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  1. Article ; Online: IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.

    Park, Hyun Jung / Lee, Sung Won / Van Kaer, Luc / Lee, Myeong Sup / Hong, Seokmann

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Interleukin-7 (IL-7) plays a vital role in the homeostasis of ... ...

    Abstract Interleukin-7 (IL-7) plays a vital role in the homeostasis of CD4
    MeSH term(s) Animals ; Humans ; Mice ; CD8-Positive T-Lymphocytes/pathology ; Cytokines ; Dermatitis, Atopic/drug therapy ; Disease Models, Animal ; Interleukin-7/genetics ; Interleukin-7/metabolism ; Skin/pathology ; Skin Diseases/pathology ; Th2 Cells
    Chemical Substances Cytokines ; Interleukin-7
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129956
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  2. Article ; Online: IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice

    Hyun Jung Park / Sung Won Lee / Luc Van Kaer / Myeong Sup Lee / Seokmann Hong

    International Journal of Molecular Sciences, Vol 24, Iss 9956, p

    2023  Volume 9956

    Abstract: Interleukin-7 (IL-7) plays a vital role in the homeostasis of CD4 + and CD8 + T cells. Although IL-7 has been implicated in T helper (Th)1- and Th17-mediated autoinflammatory diseases, its role in Th2-type allergic disorders, such as atopic dermatitis ( ... ...

    Abstract Interleukin-7 (IL-7) plays a vital role in the homeostasis of CD4 + and CD8 + T cells. Although IL-7 has been implicated in T helper (Th)1- and Th17-mediated autoinflammatory diseases, its role in Th2-type allergic disorders, such as atopic dermatitis (AD), remains unclear. Thus, to elucidate the effects of IL-7 deficiency on AD development, we generated IL-7-deficient AD-prone mice by backcrossing IL-7 knockout (KO) B6 mice onto the NC/Nga (NC) mouse strain, a model for human AD. As expected, IL-7 KO NC mice displayed defective development of conventional CD4 + and CD8 + T cells compared with wild type (WT) NC mice. However, IL-7 KO NC mice presented with enhanced AD clinical scores, IgE hyperproduction, and increased epidermal thickness compared with WT NC mice. Moreover, IL-7 deficiency decreased Th1, Th17, and IFN-γ-producing CD8 + T cells but increased Th2 cells in the spleen of NC mice, indicating that a reduced Th1/Th2 ratio correlates with severity of AD pathogenesis. Furthermore, significantly more basophils and mast cells infiltrated the skin lesions of IL-7 KO NC mice. Taken together, our findings suggest that IL-7 could be a useful therapeutic target for treating Th2-mediated skin inflammations, such as AD.
    Keywords IL-7 ; atopic dermatitis ; NC/Nga mice ; CD4 + T cells ; CD8 + T cells ; IFN-γ ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Effect of Furosemide on Prevertebral Soft Tissue Swelling after Anterior Cervical Fusion: A Comparative Study with Dexamethasone.

    Jang, Ju-Sung / Lee, Young-Seok / Ko, Myeong Jin / Wui, Seong Hyun / Song, Kwang-Sup / Park, Seung Won

    Asian spine journal

    2024  Volume 18, Issue 1, Page(s) 66–72

    Abstract: Study design: Retrospective cohort study.: Purpose: This study aimed to investigate the effect of furosemide on prevertebral soft tissue swelling (PSTS) after anterior cervical fusion (ACF) and compare it with the effect of dexamethasone.: Overview ...

    Abstract Study design: Retrospective cohort study.
    Purpose: This study aimed to investigate the effect of furosemide on prevertebral soft tissue swelling (PSTS) after anterior cervical fusion (ACF) and compare it with the effect of dexamethasone.
    Overview of literature: Postoperative PSTS is a common complication of ACF. Dexamethasone has been used for its treatment; however, its efficacy remains controversial. Furosemide may reduce PSTS if it is soft tissue edema; however, no studies have demonstrated the effect of furosemide on PSTS after ACF.
    Methods: The symptomatic PSTS group received intravenous (IV) administration of dexamethasone or furosemide. The asymptomatic PSTS group did not receive any medication. Patients were divided into the control (no medication, n=31), Dexa (IV dexamethasone, n=25), and Furo (IV furosemide, n=28) groups. PSTS was checked daily with simple radiographs and medication-induced reductions in PSTS from its peak or after medication.
    Results: The peak time (postoperative days) of PSTS in the control (2.27±0.47, p<0.05) and Dexa (1.91±0.54, p<0.01) groups were significantly later than that in the Furo group (1.38±0.74). PSTS was significantly lower in the Furo group than in the Dexa group from postoperative days 4 to 7 (p<0.05). PSTS reduction after the peak was significantly greater in the Furo group than in the control (p<0.01) and Dexa (p<0.01) groups. After starting the medication therapy, the Furo group showed a significantly greater reduction in PSTS than the Dexa group (p<0.01). No difference was found in symptom improvement among the three groups.
    Conclusions: If furosemide is used to reduce PSTS after ACF, it can effectively reduce symptoms.
    Language English
    Publishing date 2024-02-21
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2559763-2
    ISSN 1976-7846 ; 1976-1902
    ISSN (online) 1976-7846
    ISSN 1976-1902
    DOI 10.31616/asj.2023.0107
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    Zs.A 6861: Show issues Location:
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  4. Article ; Online: Neuromedin U contributes to radiation resistance in colorectal cancer via YAP/TAZ signaling activation.

