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Article ; Online: Seismology: Japan must admit it can't predict quakes.

Geller, Robert J

2017 Volume 545, Issue 7654, Page(s) 289

MeSH term(s)	Earthquakes ; Forecasting ; Humans ; Japan
Language	English
Publishing date	2017--17
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/545289c
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Article ; Online: Calculated parameters of luminal esophageal temperatures predict esophageal injury following conventional and high-power short-duration radiofrequency pulmonary vein isolation.

Grosse Meininghaus, Dirk / Freund, Robert / Kleemann, Tobias / Christoph Geller, J

Journal of cardiovascular electrophysiology

2022 Volume 33, Issue 6, Page(s) 1167–1176

Abstract: Background: Luminal esophageal temperature (LET) monitoring is not associated with reduced esophageal injury following pulmonary vein isolation (PVI).: Objective: Detailed analysis of (the temporal and spatial gradients of) LET measurements may ... ...

Abstract	Background: Luminal esophageal temperature (LET) monitoring is not associated with reduced esophageal injury following pulmonary vein isolation (PVI). Objective: Detailed analysis of (the temporal and spatial gradients of) LET measurements may better predict the risk for esophageal injury. Methods: Between January 2020 and December 2021, LET maxima, duration of LET rise above baseline, and area under the LET curve (AUC) were calculated offline and correlated with (endoscopy and endoscopic ultrasound detected) esophageal injury (i.e., mucosal esophageal lesions [ELs], periesophageal edema, and gastric motility disorders) following PVI using moderate-power moderate-duration (MPMD [25-30 W/25-30s]) and high-power short-duration (HPSD [50 W/13s]) radiofrequency (RF) settings. Results: 63 patients (69 ± 9 years old, 32 male, 51 MPMD and 12 HPSD) were studied. The esophageal injury was frequent (40% in both groups), mucosal ELs were more common with MPMD, and edema was frequently observed following HPSD. RF-duration, total RF-energy at the left atrial (LA) posterior wall, and distance between LA and esophagus were not different between patients with/without esophageal injury. In contrast, to LET and LET duration above baseline, AUC was the best predictor and significantly increased in patients with esophageal injury (3422 vs. 2444 K Conclusion: For both ablation strategies, AUC of the LET curves best predicted esophageal injury. HPSD is associated with similar rates of esophageal injury when (mostly subclinical) periesophageal alterations (that are of unclear clinical relevance) are included. Whether integration of these calculated LET parameters is useful to prevent esophageal injury remains to be seen.
MeSH term(s)	Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Body Temperature ; Catheter Ablation/adverse effects ; Humans ; Male ; Middle Aged ; Pulmonary Veins/surgery ; Temperature ; Treatment Outcome
Language	English
Publishing date	2022-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.15509
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Article: Asymptomatic esophageal perforation following high-power short-duration pulmonary vein isolation-A case of conservative cure.

Grosse Meininghaus, Dirk / Freund, Robert / Kushnir, Anton / Koerber, Britta / Geller, J Christoph / Kleemann, Tobias

HeartRhythm case reports

2022 Volume 8, Issue 10, Page(s) 661–665

Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2022.07.005
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Article ; Online: Prevention of Unintentional Medication Overdose Among Children: Time for the Promise of the Poison Prevention Packaging Act to Come to Fruition.

Budnitz, Daniel S / Lovegrove, Maribeth C / Geller, Robert J

JAMA

2020 Volume 324, Issue 6, Page(s) 550–551

MeSH term(s)	Child ; Drug Overdose/prevention & control ; Drug Packaging/legislation & jurisprudence ; Humans ; Poisoning/prevention & control ; United States
Language	English
Publishing date	2020-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2020.2152
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Article ; Online: Reply.

Lovegrove, Maribeth C / Agarwal, Maneesha / Geller, Robert J / Budnitz, Daniel S

The Journal of pediatrics

2020 Volume 222, Page(s) 264

MeSH term(s)	Child ; Child, Preschool ; Drug Storage ; Humans ; Poisoning ; Tablets
Chemical Substances	Tablets
Language	English
Publishing date	2020-04-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2020.03.040
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Article ; Online: Developing and implementing core competencies in children's environmental health for students, trainees and healthcare providers: a narrative review.

Goldman, Rose Hannah / Zajac, Lauren / Geller, Robert J / Miller, Mark D

BMC medical education

2021 Volume 21, Issue 1, Page(s) 503

Abstract: Knowledge of the health impacts of environmental exposures (such as pollution disasters, poor air quality, water contamination, climate change) on children's health has dramatically increased in the past 40 years. The World Health Organization (WHO) ... ...

