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Article ; Online: Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19?

Kuindersma, M / Spronk, P E

2020 Volume 24, Issue 1, Page(s) 526

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Ketanserin ; Lung ; Pandemics ; Pneumonia, Viral ; Respiration ; SARS-CoV-2
Chemical Substances	Ketanserin (97F9DE4CT4)
Keywords	covid19
Language	English
Publishing date	2020-08-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-020-03257-y
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Article ; Online: Mental health-related quality of life is related to delirium in intensive care patients.

Hofhuis, José G M / Schermer, Tjard / Spronk, Peter E

Intensive care medicine

2022 Volume 48, Issue 9, Page(s) 1197–1205

Abstract: ... a worse pre-admission mental quality of life than those without delirium (p < 0.001). Furthermore ... quality of life over time relative to patients without delirium (p = 0.035).: Conclusion: In this large ...

Abstract	Purpose: Delirium during intensive care unit (ICU) stay may be related to premorbid mental illness. In addition, delirium during ICU stay may also negatively affect long-term health-related quality of life. The aim of our study was to investigate if delirium in the ICU is related to premorbid mental quality of life and affects long-term mental quality of life after ICU stay. Methods: We performed a prospective cohort study in 1021 patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated mental and physical quality of life using the Short-form-12 before ICU admission, at hospital discharge, and 3, 6 and 12 months after hospital discharge. Mixed model and logistic regression models were used to analyze the data. Results: Patients who experienced a delirium during ICU stay reported a worse pre-admission mental quality of life than those without delirium (p < 0.001). Furthermore, patients who suffered from delirium during their ICU stay exhibited a significant decrease in mental quality of life over time relative to patients without delirium (p = 0.035). Conclusion: In this large follow-up study, we demonstrated that ICU survivors who experienced a delirium during ICU stay reported a significantly worse pre-admission mental health-related quality of life and a significant decrease in mental health-related quality of life in the year after hospital discharge compared with patients without delirium.
MeSH term(s)	Critical Care ; Delirium ; Follow-Up Studies ; Humans ; Intensive Care Units ; Prospective Studies ; Quality of Life
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-022-06841-8
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Article ; Online: Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19?

M. Kuindersma / P. E. Spronk

Critical Care, Vol 24, Iss 1, Pp 1-

2020 Volume 2

Keywords	COVID-19 ; Coronavirus ; Lung ; Vasoconstriction ; V/Q mismatch ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19?

Kuindersma, M / Spronk, P E

Crit Care

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #733029
Database	COVID19

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Article ; Online: Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19?

Kuindersma, M. / Spronk, P. E.

Critical Care

2020 Volume 24, Issue 1

Keywords	Critical Care and Intensive Care Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2041406-7
ISSN	1364-8535
ISSN	1364-8535
DOI	10.1186/s13054-020-03257-y
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Article ; Online: Work participation, social roles, and empowerment of Q-fever fatigue syndrome patients ≥10 years after infection.

Brus, I M / Teng, A S J / Heemskerk, S C M / Polinder, S / Tieleman, P / Hartman, E / Dollekens, B / Haagsma, J A / Spronk, I

PloS one

2024 Volume 19, Issue 4, Page(s) e0302573

Abstract: ... odds of performing all social roles less due to QFS (OR = 0.871-0.933; p<0.001-0.026), except ... for parenting and informal care provision (p = 0.070-0.460). No associations were found between empowerment and ...

Abstract	Objective: To determine work participation, social roles, and empowerment of QFS patients ≥10-year after infection. Methods: QFS patients ≥10-year after acute infection, who were of working age, participated in a cross-sectional survey study. Work participation, fulfilment of social roles, and empowerment outcomes were studied for the total population, as well as for subgroups based on employment type and current work status. Associations between empowerment, work and social roles were examined. Results: 291 participants were included. Of the 250 participants who had paid work before Q-fever, 80.4% stopped working or worked less hours due to QFS. For each social role, more than half of the participants (56.6-87.8%) spent less time on the role compared to before Q-fever. The median empowerment score was 41.0 (IQR: 37.0-44.0) out of 60. A higher empowerment score was significantly associated with lower odds of performing all social roles less due to QFS (OR = 0.871-0.933; p<0.001-0.026), except for parenting and informal care provision (p = 0.070-0.460). No associations were found between empowerment and current work status. Conclusion: Work participation and fulfilment of social roles is generally low in QFS patients. Many of the participants stopped working or are working less hours due to QFS, and most spent less time on social roles compared to before Q-fever. Minor variation was seen in total empowerment scores of participants; however, these slight differences were associated with the fulfilment of social roles, but not work participation. This new insight should be further explored in future studies.
MeSH term(s)	Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Adult ; Q Fever/epidemiology ; Q Fever/psychology ; Employment ; Empowerment ; Surveys and Questionnaires ; Fatigue ; Social Participation
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302573
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-associated vasculitis.

