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Article: Fractional Flow Reserve Derived from Coronary Imaging and Computational Fluid Dynamics.

Pantos, Ioannis / Katritsis, Demosthenes

Interventional cardiology (London, England)

2018 Volume 9, Issue 3, Page(s) 145–150

Abstract: The assessment of functional severity of atherosclerotic stenoses in patients with coronary artery disease by invasive fractional flow reserve (FFR) measurement requires coronary artery cannulation, advancement of a wire and intravenous adenosine ... ...

Abstract	The assessment of functional severity of atherosclerotic stenoses in patients with coronary artery disease by invasive fractional flow reserve (FFR) measurement requires coronary artery cannulation, advancement of a wire and intravenous adenosine infusion with inherent procedure-related risk and costs. Coronary computed tomographic angiography (CCTA) and rotational coronary angiography (RA) have been recently used in conjunction with computational fluid dynamics (CFD) and image-based modelling for the determination of FFR without the need for additional imaging, modification of acquisition protocols or administration of medication. FFR derived from CCTA was demonstrated as superior to measures of CCTA stenosis severity for determination of lesion-specific ischaemia. Estimation of FFR from RA images and CFD provides a less invasive alternative to conventional FFR measurement while estimated values are in agreement with measured values. These new, combined anatomic-functional assessments have the potential to simplify the noninvasive diagnosis of coronary artery disease with a single study to identify patients with ischaemia-causing stenosis who may benefit from revascularisation.
Language	English
Publishing date	2018-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2813989-6
ISSN	1756-1485 ; 1756-1477
ISSN (online)	1756-1485
ISSN	1756-1477
DOI	10.15420/icr.2014.9.3.145
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Article ; Online: Radiological Risks From Potential Exposure of the Population to Radiation From Orphan Radioactive Sources.

Tsilikis, Ioannis / Pantos, Ioannis / Zouliati, Ifigeneia / Koutras, Antonios / Kalinterakis, Georgios / Syllaios, Athanasios

Health physics

2019 Volume 116, Issue 5, Page(s) 715–719

Abstract: People in their everyday lives are exposed to radiation. Natural radiation is emitted from space, subsoil, and various materials which contain radioactive materials. Humans are also exposed to radiation from medical and industrial applications that use ... ...

Abstract	People in their everyday lives are exposed to radiation. Natural radiation is emitted from space, subsoil, and various materials which contain radioactive materials. Humans are also exposed to radiation from medical and industrial applications that use radioactive sources with artificial radioactive materials. Such radioactive sources may nevertheless get out of the control system and become orphan sources. Because these radiation sources are usually contained within metal shields such as lead and iron, the shields can end up as scrap metal being used in the metallurgical industry as raw material. Incidents have been recorded around the world, and several are reported in the literature and described here, where orphan sources have caused direct radiation exposure and/or environmental and personal contamination when the sources leaked. Timely and prompt recognition of an orphan radioactive source or device is crucial in order to minimize the radiological risk and its implications for the general population.
MeSH term(s)	Humans ; Radiation Exposure/adverse effects ; Radiation Exposure/analysis ; Radiation Injuries/etiology ; Radiation Injuries/prevention & control ; Radioactive Hazard Release/statistics & numerical data
Language	English
Publishing date	2019-02-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2406-5
ISSN	1538-5159 ; 0017-9078
ISSN (online)	1538-5159
ISSN	0017-9078
DOI	10.1097/HP.0000000000001003
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Article ; Online: Assessment of frailty and related outcomes in older patients with heart failure: A cohort study.

Tournas, Georgios / Kourek, Christos / Mantzaraki, Vassiliki / Georgiopoulos, Georgios / Pantos, Constantinos / Toumanidis, Savvas / Briasoulis, Alexandros / Paraskevaidis, Ioannis

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2022 Volume 67, Page(s) 42–47

Abstract: Objective: Heart failure (HF) is a common cause of morbidity and mortality in older patients. Frailty is prevalent and complicates the course of HF. We sought to investigate the impact of frailty on HF outcomes.: Methods: Patients over 65 years old ... ...

