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  1. Article ; Online: Can we reduce malaria in pregnancy and improve birth outcomes?

    Kakuru, Abel / Jagannathan, Prasanna

    Lancet (London, England)

    2023  Volume 401, Issue 10381, Page(s) 973–975

    MeSH term(s) Pregnancy ; Female ; Humans ; Malaria/epidemiology ; Malaria/prevention & control ; Pregnancy Complications, Infectious/prevention & control ; Pregnancy Outcome/epidemiology ; Pregnancy Complications, Parasitic/prevention & control ; Premature Birth
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00101-0
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  2. Article ; Online: Type I regulatory T cells in malaria: of mice and men.

    Nideffer, Jason / Jagannathan, Prasanna

    The Journal of clinical investigation

    2023  Volume 133, Issue 1

    Abstract: Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not ... ...

    Abstract Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not been characterized. In this issue of the JCI, Edward, Ng, and colleagues identified a conserved transcriptional signature that distinguished Tr1 (IL-10+IFN-γ+) from Th1 (IL-10-IFN-γ+) cells in human and mouse malaria. This signature implicated genes encoding inhibitory receptors - including CTLA-4 and LAG-3 - and transcription factors - including cMAF. The authors identified coinhibitory receptor expression that distinguished Tr1 cells from other CD4+ T cell subsets. Furthermore, cMAF - and, to a lesser extent, BLIMP-1 - promoted IL-10 production in human CD4+ T cells. BLIMP-1 also played a role in supporting the expression of inhibitory receptors. These findings describe a few key features that seem to be conserved by Tr1 cells across multiple species, disease contexts, and marker definitions.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Interleukin-10/genetics ; Cell Differentiation ; T-Lymphocyte Subsets ; Malaria
    Chemical Substances Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI166019
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  3. Article ; Online: Malaria in 2022: Increasing challenges, cautious optimism.

    Jagannathan, Prasanna / Kakuru, Abel

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2678

    MeSH term(s) Humans ; Malaria/epidemiology ; Malaria/prevention & control ; Optimism
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30133-w
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  4. Article ; Online: Type I regulatory T cells in malaria

    Jason Nideffer / Prasanna Jagannathan

    The Journal of Clinical Investigation, Vol 133, Iss

    of mice and men

    2023  Volume 1

    Abstract: Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not ... ...

    Abstract Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease contexts has not been characterized. In this issue of the JCI, Edward, Ng, and colleagues identified a conserved transcriptional signature that distinguished Tr1 (IL-10+IFN-γ+) from Th1 (IL-10–IFN-γ+) cells in human and mouse malaria. This signature implicated genes encoding inhibitory receptors — including CTLA-4 and LAG-3 — and transcription factors — including cMAF. The authors identified coinhibitory receptor expression that distinguished Tr1 cells from other CD4+ T cell subsets. Furthermore, cMAF — and, to a lesser extent, BLIMP-1 — promoted IL-10 production in human CD4+ T cells. BLIMP-1 also played a role in supporting the expression of inhibitory receptors. These findings describe a few key features that seem to be conserved by Tr1 cells across multiple species, disease contexts, and marker definitions.
    Keywords Medicine ; R
    Subject code 570
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Immunity after SARS-CoV-2 infections.

    Jagannathan, Prasanna / Wang, Taia T

    Nature immunology

    2021  Volume 22, Issue 5, Page(s) 539–540

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00923-3
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  6. Article ; Online: Malaria in 2022

    Prasanna Jagannathan / Abel Kakuru

    Nature Communications, Vol 13, Iss 1, Pp 1-

    Increasing challenges, cautious optimism

    2022  Volume 3

    Abstract: Malaria cases and deaths remain unacceptably high and are resurgent in several settings, though recent developments inspire optimism. This includes the approval of the world’s first malaria vaccine and results from novel vaccine candidates and trials ... ...

    Abstract Malaria cases and deaths remain unacceptably high and are resurgent in several settings, though recent developments inspire optimism. This includes the approval of the world’s first malaria vaccine and results from novel vaccine candidates and trials testing innovative combinatorial interventions.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Sex-Linked Differences in Malaria Risk Across the Lifespan.

    Briggs, Jessica / Murray, Margaret / Nideffer, Jason / Jagannathan, Prasanna

    Current topics in microbiology and immunology

    2023  Volume 441, Page(s) 185–208

    Abstract: Despite the high burden of malaria worldwide, there is surprisingly scarce research on sex-based differences in malaria outside of pregnancy. A more thorough understanding of sexual dimorphism in malaria, and what underlies these sex-based differences, ... ...

    Abstract Despite the high burden of malaria worldwide, there is surprisingly scarce research on sex-based differences in malaria outside of pregnancy. A more thorough understanding of sexual dimorphism in malaria, and what underlies these sex-based differences, could elucidate the underlying mechanisms driving malaria pathogenesis and has the potential to inform malaria control efforts, including new vaccines. This review summarizes our current understanding of sex-based differences in the epidemiology of malaria across the lifespan, potential sex- or gender-based mechanisms driving these differences, and the knowledge gaps that need to be addressed.
    MeSH term(s) Female ; Pregnancy ; Humans ; Longevity ; Sex Characteristics ; Malaria/epidemiology ; Malaria/prevention & control
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 210099-X
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-031-35139-6_7
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  8. Article ; Online: How does malaria in pregnancy impact malaria risk in infants?

