma / Ong, Benjamin / Robinson, Gail A / Tolkacheva, Valeriya / McMahon, Katie L

Brain and language

2023 Volume 239, Page(s) 105244

Abstract: Surgical resection of brain tumours is associated with an increased risk of aphasia. However, relatively little is known about outcomes in the chronic phase (i.e., >6 months). Using voxel-based lesion symptom mapping (VLSM) in 46 patients, we ... ...

Abstract	Surgical resection of brain tumours is associated with an increased risk of aphasia. However, relatively little is known about outcomes in the chronic phase (i.e., >6 months). Using voxel-based lesion symptom mapping (VLSM) in 46 patients, we investigated whether chronic language impairments are related to the location of surgical resection, residual tumour characteristics (e.g., peri-resection treatment effects, progressive infiltration, oedema) or both. Approximately 72% of patients scored below the cut-off for aphasia. Action naming and spoken sentence comprehension deficits were associated with lesions in the left anterior temporal and inferior parietal lobes, respectively. Voxel-wise analyses revealed significant associations between ventral language pathways and action naming deficits. Reading impairments were also associated with increasing disconnection of cerebellar pathways. The results indicate chronic post-surgical aphasias reflect a combination of resected tissue and tumour infiltration of language-related white matter tracts, implicating progressive disconnection as the critical mechanism of impairment.
MeSH term(s)	Humans ; Brain/pathology ; Brain Mapping ; Aphasia/diagnostic imaging ; Aphasia/etiology ; Comprehension ; Language ; Magnetic Resonance Imaging ; Stroke/complications
Language	English
Publishing date	2023-03-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	7448-2
ISSN	1090-2155 ; 0093-934X
ISSN (online)	1090-2155
ISSN	0093-934X
DOI	10.1016/j.bandl.2023.105244
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Article ; Online: Right hemispheric structural connectivity and poststroke language recovery.

Sihvonen, Aleksi J / Vadinova, Veronika / Garden, Kimberley L / Meinzer, Marcus / Roxbury, Tracy / O'Brien, Kate / Copland, David / McMahon, Katie L / Brownsett, Sonia L E

Human brain mapping

2023 Volume 44, Issue 7, Page(s) 2897–2904

Abstract: Poststroke aphasia typically results from brain damage to the left-lateralized language network. The contribution of the right-lateralized homologues in aphasia recovery remains equivocal. In this longitudinal observational study, we specifically ... ...

Abstract	Poststroke aphasia typically results from brain damage to the left-lateralized language network. The contribution of the right-lateralized homologues in aphasia recovery remains equivocal. In this longitudinal observational study, we specifically investigated the role of right hemisphere structural connectome in aphasia recovery. Twenty-two patients with aphasia after a left hemispheric stroke underwent comprehensive language assessment at the early subacute and chronic stages. A novel structural connectometry approach, using multi-shell diffusion-weighted MRI data collected at the early subacute stage, was used to evaluate the relationship between right hemisphere white matter connectome and language production and comprehension abilities at early subacute stage. Moreover, we evaluated the relationship between early subacute right hemisphere white matter connectome and longitudinal change in language production and comprehension abilities. All results were corrected for multiple comparisons. Connectometry analyses revealed negative associations between early subacute stage right hemisphere structural connectivity and language production, both cross-sectionally and longitudinally (p
MeSH term(s)	Humans ; Stroke ; Aphasia ; Language ; Diffusion Magnetic Resonance Imaging ; White Matter
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26252
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Article ; Online: Clinical validation of circulating GDF15/MIC-1 as a marker of response to docetaxel and survival in men with metastatic castration-resistant prostate cancer.

Mahon, Kate L / Sutherland, Sarah Im / Lin, Hui Ming / Stockler, Martin R / Gurney, Howard / Mallesara, Girish / Briscoe, Karen / Marx, Gavin / Higano, Celestia S / de Bono, Johann S / Chi, Kim N / Clark, Georgina / Breit, Samuel N / Brown, David A / Horvath, Lisa G

The Prostate

2024 Volume 84, Issue 8, Page(s) 747–755

Abstract: Background: Elevated circulating growth differentiation factor (GDF15/MIC-1), interleukin 4 (IL4), and IL6 levels were associated with resistance to docetaxel in an exploratory cohort of men with metastatic castration-resistant prostate cancer (mCRPC). ... ...

