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  1. Article: Pulmonary Complications and Mortality in Patients with SARS-CoV-2 Undergoing Elective and Emergent Hand Surgery.

    Adams, Alexander J / Dohse, Nicolas / Miller, Andrew / Tosti, Rick

    Journal of hand and microsurgery

    2023  Volume 15, Issue 5, Page(s) 371–375

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 0974-3227
    ISSN 0974-3227
    DOI 10.1055/s-0043-1760765
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  2. Article ; Online: Editorial

    Rick A. Adams / Xiaosi Gu

    Computational Psychiatry, Vol 5, Iss

    2021, A New Chapter

    2021  Volume 1

    Keywords Computer applications to medicine. Medical informatics ; R858-859.7 ; Psychiatry ; RC435-571 ; Consciousness. Cognition ; BF309-499
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Canonical Correlation Analysis for Identifying Biotypes of Depression.

    Mihalik, Agoston / Adams, Rick A / Huys, Quentin

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2020  Volume 5, Issue 5, Page(s) 478–480

    MeSH term(s) Depression/diagnosis ; Humans
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2020.02.002
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  4. Article ; Online: Extensor tendon transfer for fracture-related extensor pollicis longus rupture: Long-term outcome case series.

    Adams, Alexander J / Patel, Saral J / Arango, Sebastian D / Smithson, Kaleb / Tosti, Rick J / Miller, Andrew J

    Journal of hand therapy : official journal of the American Society of Hand Therapists

    2024  

    Abstract: Background: Spontaneous rupture of the extensor pollicis longus (EPL) tendon following both nonoperative and operative treatment of distal radius fractures has been well described.: Purpose: The purpose of this study was to assess long-term outcomes ... ...

    Abstract Background: Spontaneous rupture of the extensor pollicis longus (EPL) tendon following both nonoperative and operative treatment of distal radius fractures has been well described.
    Purpose: The purpose of this study was to assess long-term outcomes of extensor indicis proprius to EPL tendon transfers for patients following distal radius fracture and EPL tendon repair.
    Study design: Retrospective case series focusing on long-term clinical outcomes.
    Methods: A retrospective review was conducted for patients who sustained a distal radius fracture and subsequently underwent extensor tendon transfer from 2005-2015 at a private practice center. Outcome measures including index finger (IF) metacarpophalangeal (MCP) and thumb interphalangeal (IP) active range of motion (ROM), digital extension against resistance, subjective complaints, and QuickDASH scores were recorded at final follow-up.
    Results: Seven patients were included in the study. There were six females and one male subject, mean age of 54 ± 13 years at injury of EPL, and 5/7 involved the left upper extremity. For isolated function, 7/7 (100%) patients had isolated, active IF MCP extension, 6/7 (86%) could extend IF MCP and thumb IP against resistance. Mean IF MCP extension was 1° ± 2°, mean IF MCP flexion was 89° ± 2°, mean thumb IP extension was -5° ± 4°, and mean thumb IP flexion was 67° ± 15°. Mean QuickDASH score was 16 ± 14.
    Conclusions: This series shows good long-term functional and patient reported outcomes in patients following extensor indicis proprius to EPL tendon transfers at a single center.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639284-2
    ISSN 1545-004X ; 0894-1130
    ISSN (online) 1545-004X
    ISSN 0894-1130
    DOI 10.1016/j.jht.2024.02.004
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  5. Article ; Online: Structure learning enhances concept formation in synthetic Active Inference agents.

    Neacsu, Victorita / Mirza, M Berk / Adams, Rick A / Friston, Karl J

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0277199

    Abstract: Humans display astonishing skill in learning about the environment in which they operate. They assimilate a rich set of affordances and interrelations among different elements in particular contexts, and form flexible abstractions (i.e., concepts) that ... ...

    Abstract Humans display astonishing skill in learning about the environment in which they operate. They assimilate a rich set of affordances and interrelations among different elements in particular contexts, and form flexible abstractions (i.e., concepts) that can be generalised and leveraged with ease. To capture these abilities, we present a deep hierarchical Active Inference model of goal-directed behaviour, and the accompanying belief update schemes implied by maximising model evidence. Using simulations, we elucidate the potential mechanisms that underlie and influence concept learning in a spatial foraging task. We show that the representations formed-as a result of foraging-reflect environmental structure in a way that is enhanced and nuanced by Bayesian model reduction, a special case of structure learning that typifies learning in the absence of new evidence. Synthetic agents learn associations and form concepts about environmental context and configuration as a result of inferential, parametric learning, and structure learning processes-three processes that can produce a diversity of beliefs and belief structures. Furthermore, the ensuing representations reflect symmetries for environments with identical configurations.
    MeSH term(s) Humans ; Concept Formation ; Bayes Theorem ; Learning
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277199
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  6. Article ; Online: Voxel-wise multivariate analysis of brain-psychosocial associations in adolescents reveals six latent dimensions of cognition and psychopathology.

