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Article ; Online: Emotion processes and perceptual control of action choice.

Scherer, Klaus R

2023 Volume 37, Issue 7, Page(s) 1161–1166

Abstract: This editorial introduces an invited article by Andreas Eder on a new perceptual control theory ...

Abstract	This editorial introduces an invited article by Andreas Eder on a new perceptual control theory of action choice, based on the comparison of real and simulated interoceptive signals generated by action alternatives. Eder extends the cognitive action-control framework, postulating a bi-directional connection between outcomes and actions by introducing "emotional feelings", defined as valued interoceptive signals from the body. An invited commentary by Agnes Moors compares this theory with her own goal-directed theory of action control. While agreeing on the central role of a control cycle and the goal-directed nature of emotional actions, Moors disagrees on the content of the representations involved in the control cycle and the nature of the feelings involved. A second commentary by Bob Bramson and Karin Roelofs discusses the issues of the distinction between perception control vs. action control, the need for biologically plausible implementation alternatives, and potential implications for psychopathology and clinical intervention. Finally, the potential relevance of predictive coding theory and the role of appraisal processes in emotion generation with respect to their bearing on action comparison and choice are discussed.
MeSH term(s)	Humans ; Emotions ; Choice Behavior
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Editorial
ZDB-ID	639123-0
ISSN	1464-0600 ; 0269-9931
ISSN (online)	1464-0600
ISSN	0269-9931
DOI	10.1080/02699931.2023.2269828
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Article: Concurrent dermoid and epidermoid cysts in an adolescent patient: a case report.

Taylor, Justin J / Scherer, Andrea G / Shao, Lei / Westmoreland, Tamarah J

Oxford medical case reports

2023 Volume 2023, Issue 10, Page(s) omad105

Abstract: Dermoid and epidermoid cysts are benign lesions of ectodermal origin which are pathologically distinct entities, although often clinically indistinguishable. Cyst location, mobility, and appearance on MRI can help distinguish the two, however the ... ...

Abstract	Dermoid and epidermoid cysts are benign lesions of ectodermal origin which are pathologically distinct entities, although often clinically indistinguishable. Cyst location, mobility, and appearance on MRI can help distinguish the two, however the distinction is mostly academic since both types have similar management. Co-occurrence of dermoid and epidermoid cysts together in the same patient has not been observed in the literature, however one case of an epidermoid cyst evolving into a dermoid cyst has been documented. In this case report, we identify a 16-year-old male with three separate cysts of the scalp and leg which, after histopathological analysis following surgical resection, were found to represent both dermoid and epidermoid cysts. We offer potential explanations for this rare occurrence in the absence of a genetic syndrome and highlight the importance of performing a thorough work-up of patients with multiple cysts.
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omad105
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Article ; Online: Parental Nonadherence to Health Policy Recommendations for Prevention of COVID-19 Transmission Among Children.

Levy, Andrea Gurmankin / Thorpe, Alistair / Scherer, Laura D / Scherer, Aaron M / Butler, Jorie M / Shoemaker, Holly / Fagerlin, Angela

JAMA network open

2023 Volume 6, Issue 3, Page(s) e231587

MeSH term(s)	Child ; Humans ; COVID-19/prevention & control ; Patient Compliance ; Parents
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.1587
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Book ; Online: (Table S1) Chronostratigraphic constrains for sediment core AND1-1B, supplementary data to: Naish, Tim R; Powell, Ross; Levy, R; Wilson, Gary S; Scherer, Reed P; Talarico, Franco; Krissek, Lawrence A; Niessen, Frank; Pompilio, Massimo; Wilson, Terry; Carter, Lionel; DeConto, Robert M; Huybers, P; McKay, R; Pollard, David; Ross, J; Winter, Diane M; Barrett, Peter J; Browne, G; Cody, R; Cowan, Ellen A; Crampton, J; Dunbar, Gavin B; Dunbar, N; Florindo, Fabio; Gebhardt, Andrea Catalina; Graham, IJ; Hannah, Mike J; Hansaraj, D; Harwood, David M; Helling, D; Henrys, Stuart; Hinnov, L; Kuhn, Gerhard; Kyle, Philip R; Läufer, Andreas L; Maffioli, P; Magens, Diana; Mandernack, Kevin W; McIntosh, WC; Millan, C; Morin, Roger H; Ohneiser, Christian; Paulsen, Timothy S; Persico, Davide; Raine, J Ian; Reed, J; Riesselman, C; Sagnotti, Leo; Schmitt, D R; Sjunneskog, C; Strong, P; Taviani, Marco; Vogel, Stefan; Wilch, T; Williams, Trevor (2009): Obliquity-paced Pliocene West Antarctic ice sheet oscillations. Nature, 458(7236), 322-329