    Jagannathan, Prasanna

    BMC medicine

    2018  Volume 16, Issue 1, Page(s) 212

    Abstract: Malaria in pregnancy not only exerts profound negative consequences on the health of the mother and developing fetus, but may also alter the risk of malaria during infancy. Although mechanisms driving this altered risk remain unclear, in utero exposure ... ...

    Abstract Malaria in pregnancy not only exerts profound negative consequences on the health of the mother and developing fetus, but may also alter the risk of malaria during infancy. Although mechanisms driving this altered risk remain unclear, in utero exposure to malaria antigens may impact the development of fetal and infant innate immunity. In an article in BMC Medicine, Natama et al. describe an ambitious analysis of basal and TLR-stimulated cord blood responses among a birth cohort in Burkina Faso. Basal levels of several cytokines, chemokines, and growth factors were shown to be significantly lower in cord blood with histopathologic evidence of placental malaria. Additionally, following TLR7/8 stimulation, samples obtained from infants of mothers with placental malaria were hyper-responsive compared to those without evidence of prenatal malaria exposure. Furthermore, several responses impacted by placental malaria were associated with differential malaria risk in infancy. Understanding how malaria in pregnancy shapes immune responses in infants will provide critical insight into the rational design of malaria control strategies during pregnancy, including intermittent preventative treatment in pregnancy and vaccines.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1187-3.
    MeSH term(s) Burkina Faso ; Female ; Humans ; Immunity, Innate ; Infant ; Infant, Newborn ; Malaria ; Parturition ; Pregnancy ; Pregnancy Complications, Parasitic
    Language English
    Publishing date 2018-11-20
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-018-1210-8
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  9. Article ; Online: How does malaria in pregnancy impact malaria risk in infants?

    Prasanna Jagannathan

    BMC Medicine, Vol 16, Iss 1, Pp 1-

    2018  Volume 3

    Abstract: Abstract Malaria in pregnancy not only exerts profound negative consequences on the health of the mother and developing fetus, but may also alter the risk of malaria during infancy. Although mechanisms driving this altered risk remain unclear, in utero ... ...

    Abstract Abstract Malaria in pregnancy not only exerts profound negative consequences on the health of the mother and developing fetus, but may also alter the risk of malaria during infancy. Although mechanisms driving this altered risk remain unclear, in utero exposure to malaria antigens may impact the development of fetal and infant innate immunity. In an article in BMC Medicine, Natama et al. describe an ambitious analysis of basal and TLR-stimulated cord blood responses among a birth cohort in Burkina Faso. Basal levels of several cytokines, chemokines, and growth factors were shown to be significantly lower in cord blood with histopathologic evidence of placental malaria. Additionally, following TLR7/8 stimulation, samples obtained from infants of mothers with placental malaria were hyper-responsive compared to those without evidence of prenatal malaria exposure. Furthermore, several responses impacted by placental malaria were associated with differential malaria risk in infancy. Understanding how malaria in pregnancy shapes immune responses in infants will provide critical insight into the rational design of malaria control strategies during pregnancy, including intermittent preventative treatment in pregnancy and vaccines. Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1187-3
    Keywords Malaria ; innate immunity ; malaria in pregnancy ; cord blood ; TLR stimulation ; Medicine ; R
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: γδ T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance.

    Dantzler, Kathleen W / Jagannathan, Prasanna

    Frontiers in immunology

    2018  Volume 9, Page(s) 2445

    Abstract: Uniquely expressing diverse innate-like and adaptive-like functions, γδ T cells exist as specialized subsets, but are also able to adapt in response to environmental cues. These cells have long been known to rapidly proliferate following primary malaria ... ...

    Abstract Uniquely expressing diverse innate-like and adaptive-like functions, γδ T cells exist as specialized subsets, but are also able to adapt in response to environmental cues. These cells have long been known to rapidly proliferate following primary malaria infection in humans and mice, but exciting new work is shedding light into their diverse functions in protection and following repeated malaria infection. In this review, we examine the current knowledge of functional specialization of γδ T cells in malaria, and the mechanisms dictating recognition of malaria parasites and resulting proliferation. We discuss γδ T cell plasticity, including changing interactions with other immune cells during recurrent infection and potential for immunological memory in response to repeated stimulation. Building on recent insights from human and murine experimental studies and vaccine trials, we propose areas for future research, as well as applications for therapeutic development.
    MeSH term(s) Animals ; Antigens, Protozoan/immunology ; Cell Proliferation ; Disease Resistance ; Humans ; Immune Tolerance ; Immunity, Cellular ; Immunologic Memory ; Lymphocyte Activation ; Malaria/immunology ; Malaria Vaccines/immunology ; Mice ; Plasmodium malariae/physiology ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocytes/immunology
    Chemical Substances Antigens, Protozoan ; Malaria Vaccines ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2018-10-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02445
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