Busch, Matthias H / Ysermans, Renée / Aendekerk, Joop P / Timmermans, Sjoerd A M E G / Potjewijd, Judith / Damoiseaux, Jan G M C / Spronk, Henri M H / Ten Cate, Hugo / Reutelingsperger, Chris P / Nagy, Magdolna / van Paassen, Pieter

Blood advances

2024 Volume 8, Issue 5, Page(s) 1295–1304

Abstract: ... AT levels were significantly higher in patients with VTE than in those without VTE (P = .044 ...

Abstract	Abstract: The risk of a venous thrombotic event (VTE) is increased in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV); however, a detailed understanding of the underlying mechanisms of hypercoagulability is limited. We assessed prospectively different coagulation parameters in 71 patients with active AAV at baseline and after 6 months of follow-up. D-dimers and fibrinogen were increased in most patients at presentation and remained elevated in half of the patients. Particularly, thrombin-antithrombin (T:AT) complex and activated coagulation factors in complex with their natural inhibitors of the intrinsic coagulation pathway (ie, activated FXII:C1 esterase inhibitor [FXIIa:C1Inh], FXIa:AT, and FXIa:alpha1-antitrypsin [FXIa:α1AT]) were profoundly elevated in patients at baseline. Thrombin formation was dominantly correlated with coagulation factors of the intrinsic pathway (ie, FXIIa:AT, FXIa:AT, FXIa:α1AT, and FXIa:C1Inh) compared to the extrinsic pathway (ie, FVIIa:AT). Hypercoagulability correlated with higher disease activity, ANCA levels, C-reactive protein, serum creatinine, and proteinuria. VTEs were observed in 5 out of 71 (7%) patients within 1 month (interquartile range, 1-5) after inclusion. Baseline T:AT levels were significantly higher in patients with VTE than in those without VTE (P = .044), but other clinical or laboratory markers were comparable between both groups. Hypercoagulability is dominantly characterized by activation of the intrinsic coagulation pathway and elevated D-dimers in active AAV. The driving factors of hypercoagulability are yet to be studied but are most likely related to an interplay of increased disease activity, vascular inflammation, and endothelial damage. Future targets for intervention could include inhibitors of the intrinsic coagulation pathway and compounds specifically reducing the hyperinflammatory state.
MeSH term(s)	Humans ; Antibodies, Antineutrophil Cytoplasmic ; Thrombin ; Blood Coagulation ; Thrombophilia/etiology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023011937
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Article ; Online: Electrolyte monitoring during regional citrate anticoagulation in continuous renal replacement therapy.

Warnar, C / Faber, E / Katinakis, P A / Schermer, T / Spronk, P E

Journal of clinical monitoring and computing

2021 Volume 36, Issue 3, Page(s) 871–877

Abstract: Patients with acute kidney injury who need continuous renal replacement therapy with locoregional citrate anticoagulation are at risk of citrate accumulation with disruption of the calcium balance. We aimed to evaluate the safety of detecting citrate ... ...