    Sim, Myeong-Kyu / Park, Ji-Eun / Kim, So-Ra / Lee, Jeeyong / Kim, Eun Ju / Kim, Younjoo / Shin, Ui Sup / Kim, Hyunggee / Kim, Kwang Seok

    Oncology reports

    2023  Volume 50, Issue 4

    Abstract: Resistance to radiation therapy remains a treatment obstacle for patients with high‑risk colorectal cancer. Neuromedin U ( ...

    Abstract Resistance to radiation therapy remains a treatment obstacle for patients with high‑risk colorectal cancer. Neuromedin U (
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/radiotherapy ; Neuropeptides ; Phosphorylation ; Signal Transduction ; Radiation Tolerance
    Chemical Substances neuromedin U (117505-80-3) ; Neuropeptides
    Language English
    Publishing date 2023-08-18
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2023.8615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4213: Show issues Location:
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  5. Article: Quantitative Analysis of Bioactive Phenanthrenes in

    Kim, Minyoul / Gu, Myeong Ju / Lee, Joon-Goo / Chin, Jungwook / Bae, Jong-Sup / Hahn, Dongyup

    Antioxidants (Basel, Switzerland)

    2019  Volume 8, Issue 11

    Abstract: Dioscorea ... ...

    Abstract Dioscorea batatas
    Language English
    Publishing date 2019-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox8110541
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  6. Article: Novel Butein Derivatives Repress DDX3 Expression by Inhibiting PI3K/AKT Signaling Pathway in MCF-7 and MDA-MB-231 Cell Lines.

    Rampogu, Shailima / Kim, Seong Min / Shaik, Baji / Lee, Gihwan / Kim, Ju Hyun / Kim, Gon Sup / Lee, Keun Woo / Kim, Myeong Ok

    Frontiers in oncology

    2021  Volume 11, Page(s) 712824

    Abstract: Background: Breast cancer is one of the major causes of mortalities noticed in women globally. DDX3 has emerged as a potent target for several cancers, including breast cancer to which currently there are no reported or approved drugs.: Methods: To ... ...

    Abstract Background: Breast cancer is one of the major causes of mortalities noticed in women globally. DDX3 has emerged as a potent target for several cancers, including breast cancer to which currently there are no reported or approved drugs.
    Methods: To find effective cancer therapeutics, three compounds were computationally designed tweaking the structure of natural compound butein. These compounds were synthesized and evaluated for their anticancer property in MCF-7 and MDA-MB-231 cell lines targeting DDX3. The
    Results: The cell viability results showed that the have induced dose dependent suppression of DDX3 expression. Additionally,
    Conclusions: Our results shed light on the anticancer ability of the designed compounds. These compounds can be employed as chemical spaces to design new prospective drug candidates. Additionally, our computational method can be adapted to design new chemical scaffolds as plausible inhibitors.
    Language English
    Publishing date 2021-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.712824
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  7. Article ; Online: Enhanced Antitumor Immune Response in 2'-5' Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy.

    Sim, Chan Kyu / Lee, Jung Hoon / Baek, In-Jeoung / Lee, Sang-Wook / Lee, Myeong Sup

    Journal of immunology research

    2019  Volume 2019, Page(s) 7596786

    Abstract: Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to ... ...

    Abstract Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. Thus, OASL1-deficient (
    MeSH term(s) 2',5'-Oligoadenylate Synthetase/antagonists & inhibitors ; 2',5'-Oligoadenylate Synthetase/genetics ; Animals ; Antineoplastic Agents ; Cisplatin/therapeutic use ; Interferon Type I/immunology ; Interferon-gamma/immunology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/radiotherapy ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Targeted Therapy ; Neoplasm Metastasis
    Chemical Substances Antineoplastic Agents ; Interferon Type I ; Interferon-gamma (82115-62-6) ; Oasl1 protein, mouse (EC 2.7.7.-) ; 2',5'-Oligoadenylate Synthetase (EC 2.7.7.84) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-03-31
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2019/7596786
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  8. Article ; Online: Efficacy of TnR Nasal Mesh for prevention of septal perforation during septoplasty.

