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  1. Article ; Online: The impact of the coronavirus pandemic on sedation in critical care: volatile anesthetics in the ICU.

    Jerath, Angela / Slessarev, Marat

    Current opinion in critical care

    2022  Volume 29, Issue 1, Page(s) 14–18

    Abstract: Purpose of review: To reflect on the impact of the coronavirus pandemic on sedation for mechanically ventilated patients.: Recent findings: Shortages of intravenous sedatives during coronavirus pandemic renewed interest in using widely available ... ...

    Abstract Purpose of review: To reflect on the impact of the coronavirus pandemic on sedation for mechanically ventilated patients.
    Recent findings: Shortages of intravenous sedatives during coronavirus pandemic renewed interest in using widely available inhaled anaesthetics for sedation of critically ill patients. Universally used for surgical anaesthesia, inhaled anaesthetics may offer therapeutic advantages in patients with acute lung injury with good sedation profiles, rapid clearance and lower lung inflammation in pilot trials. However, enabling ICU sedation with inhaled anaesthetics required technological and human resource innovation during the chaos of the global pandemic. The disruption of standard sedation practices is challenging during normal operations, yet pandemic facilitated innovation in this field by fostering cross-discipline collaboration supported by healthcare professionals, hospitals, research institutes and regulators.
    Summary: Although further research is needed to establish the role of inhaled anaesthetics in critical care sedation toolkit, maintaining the spirit of innovation ignited during the recent coronavirus pandemic would require ongoing collaboration and streamlining of processes among healthcare, research and regulatory institutions.
    MeSH term(s) Humans ; Coronavirus ; Anesthetics, Inhalation/therapeutic use ; Pandemics ; Critical Care ; Hypnotics and Sedatives/therapeutic use ; Anesthesia ; Coronavirus Infections/epidemiology ; Intensive Care Units ; Critical Illness/therapy ; Respiration, Artificial ; Conscious Sedation
    Chemical Substances Anesthetics, Inhalation ; Hypnotics and Sedatives
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ensuring the Permanent Cessation of Brain Function During Normothermic Regional Perfusion.

    Slessarev, Marat / Gofton, Teneille / Shemie, Sam D

    Transplantation

    2022  Volume 106, Issue 9, Page(s) 1726–1727

    MeSH term(s) Brain ; Organ Preservation ; Perfusion ; Tissue Donors
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  3. Article ; Online: Anticytokine Therapies in Severe Coronavirus Disease 2019 Should Be Informed by Detailed Inflammatory Profiling and Specific Therapeutic Targets.

    Slessarev, Marat / Fraser, Douglas D

    Critical care explorations

    2020  Volume 2, Issue 10, Page(s) e0246

    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000246
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  4. Article ; Online: The Utility of Invasive Hemodynamics in the Management of Cardiogenic Shock.

    Singer, Zachary / Nagpal, Dave / Slessarev, Marat / Durocher, Daniel / Ward, Michael R

    The Canadian journal of cardiology

    2023  Volume 39, Issue 4, Page(s) 420–422

    MeSH term(s) Humans ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Hemodynamics
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.02.002
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    Zs.A 2150: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Evidence-Based Considerations for the Design of an Open-Source Ventilator: A Systematic Review.

    Dave, Chintan / Sivajohan, Asaanth / Basmaji, John / Slessarev, Marat

    Critical care explorations

    2022  Volume 4, Issue 7, Page(s) e0723

    Abstract: To inform the design of open-source ventilators, we performed a systematic review of clinical practice guidelines (CPGs) to consolidate the evidence on mechanical ventilation strategies that result in improved patient-important outcomes for acute hypoxic ...

    Abstract To inform the design of open-source ventilators, we performed a systematic review of clinical practice guidelines (CPGs) to consolidate the evidence on mechanical ventilation strategies that result in improved patient-important outcomes for acute hypoxic respiratory failure.
    Data sources: We developed a search strategy to identify relevant CPGs from Ovid Medline, Ovid Medline In-Process & Other Non-Indexed Citations, Embase, the Cochrane Library, Mendeley, and Google scholar from 2010 to February 17, 2022.
    Study selection: Using a two-step screening process with two independent reviewers, we included CPGs that made recommendations on mechanical ventilation strategies of interest. Guidelines that reported at least one recommendation about mechanical ventilation in ICU patients with acute hypoxic respiratory failure were included.
    Data extraction: From the 13 eligible guidelines, we collected data on country, aim, patient population, impact on morbidity and mortality (effect size and CIs), recommendations, strength of Recommendation (as per Grading of Recommendations, Assessment, Development and Evaluations), and details of supporting evidence base.
    Data synthesis: We identified three ventilation strategies that confer a mortality and morbidity benefit for ventilated patients with acute hypoxic respiratory failure: low-tidal volume ventilation, plateau pressures of less than 30 cm H
    Conclusions: Our systematic review of international CPGs identified no recommendations favoring specific mode of ventilation and three ventilation strategies that confer mortality and morbidity benefits, backed by moderate-to-strong evidence. Ventilator design teams must include the ability to consistently provide and measure low-tidal volume ventilation, plateau pressures of less than 30 cm H
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000723
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  6. Article ; Online: Nontherapeutic research with imminently dying and recently deceased study populations: addressing practical and ethical challenges.

