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Article ; Online: Comparing Self-Reported and Aggregated Racial Classification for American Indian/Alaska Native Youths in YRBSS: 2021.

Gatewood, Ashton / Hendrix-Dicken, Amy D / Hartwell, Micah

2024 Volume 114, Issue 4, Page(s) 403–406

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Child ; Humans ; Adolescent ; United States/epidemiology ; Health Behavior ; Self Report ; Alaska Natives ; American Indian or Alaska Native ; Cross-Sectional Studies ; Population Surveillance/methods ; Risk-Taking ; Indians, North American
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2023.307561
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Article: Patent and non patent strategies in R&D based entrepreneurship

Burke, Andrew / Hartwell, Ian

International review of entrepreneurship : IRE Vol. 7, No. 1/4 , p. 151-160

a 4 step test

2009 Volume 7, Issue 1, Page(s) 151–160

Author's details	Andrew Burke; Ian Hartwell
Keywords	Entrepreneurship-Ansatz ; Innovationswettbewerb ; Innovation ; Patent
Language	English
Publisher	Senate Hall Academic Publishing
Publishing place	Shankill, Co. Dublin
Document type	Article
ZDB-ID	2556899-1
ISSN	2009-2822
Database	ECONomics Information System

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Article ; Online: Eastern Association for the Surgery of Trauma (EAST) System Wellness White Paper: An Evaluation of Wellness from a Systems Perspective.

Appelbaum, Rachel D / Butler, Dale / Stirparo, Joseph J / Coleman, Jamie / Hartwell, Jennifer L / Cunningham, Kyle

The journal of trauma and acute care surgery

2024

Abstract: Abstract: Providers are charged with responsibility to maintain their own health and wellness [1,2]. Wellness or wellbeing is multifactorial and complex, but the construct lacks clarity [3]. Wellness can impact patient safety and it has significant ... ...

Abstract	Abstract: Providers are charged with responsibility to maintain their own health and wellness [1,2]. Wellness or wellbeing is multifactorial and complex, but the construct lacks clarity [3]. Wellness can impact patient safety and it has significant financial implications. Both financial and healthcare industries have recognized this multifactorial issue, and have applied research and resources to the issue of employee wellness and wellbeing [4]. Thus, solutions to sustainable change must be multi-tiered and intentional [1,5].We reviewed the wellness literature with a focus on systems to provide a framework for consensus-building for a quality Acute Care Surgery system. Within this review we highlight several categories for consideration: 1) provider wellness 2) culture of safety, 3)learning health systems, and 4) organizational perspectives, Figure 1. Finally, we provide specific system recommendations for the Acute Care Surgery practice. We aim to support personal safety, longevity, and preserve our workforce by creating a system that works for its providers.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004311
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Article: Public Interest in Montelukast Prior to and After Announcement of Black Box Warning and Associations With Adverse Event Reports.

Abdelkader, Samer / Hartwell, Micah / Hendrix-Dicken, Amy D / Escala, Michelle / Condren, Michelle

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2024 Volume 29, Issue 1, Page(s) 90–92

Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-29.1.90
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Article ; Online: Steroid Use for Management of Vasoactive Resistant Shock in Pediatric Cardiac Intensive Care Patients: Experience of the Consortium of Congenital Cardiac Care-Measurement of Nursing Practice.

Diller, Christin N / Hartwell, Lauren / Connor, Jean A

Dimensions of critical care nursing : DCCN

2023 Volume 41, Issue 3, Page(s) 151–156

Abstract: ... existed as 3 centers (14%) use 50 mg/m2/d, 6 (29%) use 100 mg/m2/d, and 8 (38%) indicated that dosing ...