Abstract	Patients with acute kidney injury who need continuous renal replacement therapy with locoregional citrate anticoagulation are at risk of citrate accumulation with disruption of the calcium balance. We aimed to evaluate the safety of detecting citrate accumulation and adjusting electrolyte disbalances during continuous venovenous hemodialysis (CVVHD) in critically ill patients with acute kidney injury using a blood sample frequency every 6 h. A prospective single center study in critically ill intensive care unit patients who suffered from acute kidney injury with the need of renal replacement therapy. We evaluated the deviations in pH, bicarbonate and calcium during CVVHD treatment with local regional citrate anticoagulation. Values indicate median and interquartile range. Severe hypocalcemia (below 1.04 mmol/L) or hypercalcemia (above 1.31 mmol/L) occurred in 10.5% and 4.8% respectively. During treatment changes of systemic ionized calcium, post-filter ionized calcium, pH and bicarbonate were corrected with protocolized adjustments. No arrhythmias or citrate accumulation were seen. The values stabilized after 42 h and after that no statistically significant changes were observed. After 42 h of citrate CVVHD, systemic ionized calcium, pH and bicarbonate levels stabilized. A blood sample frequency every 6 h is probably safe to detect citrate accumulation and to adjust the settings of electrolytes to avoid serious electrolyte disturbances in ICU patients without severe metabolic acidosis or severe liver failure.
MeSH term(s)	Acute Kidney Injury ; Anticoagulants/therapeutic use ; Bicarbonates ; Calcium ; Citrates ; Citric Acid ; Continuous Renal Replacement Therapy ; Critical Illness ; Electrolytes ; Humans ; Prospective Studies ; Renal Dialysis ; Renal Replacement Therapy
Chemical Substances	Anticoagulants ; Bicarbonates ; Citrates ; Electrolytes ; Citric Acid (2968PHW8QP) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1418733-4
ISSN	1573-2614 ; 1387-1307 ; 0748-1977
ISSN (online)	1573-2614
ISSN	1387-1307 ; 0748-1977
DOI	10.1007/s10877-021-00719-8
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Article ; Online: Nephrotoxicity of continuous amphotericin B in critically ill patients with abdominal sepsis: a retrospective analysis with propensity score matching-authors' response.

Geersing, T H / Franssen, E J F / Spronk, P E / van Kan, H J M / den Reijer, M / van der Voort, P H J

The Journal of antimicrobial chemotherapy

2022 Volume 77, Issue 8, Page(s) 2309–2311

MeSH term(s)	Amphotericin B/adverse effects ; Communicable Diseases ; Critical Illness ; Humans ; Intraabdominal Infections/drug therapy ; Propensity Score ; Renal Insufficiency ; Retrospective Studies ; Sepsis/drug therapy
Chemical Substances	Amphotericin B (7XU7A7DROE)
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkac203
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Article ; Online: Health-related quality of life in ICU survivors-10 years later.

Hofhuis, José G M / Schrijvers, Augustinus J P / Schermer, Tjard / Spronk, Peter E

Scientific reports

2021 Volume 11, Issue 1, Page(s) 15189

Abstract: ... scores of four HRQOL dimensions (i.e., physical functioning (p < 0.001; mean 54, SD 32, effect size 0.77 ... 95% CI [0.54-1.0]), role-physical (p < 0.001; mean 44, SD 47, effect size 0.65, 95% CI [0.41-0.68 ... general health (p < 0.001; mean 52, SD 27, effect size 0.48; 95% CI 0.25-0.71) and social functioning (p ...

Abstract	Many Intensive Care (ICU) survivors experience long lasting impairments in physical and psychological health as well as social functioning. The objective of our study was to evaluate these effects up to 10 years after ICU discharge. We performed a long-term prospective cohort study in patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated health-related quality of life (HRQOL) before ICU admission using the Short-form-36 (SF-36), at ICU discharge, at hospital discharge and at 1, 2, 5 and 10 years follow up (all by patients). Changes in HRQOL were assessed based on linear mixed modeling. We included a total of 749 patients (from 2000 to 2008). During 10 years 475 (63.4%) patients had died, 125 (16.7%) patients were lost to follow up and 149 (19.9%) patients could be evaluated. The mean scores of four HRQOL dimensions (i.e., physical functioning (p < 0.001; mean 54, SD 32, effect size 0.77, 95% CI [0.54-1.0]), role-physical (p < 0.001; mean 44, SD 47, effect size 0.65, 95% CI [0.41-0.68] general health (p < 0.001; mean 52, SD 27, effect size 0.48; 95% CI 0.25-0.71) and social functioning (p < 0.001; mean 72, SD 32, effect size 0.41, 95% CI [0.19-0.64]) were still lower 10 years after ICU discharge compared with pre-admission levels (n = 149) and with an age reference population. Almost all SF-36 dimensions changed significantly over time from ICU discharge up to 10 years after ICU discharge. Over the 10 year follow up physical functioning of medical-surgical ICU survivors remains impaired compared with their pre-admission values and an age reference population. However, effect sizes showed no significant differences suggesting that surviving patients largely regained their age-specific HRQOL at 10 years.
MeSH term(s)	Aged ; Cohort Studies ; Critical Care/psychology ; Female ; Humans ; Intensive Care Units ; Linear Models ; Male ; Middle Aged ; Netherlands ; Prospective Studies ; Quality of Life/psychology ; Survivors/psychology ; Time Factors
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-94637-z
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