Abstract	Background: Elevated circulating growth differentiation factor (GDF15/MIC-1), interleukin 4 (IL4), and IL6 levels were associated with resistance to docetaxel in an exploratory cohort of men with metastatic castration-resistant prostate cancer (mCRPC). This study aimed to establish level 2 evidence of cytokine biomarker utility in mCRPC. Methods: IntVal: Plasma samples at baseline (BL) and Day 21 docetaxel (n = 120). ExtVal: Serum samples at BL and Day 42 of docetaxel (n = 430). IL4, IL6, and GDF15 levels were measured by ELISA. Monocytes and dendritic cells were treated with 10% plasma from men with high or low GDF15 or recombinant GDF15. Results: IntVal: Higher GDF15 levels at BL and Day 21 were associated with shorter overall survival (OS) (BL; p = 0.03 and Day 21; p = 0.004). IL4 and IL6 were not associated with outcomes. ExtVal: Higher GDF15 levels at BL and Day 42 predicted shorter OS (BL; p < 0.0001 and Day 42; p < 0.0001). Plasma from men with high GDF15 caused an increase in CD86 expression on monocytes (p = 0.03), but was not replicated by recombinant GDF15. Conclusions: Elevated circulating GDF15 is associated with poor prognosis in men with mCRPC receiving docetaxel and may be a marker of changes in the innate immune system in response to docetaxel resistance. These findings provide a strong rationale to consider GDF15 as a biomarker to guide a therapeutic trial of drugs targeting the innate immune system in combination with docetaxel in mCRPC.
MeSH term(s)	Humans ; Male ; Growth Differentiation Factor 15/blood ; Docetaxel/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/blood ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/mortality ; Biomarkers, Tumor/blood ; Aged ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Middle Aged ; Interleukin-4/blood ; Interleukin-6/blood ; Drug Resistance, Neoplasm ; Monocytes/pathology ; Monocytes/drug effects
Chemical Substances	Growth Differentiation Factor 15 ; Docetaxel (15H5577CQD) ; GDF15 protein, human ; Biomarkers, Tumor ; Antineoplastic Agents ; Interleukin-4 (207137-56-2) ; Interleukin-6
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study ; Research Support, N.I.H., Extramural
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.24691
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Article ; Online: How school policies, strategies, and relational factors contribute to teacher victimization and school safety.

Astor, Ron Avi / Benbenishty, Rami / Capp, Gordon P / Watson, Kate R / Wu, Chaoyue / McMahon, Susan D / Worrell, Frank C / Reddy, Linda A / Martinez, Andrew / Espelage, Dorothy L / Anderman, Eric M

Journal of community psychology

2023 Volume 52, Issue 1, Page(s) 39–57

Abstract: In this study, we examined how school policies and strategies (i.e., positive discipline, hardening strategies, and positive behavioral strategies) affect teacher relational factors and teacher reports of victimization and safety. Specifically, we ... ...

Abstract	In this study, we examined how school policies and strategies (i.e., positive discipline, hardening strategies, and positive behavioral strategies) affect teacher relational factors and teacher reports of victimization and safety. Specifically, we examined the mediational roles of teacher support of student learning, maltreatment of students by teachers, and teachers' differential treatment of students in schools. Using a sample of 6643 pre-K-12th-grade teachers, path analysis results revealed that positive behavior strategies, hardening strategies, and positive discipline were indirectly associated with teacher victimization and sense of safety. Additionally, teachers' perceptions of other teachers maltreating students had the greatest contributions to their sense of safety and victimization by students. Positive discipline was directly and indirectly associated with teacher victimization and safety. Implications and directions for future studies are discussed.
MeSH term(s)	Humans ; School Teachers ; Schools ; Crime Victims ; Bullying/prevention & control ; Educational Personnel
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491194-2
ISSN	1520-6629 ; 0090-4392
ISSN (online)	1520-6629
ISSN	0090-4392
DOI	10.1002/jcop.23084
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Article ; Online: Mainstream consent programs for genetic counseling in cancer patients: A systematic review.

Scheinberg, Tahlia / Young, Alison / Woo, Henry / Goodwin, Annabel / Mahon, Kate L / Horvath, Lisa G

Asia-Pacific journal of clinical oncology

2020 Volume 17, Issue 3, Page(s) 163–177

Abstract: As demand for germline genetic testing for cancer patients increases, novel methods of genetic counseling are required. One such method is the mainstream consent pathway, whereby a member of the oncology team (rather than a genetic specialist) is ... ...