    Park, Ji-Hwan / Lee, Dong-Joo / Seo, Myeong-Gu / Kim, Hwa-Bin / Kim, Sung-Dong / Cho, Kyu-Sup

    Auris, nasus, larynx

    2021  Volume 49, Issue 3, Page(s) 401–406

    Abstract: Objective: Septoplasty has been reported as the most common cause of the septal perforation. The interposition of the graft materials between the flaps at the site of the tear may be helpful to decrease the likelihood of septal perforation. The purpose ... ...

    Abstract Objective: Septoplasty has been reported as the most common cause of the septal perforation. The interposition of the graft materials between the flaps at the site of the tear may be helpful to decrease the likelihood of septal perforation. The purpose of this study was to investigate the efficacy of TnR Nasal Mesh on the prevention of septal perforation following septoplasty.
    Methods: Among 46 patients had septal perforation after septoplasty, 35 patients were treated with TnR Nasal Mesh and 11 with autologous septal cartilage for bilateral mucosal tears at the corresponding area of the nasal septum. TnR Nasal Mesh or septal cartilage was placed between the injured mucoperichondrial flaps and confirmed in its original position at both sides under nasal endoscope. Objective endoscopic examination for septal mucosa status was evaluated between the patients who were treated with TnR Nasal Mesh or septal cartilage.
    Results: Twenty patients (57.1%) showed complete bilateral mucosa healing and nine (25.7%) had unilateral healing after TnR Nasal Mesh insertion. However, complete bilateral and unilateral mucosa healing was observed in 4 (36.4%) and 1 patients (9.1%) treated with septal cartilage, respectively. Complete healing rate for septal perforation was significantly higher in TnR Nasal Mesh than in septal cartilage insertion (p=0.022). None of the patients showed complications or adverse reactions after TnR Nasal Mesh or septal cartilage treatment.
    Conclusion: TnR Nasal Mesh insertion after bilateral septal mucosal tear during septoplasty reduces permanent septal perforation without an apparent adverse effect. Therefore, TnR Nasal Mesh may be a safe and effective graft material for the prevention of septal perforation following septoplasty.
    MeSH term(s) Humans ; Nasal Septal Perforation/surgery ; Nasal Septum/surgery ; Rhinoplasty ; Surgical Flaps ; Surgical Mesh ; Treatment Outcome
    Language English
    Publishing date 2021-10-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2021.09.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules.

    Jeon, Eun Young / Choi, Da-Som / Choi, Seunghyun / Won, Ju-Young / Jo, Yunju / Kim, Hye-Bin / Jung, Youngmee / Shin, Sang Chul / Min, Hophil / Choi, Hae Woong / Lee, Myeong Sup / Park, Yoon / Chung, Justin J / Jin, Hyung-Seung

    Bioengineering & translational medicine

    2022  Volume 8, Issue 1, Page(s) e10362

    Abstract: Adoptive cell therapy (ACT) with antigen-specific T cells is a promising treatment approach for solid cancers. Interleukin-2 (IL-2) has been utilized in boosting the efficacy of ACT. However, the clinical applications of IL-2 in combination with ACT is ... ...

    Abstract Adoptive cell therapy (ACT) with antigen-specific T cells is a promising treatment approach for solid cancers. Interleukin-2 (IL-2) has been utilized in boosting the efficacy of ACT. However, the clinical applications of IL-2 in combination with ACT is greatly limited by short exposure and high toxicities. Herein, a complex coacervate was designed to intratumorally deliver IL-2 in a sustained manner and protect against proteolysis. The complex coacervate consisted of fucoidan, a specific IL-2 binding glycosaminoglycan, and poly-
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6761
    ISSN 2380-6761
    DOI 10.1002/btm2.10362
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  10. Article: Loss of PGRMC1 Delays the Progression of Hepatocellular Carcinoma via Suppression of Pro-Inflammatory Immune Responses.

    Lee, Sang R / Lee, Jong Geol / Heo, Jun H / Jo, Seong Lae / Ryu, Jihoon / Kim, Globinna / Yon, Jung-Min / Lee, Myeong Sup / Lee, Geun-Shik / An, Beum-Soo / Shin, Hyun-Jin / Woo, Dong-Cheol / Baek, In-Jeoung / Hong, Eui-Ju

    Cancers

    2021  Volume 13, Issue 10

    Abstract: Pgrmc1 is a non-canonical progesterone receptor related to the lethality of various types of cancer. PGRMC1 has been reported to exist in co-precipitated protein complexes with epidermal growth factor receptor (EGFR), which is considered a useful ... ...

    Abstract Pgrmc1 is a non-canonical progesterone receptor related to the lethality of various types of cancer. PGRMC1 has been reported to exist in co-precipitated protein complexes with epidermal growth factor receptor (EGFR), which is considered a useful therapeutic target in hepatocellular carcinoma (HCC). Here, we investigated whether
    Language English
    Publishing date 2021-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13102438
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