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  1. Article ; Online: Item Response Theory Analysis: PROMIS® Anxiety Form and Generalized Anxiety Disorder Scale.

    Liu, Wen / Dindo, Lilian / Hadlandsmyth, Katherine / Unick, George Jay / Zimmerman, M Bridget / St Marie, Barbara / Embree, Jennie / Tripp-Reimer, Toni / Rakel, Barbara

    Western journal of nursing research

    2021  Volume 44, Issue 8, Page(s) 765–772

    Abstract: Little research has compared item functioning of the Patient-Reported Outcomes Measurement Information System ( ... ...

    Abstract Little research has compared item functioning of the Patient-Reported Outcomes Measurement Information System (PROMIS
    MeSH term(s) Anxiety/diagnosis ; Anxiety Disorders/diagnosis ; Humans ; Patient Health Questionnaire ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Self Report ; Surveys and Questionnaires
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632788-6
    ISSN 1552-8456 ; 0193-9459
    ISSN (online) 1552-8456
    ISSN 0193-9459
    DOI 10.1177/01939459211015985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial.

    Lambert, Jennifer E / Parnell, Jill A / Tunnicliffe, Jasmine M / Han, Jay / Sturzenegger, Troy / Reimer, Raylene A

    Clinical nutrition (Edinburgh, Scotland)

    2016  Volume 36, Issue 1, Page(s) 126–133

    Abstract: ... obese adults.: Methods: Participants (9 M/41 F; age 44 ± 15 y, BMI 32.9 ± 5.9 kg/m: Results ...

    Abstract Background & aims: The purpose of this randomized, double-blind, placebo-controlled study was to assess the effects of yellow pea fiber intake on body composition and metabolic markers in overweight/obese adults.
    Methods: Participants (9 M/41 F; age 44 ± 15 y, BMI 32.9 ± 5.9 kg/m
    Results: The PF group lost 0.87 ± 0.37 kg of body weight, primarily due to body fat (-0.74 ± 0.26 kg), whereas PL subjects gained 0.40 ± 0.39 kg of weight over the 12 weeks (P = 0.022). The PF group consumed 16% less energy at the follow-up lunch buffet (P = 0.026), whereas the PL group did not change. During the OGTT, glucose area under the curve (AUC) was lower in PF subjects at follow-up (P = 0.029); insulin increased in both groups over time (P = 0.008), but more so in the PL group (38% higher AUC vs. 10% higher in the PF group). There were no differences in gut microbiota between groups.
    Conclusions: In the absence of other lifestyle changes, incorporating 15 g/day yellow pea fiber may yield small but significant metabolic benefits and aid in obesity management. Clinical Trial Registry: ClinicalTrials.gov NCT01719900.
    MeSH term(s) Adiposity ; Adolescent ; Adult ; Aged ; Blood Glucose/metabolism ; Body Composition ; Body Mass Index ; Body Weight ; Diet ; Dietary Fiber/administration & dosage ; Double-Blind Method ; Energy Intake ; Female ; Follow-Up Studies ; Gastrointestinal Microbiome ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Male ; Middle Aged ; Obesity/diet therapy ; Overweight/diet therapy ; Pisum sativum/chemistry ; Young Adult
    Chemical Substances Blood Glucose ; Dietary Fiber ; Insulin
    Language English
    Publishing date 2016-01-11
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2015.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes

    Reimer, Jay M / Syedain, Zeeshan H / Haynie, Bee H.T / Tranquillo, Robert T

    Biomaterials. 2015 Sept., v. 62

    2015  

    Abstract: Pediatric patients account for a small portion of the heart valve replacements performed, but a pediatric pulmonary valve replacement with growth potential remains an unmet clinical need. Herein we report the first tubular heart valve made from two ... ...

