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  1. Article ; Online: The Brief Case: the Boy Who Cried Worm.

    Nguyen, David C / Desai, Ankita P / Cherian, Sree S

    Journal of clinical microbiology

    2023  Volume 61, Issue 1, Page(s) e0055322

    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00553-22
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    Zs.A 1188: Show issues Location:
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  2. Article ; Online: Fever and Syncope in a 17-year-old Girl.

    Ackerman, Aaron / Lim, Peter Paul / Desai, Ankita

    Pediatrics in review

    2023  Volume 44, Issue S1, Page(s) S3–S5

    MeSH term(s) Female ; Humans ; Adolescent ; Syncope/etiology ; Electrocardiography ; Fever
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2022-005892
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  3. Article ; Online: Clinical Utility of Flow-Cytometry for Diagnosis and Genotype Phenotype Correlation in a Cohort of X-linked Agammaglobulinemia Patients.

    Yadav, Reetika Malik / Desai, Sneha Sawant / Gupta, Maya / Dalvi, Aparna / Bargir, Umair Ahmad / Jodhawat, Neha / Setia, Priyanka / Shinde, Shweta / Parab, Ankita / Gada, Ashita / Taur, Prasad / Desai, Mukesh / Madkaikar, Manisha

    Indian journal of pediatrics

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-024-05127-9
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  4. Article ; Online: Severe COVID-19 outcomes in pediatrics

    Amit Bahl / Nicholas Mielke / Steven Johnson / Ankita Desai / Lihua Qu

    The Lancet Regional Health. Americas, Vol 18, Iss , Pp 100405- (2023)

    An observational cohort analysis comparing Alpha, Delta, and Omicron variantsResearch in context

    1480  

    Abstract: Summary: Objective: COVID-19 can rarely lead to severe illness in pediatric patients. The aim of this study was to determine if severe outcomes in pediatric COVID-19 have changed over the course of the pandemic. Methods: This was a multicenter, ... ...

    Abstract Summary: Objective: COVID-19 can rarely lead to severe illness in pediatric patients. The aim of this study was to determine if severe outcomes in pediatric COVID-19 have changed over the course of the pandemic. Methods: This was a multicenter, observational cohort analysis from a large regional healthcare system in metro Detroit using electronic health record data to evaluate emergency visits, hospitalization, and severe COVID-19 disease in pediatric patients. Consecutive pediatric patients presenting to the emergency department with a primary diagnosis of COVID-19 were included. Outcomes data was gathered from three distinct time intervals that coincided with Alpha, Delta, and Omicron variant predominance (Time interval 1 (T1) 1/1/2021–6/30/2021: Alpha, T2 7/1/2021–12/31/2021: Delta, T3 1/1/2022–6/16/2022): Omicron. The primary outcome was severe disease inclusive of composite intensive care unit admission, mechanical ventilation, multisystem inflammatory syndrome in children (MIS-C), myocarditis, or death. Secondary outcomes included severe outcomes considering viral coinfection and vaccination status. Results: Between 1/1/2021 and 6/16/2022, there were 4517 emergency COVID-19 visits, of which 12.5% (566) of children were hospitalized. 24.4% (138), 31.6% (179), and 44.0% (249) of admissions occurred during T1, T2 and T3 respectively. Most patients were male (55.1%) and 59.9% identified as Caucasian. The median age was 5.0 (interquartile range 1.0, 13.0) with infants comprising 22.8% (129), toddlers 25.1% (142), children 23.0% (130), and teenagers 29.2% (165). Over the course of the pandemic, the proportion of infants in hospitalization increased from 16.7% in T1 to 19.6% in T2 to 28.5% in T3 (p < 0.01) while the proportion of teenagers in hospitalization decreased from 39.1% in T1 to 31.3% in T2 to 22.1% in T3 (p < 0.001). Oxygen therapy was required in a minority (29.9%) of cases with supplemental oxygen utilized the least in T3 (16.5%) and most in T2 (30.2%). Composite severe disease decreased ...
    Keywords SARS-CoV-2 ; COVID-19 ; Omicron ; Delta ; Alpha ; Viral co-infection ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Inpatient allergy delabeling of pediatric patients with low-risk penicillin allergy status through direct oral amoxicillin challenge.

    Lim, Peter Paul C / Moore, LeAnne N / Minich, Nori Mercuri / Wessell, Kathryn Ruda / Desai, Ankita P

    Allergy and asthma proceedings

    2023  Volume 45, Issue 1, Page(s) 61–69

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Child ; Humans ; Amoxicillin/adverse effects ; Anti-Bacterial Agents/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Hypersensitivity ; Inpatients ; Penicillins/adverse effects ; Skin Tests
    Chemical Substances Amoxicillin (804826J2HU) ; Anti-Bacterial Agents ; Penicillins
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2024.45.230069
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  6. Article ; Online: Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.

    Desai, Meghal / Hemant / Deo, Ankita / Naik, Jagyanseni / Dhamale, Prathamesh / Kshirsagar, Avinash / Bose, Tania / Majumdar, Amitabha

    PLoS biology

    2024  Volume 22, Issue 4, Page(s) e3002585

    Abstract: Orb2 the Drosophila homolog of cytoplasmic polyadenylation element binding (CPEB) protein forms prion-like oligomers. These oligomers consist of Orb2A and Orb2B isoforms and their formation is dependent on the oligomerization of the Orb2A isoform. ... ...

