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Article ; Online: Eradication of Nontuberculous Mycobacteria in People with Cystic Fibrosis Treated with Elexacaftor/Tezacaftor/Ivacaftor: A Multicenter Cohort Study.

Wiesel, Vered / Aviram, Micha / Mei-Zahav, Meir / Dotan, Miri / Prais, Dario / Cohen-Cymberknoh, Malena / Gur, Michal / Bar-Yoseph, Ronen / Livnat, Galit / Goldbart, Aviv / Hazan, Guy / Hazan, Itai / Golan-Tripto, Inbal

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

2023 Volume 23, Issue 1, Page(s) 41–49

Abstract: Background: The prevalence of nontuberculous mycobacteria (NTM) infections is rising in people with cystic fibrosis (pwCF). NTM infection, especially infection with Mycobacterium abscessus complex (MABC), is commonly associated with severe lung ... ...

Abstract	Background: The prevalence of nontuberculous mycobacteria (NTM) infections is rising in people with cystic fibrosis (pwCF). NTM infection, especially infection with Mycobacterium abscessus complex (MABC), is commonly associated with severe lung deterioration. The current treatment modalities, including multiple intravenous antibiotics, frequently fail to achieve airway eradication. Although treatment with elexacaftor/tezacaftor/ivacaftor (ETI) has been shown to modulate the lung microbiome, data regarding its role in eradicating NTM in pwCF is lacking. Our aim was to evaluate the impact of ETI on the rate of NTM eradication in pwCF. Methods: This retrospective multicenter cohort study included pwCF from five CF centers in Israel. PwCF aged older than 6 who had at least one positive NTM airway culture in the past two years and were treated with ETI for at least one year were included. The annual NTM and bacterial isolations, pulmonary function tests, and body mass index were analyzed before and after ETI treatment. Results: Fifteen pwCF were included (median age 20.9 years, 73.3% females, 80% pancreatic insufficient). In nine patients (66%) NTM isolations were eradicated following treatment with ETI. Seven of them had MABC. The median time between the first NTM isolation and treatment with ETI was 2.71 years (0.27-10.35 years). Eradication of NTM was associated with improved pulmonary function tests (p<0.05). Conclusions: For the first time, we report successful eradication of NTM, including MABC, following treatment with ETI in pwCF. Additional studies are needed to assess whether treatment with ETI can result in the long-term eradication of NTM.
MeSH term(s)	Female ; Humans ; Aged ; Young Adult ; Adult ; Male ; Nontuberculous Mycobacteria ; Cystic Fibrosis/complications ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/epidemiology ; Cohort Studies ; Mycobacterium abscessus ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology ; Cystic Fibrosis Transmembrane Conductance Regulator ; Benzodioxoles ; Indoles ; Aminophenols ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones
Chemical Substances	elexacaftor (RRN67GMB0V) ; ivacaftor (1Y740ILL1Z) ; tezacaftor ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Benzodioxoles ; Indoles ; Aminophenols ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones
Language	English
Publishing date	2023-05-10
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	2084724-5
ISSN	1873-5010 ; 1569-1993
ISSN (online)	1873-5010
ISSN	1569-1993
DOI	10.1016/j.jcf.2023.05.003
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Zs.A 6028: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 459: Show issues

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Article ; Online: The new face of cystic fibrosis in the era of population genetic carrier screening.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

2023

Abstract: Background: Population genetic carrier screening (PGCS) for cystic fibrosis (CF) has been offered to couples in Israel since 1999 and was included in a fully subsidized national program in 2008. We evaluated the impact of PGCS on CF incidence, genetic ... ...