    Abstract Pediatric patients account for a small portion of the heart valve replacements performed, but a pediatric pulmonary valve replacement with growth potential remains an unmet clinical need. Herein we report the first tubular heart valve made from two decellularized, engineered tissue tubes attached with absorbable sutures, which can meet this need, in principle. Engineered tissue tubes were fabricated by allowing ovine dermal fibroblasts to replace a sacrificial fibrin gel with an aligned, cell-produced collagenous matrix, which was subsequently decellularized. Previously, these engineered tubes became extensively recellularized following implantation into the sheep femoral artery. Thus, a tubular valve made from these tubes may be amenable to recellularization and, ideally, somatic growth.The suture line pattern generated three equi-spaced leaflets in the inner tube, which collapsed inward when exposed to back pressure, per tubular valve design. Valve testing was performed in a pulse duplicator system equipped with a secondary flow loop to allow for root distention. All tissue-engineered valves exhibited full leaflet opening and closing, minimal regurgitation (<5%), and low systolic pressure gradients (<2.5 mmHg) under pulmonary conditions. Valve performance was maintained under various trans-root pressure gradients and no tissue damage was evident after 2 million cycles of fatigue testing.
    Keywords fibrin ; fibroblasts ; gels ; patients ; sheep ; sutures ; tissue engineering ; covid19
    Language English
    Dates of publication 2015-09
    Size p. 88-94.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2015.05.009
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Tubular heart valves from decellularized engineered tissue.

    Syedain, Zeeshan H / Meier, Lee A / Reimer, Jay M / Tranquillo, Robert T

    Annals of biomedical engineering

    2013  Volume 41, Issue 12, Page(s) 2645–2654

    Abstract: A novel tissue-engineered heart valve (TEHV) was fabricated from a decellularized tissue tube mounted on a frame with three struts, which upon back-pressure cause the tube to collapse into three coapting "leaflets." The tissue was completely biological, ... ...

    Abstract A novel tissue-engineered heart valve (TEHV) was fabricated from a decellularized tissue tube mounted on a frame with three struts, which upon back-pressure cause the tube to collapse into three coapting "leaflets." The tissue was completely biological, fabricated from ovine fibroblasts dispersed within a fibrin gel, compacted into a circumferentially aligned tube on a mandrel, and matured using a bioreactor system that applied cyclic distension. Following decellularization, the resulting tissue possessed tensile mechanical properties, mechanical anisotropy, and collagen content that were comparable to native pulmonary valve leaflets. When mounted on a custom frame and tested within a pulse duplicator system, the tubular TEHV displayed excellent function under both aortic and pulmonary conditions, with minimal regurgitant fractions and transvalvular pressure gradients at peak systole, as well as well as effective orifice areas exceeding those of current commercially available valve replacements. Short-term fatigue testing of one million cycles with pulmonary pressure gradients was conducted without significant change in mechanical properties and no observable macroscopic tissue deterioration. This study presents an attractive potential alternative to current tissue valve replacements due to its avoidance of chemical fixation and utilization of a tissue conducive to recellularization by host cell infiltration.
    MeSH term(s) Animals ; Heart Valves/physiology ; Sheep ; Stress, Mechanical ; Tensile Strength ; Tissue Engineering
    Language English
    Publishing date 2013-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-013-0872-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes.

    Reimer, Jay M / Syedain, Zeeshan H / Haynie, Bee H T / Tranquillo, Robert T

    Biomaterials

    2015  Volume 62, Page(s) 88–94

    Abstract: Pediatric patients account for a small portion of the heart valve replacements performed, but a pediatric pulmonary valve replacement with growth potential remains an unmet clinical need. Herein we report the first tubular heart valve made from two ... ...

    Abstract Pediatric patients account for a small portion of the heart valve replacements performed, but a pediatric pulmonary valve replacement with growth potential remains an unmet clinical need. Herein we report the first tubular heart valve made from two decellularized, engineered tissue tubes attached with absorbable sutures, which can meet this need, in principle. Engineered tissue tubes were fabricated by allowing ovine dermal fibroblasts to replace a sacrificial fibrin gel with an aligned, cell-produced collagenous matrix, which was subsequently decellularized. Previously, these engineered tubes became extensively recellularized following implantation into the sheep femoral artery. Thus, a tubular valve made from these tubes may be amenable to recellularization and, ideally, somatic growth. The suture line pattern generated three equi-spaced leaflets in the inner tube, which collapsed inward when exposed to back pressure, per tubular valve design. Valve testing was performed in a pulse duplicator system equipped with a secondary flow loop to allow for root distention. All tissue-engineered valves exhibited full leaflet opening and closing, minimal regurgitation (<5%), and low systolic pressure gradients (<2.5 mmHg) under pulmonary conditions. Valve performance was maintained under various trans-root pressure gradients and no tissue damage was evident after 2 million cycles of fatigue testing.
    MeSH term(s) Animals ; Bioprosthesis ; Cell-Free System ; Cells, Cultured ; Equipment Failure Analysis ; Fibroblasts/transplantation ; Heart Valve Prosthesis ; Prosthesis Design ; Pulmonary Valve/cytology ; Pulmonary Valve/growth & development ; Sheep ; Tissue Engineering/methods
    Keywords covid19
    Language English
    Publishing date 2015-05-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2015.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial

