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  1. Article ; Online: Concept of risk factor as an estimate of association and treatment effect: Measures and meaning.

    Enríquez-Navascués, Jose M / Aguirre-Allende, Ignacio

    Cirugia espanola

    2022  Volume 100, Issue 10, Page(s) 652–655

    MeSH term(s) Humans ; Risk Factors
    Language English
    Publishing date 2022-06-24
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2021.10.018
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  2. Article ; Online: Exactitud diagnóstica en el cáncer de esófago localizado. Estudio observacional retrospectivo.

    Andrés-Imaz, Ainhoa / Martí-Gelonch, Laura / Eizaguirre-Letamendia, Emma / Asensio-Gallego, José I / Enríquez-Navascués, José M

    Cirugia y cirujanos

    2023  Volume 91, Issue 1, Page(s) 42–49

    Abstract: Objective: To assess the accuracy of the diagnostic tests for a correct clinical tumor staging in localized esophageal cancer (EC).: Method: Retrospective observational study of patients who underwent esophagectomy for cancer in a referral hospital ... ...

    Title translation Staging accuracy in resecable esophageal cancer. Observational retrospective study.
    Abstract Objective: To assess the accuracy of the diagnostic tests for a correct clinical tumor staging in localized esophageal cancer (EC).
    Method: Retrospective observational study of patients who underwent esophagectomy for cancer in a referral hospital between January 2003 and September 2019. Those patients who received neoadjuvant treatment were excluded in order to avoid bias from downstaging effects. The preoperative stage was compared with the pathological stage of the surgical specimen. Computed tomography (CT) , endoscopic ultrasound (EUS) and positron emission tomography (PET) were evaluated. The pT stage was correlated with the tumor length described in the esophagram (EG).
    Results: Among the 63 patients included, the clinical staging was correct in 16 (global accuracy 25.4%), it was overstaged in 21 (33.2%) and understaged in 26 (41.3%). For cT staging, the accuracy of EUS was higher than that of CT (46.6% and 34.9%, respectively), specially for early stages. EG tumor length correlated with pT stage (p < 0.05). For cN staging, PET had the highest sensitivity (50.0%) and negative predictive value (75.0%).
    Conclusions: Despite the multiple diagnostic tools used, the global accuracy of clinical staging in localized EC is still a challenge. The lack of a test that stands out significantly from the others reinforces the need to use them in a complementary way.
    MeSH term(s) Humans ; Neoplasm Staging ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/surgery ; Retrospective Studies ; Endosonography/methods ; Esophagectomy
    Language English
    Publishing date 2023-02-08
    Publishing country Mexico
    Document type Observational Study ; Journal Article
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.21000722
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  3. Article ; Online: Peristomal pyoderma gangrenosum in a patient with inflammatory bowel disease.

    Garcia Dominguez, Amaia / Saralegui Ansorena, Yolanda / Artola Etxeberria, Marta / Enríquez-Navascués, Jose María

    Cirugia espanola

    2021  Volume 99, Issue 6, Page(s) 464

    MeSH term(s) Chronic Disease ; Humans ; Ileostomy/adverse effects ; Inflammatory Bowel Diseases ; Pyoderma Gangrenosum/etiology
    Language English
    Publishing date 2021-05-24
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2021.05.004
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  4. Article ; Online: Use of Darvadstrocel (Allogenic Stem Cell Therapy) for Crohn's Fistulas in Real Clinical Practice: The National Project to Implement Mesenchymal Stem Cell for the Treatment of Perianal Crohn's Fistula (the PRIME Study).

    Herreros, Maria Dolores / Ramirez, Jose-Manuel / Otero-Piñeiro, Ana M / Martí-Gallostra, Marc / Badiola, Izaskun / Enríquez-Navascues, Jose M / Millan, Monica / Barreiro, Erica / de la Portilla de Juan, Fernando / Suárez Alecha, Javier / Garcia-Olmo, Damian

    Diseases of the colon and rectum

    2024  

    Abstract: Background: Perianal fistulas may affect 15-50% of patients with Crohn's disease. Treatment is complex, requiring a multidisciplinary approach. Darvadstrocel (allogenic mesenchymal cells obtained from lipoaspirates) was approved in 2018 by the European ... ...