Abstract	Background: Population genetic carrier screening (PGCS) for cystic fibrosis (CF) has been offered to couples in Israel since 1999 and was included in a fully subsidized national program in 2008. We evaluated the impact of PGCS on CF incidence, genetic and clinical features. Methods: This was a retrospective national study. Demographic and clinical characteristics of children with CF born in Israel between 2008 and 2018 were obtained from the national CF registry and from patients' medical records. Data on CF births, preimplantation genetic testing (PGT), pregnancy termination and de-identified data from the PGCS program were collected. Results: CF births per 100,000 live births decreased from 8.29 in 2008 to 0.54 in 2018 (IRR = 0.84, p < 0.001). The CF pregnancy termination rate did not change (IRR = 1, p= 0.9) while the CF-related PGT rate increased markedly (IRR = 1.33, p < 0.001). One hundred and two children were born with CF between 2008 and 2018 with a median age at diagnosis of 4.8 months, range 0-111 months. Unlike the generally high uptake nationally, 65/102 had not performed PGCS. Even if all had utilized PGCS, only 51 would have been detected by the existing genetic screening panel. Clinically, 34 % of children were pancreatic sufficient compared to 23 % before 2008 (p = 0.04). Conclusions: Since institution of a nationwide PGCS program, the birth of children with CF decreased markedly. Residual function variants and pancreatic sufficiency were more common. A broader genetic screening panel and increased PGCS utilization may further decrease the birth of children with CF.
Language	English
Publishing date	2023-11-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2084724-5
ISSN	1873-5010 ; 1569-1993
ISSN (online)	1873-5010
ISSN	1569-1993
DOI	10.1016/j.jcf.2023.11.003
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Zs.MO 459: Show issues

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Article ; Online: A Single Low-Dose of Methylphenidate Improves Abnormal Visual Field Testing.

Sternfeld, Amir / Bialer, Omer Y / Keidar, Dotan / Megiddo, Elinor / Budnik, Ivan / Stiebel-Kalish, Hadas / Livnat, Tami

Current eye research

2020 Volume 46, Issue 8, Page(s) 1232–1239

Abstract: Purpose: To evaluate the effect of methylphenidate on visual field testing in healthy adults with abnormal visual field results.: Methods: This prospective, randomized, controlled interventional clinical trial comprised all patients who had abnormal ... ...

Abstract	Purpose: To evaluate the effect of methylphenidate on visual field testing in healthy adults with abnormal visual field results. Methods: This prospective, randomized, controlled interventional clinical trial comprised all patients who had abnormal visual field test results and normal eye examination and ophthalmic history. Eligible patients were randomly assigned to either the study group or the control group. All patients repeated their visual field testing. Study group patients received a single dose of 10 mg methylphenidate prior to that. The main outcome measures were the percent difference in mean deviation and pattern standard deviation between the second and first visual fields. Results: The methylphenidate group had greater improvement in all parameters. Mean deviation improved by median 68% (IQR 19%-78%) in the methylphenidate group vs. 27% [-5% to 55%] in the controls. However, this was not statistically significant ( Conclusions: A single low dose of methylphenidate can improve visual field testing in subjects without ocular pathology, and even more in those with prior experience in perimetry.
MeSH term(s)	Adult ; Aged ; Central Nervous System Stimulants/administration & dosage ; Dopamine Uptake Inhibitors/administration & dosage ; Female ; Humans ; Male ; Methylphenidate/administration & dosage ; Middle Aged ; Prospective Studies ; Vision Disorders/drug therapy ; Vision Disorders/physiopathology ; Visual Field Tests ; Visual Fields/drug effects ; Visual Fields/physiology
Chemical Substances	Central Nervous System Stimulants ; Dopamine Uptake Inhibitors ; Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2020-12-21
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2020.1858430
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Zs.A 1775: Show issues

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Article ; Online: Retinal Penetration of Intravitreally Injected Tissue Plasminogen Activator: A Rat Model Study.

Tal, Kfir / Dotan, Assaf / Nisgav, Yael / Dachbash, Mor / Gal-Or, Orly / Ehrlich, Rita / Gaton, Dan D / Weinberger, Dov / Livnat, Tami

Ophthalmic research

2017

Abstract: Purpose: To determine whether intravitreal unconjugated tissue plasminogen activator (tPA) (alteplase) can penetrate the intact neural retina and reach the subretinal space in an experimental model.: Methods: This study was performed in 24 Sprague- ... ...