    Lambert, Jennifer E / Jill A. Parnell / Jasmine M. Tunnicliffe / Jay Han / Troy Sturzenegger / Raylene A. Reimer

    Clinical nutrition. 2017 Feb., v. 36

    2017  

    Abstract: ... 9 M/41 F; age 44 ± 15 y, BMI 32.9 ± 5.9 kg/m2) received isocaloric doses of placebo (PL) or ...

    Abstract The purpose of this randomized, double-blind, placebo-controlled study was to assess the effects of yellow pea fiber intake on body composition and metabolic markers in overweight/obese adults.Participants (9 M/41 F; age 44 ± 15 y, BMI 32.9 ± 5.9 kg/m2) received isocaloric doses of placebo (PL) or pea fiber (PF; 15 g/d) wafers for 12 weeks. Outcome measures included changes in anthropometrics, body composition (DXA), oral glucose tolerance test (OGTT), food intake (ad libitum lunch buffet), and biochemical indices.The PF group lost 0.87 ± 0.37 kg of body weight, primarily due to body fat (−0.74 ± 0.26 kg), whereas PL subjects gained 0.40 ± 0.39 kg of weight over the 12 weeks (P = 0.022). The PF group consumed 16% less energy at the follow-up lunch buffet (P = 0.026), whereas the PL group did not change. During the OGTT, glucose area under the curve (AUC) was lower in PF subjects at follow-up (P = 0.029); insulin increased in both groups over time (P = 0.008), but more so in the PL group (38% higher AUC vs. 10% higher in the PF group). There were no differences in gut microbiota between groups.In the absence of other lifestyle changes, incorporating 15 g/day yellow pea fiber may yield small but significant metabolic benefits and aid in obesity management.Clinical Trial Registry: ClinicalTrials.gov NCT01719900.
    Keywords adults ; body fat ; body mass index ; dual-energy X-ray absorptiometry ; energy intake ; food intake ; glucose ; glucose tolerance tests ; insulin ; intestinal microorganisms ; lifestyle ; lunch ; obesity ; peas ; placebos ; randomized clinical trials ; wafers
    Language English
    Dates of publication 2017-02
    Size p. 126-133.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2015.12.016
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity.

    Mayengbam, Shyamchand / Lambert, Jennifer E / Parnell, Jill A / Tunnicliffe, Jasmine M / Nicolucci, Alissa C / Han, Jay / Sturzenegger, Troy / Shearer, Jane / Mickiewicz, Beata / Vogel, Hans J / Madsen, Karen L / Reimer, Raylene A

    The Journal of nutritional biochemistry

    2018  Volume 64, Page(s) 228–236

    Abstract: Low dietary fiber intake is associated with higher rates of microbiota-associated chronic diseases such as obesity. Low-fiber diets alter not only microbial composition but also the availability of metabolic end products derived from fermentation of ... ...

