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  1. Article: DGAKI-Ehrenmedaille für Prof. Dr. Erwin W. Gelfand

    Gelfand, Erwin W.

    Allergo-Journal

    2013  Volume 22, Issue 7, Page(s) 513

    Language German
    Document type Article
    ZDB-ID 1136943-7
    ISSN 0941-8849
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
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  2. Article ; Online: Gene editing in allergic diseases: Identification of novel pathways and impact of deleting allergen genes.

    Wang, Meiqin / Schedel, Michaela / Gelfand, Erwin W

    The Journal of allergy and clinical immunology

    2024  

    Abstract: Gene editing technology has emerged as a powerful tool in all aspects of health research and continues to advance our understanding of critical and essential elements in disease pathophysiology. The clustered regularly interspaced short palindromic ... ...

    Abstract Gene editing technology has emerged as a powerful tool in all aspects of health research and continues to advance our understanding of critical and essential elements in disease pathophysiology. The clustered regularly interspaced short palindromic repeats (CRISPR) gene editing technology has been used with precision to generate gene knockouts, alter genes, and identify genes that cause disease. The full spectrum of allergic/atopic diseases, in part because of shared pathophysiology, is ripe for studies with this technology. In this way, novel culprit genes are being identified and allow for manipulation of triggering allergens to reduce allergenicity and disease. Notwithstanding current limitations on precision and potential off-target effects, newer approaches are rapidly being introduced to more fully understand specific gene functions as well as the consequences of genetic manipulation. In this review, we examine the impact of editing technologies of novel genes relevant to peanut allergy and asthma as well as how gene modification of common allergens may lead to the deletion of allergenic proteins.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Registries are shaping how we think about primary immunodeficiency diseases.

    Abbott, Jordan K / Gelfand, Erwin W

    The Journal of allergy and clinical immunology

    2022  Volume 149, Issue 6, Page(s) 1943–1945

    MeSH term(s) Genetic Diseases, Inborn ; Humans ; Primary Immunodeficiency Diseases ; Registries
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Anti-allergic properties of antihistamines

    Gelfand, Erwin W.

    presented at the international consensus meeting, New Orleans, Louisiana, March 14 - 15, 2001

    (The journal of allergy and clinical immunology ; 112,4, Suppl.)

    2003  

    Author's details guest ed. Erwin W. Gelfand
    Series title The journal of allergy and clinical immunology ; 112,4, Suppl.
    Collection
    Language English
    Size 4A S., S. S41 - S100 : Ill., graph. Darst.
    Publisher Mosby
    Publishing place St. Louis, Mo
    Publishing country United States
    Document type Book
    HBZ-ID HT013830011
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Uh III Zs 92 -112,4,Suppl.- verfügbar in Königswinter Königswinter

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  5. Book ; Conference proceedings: Asthma clinical trials vs real world effectiveness: comparing apples to oranges

    Gelfand, Erwin W.

    [symposium at the 60th anniversary AAAAI annual meeting in Denver, Colorado in March 2003]

    (The journal of allergy and clinical immunology ; 112,5, Suppl.)

    2003  

    Author's details guest ed. Erwin W. Gelfand
    Series title The journal of allergy and clinical immunology ; 112,5, Suppl.
    Collection
    Language English
    Size 3A S., S. S101 - S115 : graph. Darst.
    Publisher Mosby
    Publishing place St. Louis, Mo
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013861106
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Uh III Zs 92 -112,5,Suppl.- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma.

    Gelfand, Erwin W

    Seminars in immunology

    2017  Volume 33, Page(s) 44–51

    Abstract: For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from asthmatics or ... ...

    Abstract For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from asthmatics or experimental animals adds support to this notion. However, targeting of the leukotriene pathways has had, in general, limited success. The single exception in asthma therapy has been targeting of the cysteinyl leukotriene receptor 1, which clinically has proven effective but only in certain clinical situations. Interference with 5-lipoxygenase has had limited success, in part due to adverse drug effects. The importance of the LTB4-BLT1 pathway in asthma pathogenesis has extensive experimental support and findings, albeit limited, from clinical samples. The LTB4-BLT1 pathway was shown to be important as a neutrophil chemoattractant. Despite observations made more than two decades ago, the LTB4-BLT1 pathway has only recently been shown to exhibit important activities on subsets of T lymphocytes, both as a chemoattractant and on lymphocyte activation, as well as on dendritic cells, the major antigen presenting cell in the lung. The role of BLT2 in asthma remains unclear. Targeting of components of the LTB4-BLT1 pathway offers innovative therapeutic opportunities especially in patients with asthma that remain uncontrolled despite intensive corticosteroid treatment.
    MeSH term(s) Animals ; Asthma/immunology ; Chemotaxis ; Dendritic Cells/immunology ; Humans ; Leukotriene B4/metabolism ; Lymphocyte Activation ; Neutrophils/immunology ; Receptors, Leukotriene B4/metabolism ; Signal Transduction ; T-Lymphocytes/immunology
    Chemical Substances LTB4R protein, human ; LTB4R2 protein, human ; Receptors, Leukotriene B4 ; Leukotriene B4 (1HGW4DR56D)
    Language English
    Publishing date 2017-10-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2017.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2843: Show issues Location:
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  7. Article ; Online: Confronting the Challenges of Severe Asthma.