Abstract	Purpose: To determine whether intravitreal unconjugated tissue plasminogen activator (tPA) (alteplase) can penetrate the intact neural retina and reach the subretinal space in an experimental model. Methods: This study was performed in 24 Sprague-Dawley rats aged 12 weeks. Under general anesthesia, the right eye was injected with either 0.75 μg of 3 μL tPA (14 rats; study group) or saline (10 rats, control group) into the vitreous. Animals were euthanized at 3, 24, and 48 h. The eyes were enucleated, and cryosections were prepared for immunofluorescence staining. Goat anti-tPA antibody was used to detect tPA. Results: In the study group, staining for tPA was detected in the deep retinal layers in all eyes. The staining was deeper and more intense at 3 and 24 h than at 48 h. There was no tPA staining in the retina of eyes injected with saline. Conclusions: This experimental study shows that unconjugated tPA administered into the vitreous is capable of penetrating the deep retinal layers and the subretinal space. These findings suggest that further clinical research is warranted on the benefits of intravitreal tPA in the treatment of submacular hemorrhage.
Language	English
Publishing date	2017-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	205708-6
ISSN	1423-0259 ; 0030-3747
ISSN (online)	1423-0259
ISSN	0030-3747
DOI	10.1159/000477621
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Zs.A 559: Show issues

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Article ; Online: Scleral cross-linking using riboflavin and ultraviolet-a radiation for prevention of progressive myopia in a rabbit model.

Dotan, Assaf / Kremer, Israel / Livnat, Tami / Zigler, Arie / Weinberger, Dov / Bourla, Dan

Experimental eye research

2014 Volume 127, Page(s) 190–195

Abstract: Our study demonstrates the effect of scleral cross-linking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. Axial length of the eyeball was measured by A-scan ultrasound in 22 New Zealand white rabbits ... ...

Abstract	Our study demonstrates the effect of scleral cross-linking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. Axial length of the eyeball was measured by A-scan ultrasound in 22 New Zealand white rabbits aged 13 days. The right eyes then underwent 360-degree conjunctival peritomy with (experimental group, n = 11) or without (control group, n = 11) scleral cross-linking, followed by tarsorrhaphy. The left eyes served as a control eye. In the experimental group, the right eyeballs were divided into quadrants, and every quadrant had either 2 (n = 8) or 6 (n = 3) scleral irradiation zones, each with an area of 0.2 cm² and radius of 4 mm. Cross-linking was performed by dropping 0.1% dextran-free riboflavin-5-phosphate onto the irradiation zones at 20 s before ultraviolet-A irradiation and every 20 s during the 200-s irradiation time. UVA radiation (370 nm) was applied perpendicular to the sclera at 57 mW/cm² (total UVA light dose, 57 J/cm²). Tarsorrhaphies were removed on day 55, followed by repeated axial-length measurement. In the control group, mean axial length in the right eyes increased from 10.50 ± 0.67 mm at baseline to 15.69 ± 0.39 mm 55 days later, for a mean change of 5.19 ± 0.85 mm. In the experimental group, corresponding values were 10.68 ± 0.74 mm and 14.29 ± 0.3 mm, for a mean change of 3.61 ± 0.76 mm. The between-group difference in the change in mean axial length was statistically significant (p < 0.001, Mann-Whitney nonparametric test). The present manuscript demonstrates that scleral cross-linking with riboflavin and ultraviolet-A radiation effectively prevents occlusion-induced axial elongation in a rabbit model.
MeSH term(s)	Animals ; Animals, Newborn ; Axial Length, Eye/drug effects ; Collagen/metabolism ; Cross-Linking Reagents/therapeutic use ; Disease Models, Animal ; Disease Progression ; Eyelids/surgery ; Myopia/metabolism ; Myopia/pathology ; Myopia/prevention & control ; Photosensitizing Agents/therapeutic use ; Rabbits ; Riboflavin/therapeutic use ; Sclera/metabolism ; Ultraviolet Rays
Chemical Substances	Cross-Linking Reagents ; Photosensitizing Agents ; Collagen (9007-34-5) ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Journal Article
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2014.07.019
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Article ; Online: Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model.

Dotan, Assaf / Kremer, Israel / Gal-Or, Orly / Livnat, Tami / Zigler, Arie / Bourla, Dan / Weinberger, Dov

Journal of visualized experiments : JoVE

2016 , Issue 110, Page(s) e53201

Abstract: Myopic individuals, especially those with severe myopia, are at higher-than-normal risk of cataract, glaucoma, retinal detachment and chorioretinal abnormalities. In addition, pathological myopia is a common irreversible cause of visual impairment and ... ...