Naish, Tim R / Krissek, Lawrence A / Levy, R / Niessen, Frank / Pompilio, Massimo / Powell, Ross / Scherer, Reed P / Talarico, Franco / Wilson, Gary S / al., et

2009

Abstract: Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages (Hays et al., 1976, doi:10.1126/science.194.4270.1121), fundamental ... ...

Abstract	Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages (Hays et al., 1976, doi:10.1126/science.194.4270.1121), fundamental questions remain over the response of the Antarctic ice sheets to orbital cycles (Raymo and Huybers, 2008, doi:10.1038/nature06589). Furthermore, an understanding of the behaviour of the marine-based West Antarctic ice sheet (WAIS) during the 'warmer-than-present' early-Pliocene epoch (~5-3 Myr ago) is needed to better constrain the possible range of ice-sheet behaviour in the context of future global warming (Solomon et al., 2007). Here we present a marine glacial record from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf by the ANDRILL programme and demonstrate well-dated, ~40-kyr cyclic variations in ice-sheet extent linked to cycles in insolation influenced by changes in the Earth's axial tilt (obliquity) during the Pliocene. Our data provide direct evidence for orbitally induced oscillations in the WAIS, which periodically collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment when planetary temperatures were up to ~3° C warmer than today ( Kim and Crowley, 2000, doi:10.1029/1999PA000459) and atmospheric CO2 concentration was as high as ~400 p.p.m.v. (van der Burgh et al., 1993, doi:10.1126/science.260.5115.1788, Raymo et al., 1996, doi:10.1016/0377-8398(95)00048-8). The evidence is consistent with a new ice-sheet/ice-shelf model (Pollard and DeConto, 2009, doi:10.1038/nature07809) that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated with the loss of the WAIS and up to +3 m in equivalent sea level from the East Antarctic ice sheet, in response to ocean-induced melting paced by obliquity. During interglacial times, diatomaceous sediments indicate high surface-water productivity, minimal summer sea ice and air temperatures above freezing, suggesting an additional influence of surface melt (Huybers, 2006, doi:10.1126/science.1125249) under conditions of elevated CO2.
Language	English
Dates of publication	2009-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1038/nature07867
DOI	10.1594/PANGAEA.769658
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Impact of prior COVID-19 infection on perceptions about the benefit and safety of COVID-19 vaccines.

Thorpe, Alistair / Gurmankin Levy, Andrea / Scherer, Laura D / Scherer, Aaron M / Drews, Frank A / Butler, Jorie M / Fagerlin, Angela

American journal of infection control

2023 Volume 52, Issue 1, Page(s) 125–128

Abstract: In this online survey of 1,733 US adults in December 2021, respondents believed COVID-19 vaccines are less beneficial and less safe for someone who had already had COVID-19. Those who experienced COVID-19 after being vaccinated believed that the vaccines ...

Abstract	In this online survey of 1,733 US adults in December 2021, respondents believed COVID-19 vaccines are less beneficial and less safe for someone who had already had COVID-19. Those who experienced COVID-19 after being vaccinated believed that the vaccines are less beneficial and less safe than those who had not. Findings highlight the need to better communicate evolving evidence of COVID-19 vaccine benefit and safety and to tailor communications to peoples' COVID-19 history and vaccination status.
MeSH term(s)	Adult ; Humans ; Communication ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Vaccination/adverse effects ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2023.08.002
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Article: 5‐Fluoruracil – Bestimmung von α‐Fluor‐β‐alanin in Urin mittels GC‐MS/MS : Biomonitoring Methods in German language, 2019

Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Schierl, Rudolf / Fischer, Elke / Scherer, Gerhard / Hagedorn, Heinz Werner / Göen, Thomas / Hartwig, Andrea / MAK Commission

The MAK collection for occupational health and safety, 4(1):337-352

2019

Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits ... ...

