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Article ; Online: Letter to the editor regarding "do X-ray-occult fractures play a role in chronic pain following a whiplash injury?" by Hertzum-Larsen R, Petersen H, Kasch H, Bendix T. Eur Spine J. 2014; DOI 10.1007/s00586-014-3362-3.

Uhrenholt, Lars / Webb, Alex / Freeman, Michael

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2014 Volume 23, Issue 10, Page(s) 2223–2224

MeSH term(s)	Accidents, Traffic ; Chronic Pain/diagnostic imaging ; Female ; Fractures, Closed/diagnostic imaging ; Humans ; Male ; Pain Measurement ; Radiography ; Whiplash Injuries/diagnostic imaging
Language	English
Publishing date	2014-08-08
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-014-3492-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3437: Show issues

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Book ; Online ; E-Book: Clinical nuclear medicine

Ahmadzadehfar, Hojjat / Biersack, Hans-Jürgen / Freeman, Leonard M. / Zuckier, Lionel S.

2020

Author's details	Hojjat Ahmadzadehfar, Hans-Jürgen Biersack, Leonard M. Freeman, Lionel S. Zuckier editors
Language	English
Size	1 Online-Ressource, Illustrationen
Edition	Second edition
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020461421
ISBN	978-3-030-39457-8 ; 9783030394554 ; 3-030-39457-3 ; 3030394557
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Central amygdala contributes to stimulus facilitation and pre-stimulus vigilance during cerebellar learning.

Farley, Sean J / Freeman, John H

Neurobiology of learning and memory

2024 Volume 211, Page(s) 107925

Abstract: Our previous studies found that the central amygdala (CeA) modulates cerebellum-dependent eyeblink conditioning (EBC) using muscimol inactivation. We also found that CeA inactivation decreases cerebellar neuronal activity during the conditional stimulus ( ...

Abstract	Our previous studies found that the central amygdala (CeA) modulates cerebellum-dependent eyeblink conditioning (EBC) using muscimol inactivation. We also found that CeA inactivation decreases cerebellar neuronal activity during the conditional stimulus (CS) from the start of training. Based on these findings, we hypothesized that the CeA facilitates CS input to the cerebellum. The current study tested the CS facilitation hypothesis using optogenetic inhibition with archaerhodopsin (Arch) and excitation with channelrhodopsin (ChR2) of the CeA during EBC in male rats. Optogenetic manipulations were administered during the 400 ms tone CS or during a 400 ms pre-CS period. As predicted by the CS facilitation hypothesis CeA inhibition during the CS impaired EBC and CeA excitation during the CS facilitated EBC. Unexpectedly, CeA inhibition just prior to the CS also impaired EBC, while CeA excitation during the pre-CS pathway did not facilitate EBC. The results suggest that the CeA contributes to CS facilitation and vigilance during the pre-CS period. These putative functions of the CeA may be mediated through separate output pathways from the CeA to the cerebellum.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223366-3
ISSN	1095-9564 ; 1074-7427
ISSN (online)	1095-9564
ISSN	1074-7427
DOI	10.1016/j.nlm.2024.107925
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Zs.B 2339: Show issues

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Article ; Online: The B7:CD28 family and friends: Unraveling coinhibitory interactions.

Burke, Kelly P / Chaudhri, Apoorvi / Freeman, Gordon J / Sharpe, Arlene H

Immunity

2024 Volume 57, Issue 2, Page(s) 223–244

Abstract: Immune responses must be tightly regulated to ensure both optimal protective immunity and tolerance. Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial ... ...

Abstract	Immune responses must be tightly regulated to ensure both optimal protective immunity and tolerance. Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial inhibitory signals that maintain immune homeostasis, control resolution of inflammation, regulate host defense, and promote tolerance to prevent autoimmunity. Tumors and chronic pathogens can exploit these pathways to evade eradication by the immune system. Advances in understanding B7:CD28 pathways have ushered in a new era of immunotherapy with effective drugs to treat cancer, autoimmune diseases, infectious diseases, and transplant rejection. Here, we discuss current understanding of the mechanisms underlying the coinhibitory functions of CTLA-4, PD-1, PD-L1:B7-1 and PD-L2:RGMb interactions and less studied B7 family members, including HHLA2, VISTA, BTNL2, and BTN3A1, as well as their overlapping and unique roles in regulating immune responses, and the therapeutic potential of these insights.
MeSH term(s)	Humans ; CD28 Antigens/metabolism ; Friends ; T-Lymphocytes ; CTLA-4 Antigen/metabolism ; Immunotherapy ; Autoimmune Diseases ; B7-1 Antigen/metabolism ; Immunoglobulins/metabolism ; Butyrophilins/metabolism ; Antigens, CD/metabolism
Chemical Substances	CD28 Antigens ; CTLA-4 Antigen ; B7-1 Antigen ; HHLA2 protein, human ; Immunoglobulins ; BTNL2 protein, human ; Butyrophilins ; BTN3A1 protein, human ; Antigens, CD
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2024.01.013
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article: Mr. Key's Case of Ulceration of the Cartilages of the Larynx.