Abstract	Myopic individuals, especially those with severe myopia, are at higher-than-normal risk of cataract, glaucoma, retinal detachment and chorioretinal abnormalities. In addition, pathological myopia is a common irreversible cause of visual impairment and blindness. Our study demonstrates the effect of scleral crosslinking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. The axial length of the eyeball was measured by A-scan ultrasound in New Zealand white rabbits aged 13 days (male and female). The eye then underwent 360° conjunctival peritomy with scleral crosslinking, followed by tarsorrhaphy. Axial elongation was induced in 13 day-old New Zealand rabbits by suturing their right eye eyelids (tarsorrhaphy). The eyes were divided into quadrants, and every quadrant had two scleral irradiation zones, each with an area of 0.2 cm² and a radius of 4 mm. Crosslinking was performed by dropping 0.1% dextran-free riboflavin-5-phosphate onto the irradiation zones 20 sec before ultraviolet-A irradiation and every 20 sec during the 200 sec irradiation time. UVA radiation (370 nm) was applied perpendicular to the sclera at 57 mW/cm² (total UVA light dose, 57 J/cm²). Tarsorrhaphies were removed on day 55, followed by repeated axial length measurements. This study demonstrates that scleral crosslinking with riboflavin and ultraviolet-A radiation effectively prevents occlusion-induced axial elongation in a rabbit model.
MeSH term(s)	Animals ; Axial Length, Eye/drug effects ; Collagen/metabolism ; Cross-Linking Reagents ; Disease Models, Animal ; Female ; Male ; Myopia/metabolism ; Myopia/prevention & control ; Photosensitizing Agents/therapeutic use ; Rabbits ; Riboflavin/therapeutic use ; Sclera/metabolism ; Ultraviolet Rays
Chemical Substances	Cross-Linking Reagents ; Photosensitizing Agents ; Collagen (9007-34-5) ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2016-04-03
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ISSN	1940-087X
ISSN (online)	1940-087X
DOI	10.3791/53201
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Article ; Online: Bevacizumab clearance through the iridocorneal angle following intravitreal injection in a rat model.

Gal-Or, Orly / Dotan, Assaf / Dachbash, Mor / Tal, Kfir / Nisgav, Yael / Weinberger, Dov / Ehrlich, Rita / Livnat, Tami

Experimental eye research

2016 Volume 145, Page(s) 412–416

Abstract: Antivascular endothelial growth factor (Anti-VEGF) agents have been widely used for a variety of ocular disorders. The etiology of sustained ocular hypertension following intravitreal administration of anti-VEGF agents is yet to be unraveled. Our study ... ...

Abstract	Antivascular endothelial growth factor (Anti-VEGF) agents have been widely used for a variety of ocular disorders. The etiology of sustained ocular hypertension following intravitreal administration of anti-VEGF agents is yet to be unraveled. Our study investigates and characterizes the presence of intravitreally injected bevacizumab in the aqueous outflow channels of a rat model. Choroidal neovascularization (CNV) was induced by diode laser photocoagulation to the right eye of twelve Brown Norway rats. Bevacizumab (25 mg/ml) was injected intravitreally after 3 days. Immediately after bevacizumab injection, and 3, 6, 24 and 48 h later, animals were euthanized for immunofluorescence staining. Donkey anti-human IgG labeled with Alexa Fluor(®) 488 was used for bevacizumab immunoreactivity detection. Anti-CD31 antibody was used as a marker for Schlemm's canal endothelial cells. Untreated eyes were used as negative controls. The intensity of the immunostaining was analyzed qualitatively. Bevacizumab immunoreactivity was found in the aqueous outflow channels including the trabecular meshwork and Schlemm's canal immediately after injection, and declined incrementally within the following hours. Forty-eight hours after the injection, no bevacizumab staining was detected in the aqueous outflow channel structures. Our manuscript demonstrates the presence of bevacizumab in the trabecular meshwork and Schlemm's canal structures after intravitreal injection in a CNV induced rat model. Bevacizumab molecules passed through the aqueous outflow channels within 48 h after intravitreal bevacizumab injection.
MeSH term(s)	Angiogenesis Inhibitors/analysis ; Angiogenesis Inhibitors/pharmacokinetics ; Animals ; Anterior Chamber/metabolism ; Bevacizumab/analysis ; Bevacizumab/pharmacokinetics ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/metabolism ; Cornea/metabolism ; Disease Models, Animal ; Intravitreal Injections ; Iris/metabolism ; Male ; Rats ; Rats, Inbred BN ; Time Factors ; Trabecular Meshwork/chemistry ; Trabecular Meshwork/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Journal Article
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2016.02.006
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Zs.A 163: Show issues