    Abstract Low dietary fiber intake is associated with higher rates of microbiota-associated chronic diseases such as obesity. Low-fiber diets alter not only microbial composition but also the availability of metabolic end products derived from fermentation of fiber. Our objective was to examine the effects of dietary fiber supplementation on gut microbiota and associated fecal and serum metabolites in relation to metabolic markers of obesity. We conducted a 12-week, single-center, double-blind, placebo-controlled trial with 53 adults with overweight or obesity. They were randomly assigned to a pea fiber (PF, 15 g/d in wafer form; n=29) or control (CO, isocaloric amount of wafers; n=24) group. Blood and fecal samples were collected at baseline and 12 weeks. Serum metabolomics, gut microbiota and fecal short-chain fatty acids (SCFAs) and bile acids (BAs) were examined. Within-group but not between-group analysis showed a significant effect of treatment on serum metabolites at 12 weeks compared to baseline. Fiber significantly altered fecal SCFAs and BAs with higher acetate and reduced isovalerate, cholate, deoxycholate and total BAs content in the PF group compared to baseline. Microbiota was differentially modulated in the two groups, including an increase in the SCFA producer Lachnospira in the PF group and decrease in the CO group. The change in body weight of participants showed a negative correlation with their change in Lachnospira (r=-0.463, P=.006) abundance. The current study provides insight into the actions of pea fiber and its impact on modulating microbiota-host-metabolic axes in obesity.
    MeSH term(s) Adolescent ; Adult ; Aged ; Bile Acids and Salts/metabolism ; Dietary Fiber/pharmacology ; Dietary Supplements ; Fatty Acids, Volatile/metabolism ; Feces/chemistry ; Gastrointestinal Microbiome/drug effects ; Humans ; Middle Aged ; Obesity/diet therapy ; Obesity/metabolism ; Obesity/microbiology ; Pisum sativum/chemistry ; Tandem Mass Spectrometry ; Young Adult
    Chemical Substances Bile Acids and Salts ; Dietary Fiber ; Fatty Acids, Volatile
    Language English
    Publishing date 2018-11-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2018.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acidification in the U.S. Southeast: Causes, Potential Consequences and the Role of the Southeast Ocean and Coastal Acidification Network.

    Hall, Emily R / Wickes, Leslie / Burnett, Louis E / Scott, Geoffrey I / Hernandez, Debra / Yates, Kimberly K / Barbero, Leticia / Reimer, Janet J / Baalousha, Mohammed / Mintz, Jennifer / Cai, Wei-Jun / Craig, J Kevin / DeVoe, M Richard / Fisher, William S / Hathaway, Terri K / Jewett, Elizabeth B / Johnson, Zackary / Keener, Paula / Mordecai, Rua S /
    Noakes, Scott / Phillips, Charlie / Sandifer, Paul A / Schnetzer, Astrid / Styron, Jay

    Frontiers in Marine Science

    2020  Volume 7, Page(s) 1–548

    Abstract: Coastal acidification in southeastern U.S. estuaries and coastal waters is influenced by biological activity, run-off from the land, and increasing carbon dioxide in the atmosphere. Acidification can negatively impact coastal resources such as shellfish, ...

    Abstract Coastal acidification in southeastern U.S. estuaries and coastal waters is influenced by biological activity, run-off from the land, and increasing carbon dioxide in the atmosphere. Acidification can negatively impact coastal resources such as shellfish, finfish, and coral reefs, and the communities that rely on them. Organismal responses for species located in the U.S. Southeast document large negative impacts of acidification, especially in larval stages. For example, the toxicity of pesticides increases under acidified conditions and the combination of acidification and low oxygen has profoundly negative influences on genes regulating oxygen consumption. In corals, the rate of calcification decreases with acidification and processes such as wound recovery, reproduction, and recruitment are negatively impacted. Minimizing the changes in global ocean chemistry will ultimately depend on the reduction of carbon dioxide emissions, but adaptation to these changes and mitigation of the local stressors that exacerbate global acidification can be addressed locally. The evolution of our knowledge of acidification, from basic understanding of the problem to the emergence of applied research and monitoring, has been facilitated by the development of regional Coastal Acidification Networks (CANs) across the United States. This synthesis is a product of the Southeast Coastal and Ocean Acidification Network (SOCAN). SOCAN was established to better understand acidification in the coastal waters of the U.S. Southeast and to foster communication among scientists, resource managers, businesses, and governments in the region. Here we review acidification issues in the U.S. Southeast, including the regional mechanisms of acidification and their potential impacts on biological resources and coastal communities. We recommend research and monitoring priorities and discuss the role SOCAN has in advancing acidification research and mitigation of and adaptation to these changes.
    Language English
    Publishing date 2020-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2757748-X
    ISSN 2296-7745
    ISSN 2296-7745
    DOI 10.3389/fmars.2020.00548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A clinically relevant model of acute respiratory distress syndrome in human-size swine.