    Abstract Background: Perianal fistulas may affect 15-50% of patients with Crohn's disease. Treatment is complex, requiring a multidisciplinary approach. Darvadstrocel (allogenic mesenchymal cells obtained from lipoaspirates) was approved in 2018 by the European and Spanish Agencies of Medicines and Medical Products as a treatment for fistulas in Crohn's disease. Recent European Crohn's and Colitis Organisation and Spanish Working Group on Crohn's Disease and Ulcerative Colitis guidelines state that darvadstrocel is effective with a favorable safety profile and a strong level of evidence (2).
    Objective: Presenting real-world effectiveness data for darvadstrocel in a Spanish population.
    Design: Observational retrospective cohort study with prospective data gathering.
    Settings: Fourteen institutions.
    Patients: From November 2019-April 2022, all patients (73) treated with darvadstrocel in these institutions were included, fulfilling the following criteria: 1) complex fistula/s in a patient with Crohn's disease; 2) failure of conventional and antitumor necrosis factor treatment; 3) absence of collections >2 cm confirmed by pelvic MRI scan at the time of surgery.
    Interventions: Darvadstrocel treatment.
    Main outcome measures: Clinical response (closure of ≥50% of external openings), complete clinical closure (100% of external openings) and radiological closure (no fluid collection >2 cm, no edema or inflammation) evaluated 6 months after treatment.
    Results: Clinical response was observed in 63 patients (86.3%), complete clinical closure in 50 patients (68.5%) and radiological closure in 45 patients (69.2%). Combined clinical and radiological response was observed in 41 patients (63.1%). Not all clinically healed patients had radiological closure and vice versa. No serious adverse events were reported.
    Limitations: Retrospective.
    Conclusions: Study results were consistent with those reported in previous clinical trials, real-world efficacy findings from the INSPIRE study (assessing darvadstrocel effectiveness in Europe, Israel, Switzerland, UK, and Japan) and previously published literature. Darvadstrocel was effective and demonstrated a favorable safety profile when used in normal clinical practice for treatment of fistulas in Crohn's disease. See Video Abstract.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000003216
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  5. Article ; Online: Care burden and outcome of the surgical management of ulcerative colitis: A retrospective analysis of the last 20 years in a tertiary hospital in Spain.

    Aguirre-Allende, Ignacio / Enríquez-Navascués, Jose M / Elorza, Garazi / Etxart, Ane / Echeveste, Ainhoa / Borda-Arrizabalaga, Nerea / Placer, Carlos / Saralegui, Yolanda

    Cirugia espanola

    2021  

    Abstract: Aim: To analyze the surgical burden of UC care in the last two decades, analyzing the characteristics of the patients, surgical indications along with the short and long-term results.: Method: Single-center retrospective cohort analysis of UC ... ...

    Abstract Aim: To analyze the surgical burden of UC care in the last two decades, analyzing the characteristics of the patients, surgical indications along with the short and long-term results.
    Method: Single-center retrospective cohort analysis of UC patients undergoing abdominal and anorectal surgery between January 2000 and December 2020. The care burden, clinical data and results were analyzed according to distribution by decades.
    Results: 128 patients, 37% female, underwent 376 surgical interventions (296 intestinal procedures and 80 anorectal). Mean follow-up for the cohort was 106±64 months. Timing from diagnosis to first surgery was under 5 years in 53.3%. In the second decade of the study there were fewer operated patients (73 vs. 48) as well as the total number of interventions per patient (2.7 vs. 2.0). The proportion between elective and urgent surgery was reversed in the second decade, observing an increase in laparoscopic surgery (70% vs. 8%) together with a decrease in major postoperative morbidity (Clavien-Dindo≥IIIa) (20% vs 8.4%). 80 patients underwent a restorative proctocolectomy, with a failure of 5% at 1 year but 23.7% in the long term. 37 patients required anorectal surgery, of which 26 (71%) were serial interventions, most due to septic complications of the pouches.
    Conclusions: The number of colectomies and interventions per patient decreased in the last decade, while there were improvements in morbidity and surgical approach. The need for sequential surgeries and long-term active instrumental surveillance for possible functional deterioration constitutes a significant clinical burden.
    Language Spanish
    Publishing date 2021-09-08
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2021.08.008
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  6. Article ; Online: Late anastomotic leakages in rectal surgery: a wake-up call about their impact on long-term results.