Institution	Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
Abstract	The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits the determination of α‐fluoro‐β‐alanine (FBAL), the main metabolite of 5‐fluorouracil, at low concentration levels and can be used for the biomonitoring of exposed individuals (manufacture, pharmacy, medicine). To this end, urine samples are spiked with 13C‐FBAL as internal standard (IS) and acidified with 0.1 M hydrochloric acid. The samples are then extracted and purified using a strong cation exchanger. After resuspension and derivatisation, FBAL is analysed using GC‐MS/MS in the MRM (Multiple Reaction Monitoring) mode and quantified with reference to the internal standard. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed.
Keywords	5-Fluoruracil ; Analysen in biologischem Material ; Biomonitoring ; Biomonitoring-Methoden ; Biomonitoring Methods ; GC-MS/MS ; Gaschromatographie-Massenspektrometrie ; Urin ; α-Fluor-β-alanin
Language	German
Document type	Article
DOI	10.4126/FRL01-006455588
Database	Repository for Life Sciences

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Article: 5‐Fluorouracil – Determination of α‐fluoro‐β‐alanine in urine by GC‐MS/MS : Biomonitoring Methods, 2019

The MAK collection for occupational health and safety, 4(1):303-316

2019

Institution	Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
Abstract	The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits the determination of α‐fluoro‐β‐alanine (FBAL), the main metabolite of 5‐fluorouracil, at low concentration levels and can be used for the biomonitoring of exposed individuals (manufacture, pharmacy, medicine). To this end, urine samples are spiked with 13C‐FBAL as internal standard (IS) and acidified with 0.1 M hydrochloric acid. The samples are then extracted and purified using a strong cation exchanger. After resuspension and derivatisation, FBAL is analysed using GC‐MS/MS in the MRM (Multiple Reaction Monitoring) mode and quantified with reference to the internal standard. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed.
Keywords	5-fluorouracil ; Analyses in Biological Materials ; Biomonitoring-Methoden ; Biomonitoring Methods ; GC-MS/MS ; biomonitoring ; gas chromatography mass spectrometry ; urine ; α-fluoro-β-alanine
Language	English
Document type	Article
DOI	10.4126/FRL01-006455590
Database	Repository for Life Sciences

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Article: Tabakspezifische Nitrosamine – Bestimmung von N‐Nitrosoanabasin, N‐Nitrosoanatabin, N‐Nitrosonornikotin und 4‐(Methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol in Urin mittels LC‐MS/MS : Biomonitoring methods in German language, 2019

Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Scherer, Gerhard / Gilch, Gerhard / Köhler, Dominique / Völkel, Wolfgang / Göen, Thomas / Hartwig, Andrea / MAK Commission

The MAK collection for occupational health and safety, 4(4):2442-2468

2019

Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and validated the presented biomonitoring method. This analytical method ... ...

Institution	Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
Abstract	The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and validated the presented biomonitoring method. This analytical method permits the determination of tobacco‐specific nitrosamines (TSNA) in urine using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). The parameters in question are N‐nitrosoanabasine (NAB), N‐nitrosoanatabine (NAT), N‐nitrosonornicotine (NNN) and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL). NNAL is a metabolite of 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK). Due to its sensitivity, this method is suitable for the detection of the aforementioned analytes in the urine of smokers. NNAL can also be quantified in the urine of passive smokers. The analytes NAB, NAT, NNN and NNAL are present in urine in both free and glucuronidated forms. For the determination of the total TSNA level in urine, the glucuronides are cleaved by enzymatic hydrolysis and then the analytes are isolated and concentrated using solid phase extraction (SPE). Two sorbent materials are used for sample preparation via SPE, first a material based on molecularly imprinted polymers and then a mixed‐mode cation exchange polymer. Analysis is performed by LC‐MS/MS. Deuterated internal standards are used for calibration. Calibration standards are prepared in pooled urine obtained from non‐smokers and are processed in the same way as the samples to be analysed.
Keywords	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol ; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanon ; Analysen in biologischem Material ; Biomonitoring ; Biomonitoring-Methoden ; Biomonitoring Methods ; Hochleistungsflüssigchromatographie-Tandemmassenspektrometrie ; LC-MS/MS ; N-Nitrosoanabasin ; N-Nitrosoanatabin ; N-Nitrosonornikotin ; NNAL ; NNK ; NNN ; NAB ; NAT ; TSNA ; Urin ; tabakspezifische Nitrosamine
Language	German
Document type	Article
DOI	10.4126/FRL01-006455556
Database	Repository for Life Sciences

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Article: Tobacco‐specific nitrosamines – Determination of N‐nitrosoanabasine, N‐nitrosoanatabine, N‐nitrosonornicotine and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol in urine by LC‐MS/MS : Biomonitoring methods, 2019

The MAK collection for occupational health and safety, 4(4):2416-2441

2019

Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and validated the presented biomonitoring method. This analytical method ... ...

