Article: T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual.
2023 Volume 11, Issue 6
Abstract: ... of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T ...
| Abstract | Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual's immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection. |
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| Language | English |
| Publishing date | 2023-06-12 |
| Publishing country | Switzerland |
| Document type | Case Reports |
| ZDB-ID | 2720891-6 |
| ISSN | 2076-2607 |
| ISSN | 2076-2607 |
| DOI | 10.3390/microorganisms11061562 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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