    Adams, Rick A / Zor, Cemre / Mihalik, Agoston / Tsirlis, Konstantinos / Brudfors, Mikael / Chapman, James / Ashburner, John / Paulus, Martin P / Mourão-Miranda, Janaina

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2024  

    Abstract: Background: Adolescence heralds the onset of much psychopathology, which may be conceptualized as an emergence of altered covariation between symptoms and brain measures. Multivariate methods can detect such modes of covariation or latent dimensions, ... ...

    Abstract Background: Adolescence heralds the onset of much psychopathology, which may be conceptualized as an emergence of altered covariation between symptoms and brain measures. Multivariate methods can detect such modes of covariation or latent dimensions, but none specifically relating to psychopathology have yet been found using population-level structural brain data. Using voxel-wise (instead of parcellated) brain data may strengthen latent dimensions' brain-psychosocial relationships, but this creates computational challenges.
    Methods: We obtained voxel-wise grey matter density and psychosocial variables from the baseline (aged 9-10 years) Adolescent Brain and Cognitive Development cohort (n=11288), and employed a state-of-the-art segmentation method, sparse partial least squares, and a rigorous machine learning framework to prevent overfitting.
    Results: We found six latent dimensions, four pertaining specifically to mental health. The mental health dimensions related to overeating, anorexia/internalizing, oppositional symptoms (all p<0.002) and ADHD symptoms (p=0.03). ADHD related to increased and internalizing related to decreased grey matter density in dopaminergic and serotonergic midbrain areas, whereas oppositional symptoms related to increased grey matter in a noradrenergic nucleus. Internalizing related to increased and oppositional symptoms to reduced grey matter density in insula, cingulate and auditory cortices. Striatal regions featured strongly, with reduced caudate nucleus grey matter in ADHD, and reduced putamen grey matter in oppositional/conduct problems. Voxel-wise grey matter density generated stronger brain-psychosocial correlations than brain parcellations.
    Conclusions: Voxel-wise brain data strengthen latent dimensions of brain-psychosocial covariation and sparse multivariate methods increase their psychopathological specificity. Internalizing and externalizing are associated with opposite grey matter changes in similar cortical and subcortical areas.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2024.03.006
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  7. Article ; Online: Legally protecting apologies shrinks the clinician-patient relationship.

    Iedema, Rick / Sandal, Jane / Adams, Mary

    BMJ (Clinical research ed.)

    2019  Volume 366, Page(s) l5472

    MeSH term(s) Disclosure ; Humans ; Medical Errors ; Patient Safety
    Language English
    Publishing date 2019-09-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.l5472
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  8. Article: Pulmonary Complications and Mortality in Patients with SARS-CoV-2 Undergoing Elective and Emergent Hand Surgery

    Adams, Alexander J. / Dohse, Nicolas / Miller, Andrew / Tosti, Rick

    Journal of Hand and Microsurgery

    2023  Volume 15, Issue 05, Page(s) 371–375

    Abstract: Background: Patients acutely infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have increased risk for postsurgical pulmonary complications and mortality, particularly with general anesthesia. Surgery is often delayed to ... ...

    Abstract Background: Patients acutely infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have increased risk for postsurgical pulmonary complications and mortality, particularly with general anesthesia. Surgery is often delayed to mitigate risk; however, excessive delays may result in morbidity. Optimal criteria for delaying surgery in patients with or without symptoms are unknown. This study aimed to evaluate any complications following hand surgery in patients testing positive for SARS-CoV-2.
    Methods: We retrospectively reviewed patients with a positive polymerase chain reaction test within 60 days before or after hand surgery between March 31, 2020 and March 31, 2021. Patients were telephoned also to supplement records. Type of surgery, type of anesthesia, comorbidities, timing of surgery, onset of symptoms, and complications were recorded.
    Results: We identified 21 patients undergoing 26 procedures, of which 21 (81%) were emergency procedures and 5 (19%) were elective. Mean age was 37 years (range: 17–71). General anesthesia was used in 88% of cases, with mean duration of 110 minutes. SARS-CoV-2 was diagnosed on average 6 days preoperatively (range: 39 days preop–14 days postop). Positive tests were usually identified preoperatively (50%), versus day-of-surgery (25%) or postoperatively (25%). Patients were symptomatic in only 27% of cases, and completely asymptomatic in 73%. No asymptomatic patients developed complications. One patient suffered a fracture malunion after delayed surgery. Pulmonary complications were noted in 3 patients; all had prior pulmonary disease and underwent emergency surgeries under general anesthesia. Overall mortality rate was 0%.
    Conclusion: Pulmonary complications and mortality are low following hand surgery in asymptomatic patients with a positive SARS-CoV-2 test.
    Keywords SARS-CoV-2 ; hand surgery ; morbidity ; mortality
    Language English
    Publishing date 2023-01-23
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 0974-6897 ; 0974-3227
    ISSN (online) 0974-6897
    ISSN 0974-3227
    DOI 10.1055/s-0043-1760765
    Database Thieme publisher's database

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  9. Article ; Online: Reduced grid-like theta modulation in schizophrenia.

