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Article: Pembrolizumab-related autoimmune hemolytic anemia in a patient with metastatic lung adenocarcinoma: a case report.

Baek, Dong Won / Chae, Yee Soo

Yeungnam University journal of medicine

2021 Volume 38, Issue 4, Page(s) 366–370

Abstract: Immune checkpoint inhibitors (ICIs) have become the main drugs for programmed cell death receptor-1 or ligand-1 expressing non-small cell lung cancer (NSCLC) combined with conventional chemotherapy. ICIs are generally more tolerable than cytotoxic ... ...

Abstract	Immune checkpoint inhibitors (ICIs) have become the main drugs for programmed cell death receptor-1 or ligand-1 expressing non-small cell lung cancer (NSCLC) combined with conventional chemotherapy. ICIs are generally more tolerable than cytotoxic chemotherapies in terms of toxicity, and ICI-related adverse events are mild and manageable. However, these drugs may lead to unexpected severe adverse events such as immune-related hematologic toxicities, which could be life-threatening. Here, a rare case of a pembrolizumab-related adverse event in a patient with NSCLC who showed early-onset hemolytic anemia and recovered by high-dose steroid and a series of plasma exchanges is reported.
Language	English
Publishing date	2021-03-23
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2384-0293
ISSN	2384-0293
DOI	10.12701/yujm.2021.00899
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Article ; Online: A Graphene-Coated Silicon Wafer Plate Improves the Sensitivity and Reproducibility of MALDI-TOF MS Analysis of Proteins.

Choi, Yoon Kyung / Cheon, Dong Huey / Yang, Won Suk / Baek, Je-Hyun

Journal of the American Society for Mass Spectrometry

2023 Volume 34, Issue 9, Page(s) 2034–2042

Abstract: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used to analyze small and large molecules. However, proteins are difficult to analyze with MALDI-TOF MS in clinical applications because of their low ... ...

Abstract	Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used to analyze small and large molecules. However, proteins are difficult to analyze with MALDI-TOF MS in clinical applications because of their low ionization efficiency and heterogeneous crystallization with the matrix on the sample spots. Here, we investigate the potential of a customized graphene-coated silicon wafer (G/SiO
MeSH term(s)	Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Graphite ; Silicon ; Reproducibility of Results ; Silicon Dioxide ; Proteins
Chemical Substances	Graphite (7782-42-5) ; Silicon (Z4152N8IUI) ; Silicon Dioxide (7631-86-9) ; Proteins
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.3c00201
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Zs.A 4618: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of Taekkyon-based exercise program on balance, lower extremity strength, and gait parameters in community-dwelling older women: Randomized controlled trial.

Kim, Chang Yong / Jeong, Hye Won / Baek, Chang Yoon / Kim, Suhng Wook / Kim, Hyeong Dong

Medicine

2024 Volume 103, Issue 11, Page(s) e37463

Abstract: Background: As individuals age, they experience a decline in muscle strength and balance, leading to diminished functional capacity and an increased risk of falls. The purpose of the current study was to investigate the effects of the Taekkyon-based ... ...

Abstract	Background: As individuals age, they experience a decline in muscle strength and balance, leading to diminished functional capacity and an increased risk of falls. The purpose of the current study was to investigate the effects of the Taekkyon-based exercise program on balance, muscle strength, and gait ability in women aged over 65-year-old residing in the local community. Methods: Forty-eight subjects were randomly allocated into the Taekkyon-based exercise program as an experimental group (EG = 25; mean age: 71.68 ± 3.26) or a fall prevention program as a control group (CG = 23; mean age: 73.65 ± 5.88). EG participants received 1-hour Taekkyon exercise sessions twice a week for 12 consecutive weeks. CG participants received a typical fall prevention program. The measurements in each group included assessments of balance levels (the timed up-and-go test, one-leg stance, and functional reach test), lower extremity strength (the 5-chair stand test and 30-second chair stand test), and gait parameters (cadence, step length, step width, stride length, stride time, and gait velocity) before and after the intervention. Results: After the intervention, balance (timed up-and-go test, one-leg stance, and functional reach test), lower extremity strength (5-chair stand test and 30-second chair stand test), and gait parameters (cadence, stride time, and gait velocity) showed a significant improvement in EG participants compared to CG participants (P < .05). Compared to the normal value of balance ability and strength of elderly women over 65 years of age, most outcomes were greater than average normal values for those receiving Taekkyon exercise. Conclusion: Taekkyon-based exercise program was more effective in improving balance, lower extremity strength, and gait capacity than the usual fall prevention program in elderly women over 65 years of age. Its effects can approach normal values for women in this age group. The 12-week Taekkyon-based exercise program could be useful as part of a fall prevention program to elderly people.
MeSH term(s)	Aged ; Humans ; Female ; Exercise Therapy ; Independent Living ; Postural Balance/physiology ; Gait/physiology ; Muscle Strength/physiology ; Accidental Falls/prevention & control ; Lower Extremity
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037463
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Article ; Online: Relationship of FDG PET/CT imaging features with tumor immune microenvironment and prognosis in colorectal cancer: a retrospective study.