Abstract	Knowledge of the health impacts of environmental exposures (such as pollution disasters, poor air quality, water contamination, climate change) on children's health has dramatically increased in the past 40 years. The World Health Organization (WHO) estimated that 23% of all deaths worldwide were attributable to the environment, and 26% of deaths in children less than 5 years old could be prevented with removal of environmental risks factors. Yet, little has permeated medical education, leaving pediatric providers ill equipped to address these issues. To address this gap, members from the Pediatric Environmental Health Specialty Units, a United States nationwide network of academically affiliated experts who have created numerous environmental health educational materials and programs, have identified fifteen core environmental health (EH) competencies needed by health care providers to enable them to effectively address environmental health concerns. These competencies can serve as the foundation for the development and implementation of relevant educational programs. The core EH competencies are based upon these foundational elements: 1) Definition of "children's environmental health" that describes how environmental exposures (positive and negative) in early life influence the health and development in childhood and across the entire human life span 2) Children are not "little adults" and so have unique vulnerabilities to environmental hazards; 3) Environmental health inequities exist, causing some children to have a disproportionate amount of unhealthy exposures and consequently a greater risk of adverse effects; 4) Climate change will translate to numerous adverse health effects that will particularly affect children worldwide. In this article, the authors describe the core environmental health competencies and provide resources, online tools, strategies, and examples targeted to all levels of training and practice to better enable leaders and educators to bring this important content to the forefront.
MeSH term(s)	Adult ; Child ; Child Health ; Child, Preschool ; Education, Medical ; Environmental Health ; Health Personnel ; Humans ; Students ; United States
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-021-02921-3
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Article ; Online: Incidence and clinical relevance of upper gastrointestinal pathology during preprocedural endoscopy in patients undergoing pulmonary vein isolation.

Grosse Meininghaus, Dirk / Freund, Robert / Heimbaecher, Lukas / Kleemann, Tobias / Kushnir, Anton / Geller, J Christoph

Clinical research in cardiology : official journal of the German Cardiac Society

2022 Volume 111, Issue 9, Page(s) 1069–1076

Abstract: Background: Reflux-induced esophagitis might facilitate ablation-induced esophageal lesions (ELs) following pulmonary vein isolation (PVI), and these may progress to atrio-esophageal fistula (AEF). In contrast, preexisting ELs are not prone to ... ...

Abstract	Background: Reflux-induced esophagitis might facilitate ablation-induced esophageal lesions (ELs) following pulmonary vein isolation (PVI), and these may progress to atrio-esophageal fistula (AEF). In contrast, preexisting ELs are not prone to progression but may affect procedure planning. Objective: To study the incidence of preexisting esophageal and upper gastrointestinal (UGI) pathology in patients undergoing PVI, and the relation to ablation-induced ELs. Methods: From 08/2018 to 09/2021, consecutive patients undergoing (radiofrequency [RF] or cryoballoon [CB]) PVI were examined by esophagogastroscopy (EGD) before and following ablation. Postprocedural endoscopic ultrasound (EUS) was added in 2021. Results: 412 patients (median age 67.5 [IQR 61.3-75.0] years, 56.1% male) were studied. Preprocedural EGD showed abnormalities in 226/399 patients, 15% in the lower third of the esophagus. Half (99/226) were relevant for PVI, 13 procedures were postponed, 6 due to pathological EGD results. A third of the patients with new esophageal injury following ablation had preexisting esophagitis which was associated with a trend for a higher incidence of ELs after RF ablation (12.5 vs. 6.9%, p = 0.232), and a six- and two-fold higher rate of food retention after CB-PVI (28.6 vs. 4.5%, p = 0.008) and RF ablation (8.3 vs. 4.4%, p = 0.279), respectively. Conclusion: (1) EGD before PVI showed UGI abnormalities in > 50% of patients, one-fourth of these relevant for PVI. (2) Esophageal inflammation was associated with a higher incidence of post-ablation (peri)-esophageal injury. Whether having this information before ablation is able to reduce ELs or AEF remains to be shown.
MeSH term(s)	Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Cryosurgery/methods ; Endoscopy ; Esophageal Fistula ; Esophagitis/diagnosis ; Esophagitis/epidemiology ; Esophagitis/etiology ; Female ; Humans ; Incidence ; Male ; Pulmonary Veins/surgery ; Treatment Outcome
Language	English
Publishing date	2022-06-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-022-02050-x
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Article ; Online: Upper Extremity Crotalid Envenomation: A Review of Incidence and Recent Trends in Management of Snakebites.