Abstract	Objective: Heart failure (HF) is a common cause of morbidity and mortality in older patients. Frailty is prevalent and complicates the course of HF. We sought to investigate the impact of frailty on HF outcomes. Methods: Patients over 65 years old hospitalized with acute decompensated HF and mildly reduced or preserved EF, between September 2017 and September 2019 were enrolled in the study. Before hospital discharge at euvolemic state, patients underwent six-minute walk test (6MWT) and frailty assessment using FRIED and modified SOF scores. Predictors of death, readmissions, and increase in diuretic dose were analyzed by multivariable logistic regression models. Results: We enrolled 193 consecutive patients (mean age 78.6 ± 8.4 years, 29.5% males, 59.6% with HF and preserved EF). All patients had at least one comorbidity (40.9% coronary artery disease, 71% diabetes, and 86% hypertension). The mean 6MWT distance was 316.2 meters. According to FRIED score, 4.7% were normal and 17.6% were categorized as pre-frail and 77.7% as frail, while according to SOF index 9.8% were normal, 15% were categorized as pre-frail and 75.1% as frail. Frail patients according to both indices had a higher risk of 90-day readmissions, uptitration of diuretics within 90 days (p < 0.001 for both) and numerically but not significantly higher risk of death. Frailty status was independently associated with higher risk of 90-day readmissions, uptitration of diuretics, and higher BNP at 90 days. Conclusions: Frailty in older patients with HF is common and associated with worse prognosis. Pre-discharge frailty assessment may aid in identification of patients at high-risk for short-term complications.
MeSH term(s)	Aged ; Aged, 80 and over ; Cohort Studies ; Diuretics/therapeutic use ; Female ; Frailty/complications ; Frailty/epidemiology ; Heart Failure/complications ; Heart Failure/epidemiology ; Hospitalization ; Humans ; Male
Chemical Substances	Diuretics
Language	English
Publishing date	2022-04-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2022.04.004
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Article ; Online: Safety and tolerability of regadenoson compared with dipyridamole in myocardial perfusion imaging in patients scheduled to undergo medium to high-risk noncardiac surgery: a randomized controlled study.

Stavrou, Petros Z / Polytarchou, Kali / Giannopoulou, Chariklia / Pantos, Kostas / Mourouzis, Iordanis / Datseris, Ioannis / Manolis, Antonis S

Nuclear medicine communications

2021 Volume 43, Issue 3, Page(s) 256–264

Abstract: Objective: Regadenoson is the first Food and Drug Administration-approved selective A2A adenosine receptor agonist used in myocardial perfusion imaging. Its main benefits are its simplified and brief protocol, along with the ability to be administered ... ...

Abstract	Objective: Regadenoson is the first Food and Drug Administration-approved selective A2A adenosine receptor agonist used in myocardial perfusion imaging. Its main benefits are its simplified and brief protocol, along with the ability to be administered safely in patients with asthma or chronic obstructive pulmonary disease of moderate severity. This study aims to identify any potential benefits of regadenoson, regarding the frequency of adverse reactions and its tolerability, over dipyridamole. Methods: This is a randomized controlled study of 200 patients scheduled for medium to high-risk noncardiac surgery, of whom 100 were stressed with regadenoson (study group) and the rest with dipyridamole (control group). Results: A greater proportion of adverse reactions was recorded in the regadenoson group as compared to the dipyridamole group (53 vs. 36%; P = 0.023), though the duration of most adverse reactions was shorter in the regadenoson group. Dyspnea (P < 0.001) and gastrointestinal disturbances (P = 0.001) were significantly more frequent in the regadenoson group. The use of aminophylline in patients who developed any adverse events was similar in the two groups (P > 0.05). When multiple regression analyses were performed, differences in adverse reactions between the two groups were no longer significant (odds ratio = 1.96; 95% confidence interval, 0.88-3.25; P = 0.11). Conclusion: In our group of patients scheduled for myocardial perfusion imaging for preoperative assessment, the two agents, regadenoson and dipyridamole, have no significant differences in the frequency of mild adverse reactions and in aminophylline use, with regadenoson also having the advantage of faster symptom resolution. Nevertheless, dipyridamole can be considered as a well-tolerated and low-cost alternative.
MeSH term(s)	Purines ; Pyrazoles
Chemical Substances	Purines ; Pyrazoles ; regadenoson (2XLN4Y044H)
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000001513
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Zs.A 1577: Show issues

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Article ; Online: Reduced peripheral blood superoxide dismutase 2 expression in sickle cell disease.