Abstract	Background: Although a variety of doses and duration of hydrocortisone have been reported as a treatment modality for congenital heart surgery patients with refractory hypotension, there remains a lack of understanding of the clinical use in pediatric cardiac programs. Objectives: The aim of this study was to describe the current practice of steroid use for refractory hypotension in postoperative congenital heart surgery patients. Method: Survey participants were recruited from the Consortium of Congenital Cardiac Care-Measurement of Nursing Practice. The survey focused on 4 areas: diagnosis, intervention, duration of therapy, and clinical decision making. Data were summarized using descriptive statistics. Results: Among the programs, 24 of 31 (77%) responded, with 21 (95%) using hydrocortisone as a treatment modality. Most, 20 (83%), reported no written clinical guideline for the use of hydrocortisone. Variation in dosing existed as 3 centers (14%) use 50 mg/m2/d, 6 (29%) use 100 mg/m2/d, and 8 (38%) indicated that dosing varies by provider. Discussion: Nearly all centers reported using hydrocortisone for the treatment of hypotension refractory to fluid resuscitation and vasoactive medications. Substantial variation in practice exists in areas of diagnosis, dosing, and duration of hydrocortisone. More research is needed to develop a clinical practice guideline to standardize practice.
MeSH term(s)	Child ; Humans ; Hydrocortisone/therapeutic use ; Shock, Septic ; Heart Defects, Congenital ; Critical Care ; Hypotension
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	632780-1
ISSN	1538-8646 ; 0730-4625
ISSN (online)	1538-8646
ISSN	0730-4625
DOI	10.1097/DCC.0000000000000520
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Article: Changes in vitamin D metabolism during natural and medical menopause.

Hartwell, D / Riis, B J / Christiansen, C

The Journal of clinical endocrinology and metabolism

1990 Volume 71, Issue 1, Page(s) 127–132

Abstract: ... a natural menopause. Vitamin D metabolites were determined every 3 months in these 10 women. The same ... in 1,25-dihydroxyvitamin D [1,25-(OH)2D], vitamin D-binding protein, or the free index of 1,25-(OH)2D ... during the natural menopause. A small increase was found in 25-hydroxyvitamin D [25OHD] and 24,25-(OH)2D3 ...

Abstract	Thirty-nine women were studied longitudinally for 3 yr, during which period 10 women passed a natural menopause. Vitamin D metabolites were determined every 3 months in these 10 women. The same variables were studied in 42 premenopausal women with endometriosis treated for 6 months with nafarelin acetate (a LHRH agonist) given alone in a dose of 200 or 400 micrograms or in a dose of 400 micrograms combined with 1.2 mg norethisterone (NET)/day and followed-up for a further 6 months. No changes were seen in 1,25-dihydroxyvitamin D [1,25-(OH)2D], vitamin D-binding protein, or the free index of 1,25-(OH)2D during the natural menopause. A small increase was found in 25-hydroxyvitamin D [25OHD] and 24,25-(OH)2D3 after correction for seasonal variation. All three nafarelin groups had a significantly decreased free index of 1,25-(OH)2D, which returned to the baseline value on withdrawal of the treatment. Serum 25OHD and 24,25-(OH)2D3 were increased at 6 months and thereafter decreased to baseline values. These changes were still visible after correction for seasonal variation. Vitamin D-binding protein showed a small transient increase in the nafarelin plus NET group, but was unchanged in the other two groups. The 24-h urinary excretion of calcium increased significantly in the groups receiving nafarelin alone, whereas it remained unchanged in the nafarelin plus NET group. We conclude that detectable changes in 1,25-(OH)2D do not occur in natural menopause. Treatment with LHRH agonists produces a significant decrease in serum 1,25-(OH)2D, which does not seem to be dependent on increased bone resorption. This suggests that LHRH agonists may induce a change in other pituitary hormones involved in vitamin D regulation.
MeSH term(s)	24,25-Dihydroxyvitamin D 3/blood ; Adult ; Calcitriol/blood ; Estrogens/physiology ; Female ; Gonadotropin-Releasing Hormone/analogs & derivatives ; Gonadotropin-Releasing Hormone/pharmacology ; Humans ; Menopause/blood ; Nafarelin ; Norethindrone/pharmacology ; Ovary/drug effects ; Ovary/physiology ; Pituitary Hormones/physiology ; Seasons ; Vitamin D/blood ; Vitamin D-Binding Protein/blood
Chemical Substances	Estrogens ; Pituitary Hormones ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; Nafarelin (1X0094V6JV) ; Gonadotropin-Releasing Hormone (33515-09-2) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; Calcitriol (FXC9231JVH) ; Norethindrone (T18F433X4S)
Language	English
Publishing date	1990-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jcem-71-1-127
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Article: Comparisons between two receptor assays for 1,25-dihydroxyvitamin D.