Institution	Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
Abstract	The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and validated the presented biomonitoring method. This analytical method permits the determination of tobacco‐specific nitrosamines (TSNA) in urine using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). The parameters in question are N‐nitrosoanabasine (NAB), N‐nitrosoanatabine (NAT), N‐nitrosonornicotine (NNN) and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL). NNAL is a metabolite of 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK). Due to its sensitivity, this method is suitable for the detection of the aforementioned analytes in the urine of smokers. NNAL can also be quantified in the urine of passive smokers. The analytes NAB, NAT, NNN and NNAL are present in urine in both free and glucuronidated forms. For the determination of the total TSNA level in urine, the glucuronides are cleaved by enzymatic hydrolysis and then the analytes are isolated and concentrated using solid phase extraction (SPE). Two sorbent materials are used for sample preparation via SPE, first a material based on molecularly imprinted polymers and then a mixed‐mode cation exchange polymer. Analysis is performed by LC‐MS/MS. Deuterated internal standards are used for calibration. Calibration standards are prepared in pooled urine obtained from non‐smokers and are processed in the same way as the samples to be analysed.
Keywords	4-(methylnitrosamino)-1-(3 pyridyl)-1-butanol ; 4-(methylnitrosamino)-1-(3 pyridyl)-1-butanone ; Analyses in Biological Materials ; Biomonitoring-Methoden ; Biomonitoring Methods ; LC-MS/MS ; N-nitrosoanabasine ; N-nitrosoanatabine ; N-nitrosonornicotine ; NNAL ; NNK ; NNN ; NAB ; NAT ; TSNA ; biomonitoring ; liquid chromatography-tandem mass spectrometry ; tobacco-specific nitrosamines ; urine
Language	English
Document type	Article
DOI	10.4126/FRL01-006455558
Database	Repository for Life Sciences

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Article: Comparison of Two NIRS Tissue Oximeters (Moxy and Nimo) for Non-Invasive Assessment of Muscle Oxygenation and Perfusion.

Scholkmann, Felix / Scherer-Vrana, Andrea

Advances in experimental medicine and biology

2019 Volume 1232, Page(s) 253–259

Abstract: Background: Near-infrared spectroscopy (NIRS) tissue oximeters enable non-invasive measurement of muscle oxygenation and perfusion. Several NIRS oximeters are currently available, particularly for muscle measurements.: Aim: To evaluate the agreement ... ...

Abstract	Background: Near-infrared spectroscopy (NIRS) tissue oximeters enable non-invasive measurement of muscle oxygenation and perfusion. Several NIRS oximeters are currently available, particularly for muscle measurements. Aim: To evaluate the agreement of oxygenation and perfusion measurements obtained by two devices (Moxy, Fortiori Designs LLC, USA, and Nimo, Nirox, Italy) during an arterial occlusion test on the arm. Subject and methods: Arterial occlusions were conducted at the arm of one individual for 10 min with 200 mmHg. Measurements were made twice a day on five different days. Both NIRS devices were fixed at the arm (covering the muscles extensor carpi ulnaris, extensor digitorum, and flexor carpi ulnaris). Results: The experiment revealed that i) both devices could detect changes in muscle oxygenation and perfusion during the occlusion, but ii) the magnitudes and dynamic changes differed between the two devices. Discussion and conclusion: Both devices had different performances with regard to the measurement of tissue oxygenation and perfusion. This study shows that it might be worthwhile to compare all NIRS tissue oximeters currently available for muscle measurement in a large systematic study to increase the comparability of measurements obtained with different devices.
MeSH term(s)	Adult ; Humans ; Italy ; Male ; Muscle, Skeletal/metabolism ; Oximetry/instrumentation ; Oximetry/standards ; Oxygen/metabolism ; Oxygen Consumption ; Spectroscopy, Near-Infrared
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-11-04
Publishing country	United States
Document type	Comparative Study ; Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-34461-0_32
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