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  1. Article ; Online: New molecular targets in the treatment of rheumatoid arthritis.

    Wallace, Beth I / Cooney, Laura / Fox, David A

    Current opinion in rheumatology

    2024  Volume 36, Issue 3, Page(s) 235–240

    Abstract: Purpose of review: This review will discuss selected emerging molecular targets and associated potential therapeutic agents for rheumatoid arthritis (RA)-directed treatment.: Recent findings: Agents in active development for RA treatment include ... ...

    Abstract Purpose of review: This review will discuss selected emerging molecular targets and associated potential therapeutic agents for rheumatoid arthritis (RA)-directed treatment.
    Recent findings: Agents in active development for RA treatment include those targeted to CD40 and CD40 ligand, programmed death protein 1 (PD-1), and granulocyte-macrophage colony-stimulating factor (GM-CSF). Several other molecules with a strong theoretical role in RA pathogenesis and/or demonstrated efficacy in other autoimmune diseases are also being evaluated as potential drug targets in preclinical or translational studies in RA. These targets include interleukin 1 receptor associated kinases 1 and 4 (IRAK1, IRAK4), tyrosine kinase 2 (Tyk2), bradykinin receptor 1 (B1R), OX40 and OX40 ligand.
    Summary: Identification of molecular targets for RA treatment remains an active area of investigation, with multiple therapeutic agents in clinical and preclinical development.
    MeSH term(s) Humans ; Arthritis, Rheumatoid
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000001000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Glucocorticoid and opioid use in rheumatoid arthritis management.

    Moore, Meriah N / Wallace, Beth I

    Current opinion in rheumatology

    2021  Volume 33, Issue 3, Page(s) 277–283

    Abstract: Purpose of review: Glucocorticoids and opioids are longstanding, common treatments for rheumatoid arthritis (RA) symptoms. High-quality clinical trials have established that glucocorticoids improve outcomes in RA, but debate continues as to whether ... ...

    Abstract Purpose of review: Glucocorticoids and opioids are longstanding, common treatments for rheumatoid arthritis (RA) symptoms. High-quality clinical trials have established that glucocorticoids improve outcomes in RA, but debate continues as to whether their benefits outweigh their risks. We reviewed recent studies on patterns of glucocorticoid and opioid prescribing in RA, and associated harms.
    Recent findings: At present, a large proportion of RA patients remain on glucocorticoids and/or opioids long-term. Likelihood and risk of both glucocorticoid and opioid exposure vary across the population, and are influenced by provider factors. Opioids are also associated with delays in disease-modifying treatment initiation. Recent evidence increasingly demonstrates toxicity associated with even low-dose glucocorticoids (≤7.5 mg/day). Up to two-thirds of RA patients may be able to discontinue chronic low-dose glucocorticoids without flare or adrenal insufficiency. These new data have led to changes in clinical practice guidelines for glucocorticoid use in RA.
    Summary: Although low-dose and short-term glucocorticoid use is extremely common and effective in RA management, increasing evidence of toxicity has led experts to begin recommending that such exposure be minimized. Despite a lack of data to suggest opioids improve RA disease activity, they are used commonly, continued long-term, and associated with delayed effective therapy.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Humans ; Pain/drug therapy ; Pain/etiology ; Practice Patterns, Physicians'
    Chemical Substances Analgesics, Opioid ; Antirheumatic Agents ; Glucocorticoids
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000788
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  3. Article ; Online: Burst Case Scenario: Why Shorter May Not Be Any Better When It Comes to Corticosteroids.

    Wallace, Beth I / Waljee, Akbar K

    Annals of internal medicine

    2020  Volume 173, Issue 5, Page(s) 390–391

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Cohort Studies ; Humans ; Population
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2020-07-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-4234
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  4. Article: Bilateral Cricoarytenoid Joint Fixation in a Patient With Psoriasis.

    Joyce, Elizabeth V / Wallace, Beth I / Morrison, Robert J

    The Journal of rheumatology

    2021  Volume 48, Issue 6, Page(s) 946–947

    MeSH term(s) Humans ; Joint Diseases ; Psoriasis
    Language English
    Publishing date 2021-08-06
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.200986
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  5. Article ; Online: Development of a Machine Learning Model to Predict the Use of Surgery in Patients With Rheumatoid Arthritis.

    Baxter, Natalie B / Lin, Ching-Heng / Wallace, Beth I / Chen, Jung-Sheng / Kuo, Chang-Fu / Chung, Kevin C

    Arthritis care & research

    2024  Volume 76, Issue 5, Page(s) 636–643

    Abstract: Objective: One in five patients with rheumatoid arthritis (RA) rely on surgery to restore joint function. However, variable response to disease-modifying antirheumatic drugs (DMARDs) complicates surgical planning, and it is difficult to predict which ... ...