Lee, Jeong Won / Ahn, Hyein / Yoo, Ik Dong / Hong, Sun-Pyo / Baek, Moo-Jun / Kang, Dong Hyun / Lee, Sang Mi

Cancer imaging : the official publication of the International Cancer Imaging Society

2024 Volume 24, Issue 1, Page(s) 53

Abstract: Background: Imaging features of colorectal cancers on 2-deoxy-2-[: Methods: A total of 119 patients with colorectal cancer who underwent FDG PET/CT for staging work-up and received curative surgical resection were retrospectively enrolled. From PET/ ... ...

Abstract	Background: Imaging features of colorectal cancers on 2-deoxy-2-[ Methods: A total of 119 patients with colorectal cancer who underwent FDG PET/CT for staging work-up and received curative surgical resection were retrospectively enrolled. From PET/CT images, 10 first-order imaging features of primary tumors, including intensity of FDG uptake, volumetric metabolic parameters, and metabolic heterogeneity parameters, as well as FDG uptake in the bone marrow and spleen were measured. The degrees of CD4+, CD8+, and CD163 + cell infiltration and interleukin-6 (IL-6) and matrix metalloproteinase-11 (MMP-11) expression were graded through immunohistochemical analysis of surgical specimens. The relationship between FDG PET/CT imaging features and immunohistochemical results was assessed, and prognostic significance of PET/CT imaging features in predicting RFS was evaluated. Results: Correlation analysis with immunohistochemistry findings showed that the degrees of CD4 + and CD163 + cell infiltration and IL-6 and MMP-11 expression were correlated with cancer imaging features on PET/CT. Patients with enhanced inflammatory response in cancer tissue demonstrated increased FDG uptake, volumetric metabolic parameters, and metabolic heterogeneity. FDG uptake in the bone marrow and spleen was positively correlated with the degree of CD163 + cell infiltration and IL-6 expression, respectively. In multivariate survival analysis, the coefficient of variation of FDG uptake in the tumor (p = 0.019; hazard ratio, 0.484 for 0.10 increase) and spleen-to-liver uptake ratio (p = 0.020; hazard ratio, 24.901 for 1.0 increase) were significant independent predictors of RFS. Conclusions: The metabolic heterogeneity of tumors and FDG uptake in the spleen were correlated with tumor immune microenvironment and showed prognostic significance in predicting RFS in patients with colorectal cancer.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18/metabolism ; Retrospective Studies ; Matrix Metalloproteinase 11 ; Radiopharmaceuticals/metabolism ; Interleukin-6 ; Prognosis ; Colorectal Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Matrix Metalloproteinase 11 (EC 3.4.24.-) ; Radiopharmaceuticals ; Interleukin-6
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1186/s40644-024-00698-4
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Article ; Online: Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model.

Won, Dong-Sung / Lee, Ki Baek / Park, Jung-Hoon / Zeng, Chu Hui / Kim, Mi Hyeon / Lee, Deok Hee

Neuroradiology

2024 Volume 66, Issue 5, Page(s) 825–834

Abstract: Purpose: The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to ... ...

Abstract	Purpose: The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated. Methods: Male New Zealand White rabbits (N = 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation. The diameter of balloon used for neck-plasty was determined 1 mm larger than origin carotid artery diameter. All rabbits were euthanized 4 weeks after their final surgery. Aneurysm neck, height, dome-to-neck (D/N) ratio, and histologic parameters were compared among the groups. Results: Aneurysm creation was technically successful in 14 out of 15 rabbits (93.3%), with one rabbit experiencing mortality due to an adverse anesthetic event during the surgery. Saccular and wide-necked aneurysms were successfully created in all rabbits. Aneurysm neck was significantly greater in groups B and C compared to group A (all P < .05). D/N ratio was significantly lower in groups B and C compared to group A (all P < .05). Additionally, tunica media thickness, vessel area, and luminal area were significantly greater in groups B and C compared to group A (all P < .05). These variables were found to be significantly greater in group B compared to group C (all P < .05). Conclusion: The creation of a wide-necked aneurysm using balloon neck-plasty after elastase induction in rabbits has been determined to be technically feasible and safe.
MeSH term(s)	Male ; Rabbits ; Animals ; Intracranial Aneurysm/pathology ; Pancreatic Elastase/adverse effects ; Disease Models, Animal ; Carotid Artery, Common
Chemical Substances	Pancreatic Elastase (EC 3.4.21.36)
Language	English
Publishing date	2024-03-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-024-03326-x
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Zs.A 658: Show issues

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Article ; Online: Reversible striatal hypermetabolism of acquired chorea associated with polycythemia vera.