    Gelfand, Erwin W / Wechsler, Michael E

    The Journal of family practice

    2019  Volume 67, Issue 10 Suppl, Page(s) S19–S26

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Asthma/physiopathology ; Asthma/therapy ; Disease Management ; Health Education/standards ; Humans ; Patient Education as Topic/standards ; Quality of Health Care ; Severity of Illness Index ; United States
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197883-4
    ISSN 1533-7294 ; 0094-3509
    ISSN (online) 1533-7294
    ISSN 0094-3509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 444: Show issues

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  8. Article ; Online: Molecular Endotypes Contribute to the Heterogeneity of Asthma.

    Gelfand, Erwin W / Schedel, Michaela

    Immunology and allergy clinics of North America

    2018  Volume 38, Issue 4, Page(s) 655–665

    Abstract: Diagnosis and management of asthma is commonly implemented based on clinical assessment. Although these nonmolecular biomarkers have been useful, limited resolution of the heterogeneity among asthmatic patients and little information regarding the ... ...

    Abstract Diagnosis and management of asthma is commonly implemented based on clinical assessment. Although these nonmolecular biomarkers have been useful, limited resolution of the heterogeneity among asthmatic patients and little information regarding the underlying pathobiology of disease in individuals have been provided. Molecular endotying using global transcriptome expression profiling associated with clinical features of asthma has improved our understanding of disease mechanisms, risk assessment of asthma exacerbations, and treatment responses, especially in patients with type 2 inflammation. Further advances in establishing pathobiological subgroups, bioactive pathways, and true disease endotypes hold potential for a more personalized medical approach in asthmatic patients.
    MeSH term(s) Asthma/genetics ; Asthma/immunology ; Humans ; Phenotype ; Sputum/immunology ; Transcriptome/genetics ; Transcriptome/immunology
    Language English
    Publishing date 2018-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2018.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Plasticity of Naturally Occurring Regulatory T Cells in Allergic Airway Disease Is Modulated by the Transcriptional Activity of

    MacBeth, Morgan / Joetham, Anthony / Gelfand, Erwin W / Schedel, Michaela

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: The impact of naturally occurring regulatory T cells (nTregs) on the suppression or induction of lung allergic responses in mice depends on the nuclear environment and the production of the pro-inflammatory cytokine interleukin 6 (IL-6). These activities ...

    Abstract The impact of naturally occurring regulatory T cells (nTregs) on the suppression or induction of lung allergic responses in mice depends on the nuclear environment and the production of the pro-inflammatory cytokine interleukin 6 (IL-6). These activities were shown to be different in nTregs derived from wild-type (WT) and CD8-deficient mice (CD8
    MeSH term(s) Adaptation, Physiological/immunology ; Animals ; Cell Plasticity/genetics ; Cell Plasticity/immunology ; Cytokines/immunology ; Hypersensitivity/immunology ; Interleukin-10/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Lung Diseases/genetics ; Lung Diseases/immunology ; Lung Diseases/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/immunology ; Promoter Regions, Genetic ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cytokines ; Interleukin-6 ; NF-kappa B ; Tumor Necrosis Factor-alpha ; interleukin-6, mouse ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intravenous immune globulin in autoimmune and inflammatory diseases.

    Gelfand, Erwin W

    The New England journal of medicine

    2013  Volume 368, Issue 8, Page(s) 777

    MeSH term(s) Autoimmune Diseases/drug therapy ; Humans ; Immunoglobulin G/physiology ; Immunoglobulins, Intravenous/therapeutic use ; Skin Diseases, Vesiculobullous/drug therapy
    Chemical Substances Immunoglobulin G ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2013-02-21
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1215489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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