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Article ; Online: Randomized Controlled Trial of Cognitive-Behavioral and Mindfulness-Based Stress Reduction on the Quality of Life of Patients With Crohn Disease.

Goren, Ganit / Schwartz, Doron / Friger, Michael / Banai, Hagar / Sergienko, Ruslan / Regev, Shirley / Abu-Kaf, Heba / Greenberg, Dan / Nemirovsky, Anna / Ilan, Karny / Lerner, Livnat / Monsonego, Alon / Dotan, Iris / Yanai, Henit / Eliakim, Rami / Ben Horin, Shomron / Slonim-Nevo, Vered / Odes, Shmuel / Sarid, Orly

Inflammatory bowel diseases

2021 Volume 28, Issue 3, Page(s) 393–408

Abstract: Background: Patients with Crohn disease have debilitating psychological symptoms, mental fatigue, and poor quality of life. Psychological intervention may improve these symptoms.: Methods: We performed a randomized parallel-group physician-blinded ... ...

Abstract	Background: Patients with Crohn disease have debilitating psychological symptoms, mental fatigue, and poor quality of life. Psychological intervention may improve these symptoms. Methods: We performed a randomized parallel-group physician-blinded trial of cognitive-behavioral and mindfulness-based stress reduction (COBMINDEX) on quality of life and psychological symptoms in adults with mild-moderate Crohn disease. COBMINDEX was taught by social workers in one-on-one video conferences over 3 months; quotidian home practice was mandated. Results: Fifty-five COBMINDEX and 61 waitlist control patients completed the study; mean age was 33 years and 65% of participants were women. At 3 months, COBMINDEX patients had significantly reduced disease activity (per Harvey-Bradshaw Index score, C-reactive protein level, and calprotectin level), increased quality of life (Short Inflammatory Bowel Disease Questionnaire [SIBDQ] score increased from baseline 41 to 50; P < 0.001), decreased psychological symptoms (Global Severity Index [GSI], 0.98-0.70; P < 0.001), reduced fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue, 26-33; P < 0.001), and increased mindfulness disposition (Freiburg Mindfulness Inventory, 33-38; P < 0.001). Waitlist patients had a significant but small change in Harvey-Bradshaw Index, SIBDQ, and GSI scores, without improvement in fatigue or mindfulness. There were significant correlations (0.02 > P < 0.002) in COBMINDEX patients between baseline SIBDQ, GSI, Freiburg Mindfulness Inventory, and Functional Assessment of Chronic Illness Therapy-Fatigue scores with a relative change (baseline to 3 months) of the SIBDQ score, but none among waitlist patients. Predictors of relative change of the SIBDQ score in COBMINDEX patients included the GSI score (90% quantile; coefficient 0.52; P < 0.001), somatization (90%; 0.20; P = 0.001), depression (75%; 0.16; P = 0.03), and phobic anxiety (75%; 0.31; P = 0.008). Conclusions: COBMINDEX was effective in increasing patients' quality of life and reducing psychological symptoms and fatigue. Patients with severe baseline psychological symptoms benefited the most from COBMINDEX.
MeSH term(s)	Adult ; Cognition ; Crohn Disease/diagnosis ; Depression/psychology ; Female ; Humans ; Mindfulness ; Quality of Life ; Stress, Psychological/psychology
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izab083
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Zs.A 4530: Show issues

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Article: Scleral cross-linking using riboflavin and ultraviolet-a radiation for prevention of axial myopia in a rabbit model