    Abstract Orb2 the Drosophila homolog of cytoplasmic polyadenylation element binding (CPEB) protein forms prion-like oligomers. These oligomers consist of Orb2A and Orb2B isoforms and their formation is dependent on the oligomerization of the Orb2A isoform. Drosophila with a mutation diminishing Orb2A's prion-like oligomerization forms long-term memory but fails to maintain it over time. Since this prion-like oligomerization of Orb2A plays a crucial role in the maintenance of memory, here, we aim to find what regulates this oligomerization. In an immunoprecipitation-based screen, we identify interactors of Orb2A in the Hsp40 and Hsp70 families of proteins. Among these, we find an Hsp40 family protein Mrj as a regulator of the conversion of Orb2A to its prion-like form. Mrj interacts with Hsp70 proteins and acts as a chaperone by interfering with the aggregation of pathogenic Huntingtin. Unlike its mammalian homolog, we find Drosophila Mrj is neither an essential gene nor causes any gross neurodevelopmental defect. We observe a loss of Mrj results in a reduction in Orb2 oligomers. Further, Mrj knockout exhibits a deficit in long-term memory and our observations suggest Mrj is needed in mushroom body neurons for the regulation of long-term memory. Our work implicates a chaperone Mrj in mechanisms of memory regulation through controlling the oligomerization of Orb2A and its association with the translating ribosomes.
    MeSH term(s) Animals ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Memory, Long-Term/physiology ; HSP40 Heat-Shock Proteins/metabolism ; HSP40 Heat-Shock Proteins/genetics ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/genetics ; HSP70 Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/genetics ; Mushroom Bodies/metabolism ; mRNA Cleavage and Polyadenylation Factors/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics ; Protein Multimerization ; Transcription Factors/metabolism ; Transcription Factors/genetics
    Chemical Substances Drosophila Proteins ; Orb2 protein, Drosophila ; HSP40 Heat-Shock Proteins ; HSP70 Heat-Shock Proteins ; mRNA Cleavage and Polyadenylation Factors ; Transcription Factors
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002585
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    Zs.A 6193: Show issues Location:
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  7. Article: Correction: A Case Report of Takotsubo Cardiomyopathy With Myxedema Coma.

    Marin, Andrea C / Hechter, Sharon / Prasad, Ankita / Samad, Ayesha / Manchio, Lee / Jiang, Desai V / Okere, Arthur / Cheriyath, Pramil

    Cureus

    2023  Volume 15, Issue 3, Page(s) c105

    Abstract: This corrects the article DOI: 10.7759/cureus.32652.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.32652.].
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c105
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  8. Article: Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications.

    Dharavath, Bhasker / Butle, Ashwin / Chaudhary, Akshita / Pal, Ankita / Desai, Sanket / Chowdhury, Aniket / Thorat, Rahul / Upadhyay, Pawan / Nair, Sudhir / Dutt, Amit

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 63

    Abstract: Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes. In this study, we report the identification and functional ... ...

    Abstract Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes. In this study, we report the identification and functional characterization of UBE3C-LRP5 translocation in head and neck cancer. Our whole transcriptome sequencing and RT-PCR analysis of 151 head and neck cancer tumor samples identified the LRP5-UBE3C and UBE3C-LRP5 fusion transcripts in 5.3% of patients of Indian origin (n = 151), and UBE3C-LRP5 fusion transcripts in 1.2% of TCGA-HNSC patients (n = 502). Further, whole genome sequencing identified the breakpoint of UBE3C-LRP5 translocation. We demonstrate that UBE3C-LRP5 fusion is activating in vitro and in vivo, and promotes the proliferation, migration, and invasion of head and neck cancer cells. In contrast, depletion of UBE3C-LRP5 fusion suppresses the clonogenic, migratory, and invasive potential of the cells. The UBE3C-LRP5 fusion activates the Wnt/β-catenin signaling by promoting nuclear accumulation of β-catenin, leading to upregulation of Wnt/β-catenin target genes, MYC, CCND1, TCF4, and LEF1. Consistently, treatment with the FDA-approved drug, pyrvinium pamoate, significantly reduced the transforming ability of cells expressing the fusion protein and improved survival in mice bearing tumors of fusion-overexpressing cells. Interestingly, fusion-expressing cells upon knockdown of CTNNB1, or LEF1 show reduced proliferation, clonogenic abilities, and reduced sensitivity to pyrvinium pamoate. Overall, our study suggests that the UBE3C-LRP5 fusion is a promising therapeutic target for head and neck cancer and that pyrvinium pamoate may be a potential drug candidate for treating head and neck cancer harboring this translocation.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00555-4
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  9. Article ; Online: Oral field cancerization: A critical appraisal.

    Desai, Rajiv S / Shirsat, Pankaj M / Bansal, Shivani / Prasad, Pooja / Satish Arvandekar, Ankita

    Oral oncology

    2021  Volume 118, Page(s) 105304

    MeSH term(s) Carcinoma, Squamous Cell ; Humans ; Mouth Neoplasms
    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2021.105304
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    Zs.A 4869: Show issues Location:
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  10. Article: Rushton bodies.

    Sattar, Shumail / Arvandekar, Ankita / Jena, Abinashi / Desai, Rajiv S

    Journal of oral and maxillofacial pathology : JOMFP

    2021  Volume 24, Issue 3, Page(s) 572–574

    Abstract: Rushton bodies (RBs) are hyaline bodies found in epithelial lining of the odontogenic cysts that appear as peculiar, eosinophilic, straight or curved, irregular or rounded, polycyclic glassy structures occurring with variable frequency in the epithelial ... ...

    Abstract Rushton bodies (RBs) are hyaline bodies found in epithelial lining of the odontogenic cysts that appear as peculiar, eosinophilic, straight or curved, irregular or rounded, polycyclic glassy structures occurring with variable frequency in the epithelial lining of odontogenic cysts. This article depicts the various shapes and amusing staining properties of RBs along with a brief cognizance about their much-debated origin.
    Language English
    Publishing date 2021-01-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.jomfp_427_20
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