Hartwell, D / Christiansen, C

Scandinavian journal of clinical and laboratory investigation

1988 Volume 48, Issue 2, Page(s) 109–114

Abstract: We present a competitive protein binding assay (CPBA) for 1,25(OH)2D employing 1,25(OH)2D receptor from calf thymus, which was compared with a CPBA-employing receptor from rachitic chick intestine. The thymus receptor assay was more sensitive, specific ... ...

Abstract	We present a competitive protein binding assay (CPBA) for 1,25(OH)2D employing 1,25(OH)2D receptor from calf thymus, which was compared with a CPBA-employing receptor from rachitic chick intestine. The thymus receptor assay was more sensitive, specific and precise than the intestinal receptor assay. The thymus receptor assay measured both 1,25(OH)2D2 and 1,25(OH)2D3 with equal affinity, whereas 1,25(OH)2D2 was 1.1 times less potent than 1,25(OH)2D3 in the displacement from the chick intestinal receptor. Mean serum values of 1,25(OH)2D in normal subjects, post-menopausal women, pregnant women, and patients with chronic renal failure measured by the two assay systems did not differ. Furthermore, both assays showed that 1,25(OH)2D was unchanged in post-menopausal women after treatment with vitamin D2 or vitamin D3, 4000 IU/day for 8 weeks. We conclude that the high sensitivity of the thymus receptor and the equal affinity for the D2 and D3 analogue make the thymus receptor assay a reliable alternative to the chick intestinal receptor assay.
MeSH term(s)	Adult ; Aged ; Binding, Competitive ; Calcitriol/blood ; Ergocalciferols/analogs & derivatives ; Ergocalciferols/blood ; Female ; Humans ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Radioligand Assay/methods ; Receptors, Calcitriol ; Receptors, Steroid/metabolism ; Thymus Gland/metabolism
Chemical Substances	Ergocalciferols ; Receptors, Calcitriol ; Receptors, Steroid ; 1,25-dihydroxyergocalciferol (55248-15-2) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	1988-04
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.3109/00365518809085401
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Article ; Online: Association of Depression, Comorbidities, and Sociodemographic Factors among Home Healthcare Recipients.

Monahan, Zach / Mack, Alyson / Shores, Dyani / Coffey, Sara / Mazur, Anna / Hartwell, Micah

Clinical gerontologist

2024 , Page(s) 1–9

Abstract: Objectives: More than 15 million individuals receive home health care (HHC) for chronic conditions, which allows them to maintain a level of independence and self-sufficiency. Although poor mental health can negatively impact health outcomes, little ... ...

Abstract	Objectives: More than 15 million individuals receive home health care (HHC) for chronic conditions, which allows them to maintain a level of independence and self-sufficiency. Although poor mental health can negatively impact health outcomes, little research has been done on the mental health of these individuals. Methods: Utilizing National Health Interview Survey years 2019-2022, we ran a cross-sectional analysis to determine rates of depression among individuals who indicated that they utilized HHC services, based on their sociodemographic statuses and diagnosis, as well as their rate of depression by condition whether they utilized HHC services. Results: HHC recipients were significantly more likely to be depressed if they reported being female, age 55-64, low income, low educational attainment, American Indian/Alaskan Native, Hispanic, or lived in a rural area. HHC recipients were more likely to be depressed than their non-HHC recipient counterparts. Conclusions: These results underscore the need for integrated mental health care in home health. Further, the financial burden of HHC, which may have an additional impact on stress, emphasizes the need for expanded accessibility of these services. Clinical implications: General practitioners and home health professionals should inquire about mental health concerns of these care recipients, and treat or refer accordingly.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	226146-7
ISSN	1545-2301 ; 0731-7115
ISSN (online)	1545-2301
ISSN	0731-7115
DOI	10.1080/07317115.2024.2335472
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Article: Is the effect of phototherapy in psoriasis partly due to an impact on vitamin D metabolism?