    Abstract Objective: One in five patients with rheumatoid arthritis (RA) rely on surgery to restore joint function. However, variable response to disease-modifying antirheumatic drugs (DMARDs) complicates surgical planning, and it is difficult to predict which patients may ultimately require surgery. We used machine learning to develop predictive models for the likelihood of undergoing an operation related to RA and which type of operation patients who require surgery undergo.
    Methods: We used electronic health record data to train two extreme gradient boosting machine learning models. The first model predicted patients' probabilities of undergoing surgery ≥5 years after their initial clinic visit. The second model predicted whether patients who underwent surgery would undergo a major joint replacement versus a less intensive procedure. Predictors included demographics, comorbidities, and medication data. The primary outcome was model discrimination, measured by area under the receiver operating characteristic curve (AUC).
    Results: We identified 5,481 patients, of whom 278 (5.1%) underwent surgery. There was no significant difference in the frequency of DMARD or steroid prescriptions between patients who did and did not have surgery, though nonsteroidal anti-inflammatory drug prescriptions were more common among patients who did have surgery (P = 0.03). The model predicting use of surgery had an AUC of 0.90 ± 0.02. The model predicting type of surgery had an AUC of 0.58 ± 0.10.
    Conclusions: Predictive models using clinical data have the potential to facilitate identification of patients who may undergo rheumatoid-related surgery, but not what type of procedure they will need. Integrating similar models into practice has the potential to improve surgical planning.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25287
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  6. Article ; Online: Response to Squirell et al.

    Cohen-Mekelburg, Shirley / Van, Tony / Wallace, Beth I / Berinstein, Jeffrey / Yu, Xianshi / Lewis, James / Hou, Jason / Dominitz, Jason A / Waljee, Akbar K

    The American journal of gastroenterology

    2023  Volume 118, Issue 8, Page(s) 1462–1463

    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002276
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  7. Article ; Online: Patients with lupus with COVID-19: University of Michigan experience.

    Wallace, Beth / Washer, Laraine / Marder, Wendy / Kahlenberg, J Michelle

    Annals of the rheumatic diseases

    2020  Volume 80, Issue 3, Page(s) e35

    MeSH term(s) Arthritis, Rheumatoid ; COVID-19 ; Humans ; Hydroxychloroquine ; Lupus Erythematosus, Systemic/complications
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-05-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217794
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  8. Article ; Online: Evidence to support or guide glucocorticoid tapering in rheumatoid arthritis is lacking.

    Wallace, Beth I / Wallace, David M / Waljee, Akbar K / Clauw, Daniel J

    Annals of the rheumatic diseases

    2019  Volume 78, Issue 12, Page(s) 1733–1734

    MeSH term(s) Administration, Oral ; Adult ; Arthritis, Rheumatoid/drug therapy ; Dose-Response Relationship, Drug ; Glucocorticoids/administration & dosage ; Humans ; Practice Guidelines as Topic
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2019-07-31
    Publishing country England
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2019-216009
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  9. Article: Peripartum Traumas and Mental Health Outcomes in a Low-Income Sample of NICU Mothers: A Call for Family-Centered, Trauma-Informed Care.

    Williams, Allison / Parlier-Ahmad, Anna Beth / Thompson, Erin / Wallace, Rachel / Perrin, Paul B / Ward, Alyssa / Hendricks-Muñoz, Karen D

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: Postpartum depression (PPD), postpartum anxiety (PPA), and post-traumatic stress disorder (PTSD) among birthing people have increased substantially, contributing to adverse maternal/infant dyad outcomes, with a high prevalence in the neonatal intensive ... ...

    Abstract Postpartum depression (PPD), postpartum anxiety (PPA), and post-traumatic stress disorder (PTSD) among birthing people have increased substantially, contributing to adverse maternal/infant dyad outcomes, with a high prevalence in the neonatal intensive care unit (NICU). Despite calls for trauma-informed care in the NICU and high rates of post-traumatic stress, little research has examined the rates of or the relationships between peripartum mood and adverse child experiences (ACEs) in NICU mothers or evaluated which peripartum traumas are most distressing. This study employed structural equation modeling (SEM) to explore whether peripartum-related traumas and NICU-related stressors mediated the associations between ACEs and mental health outcomes in 119 lower-income, racially diverse mothers in a Level IV NICU. Mental health concerns were prevalent and highly comorbid, including 51.3% PPA, 34.5% PPD, 39.5% post-traumatic stress, and 37% with ≥4 ACEs. The majority (53.8%) of mothers endorsed multiple peripartum traumas; NICU admission was the most common trauma (61%), followed by birth (19%), pregnancy (9%), and a medical event in the NICU (9%). Our SEMs had good fit and demonstrated that ACEs predicted peripartum distress. Trauma-informed care efforts should employ transdiagnostic approaches and recognize that women commonly present to the NICU with childhood trauma history and cumulative peripartum traumas.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10091477
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  10. Article ; Online: Scalable and sustainable approaches to address the well-being of healthcare personnel.

    Giordano, Nicholas A / Swan, Beth Ann / Johnson, Theodore M / Cimiotti, Jeannie P / Muirhead, Lisa / Wallace, Michelle / Mascaro, Jennifer S

    Journal of advanced nursing

    2022  Volume 79, Issue 2, Page(s) e12–e15

    MeSH term(s) Humans ; Health Personnel ; Occupational Stress ; Delivery of Health Care ; Burnout, Professional ; Surveys and Questionnaires
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 197634-5
    ISSN 1365-2648 ; 0309-2402
    ISSN (online) 1365-2648
    ISSN 0309-2402
    DOI 10.1111/jan.15505
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