    Kaslow, Sarah R / Reimer, Jonathan A / Pinezich, Meghan R / Hudock, Maria R / Chen, Panpan / Morris, Mariya G / Kain, Mandy L / Leb, Jay S / Ruzal-Shapiro, Carrie B / Marboe, Charles C / Bacchetta, Matthew / Dorrello, N Valerio / Vunjak-Novakovic, Gordana

    Disease models & mechanisms

    2022  Volume 15, Issue 10

    Abstract: Despite over 30 years of intensive research for targeted therapies, treatment of acute respiratory distress syndrome (ARDS) remains supportive in nature. With mortality upwards of 30%, a high-fidelity pre-clinical model of ARDS, on which to test novel ... ...

    Abstract Despite over 30 years of intensive research for targeted therapies, treatment of acute respiratory distress syndrome (ARDS) remains supportive in nature. With mortality upwards of 30%, a high-fidelity pre-clinical model of ARDS, on which to test novel therapeutics, is urgently needed. We used the Yorkshire breed of swine to induce a reproducible model of ARDS in human-sized swine to allow the study of new therapeutics, from both mechanistic and clinical standpoints. For this, animals were anesthetized, intubated and mechanically ventilated, and pH-standardized gastric contents were delivered bronchoscopically, followed by intravenous infusion of Escherichia coli-derived lipopolysaccharide. Once the ratio of arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FIO2) had decreased to <150, the animals received standard ARDS treatment for up to 48 h. All swine developed moderate to severe ARDS. Chest radiographs taken at regular intervals showed significantly worse lung edema after induction of ARDS. Quantitative scoring of lung injury demonstrated time-dependent increases in interstitial and alveolar edema, neutrophil infiltration, and mild to moderate alveolar membrane thickening. This pre-clinical model of ARDS in human-sized swine recapitulates the clinical, radiographic and histopathologic manifestations of ARDS, providing a tool to study therapies for this highly morbid lung disease.
    MeSH term(s) Animals ; Humans ; Lipopolysaccharides/pharmacology ; Lung Injury ; Oxygen ; Respiratory Distress Syndrome ; Swine
    Chemical Substances Lipopolysaccharides ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-10-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reduced knee adduction moments for management of knee osteoarthritis:: A three month phase I/II randomized controlled trial.

    Lewinson, Ryan T / Vallerand, Isabelle A / Collins, Kelsey H / Wiley, J Preston / Lun, Victor M Y / Patel, Chirag / Woodhouse, Linda J / Reimer, Raylene A / Worobets, Jay T / Herzog, Walter / Stefanyshyn, Darren J

    Gait & posture

    2016  Volume 50, Page(s) 60–68

    Abstract: Wedged insoles are believed to be of clinical benefit to individuals with knee osteoarthritis by reducing the knee adduction moment (KAM) during gait. However, previous clinical trials have not specifically controlled for KAM reduction at baseline, thus ... ...

    Abstract Wedged insoles are believed to be of clinical benefit to individuals with knee osteoarthritis by reducing the knee adduction moment (KAM) during gait. However, previous clinical trials have not specifically controlled for KAM reduction at baseline, thus it is unknown if reduced KAMs actually confer a clinical benefit. Forty-eight participants with medial knee osteoarthritis were randomly assigned to either a control group where no footwear intervention was given, or a wedged insole group where KAM reduction was confirmed at baseline. KAMs, Knee Injury and Osteoarthritis Outcome Score (KOOS) and Physical Activity Scale for the Elderly (PASE) scores were measured at baseline. KOOS and PASE surveys were re-administered at three months follow-up. The wedged insole group did not experience a statistically significant or clinically meaningful change in KOOS pain over three months (p=0.173). Furthermore, there was no association between change in KAM magnitude and change in KOOS pain over three months within the wedged insole group (R
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1162323-8
    ISSN 1879-2219 ; 0966-6362
    ISSN (online) 1879-2219
    ISSN 0966-6362
    DOI 10.1016/j.gaitpost.2016.08.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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