Armenis, Iakovos / Kalotychou, Vassiliki / Tzanetea, Revekka / Moyssakis, Ioannis / Anastasopoulou, Dimitra / Pantos, Costas / Konstantopoulos, Kostas / Rombos, Ioannis

Annals of hematology

2019 Volume 98, Issue 7, Page(s) 1561–1572

Abstract: Sickle cell disease (SCD), a hereditary form of chronic hemolytic anemia, is characterized by acute vascular occlusion and chronic complications as pulmonary hypertension (PH), a hallmark of higher mortality. This study aimed to determine peripheral ... ...

Abstract	Sickle cell disease (SCD), a hereditary form of chronic hemolytic anemia, is characterized by acute vascular occlusion and chronic complications as pulmonary hypertension (PH), a hallmark of higher mortality. This study aimed to determine peripheral blood expression of superoxide dismutase 2 (SOD2), a major mitochondrial antioxidant enzyme in SCD patients on the mRNA level and compared it with SOD2 expression in healthy individuals. It also aimed to detect possible differences in SOD2 expression among patients with/without specific SCD complications and to detect possible correlations with patient laboratory parameters. SOD2 mRNA levels were significantly lower in SCD patients in comparison with controls and correlated with red blood cell count, reticulocyte count, platelet count, C-reactive protein, ferritin, and brain natriuretic peptide values. SCD patients with echocardiographic indications of PH featured significantly reduced SOD2 expression in comparison with patients without such indications. Consequently, SOD2 expression emerges as a potential biomarker of PH in SCD being a link among hemolysis, inflammation, iron overload, oxidative stress, and SCD cardiopathy.
MeSH term(s)	Adult ; Anemia, Sickle Cell/enzymology ; Anemia, Sickle Cell/pathology ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Female ; Ferritins/blood ; Gene Expression Regulation, Enzymologic ; Humans ; Male ; Natriuretic Peptide, Brain/blood ; Platelet Count ; Reticulocyte Count ; Superoxide Dismutase/blood
Chemical Substances	Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; Superoxide Dismutase (EC 1.15.1.1) ; superoxide dismutase 2 (EC 1.15.1.1)
Language	English
Publishing date	2019-05-16
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-019-03709-8
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Article ; Online: Comparison of the longevity of implantable cardioverter-defibrillator devices by different manufacturers.

Siontis, Konstantinos C / Pantos, Ioannis / Katritsis, Demosthenes G

International journal of cardiology

2014 Volume 175, Issue 2, Page(s) 380–382

MeSH term(s)	Animals ; Cardiac Resynchronization Therapy/trends ; Defibrillators, Implantable/standards ; Defibrillators, Implantable/trends ; Humans ; Manufacturing Industry/standards ; Manufacturing Industry/trends
Language	English
Publishing date	2014-08-01
Publishing country	Netherlands
Document type	Comparative Study ; Letter ; Review
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2014.05.042
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Article ; Online: Prospective Assessment of Biomarkers of Hypercoagulability for the Identification of Patients With Severe Coronary Artery Disease. The ROADMAP-CAD Study.

Gerotziafas, Grigoris T / Zografos, Theodoros / Pantos, Ioannis / Lefkou, Eleftheria / Carlo, Audrey / Fareed, Jawed / Van Dreden, Patrick / Katritsis, Demosthenes

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2020 Volume 26, Page(s) 1076029620964590

Abstract: In patients with stable coronary artery disease (CAD) blood hypercoagulability figures among factors leading to thrombosis. Tissue factor (TF) exposure at ruptured plaque initiates blood coagulation and hypercoagulability is responsible for thrombus ... ...