Staberg, B / Oxholm, A / Klemp, P / Hartwell, D

Acta dermato-venereologica

1988 Volume 68, Issue 5, Page(s) 436–439

Abstract: To elucidate the effect of phototherapy on vitamin D metabolism in psoriatics, the serum ... concentrations of the major vitamin D metabolites (25-hydroxy-vitamin D (25(OH)D), 1,25-dihydroxy-vitamin D (1,25 ... OH)2D), and 24,25-dihydroxy-vitamin D (24,25(OH)2D)) were studied in 10 patients with disseminated ...

Abstract	To elucidate the effect of phototherapy on vitamin D metabolism in psoriatics, the serum concentrations of the major vitamin D metabolites (25-hydroxy-vitamin D (25(OH)D), 1,25-dihydroxy-vitamin D (1,25(OH)2D), and 24,25-dihydroxy-vitamin D (24,25(OH)2D)) were studied in 10 patients with disseminated psoriasis, both before and after phototherapy. Some 3-4 weeks of Goeckerman therapy induced significantly increased serum levels of 25(OH)D (mean: 24.6 ng/ml versus 54.4 ng/ml; (p less than 0.001] and 24,25(OH)2D (mean: 2.01 ng/ml versus 3.49 ng/ml; (p less than 0.001)). After phototherapy the mean serum level of 1,25(OH)2D increased nearly to the level found in healthy controls (mean: 23.8 vs. 32.2 pg/ml). However, this increase was not significant. It is shown that conventional phototherapy does have an impact on vitamin D metabolism in psoriatics. Since previous investigations have indicated an abnormal vitamin D metabolism in patients with psoriasis, it is possible that the beneficial effect of phototherapy in this disease might be due partly to an impact on vitamin D metabolism.
MeSH term(s)	Adult ; Aged ; Humans ; Hydroxycholecalciferols/metabolism ; Middle Aged ; Psoriasis/metabolism ; Psoriasis/therapy ; Ultraviolet Therapy
Chemical Substances	Hydroxycholecalciferols
Language	English
Publishing date	1988
Publishing country	Sweden
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
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Article: Vitamin D metabolites--relation to age, menopause and endometriosis.

Hartwell, D / Rødbro, P / Jensen, S B / Thomsen, K / Christiansen, C

Scandinavian journal of clinical and laboratory investigation

1990 Volume 50, Issue 2, Page(s) 115–121

Abstract: We investigated the influence of menopause, age and sex on vitamin D metabolism in a large group ... Furthermore, we studied the vitamin D metabolism in 42 women with endometriosis. The vitamin D metabolites did ... not show dependence on age or on duration of menopause. The serum concentrations of vitamin D ...

Abstract	We investigated the influence of menopause, age and sex on vitamin D metabolism in a large group of healthy women (n = 113) and men (n = 108) and in a group of early postmenopausal women (n = 124). Furthermore, we studied the vitamin D metabolism in 42 women with endometriosis. The vitamin D metabolites did not show dependence on age or on duration of menopause. The serum concentrations of vitamin D metabolites did not differ in normal men and women. There were highly significant seasonal oscillations for 25(OH)D and 24,25(OH)2D3 but not for 1,25(OH)2D. Women with endometriosis had significantly elevated serum 1,25(OH)2D compared to the normal women. Our study indicates that ageing is not associated with a significant depletion of 25(OH)D, 24,25(OH)2D or 1,25(OH)2D in normal men and women up to the age of 75 years. Furthermore, changes in vitamin D metabolism seem not to be an important factor in early postmenopausal bone loss. Our results on patients with endometriosis indicate that these patients may have some calcium-metabolic disturbances.
MeSH term(s)	24,25-Dihydroxyvitamin D 3/blood ; Adult ; Aged ; Aging/blood ; Calcifediol/blood ; Calcitriol/blood ; Calcium/blood ; Endometriosis/blood ; Female ; Humans ; Male ; Menopause/blood ; Middle Aged ; Osteoporosis, Postmenopausal/blood ; Phosphates/blood ; Seasons ; Vitamin D/blood
Chemical Substances	Phosphates ; Vitamin D (1406-16-2) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; Calcitriol (FXC9231JVH) ; Calcifediol (P6YZ13C99Q) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	1990-04
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.3109/00365519009089142
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