Abstract	As demand for germline genetic testing for cancer patients increases, novel methods of genetic counseling are required. One such method is the mainstream consent pathway, whereby a member of the oncology team (rather than a genetic specialist) is responsible for counseling, consenting, and arranging genetic testing for cancer patients. We systematically reviewed the literature for evidence evaluating mainstream pathways for patients with breast, ovarian, colorectal, and prostate cancer. Medline, EMBASE, and Cochrane Library were searched for studies that met inclusion and exclusion criteria. Article references were checked for additional studies. Trial databases were searched for ongoing studies. Of the 13 papers that met inclusion criteria, 11 individual study groups were identified (two study groups had two publications each). Ten of the 11 studies evaluated the acceptability, feasibility, and impact of BRCA testing for patients and/or clinicians in different clinical settings in breast and ovarian cancer, while the final study explored the attitudes of colorectal specialists toward genetic testing for colorectal cancer. None involved prostate cancer. Overall, mainstream pathways were acceptable and feasible. Medical oncologist- and nurse-driven pathways were particularly successful, with both patients and clinicians satisfied with this process. Although the content of pretest counseling was less consistent compared with counseling via the traditional model, patients were largely satisfied with the education they received. Further research is required to evaluate the mainstream pathway for men with prostate cancer.
MeSH term(s)	Genetic Counseling/methods ; Genetic Counseling/psychology ; Genetic Counseling/standards ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Humans ; Informed Consent ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/psychology ; Oncologists/standards
Language	English
Publishing date	2020-04-20
Publishing country	Australia
Document type	Journal Article ; Systematic Review
ZDB-ID	2187409-8
ISSN	1743-7563 ; 1743-7555
ISSN (online)	1743-7563
ISSN	1743-7555
DOI	10.1111/ajco.13334
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Article: Nudging toward vaccination: a systematic review.

Reñosa, Mark Donald C / Landicho, Jeniffer / Wachinger, Jonas / Dalglish, Sarah L / Bärnighausen, Kate / Bärnighausen, Till / McMahon, Shannon A

BMJ global health

2021 Volume 6, Issue 9

Abstract: Background: Vaccine hesitancy (VH) and the global decline of vaccine coverage are a major global health threat, and novel approaches for increasing vaccine confidence and uptake are urgently needed. 'Nudging', defined as altering the environmental ... ...

Abstract	Background: Vaccine hesitancy (VH) and the global decline of vaccine coverage are a major global health threat, and novel approaches for increasing vaccine confidence and uptake are urgently needed. 'Nudging', defined as altering the environmental context in which a decision is made or a certain behaviour is enacted, has shown promising results in several health promotion strategies. We present a comprehensive synthesis of evidence regarding the value and impact of nudges to address VH. Methods: We conducted a systematic review to determine if nudging can mitigate VH and improve vaccine uptake. Our search strategy used Medical Subject Headings (MeSH) and non-MeSH terms to identify articles related to nudging and vaccination in nine research databases. 15 177 titles were extracted and assessed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The final list of included articles was evaluated using the Mixed Methods Appraisal Tool and the Grading of Recommendations, Assessment, Development and Evaluations framework. Findings: Identified interventions are presented according to a framework for behaviour change, MINDSPACE. Articles (n=48) from 10 primarily high-income countries were included in the review. Nudging-based interventions identified include using reminders and recall, changing the way information is framed and delivered to an intended audience, changing the messenger delivering information, invoking social norms and emotional affect (eg, through storytelling, dramatic narratives and graphical presentations), and offering incentives or changing defaults. The most promising evidence exists for nudges that offer incentives to parents and healthcare workers, that make information more salient or that use trusted messengers to deliver information. The effectiveness of nudging interventions and the direction of the effect varies substantially by context. Evidence for some approaches is mixed, highlighting a need for further research, including how successful interventions can be adapted across settings. Conclusion: Nudging-based interventions show potential to increase vaccine confidence and uptake, but further evidence is needed for the development of clear recommendations. The ongoing COVID-19 pandemic increases the urgency of undertaking nudging-focused research. Prospero registration number: CRD42020185817.
MeSH term(s)	COVID-19 ; Health Personnel ; Humans ; Pandemics ; SARS-CoV-2 ; Vaccination
Language	English
Publishing date	2021-09-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2021-006237
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