Abstract	In patients with stable coronary artery disease (CAD) blood hypercoagulability figures among factors leading to thrombosis. Tissue factor (TF) exposure at ruptured plaque initiates blood coagulation and hypercoagulability is responsible for thrombus formation. Early identification of patients eligible for angiography is a challenging issue for effective prevention of ACS. This pilot study aimed to identify biomarkers of hypercoagulability that can be prospectively used in risk assessment tools for the evaluation of CAD severity. Biomarkers of hypercoagulability could be a used for the evaluation of CAD severity. Platelet-poor plasma from 66 patients who were referred to coronary angiography was assessed for thrombin generation, phospholipid-dependent clotting time
MeSH term(s)	Aged ; Biomarkers/blood ; Blood Coagulation ; Blood Coagulation Tests ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Risk Assessment ; Thrombophilia/blood ; Thrombophilia/diagnosis
Chemical Substances	Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/1076029620964590
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Article ; Online: Fractional flow reserve derived from conventional coronary angiograms and computational fluid dynamics.

Kopanidis, Anastasios / Pantos, Ioannis / Theodorakakos, Andreas / Tzanalaidou, Efthalia / Katritsis, Demosthenes

International journal of cardiology

2015 Volume 190, Page(s) 187–189

MeSH term(s)	Coronary Angiography/methods ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/physiopathology ; Fractional Flow Reserve, Myocardial/physiology ; Humans ; Hydrodynamics
Language	English
Publishing date	2015
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2015.04.132
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Article ; Online: Reuse of devices in cardiology: time for a reappraisal.

Pantos, Ioannis / Efstathopoulos, Efstathios P / Katritsis, Demosthenes G

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2013 Volume 54, Issue 5, Page(s) 376–381

MeSH term(s)	Defibrillators, Implantable ; Disposable Equipment ; Economics, Medical ; Equipment Reuse/economics ; Equipment Reuse/legislation & jurisprudence ; Equipment Safety ; Europe ; Humans ; Pacemaker, Artificial ; Percutaneous Coronary Intervention/instrumentation
Language	English
Publishing date	2013-10-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
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Article ; Online: The STAT signaling profile at the single cell level reveals novel insights in the association of FOXP3+ T regulatory cells with recurrent spontaneous abortions before and after lymphocyte immunotherapy.

Lamprianidou, Eleftheria / Daniilidis, Michail / Kordella, Chryssoula / Zoulia, Emmanouela / Nakou, Evangelia / Gerofotis, Antonios / Vasilaki, Athina / Pantos, George / Kotsianidis, Ioannis

Clinical immunology (Orlando, Fla.)

2019 Volume 210, Page(s) 108261

Abstract: Foxp3+ T regulatory cell (Tregs) are central in the pathobiology of recurrent spontaneous abortions (RSA). Signal transducer and activator of transcription (STAT) proteins instruct Treg differentiation and polarization, but the STAT signaling ... ...

Abstract	Foxp3+ T regulatory cell (Tregs) are central in the pathobiology of recurrent spontaneous abortions (RSA). Signal transducer and activator of transcription (STAT) proteins instruct Treg differentiation and polarization, but the STAT signaling architecture of Tregs in RSA and its modifications by lymphocyte immunotherapy (LIT) are yet unknown. By using single-cell phospho-specific flow cytometry we show that the STAT signaling biosignature of Tregs in women with RSA was characterized by marked downregulation of the IFNα/pSTAT1&5, IL-6/pSTAT1&3 and IL-2/pSTAT5 signaling nodes compared to age-matched fertile females. LIT partially restored all of these signaling axes in Tregs only in women who achieved pregnancy after treatment. Both the pretreatment biosignature of Tregs and its modulations by LIT were associated with therapeutic success. We conclude that STAT signaling pathways in Tregs are actively involved in the pathophysiology of RSA and may serve as a predictive tool for selecting patients who may benefit from LIT.
MeSH term(s)	Abortion, Spontaneous/diagnosis ; Abortion, Spontaneous/immunology ; Abortion, Spontaneous/therapy ; Cytokines/metabolism ; Female ; Flow Cytometry ; Forkhead Transcription Factors/metabolism ; Humans ; Immunotherapy, Adoptive/methods ; Inflammation Mediators/metabolism ; Pregnancy ; Pregnancy Outcome ; Prognosis ; Recurrence ; STAT Transcription Factors/metabolism ; Signal Transduction ; Single-Cell Analysis ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/transplantation ; Treatment Outcome
Chemical Substances	Cytokines ; FOXP3 protein, human ; Forkhead Transcription Factors ; Inflammation Mediators ; STAT Transcription Factors
Language	English
Publishing date	2019-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2019.108261
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