    Placer, Carlos / Vega, Juan / Aguirre, Ignacio / Rose, Steffen / Saralegui, Yolanda / Enríquez-Navascués, José M

    Cirugia y cirujanos

    2019  Volume 87, Issue 6, Page(s) 611–618

    Abstract: Objective: To assess the impact of the incidence of late anastomotic dehiscences, defined as those occurring after the 60: Methods: A retrospective analysis was performed reviewing all anastomotic leakages (AL) recorded in a prospective rectal cancer ...

    Title translation Dehiscencias anastomóticas tardías en la cirugía del cáncer de recto. Una llamada de atención sobre su impacto en los resultados a largo plazo.
    Abstract Objective: To assess the impact of the incidence of late anastomotic dehiscences, defined as those occurring after the 60
    Methods: A retrospective analysis was performed reviewing all anastomotic leakages (AL) recorded in a prospective rectal cancer database, from November 2006 to December 2015.
    Results: The analysis included 395 (71.5%) colo-rectal anastomosis performed in 552 patients undergoing rectal cancer surgery. Overall 32 (8.1%). AL were identified: 25 (78%) early and 7 (22%) late. Late AL compared to early AL were significantly associated with: higher ASA score (p = 0.021), higher CLS score (p = 0.005), lower rectal tumours (p = 0.014), neo-adjuvant radio-chemotherapy (p = 0.028), presence of ileostomy (p = 0.013), early hospital discharge (p = 0.048) and with the need for definitive stoma creation (p = 0.003).
    Conclusions: Late AL can represent up to 22% of all AL; with significant long-term implications such as an increase of the requirement of definitive stoma or chronic pelvic sepsis. This findings could modify the long-term outcomes in rectal cancer published. In our experience, the late AL do not represent a distinct clinical process compared to early forms, with exception of the chronological criteria.
    MeSH term(s) Aged ; Anastomotic Leak/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Rectal Neoplasms/surgery ; Retrospective Studies ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2019-10-18
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.19000531
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  7. Article ; Online: Diagnóstico inesperado en paciente con sospecha de GIST: infiltración gástrica por mieloma múltiple.

    Martí-Gelonch, Laura / Asensio-Gallego, José I / Eizaguirre-Letamendia, Emma / Murgoitio-Lazkano, Francisco J / Arana-Iñiguez, Íñigo / Enríquez-Navascués, José M

    Cirugia y cirujanos

    2020  Volume 88, Issue Suppl 2, Page(s) 90–93

    Abstract: El mieloma múltiple se caracteriza por la proliferación neoplásica medular de células plasmáticas productoras de inmunoglobulina monoclonal. Un porcentaje pequeño de pacientes presenta compromiso extramedular en forma de plasmocitoma, siendo la ... ...