Razavi, S Amir / Stewart, Christopher M / Nogee, Daniel P / Geller, Robert J / Seiler, John G

The Journal of hand surgery

2022 Volume 48, Issue 12, Page(s) 1277.e1–1277.e6

Abstract: Purpose: The goal of this study was to evaluate the recent trends in the management of upper extremity Crotalid envenomation in the state of Georgia, United States.: Methods: A retrospective review of the Georgia Poison Center database looking at the ...

Abstract	Purpose: The goal of this study was to evaluate the recent trends in the management of upper extremity Crotalid envenomation in the state of Georgia, United States. Methods: A retrospective review of the Georgia Poison Center database looking at the reported snakebites to the upper extremity between 2015 and 2020 was performed. Patient demographics, timing and location of injury, severity of envenomation, treatment, including use of antivenin and surgical intervention, and reported complications related to the use of antivenin was extracted. Results: A retrospective review of snakebites between 2015 and 2020 showed 2408 snakebite cases with a mean patient age of 37.4 years. Males incurred 62.8% of all bites. The highest incidence was in summer 52.5%, and between the hours of 5 PM to midnight 57.2%. Overall, 1010 (41.9%) of all bites were categorized as venomous snakebites (55.6% copperhead, 20% rattlesnake, 2.4% cottonmouth, and 22% miscellaneous [including 3 Elapid envenomations] or unidentified. The total number of venomous bites to the upper extremity was 575 (56.9%) and 567 patients received antivenin. Envenomation severity was mild in 29%, moderate in 45%, severe in 10%, and undetermined in 16% of cases. Crotalidae polyvalent immune Fab (Ovine) was the main antivenin used, with overall mean initial therapy dose of 6.2 vials and 59% of patients receiving maintenance therapy. Three patients (0.5%) had a severe anaphylactic reaction to antivenin requiring cessation of therapy. Seven patients had acute compartment syndrome of the upper extremity requiring fasciotomy (3 copperhead, 2 rattlesnake, and 2 unidentified). There was no reported mortality during this period. Conclusions: Hand surgeons should be familiar with the management of upper extremity Crotalid envenomation. Antivenin remains the main treatment for symptomatic patients. Crotalid snakebites rarely require operative intervention. Type of study/level of evidence: Prognostic IV.
MeSH term(s)	Male ; Humans ; Animals ; Sheep ; United States/epidemiology ; Adult ; Snake Bites/epidemiology ; Snake Bites/therapy ; Antivenins/therapeutic use ; Incidence ; Upper Extremity ; Agkistrodon
Chemical Substances	Antivenins
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	605716-0
ISSN	1531-6564 ; 0363-5023
ISSN (online)	1531-6564
ISSN	0363-5023
DOI	10.1016/j.jhsa.2022.04.016
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Article ; Online: A Tumor-admixture Model to Interrogate Immune Cell-dependent Tumorigenesis.

Noe, Jordan T / Ding, Chuanlin / Geller, Anne E / Rendon, Beatriz E / Yan, Jun / Mitchell, Robert A

Bio-protocol

2023 Volume 13, Issue 5

Abstract: A rigorous determination of effector contributions of tumor-infiltrating immune cells is critical for identifying targetable molecular mechanisms for the development of novel cancer immunotherapies. A tumor/immune cell-admixture model is an advantageous ... ...

Abstract	A rigorous determination of effector contributions of tumor-infiltrating immune cells is critical for identifying targetable molecular mechanisms for the development of novel cancer immunotherapies. A tumor/immune cell-admixture model is an advantageous strategy to study tumor immunology as the fundamental methodology is relatively straightforward, while also being adaptable to scale to address increasingly complex research queries. Ultimately, this method can provide robust experimental information to complement more traditional murine models of tumor immunology. Here, we describe a tumor/macrophage-admixture model using bone marrow-derived macrophages to investigate macrophage-dependent tumorigenesis. Additionally, we provide commentary on potential branch points for optimization with other immune cells, experimental techniques, and cancer types.
Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4630
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Article ; Online: Shake-up time for Japanese seismology.

Geller, Robert J

Nature

2011 Volume 472, Issue 7344, Page(s) 407–409

MeSH term(s)	Disaster Planning/methods ; Disaster Planning/trends ; Disasters/statistics & numerical data ; Earthquakes/mortality ; Earthquakes/statistics & numerical data ; Federal Government ; Forecasting/methods ; Humans ; Japan ; Models, Theoretical ; Pacific Ocean ; Probability ; Time Factors ; Tokyo ; Tsunamis
Language	English
Publishing date	2011-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature10105
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