Dotan, Assaf / Kremer, Israel / Gal-Or, Orly / Livnat, Tami / Zigler, Arie / Bourla, Dan / Weinberger, Dov

Journal of visualized experiments. 2016 Apr. 03, , no. 110

2016

Abstract	Myopic individuals, especially those with severe myopia, are at higher-than-normal risk of cataract, glaucoma, retinal detachment and chorioretinal abnormalities. In addition, pathological myopia is a common irreversible cause of visual impairment and blindness1-3. Our study demonstrates the effect of scleral crosslinking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. The axial length of the eyeball was measured by A-scan ultrasound in New Zealand white rabbits aged 13 days (male and female). The eye then underwent 360° conjunctival peritomy with scleral crosslinking, followed by tarsorrhaphy. Axial elongation was induced in 13 day-old New Zealand rabbits by suturing their right eye eyelids (tarsorrhaphy). The eyes were divided into quadrants, and every quadrant had two scleral irradiation zones, each with an area of 0.2 cm2 and a radius of 4 mm. Crosslinking was performed by dropping 0.1% dextran-free riboflavin-5-phosphate onto the irradiation zones 20 sec before ultraviolet-A irradiation and every 20 sec during the 200 sec irradiation time. UVA radiation (370 nm) was applied perpendicular to the sclera at 57 mW/cm2 (total UVA light dose, 57 J/cm2). Tarsorrhaphies were removed on day 55, followed by repeated axial length measurements. This study demonstrates that scleral crosslinking with riboflavin and ultraviolet-A radiation effectively prevents occlusion-induced axial elongation in a rabbit model.
Keywords	New Zealand White rabbit ; animal models ; cataract ; crosslinking ; eyelids ; females ; glaucoma ; irradiation ; males ; myopia ; rabbits ; riboflavin ; risk ; sclera ; ultraviolet radiation
Language	English
Dates of publication	2016-0403
Size	p. e53201.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/53201
Database	NAL-Catalogue (AGRICOLA)

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Article: Retinal Penetration of Intravitreally Injected Tissue Plasminogen Activator: A Rat Model Study

Tal, Kfir / Dotan, Assaf / Nisgav, Yael / Dachbash, Mor / Gal-Or, Orly / Ehrlich, Rita / Gaton, Dan D. / Weinberger, Dov / Livnat, Tami

Ophthalmic Research

2017 Volume 59, Issue 4, Page(s) 235–240

Abstract: Purpose: To determine whether intravitreal unconjugated tissue plasminogen activator (tPA) (alteplase) can penetrate the intact neural retina and reach the subretinal space in an experimental model. Methods: This study was performed in 24 Sprague-Dawley ... ...

Institution	Department of Ophthalmology, Rabin Medical Center - Beilinson Hospital, and Laboratory of Eye Research, Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
Abstract	Purpose: To determine whether intravitreal unconjugated tissue plasminogen activator (tPA) (alteplase) can penetrate the intact neural retina and reach the subretinal space in an experimental model. Methods: This study was performed in 24 Sprague-Dawley rats aged 12 weeks. Under general anesthesia, the right eye was injected with either 0.75 μg of 3 μL tPA (14 rats; study group) or saline (10 rats, control group) into the vitreous. Animals were euthanized at 3, 24, and 48 h. The eyes were enucleated, and cryosections were prepared for immunofluorescence staining. Goat anti-tPA antibody was used to detect tPA. Results: In the study group, staining for tPA was detected in the deep retinal layers in all eyes. The staining was deeper and more intense at 3 and 24 h than at 48 h. There was no tPA staining in the retina of eyes injected with saline. Conclusions: This experimental study shows that unconjugated tPA administered into the vitreous is capable of penetrating the deep retinal layers and the subretinal space. These findings suggest that further clinical research is warranted on the benefits of intravitreal tPA in the treatment of submacular hemorrhage.
Keywords	Alteplase ; Intravitreal tissue plasminogen activator ; Penetration ; Retina
Language	English
Publishing date	2017-07-20
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper
ZDB-ID	205708-6
ISSN	1423-0259 ; 0030-3747
ISSN (online)	1423-0259
ISSN	0030-3747
DOI	10.1159/000477621
Database	Karger publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 559: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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