    Murphy, Nicholas B / Weijer, Charles / Lalgudi Ganesan, Saptharishi / Dhanani, Sonny / Gofton, Teneille / Slessarev, Marat

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2023  Volume 70, Issue 4, Page(s) 596–602

    MeSH term(s) Humans ; Nontherapeutic Human Experimentation ; Research Design ; Risk Assessment ; Informed Consent
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-023-02414-5
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    Zs.A 109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Implications of the updated Canadian Death Determination Guidelines for organ donation interventions that restore circulation after determination of death by circulatory criteria.

    Murphy, Nicholas B / Weijer, Charles / Slessarev, Marat / Chandler, Jennifer A / Gofton, Teneille

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2023  Volume 70, Issue 4, Page(s) 591–595

    MeSH term(s) Humans ; Canada ; Tissue and Organ Procurement ; Tissue Donors ; Death ; Perfusion
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-023-02413-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19.

    Tschirhart, Brent J / Lu, Xiangru / Mokale Kognou, Aristide Laurel / Martin, Claudio M / Slessarev, Marat / Fraser, Douglas D / Leligdowicz, Aleksandra / Urquhart, Bradley / Feng, Qingping

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1299613

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1299613
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  9. Article: Cerebral Blood Flow Deviations in Critically Ill Patients: Potential Insult Contributing to Ischemic and Hyperemic Injury.

    Slessarev, Marat / Mahmoud, Ossama / McIntyre, Christopher W / Ellis, Christopher G

    Frontiers in medicine

    2021  Volume 7, Page(s) 615318

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.615318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Protocol for a systematic review on effective patient positioning for rapid sequence intubation.

    Sivajohan, Asaanth / Krause, Sarah Ct / Hegazy, Ahmed / Slessarev, Marat

    BMJ open

    2022  Volume 12, Issue 11, Page(s) e062988

    Abstract: Introduction: Rapid sequence intubation (RSI) is an advanced airway technique to perform endotracheal intubation in patients at high risk of aspiration. Although RSI is recognised as a life-saving technique and performed by many physicians in various ... ...

    Abstract Introduction: Rapid sequence intubation (RSI) is an advanced airway technique to perform endotracheal intubation in patients at high risk of aspiration. Although RSI is recognised as a life-saving technique and performed by many physicians in various settings (emergency departments, intensive care units), there is still a lack of consensus on various features of the procedure, most notably patient positioning. Previously, experts have commented on the unique drawbacks and benefits of various positions and studies have been published comparing patient positions and how it can affect endotracheal intubation in the context of RSI. The purpose of this systematic review is to compile the existing evidence to understand and compare how different patient positions can potentially affect the success of RSI.
    Methods and analysis: We will use MEDLINE, EMBASE and the Cochrane Library to source studies from 1946 to 2021 that evaluate the impact of patient positioning on endotracheal intubation in the context of RSI. We will include randomised control trials, case-control studies, prospective/retrospective cohort studies and mannequin simulation studies for consideration in this systematic review. Subsequently, we will generate a Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram to display how we selected our final studies for inclusion in the review. Two independent reviewers will complete the study screening, selection and extraction, with a third reviewer available to address any conflicts. The reviewers will extract this data in accordance with our outcomes of interest and display it in a table format to highlight patient-relevant outcomes and difficulty airway management outcomes. We will use the Risk of Bias tool and the Newcastle-Ottawa Scale to assess included studies for bias.
    Ethics and dissemination: This systematic review does not require ethics approval, as all patient-centred data will be reported from published studies.
    Prospero registration number: CRD42022289773.
    MeSH term(s) Humans ; Intubation, Intratracheal/methods ; Patient Positioning ; Prospective Studies ; Rapid Sequence Induction and Intubation ; Research Design ; Retrospective Studies ; Systematic Reviews as Topic ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-062988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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