Hong, Chae Moon / Yang, Seok-Yeol / Cho, Minsub / Baek, Dong Won / Ryu, Ho-Sung

Acta neurologica Belgica

2022 Volume 123, Issue 5, Page(s) 1997–2000

MeSH term(s)	Humans ; Polycythemia Vera/complications ; Chorea/diagnostic imaging ; Chorea/etiology ; Corpus Striatum/diagnostic imaging
Language	English
Publishing date	2022-08-03
Publishing country	Italy
Document type	Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-02058-0
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Article ; Online: Simultaneous Quantification of Apolipoprotein C-III

Kim, Hyojin / Cheon, Dong Huey / Yang, Won Suk / Baek, Je-Hyun

Journal of proteome research

2022 Volume 22, Issue 1, Page(s) 91–100

Abstract: Apolipoprotein C-III (APOC-III) regulates triglyceride levels, associated with a risk of cardiovascular disease. One gene generates several proteoforms, each with a different molecular mass and a unique function. Unlike peptide multiple reaction ... ...

Abstract	Apolipoprotein C-III (APOC-III) regulates triglyceride levels, associated with a risk of cardiovascular disease. One gene generates several proteoforms, each with a different molecular mass and a unique function. Unlike peptide multiple reaction monitoring (MRM), protein-MRM without digestion is required to analyze clinically relevant individual proteoforms. We developed a protein-MRM method without digestion to individually quantify APOC-III proteoforms in human serum. We optimized the protein-MRM method following 60% acetonitrile extraction with C18 filtration. Bovine serum and myoglobin served as supporting cushions and the internal standard during sample preparation, respectively. Furthermore, we evaluated the LOD, lower limit of quantification, linearity, accuracy, and precision. Good correlation compared with turbidimetric immunoassay (TIA) and peptide-MRM was observed using 30 clinical sera. Individual APOC-III
MeSH term(s)	Humans ; Apolipoprotein C-III/metabolism ; Cardiovascular Diseases/diagnosis ; Proteins ; Protein Processing, Post-Translational
Chemical Substances	Apolipoprotein C-III ; Proteins
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.2c00490
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Zs.A 6189: Show issues

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Article ; Online: Accurate determination of 11 representative phthalates and di(2-ethylhexyl) terephthalate in polyvinyl chloride using isotope dilution-gas chromatography/mass spectrometry.

Min, Sang-Won / Lim, Dong Kyu / Lee, Sunyoung / Kim, Jeongkwon / Baek, Song-Yee

Journal of chromatography. A

2023 Volume 1711, Page(s) 464454

Abstract: Phthalates are mainly used as plasticizers in polyvinyl chloride (PVC). However, prolonged exposure to phthalates poses considerable risks to human health. Consequently, the utilization of phthalates in consumer products is subject to regulations, with a ...

Abstract	Phthalates are mainly used as plasticizers in polyvinyl chloride (PVC). However, prolonged exposure to phthalates poses considerable risks to human health. Consequently, the utilization of phthalates in consumer products is subject to regulations, with a defined threshold of 0.1 %. In this study, we developed an accurate and simultaneous method for determination of 11 representative phthalates and a non-phthalate plasticizer (di(2-ethylhexyl) terephthalate, DEHT) in PVC as a higher-order reference method. Homogeneously prepared PVC samples, each containing approximately 0.1 % of the target plasticizer compounds, were analyzed using gas chromatography-mass spectrometry (GC-MS) with deuterium-labeled phthalates and DEHT. The developed method could effectively separate and quantify all target plasticizers without interference with each other and potential overlap between the isomeric forms of phthalates, di-isodecyl phthalate, and di-isononyl phthalate. The developed method has high-order metrological quality, exhibiting exceptional selectivity, accuracy, repeatability (≤ 2.17 %), reproducibility (≤ 2.16 %), and relative expanded uncertainty (≤ 5.6 %). This analytical method is thus suitable for accurately assessing the target plasticizer levels in PVC products for ensuring compliance with the established 0.1 % threshold. This method was successfully applied to quantify twelve distinct plasticizers in PVC products obtained from the Korean market, validating its effectiveness and reliability in real-world scenarios.
MeSH term(s)	Humans ; Plasticizers/analysis ; Polyvinyl Chloride/chemistry ; Reproducibility of Results ; Phthalic Acids/analysis ; Mass Spectrometry ; Gas Chromatography-Mass Spectrometry/methods ; Isotopes ; Diethylhexyl Phthalate/analysis
Chemical Substances	phthalic acid (6O7F7IX66E) ; terephthalic acid (6S7NKZ40BQ) ; Plasticizers ; Polyvinyl Chloride (9002-86-2) ; Phthalic Acids ; Isotopes ; Diethylhexyl Phthalate (C42K0PH13C)
Language	English
Publishing date	2023-10-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2023.464454
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Zs.A 813: Show issues