Freeman, J H

The Medical quarterly review

2018 Volume 4, Issue 7, Page(s) 214–215

Language	English
Publishing date	2018-11-06
Publishing country	England
Document type	Journal Article
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Article ; Online: Endoscopic Versus Microscopic Transcanal Resection of Glomus Tympanicum: A Retrospective Comparative Study.

Kunnath, Ansley J / Freeman, Michael H / Witcher, Ryan / Patro, Ankita / Lindquist, Nathan R / Tawfik, Kareem O

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2024 Volume 45, Issue 4, Page(s) 426–429

Abstract: Objective: Comparison of outcomes of microscopic and endoscopic resection of glomus tympanicum (GT) tumors.: Study design: Retrospective case review.: Setting: Single tertiary referral center.: Patients: All adult patients undergoing transcanal ...

Abstract	Objective: Comparison of outcomes of microscopic and endoscopic resection of glomus tympanicum (GT) tumors. Study design: Retrospective case review. Setting: Single tertiary referral center. Patients: All adult patients undergoing transcanal GT resection without mastoidectomy from 2007 to 2021. Interventions: Surgical resection-endoscopic versus microscopic approach. Main outcome measures: Primary outcomes were tumor recurrence at 1 year and presence of residual tumor at conclusion of surgery. Secondary outcome measures included operative time, postoperative air-bone gap, postoperative symptom resolution, and surgical complications. Results: Thirty-eight patients underwent resection of GT (74% female; mean age, 59 years). Twenty-nine cases were performed microscopically, and nine cases were performed endoscopically. Both endoscopic and microscopic approaches yielded high rates of complete tumor resection (27/29 microscopic cases, 7/9 endoscopic cases). There was no significant difference in mean operative time (2.3 hours for microscopic; 2.6 hours for endoscopic). On average, air-bone gaps (ABGs) decreased by 6.3 dB after endoscopic resection compared with 1.0 dB after microscopic resection ( p = 0.064). No patients were found to have tumor recurrence during an average follow-up interval of 21 months. Conclusions: These results suggest comparable outcomes with both endoscopic and microscopic approaches for GT resection, and decisions regarding preferred approach should be dictated by surgeon preference.
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Male ; Glomus Tympanicum ; Retrospective Studies ; Neoplasm Recurrence, Local/surgery ; Treatment Outcome ; Endoscopy/methods
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000004147
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Zs.A 1554: Show issues

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Article ; Online: Acute kidney injury in hospitalized children with proteinuria: A multicenter retrospective analysis.

Baggett, Katelyn H / Manghi, Tomas / Walter, Vonn / Thomas, Neal J / Freeman, Michael A / Krawiec, Conrad

PloS one

2024 Volume 19, Issue 3, Page(s) e0298463

Abstract: Background and objective: Acute kidney injury (AKI) is a common complication in hospitalized pediatric patients. Previous studies focused on adults found that proteinuria detected during an admission urinalysis is fit to serve as an indicator for AKI ... ...

Abstract	Background and objective: Acute kidney injury (AKI) is a common complication in hospitalized pediatric patients. Previous studies focused on adults found that proteinuria detected during an admission urinalysis is fit to serve as an indicator for AKI and associated clinical outcomes. The objective of this study is to evaluate if proteinuria on the first day of hospital services in hospitalized children is associated with AKI, need for renal replacement therapy, shock and/or antibiotic use, critical care services, and all-cause mortality at 30 days, hypothesizing that it is associated with these outcomes. Methods: This is a retrospective cohort study using TriNetX electronic health record data of patients 2 to 18 years of age who underwent urinalysis laboratory testing on hospital admission, had three subsequent days of hospital or critical care services billing codes and creatinine laboratory values, and no pre-existing renal-related complex chronic condition. This study evaluated for the frequency, odds, and severity of AKI as defined by Kidney Disease: Improving Global Outcomes modified criteria and assessed for associated clinical outcomes. Results: This study included 971 pediatric subjects [435 (44.7%) with proteinuria]. Proteinuria on the first day of hospital services was associated with an increased odds for higher severity AKI on any day of hospitalization (odds ratio [OR] 2.41, CI 1.8-3.23, p<0.001), need for renal replacement therapy (OR 4.58, CI 1.69-12.4, p = 0.001), shock and/or antibiotic use (OR 1.34, CI 1.03-1.75, p = 0.033), and all-cause mortality at 30 days post-admission (OR 10.0, CI 1.25-80.5, p = 0.013). Conclusion: Children with proteinuria on the first day of hospital care services may have an increased odds of higher severity AKI, need for renal replacement therapy, shock and/or antibiotic use, and all-cause mortality at 30 days post-admission, with no significant association found for critical care services, mechanical intubation, or inotrope or vasopressor use.
MeSH term(s)	Child ; Humans ; Acute Kidney Injury/etiology ; Anti-Bacterial Agents/therapeutic use ; Child, Hospitalized ; Hospital Mortality ; Proteinuria/complications ; Retrospective Studies ; Risk Factors ; Child, Preschool ; Adolescent
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298463
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Recommendations for the medical management of chronic venous disease: the role of micronized purified flavanoid fraction (MPFF)