    Title translation Unexpected diagnosis in a patient with suspected GIST: gastric infiltration due to multiple myeloma.
    Abstract El mieloma múltiple se caracteriza por la proliferación neoplásica medular de células plasmáticas productoras de inmunoglobulina monoclonal. Un porcentaje pequeño de pacientes presenta compromiso extramedular en forma de plasmocitoma, siendo la localización más habitual las vías respiratorias altas. La afectación gastrointestinal es rara y la clínica asociada dependerá de la localización, la extensión y el mecanismo de infiltración. La afectación gástrica en forma de tumoración tiene un aspecto y una sintomatología similares a los de otras lesiones, por lo que es necesario realizar un diagnóstico histológico para un adecuado tratamiento. A continuación se presenta el caso de un mieloma múltiple con afectación gástrica.
    Multiple myeloma is characterized by medullary neoplastic proliferation of plasma cells producing monoclonal immunoglobulin. A small percentage of patients have extramedullary involvement in form of plasmacytoma, the most common location being the upper respiratory tract. Gastrointestinal involvement is rare and the associated symptoms will depend on the location, extent and mechanism of infiltration. Gastric involvement presents an appearance and symptoms similar to other lesions, so a histological diagnosis is necessary for proper treatment. This article presents the case of multiple myeloma with gastric involvement.
    MeSH term(s) Gastrointestinal Stromal Tumors ; Humans ; Multiple Myeloma
    Language English
    Publishing date 2020-12-07
    Publishing country Mexico
    Document type Case Reports ; Journal Article
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.20000566
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  8. Article: Urgencias y atención continuada: agotamiento del actual sistema de guardias y búsqueda de nuevos modelos.

    Enríquez-Navascués, Jose M

    Cirugia espanola

    2007  Volume 83, Issue 4, Page(s) 173–179

    Abstract: Emergency surgical care is still provided by means of an 24 hours physical presence "on-call" model (encompassing a normal day followed by "on call"), and is obligatory for all staff. This defective organisation of work has become unsustainable with the ... ...

    Title translation Emergencies and continuous care: overload of the current on-call system and search for new models.
    Abstract Emergency surgical care is still provided by means of an 24 hours physical presence "on-call" model (encompassing a normal day followed by "on call"), and is obligatory for all staff. This defective organisation of work has become unsustainable with the acceptance of the European 48 hours Directive, and is gruelling due to the excessive night work and feeling of being locked in that it entails. Emergency general and digestive system surgery care cannot be provided by a single organisational model, but has to be adapted to local circumstances. It is important to separate scheduled activity from urgent, and whereas increasingly more resources are dedicated to scheduled care, sufficient resources are also required for urgent activities, that cannot be considered as simply an "on call" or a fleeting stop in scheduled activity. Core subjects in residency, creating different levels of provision and activities, the analysis of urgent activity per work period and the identification of foreseeable activity, to maintain a pro-active mentality, and the disappearance of the "overtime" concept, should help provide another care model and method of remuneration.
    MeSH term(s) Emergency Treatment ; Humans ; Models, Theoretical ; Spain ; Surgery Department, Hospital/organization & administration ; Surgical Procedures, Operative
    Language Spanish
    Publishing date 2007-12-31
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 730701-9
    ISSN 0009-739X
    ISSN 0009-739X
    DOI 10.1016/s0009-739x(08)70543-8
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  9. Article ; Online: Report of the Asociación Española de Coloproctología President.

    Enríquez-Navascues, Jose M / Espín-Basany, Eloy / Jiménez-Escobar, Fernando

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2016  Volume 18, Issue 5, Page(s) 440

    Language English
    Publishing date 2016-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.13337
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  10. Article: Surgery and emergency gastrointestinal endoscopy during the Covid-19 pandemic.

    Bujanda, Luis / Arratibel, Paula / Gil, Ines / Torrente, Silvia / Martos, Maider / Enriquez-Navascues, Jose M

    Gastroenterologia y hepatologia

    2020  Volume 44, Issue 4, Page(s) 294–296

    MeSH term(s) After-Hours Care/statistics & numerical data ; COVID-19/epidemiology ; Colonoscopy/statistics & numerical data ; Emergencies/epidemiology ; Emergency Treatment/statistics & numerical data ; Endoscopy, Gastrointestinal/statistics & numerical data ; Foreign Bodies/epidemiology ; Foreign Bodies/surgery ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/surgery ; Humans ; Intestinal Obstruction/epidemiology ; Intestinal Obstruction/surgery ; Pandemics ; Time Factors
    Keywords covid19
    Language Spanish
    Publishing date 2020-09-16
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2020.07.002
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