    Convertino, Laura / Bush, Daniel / Zheng, Fanfan / Adams, Rick A / Burgess, Neil

    Brain : a journal of neurology

    2022  Volume 146, Issue 5, Page(s) 2191–2198

    Abstract: The hippocampal formation has been implicated in the pathophysiology of schizophrenia, with patients showing impairments in spatial and relational cognition, structural changes in entorhinal cortex and reduced theta coherence with medial prefrontal ... ...

    Abstract The hippocampal formation has been implicated in the pathophysiology of schizophrenia, with patients showing impairments in spatial and relational cognition, structural changes in entorhinal cortex and reduced theta coherence with medial prefrontal cortex. Both the entorhinal cortex and medial prefrontal cortex exhibit a 6-fold (or 'hexadirectional') modulation of neural activity during virtual navigation that is indicative of grid cell populations and associated with accurate spatial navigation. Here, we examined whether these grid-like patterns are disrupted in schizophrenia. We asked 17 participants with diagnoses of schizophrenia and 23 controls (matched for age, sex and IQ) to perform a virtual reality spatial navigation task during magnetoencephalography. The control group showed stronger 4-10 Hz theta power during movement onset, as well as hexadirectional modulation of theta band oscillatory activity in the right entorhinal cortex whose directional stability across trials correlated with navigational accuracy. This hexadirectional modulation was absent in schizophrenia patients, with a significant difference between groups. These results suggest that impairments in spatial and relational cognition associated with schizophrenia may arise from disrupted grid firing patterns in entorhinal cortex.
    MeSH term(s) Humans ; Schizophrenia ; Theta Rhythm/physiology ; Entorhinal Cortex ; Grid Cells/physiology ; Hippocampus
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac416
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  10. Article ; Online: Reliability of Assessing Distal Radius Fractures on a Smartphone Versus PACS.

    Adams, Alexander J / Miller, Andrew / Tan, Emily / Shin, Eon K / Tosti, Rick

    Hand (New York, N.Y.)

    2022  Volume 19, Issue 1, Page(s) 52–57

    Abstract: Background: Communication between health care providers is becoming more intertwined with technology. During the pandemic, telehealth strategies grew exponentially. Remote viewing of imaging on a smartphone may offer efficient communication; however, ... ...

    Abstract Background: Communication between health care providers is becoming more intertwined with technology. During the pandemic, telehealth strategies grew exponentially. Remote viewing of imaging on a smartphone may offer efficient communication; however, the reliability of injury assessment when compared with traditional methods is not known. The purpose of this study was to evaluate intraobserver and interobserver reliability of distal radius fracture radiograph review for smartphone versus traditional Picture Archiving and Communication System (PACS).
    Methods: Eight evaluators (3 attending hand surgeons, 3 hand surgery fellows, 2 orthopedic residents) evaluated 26 distal radius fracture radiographs on 2 different viewers: smartphone or PACS. The reviewers were asked to record: (1) operative or nonoperative preference; (2) fracture classification (based on Fernandez and Jupiter); and (3) treatment strategy (volar plate, dorsal plate, pins, cast, bridge plate, or fragment-specific fixation). The percentage of intraobserver agreement was recorded for each observer. Reliability was calculated using Fleiss' kappa coefficient for intraobserver and interobserver agreement and graded by strength of correlation.
    Results: Intraobserver agreement averaged 97% when deciding between operative and nonoperative treatment, 76% for classification, and 84% for treatment. Kappa scores were graded as "excellent" for operative decision and "substantial" for classification and treatment. Attendings and fellows generally had higher agreement than that of residents. Interobserver agreement was graded as "substantial" for all categories for both PACS and smartphone.
    Conclusions: Evaluation of radiographs on a smartphone for the purpose of treating distal radius fractures does not appear to be significantly different from an evaluation on traditional PACS.
    MeSH term(s) Humans ; Wrist Fractures ; Smartphone ; Reproducibility of Results ; Observer Variation ; Radiology Information Systems
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277325-3
    ISSN 1558-9455 ; 1558-9447
    ISSN (online) 1558-9455
    ISSN 1558-9447
    DOI 10.1177/15589447221105547
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