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Article ; Online: Differences in the Clinical Significance of Antinuclear Antibodies According to Titers and Patterns in Children.

Park, Min Ji / Jang, Hae Min / Kim, Dongsub / Won, Dong Il / Baek, Hee Sun / Cho, Min Hyun

Clinical pediatrics

2023 Volume 62, Issue 10, Page(s) 1254–1260

Abstract: This study aimed to evaluate the differences in the clinical significance of antinuclear antibody (ANA) according to their titers and patterns in the diagnosis of systemic autoimmune diseases (AiD) in pediatric patients. Of the 2442 children who had ... ...

Abstract	This study aimed to evaluate the differences in the clinical significance of antinuclear antibody (ANA) according to their titers and patterns in the diagnosis of systemic autoimmune diseases (AiD) in pediatric patients. Of the 2442 children who had undergone an ANA test, 473 (19.4%) were positive for ANA, of whom 33 (7.0%) were diagnosed with significant AiD. The positive predictive value (PPV) for significant AiD was considerably high on application of an ANA titer of ≥1:640, and the PPV of a dense fine speckled (DFS) pattern was significantly lower compared with those of speckled and homogenous patterns. The diagnostic value of ANA positivity for AiD is limited, and the clinical significance of the DFS pattern is relatively lower compared with that of other patterns, such as homogenous and speckled patterns, in children. It is necessary to approach the significance of ANA in children individually depending on titers and patterns.
MeSH term(s)	Humans ; Child ; Antibodies, Antinuclear ; Autoimmune Diseases/diagnosis ; Clinical Relevance ; Predictive Value of Tests
Chemical Substances	Antibodies, Antinuclear
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231154948
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Zs.A 454: Show issues

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Article: One Year Experience of the Hand Allotransplantation First Performed after Korea Organ Transplantation Act (KOTA) Amendment.

Lee, Nara / Baek, Woo Yeol / Choi, Yun Rak / Joo, Dong Jin / Lee, Won Jai / Hong, Jong Won

Archives of plastic surgery

2023 Volume 50, Issue 4, Page(s) 415–421

Abstract: The revision of the Korea Organ Transplantation Act (KOTA) in 2018 included hand/arm among the organs that can be transplanted. The first hand transplantation since the revision of KOTA took place in January 2021. A 62-year-old male patient experienced ... ...

Abstract	The revision of the Korea Organ Transplantation Act (KOTA) in 2018 included hand/arm among the organs that can be transplanted. The first hand transplantation since the revision of KOTA took place in January 2021. A 62-year-old male patient experienced hand amputation on July 13, 2018, by a catapult injury. The patient first visited our institute 3 months after the injury. After serial interviews and an overall evaluation, the patient was registered on the hand transplantation waiting list in January 2020. On January 9, 2021, the patient underwent hand transplantation at the right distal forearm level. The total operation time was 17 hours 15 minutes, and the cold ischemic time was 4 hours 9 minutes. Postoperative immunosuppression was administered based on the protocol used for kidney transplantation. Two acute rejection episodes occurred, on postoperative days 33 and 41. Both rejection episodes were reversible with rescue therapy of a higher tacrolimus trough level, steroid pulse therapy, and topical immunosuppressants. Controlled passive range of motion exercise was started on postoperative day 10. Dynamic splint was applied on postoperative day 18. At 1 year, graft maintenance and functional improvement were satisfactory, and the patient showed a Disabilities of Arm, Shoulder and Hand score of 25.8. We successfully performed the first hand transplantation surgery under the KOTA amendment. It came from the organic and effective cooperation of plastic, orthopaedic, and transplantation departments and we believe it will guarantee the future ongoing success.
Language	English
Publishing date	2023-08-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2694943-X
ISSN	2234-6171 ; 2234-6163
ISSN (online)	2234-6171
ISSN	2234-6163
DOI	10.1055/a-2059-5570
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