Bush, Ronald / Comerota, Anthony / Meissner, Mark / Raffetto, Joseph D. / Hahn, Steven R. / Freeman, Katherine

recommendations from the Working Group in Chronic Venous Disease (CVD) 2016

(Phlebology ; volume 32, issue 1 suppl. (April 2017))

2017

Institution	Working Group in CVD
Author's details	Ronald Bush, Anthony Comerota, Mark Meissner, Joseph D. Raffetto, Steven R. Hahn, Katherine Freeman
Series title	Phlebology ; volume 32, issue 1 suppl. (April 2017)
Collection
Language	English
Size	19 Seiten, Illustrationen
Publisher	Sage Publications Ltd
Publishing place	London
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT019582846
Database	Catalogue ZB MED Medicine, Health

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Zs A 2538 -31,Suppl.1-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: Romantic Duration, Relationship Quality, and Attachment Insecurity among Dating Couples.

Freeman, Harry / Simons, Jeffrey / Benson, Nicholas F

International journal of environmental research and public health

2023 Volume 20, Issue 1

Abstract: For many young adults today dating is not taken as a path to marriage, but as a relationship to be considered on its own terms with a beginning, middle, and end. Yet, research has not kept pace as most studies that look at relationships over time focus ... ...

Abstract	For many young adults today dating is not taken as a path to marriage, but as a relationship to be considered on its own terms with a beginning, middle, and end. Yet, research has not kept pace as most studies that look at relationships over time focus on marriages. In the present study, we look at individual differences and normative patterns of dating relationship quality over time. We tested a path model of associations between relationship duration, attachment insecurity, and four relationship quality domains (sexual frequency, commitment, satisfaction, and companionship) among a large sample of dating young adults (
MeSH term(s)	Young Adult ; Humans ; Adult ; Sexual Behavior ; Interpersonal Relations ; Marriage ; Personal Satisfaction ; Anxiety ; Object Attachment ; Sexual Partners
Language	English
Publishing date	2023-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010856
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Article ; Online: Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.

Halverson, Hunter E / Kim, Jangjin / Freeman, John H

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 49, Page(s) 8385–8402

Abstract: Communication between the cerebellum and forebrain structures is necessary for motor learning and has been implicated in a variety of cognitive functions. The exact nature of cerebellar-forebrain interactions supporting behavior and cognition is not ... ...

Abstract	Communication between the cerebellum and forebrain structures is necessary for motor learning and has been implicated in a variety of cognitive functions. The exact nature of cerebellar-forebrain interactions supporting behavior and cognition is not known. We examined how local and network activity support learning by simultaneously recording neural activity in the cerebellum, amygdala, and anterior cingulate cortex while male and female rats were trained in trace eyeblink conditioning. Initially, the cerebellum and forebrain signal the contingency between external stimuli through increases in theta power and synchrony. Neuronal activity driving expression of the learned response was observed in the cerebellum and became evident in the anterior cingulate and amygdala as learning progressed. Aligning neural activity to the training stimuli or learned response provided a way to differentiate between learning-related activity driven by different mechanisms. Stimulus and response-related increases in theta power and coherence were observed across all three areas throughout learning. However, increases in slow gamma power and coherence were only observed when oscillations were aligned to the cerebellum-driven learned response. Percentage of learned responses, learning-related local activity, and slow gamma communication from cerebellum to forebrain all progressively increased during training. The relatively fast frequency of slow gamma provides an ideal mechanism for the cerebellum to communicate learned temporal information to the forebrain. This cerebellar response-aligned slow gamma then provides enrichment of behavior-specific temporal information to local neuronal activity in the forebrain. These dynamic network interactions likely support a wide range of behaviors and cognitive tasks that require coordination between the forebrain and cerebellum.
MeSH term(s)	Female ; Male ; Rats ; Animals ; Gyrus Cinguli ; Conditioning, Eyelid/physiology ; Cerebellum/physiology ; Conditioning, Classical/physiology ; Amygdala/physiology
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0731-23.2023
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Zs.A 1668: Show issues

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