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  1. Article ; Online: Comparative Phylogenetic Analysis of Ancient Korean Tea "Hadong Cheon-Nyeon Cha (

    Shim, Doobo / Jeon, Seung Ho / Kim, Jong Cheol / Yoon, Dong-Kyung

    Current issues in molecular biology

    2024  Volume 46, Issue 2, Page(s) 1091–1106

    Abstract: Wild teas are valuable genetic resources for studying evolution and breeding. Here, we report the complete chloroplast genome of the ancient Korean tea 'Hadong Cheon-nyeon Cha' ( ...

    Abstract Wild teas are valuable genetic resources for studying evolution and breeding. Here, we report the complete chloroplast genome of the ancient Korean tea 'Hadong Cheon-nyeon Cha' (
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46020069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5122: Show issues Location:
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  2. Article ; Online: Fully-automated multi-organ segmentation tool applicable to both non-contrast and post-contrast abdominal CT: deep learning algorithm developed using dual-energy CT images.

    Jeon, Sun Kyung / Joo, Ijin / Park, Junghoan / Kim, Jong-Min / Park, Sang Joon / Yoon, Soon Ho

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4378

    Abstract: A novel 3D nnU-Net-based of algorithm was developed for fully-automated multi-organ segmentation in abdominal CT, applicable to both non-contrast and post-contrast images. The algorithm was trained using dual-energy CT (DECT)-obtained portal venous phase ...

    Abstract A novel 3D nnU-Net-based of algorithm was developed for fully-automated multi-organ segmentation in abdominal CT, applicable to both non-contrast and post-contrast images. The algorithm was trained using dual-energy CT (DECT)-obtained portal venous phase (PVP) and spatiotemporally-matched virtual non-contrast images, and tested using a single-energy (SE) CT dataset comprising PVP and true non-contrast (TNC) images. The algorithm showed robust accuracy in segmenting the liver, spleen, right kidney (RK), and left kidney (LK), with mean dice similarity coefficients (DSCs) exceeding 0.94 for each organ, regardless of contrast enhancement. However, pancreas segmentation demonstrated slightly lower performance with mean DSCs of around 0.8. In organ volume estimation, the algorithm demonstrated excellent agreement with ground-truth measurements for the liver, spleen, RK, and LK (intraclass correlation coefficients [ICCs] > 0.95); while the pancreas showed good agreements (ICC = 0.792 in SE-PVP, 0.840 in TNC). Accurate volume estimation within a 10% deviation from ground-truth was achieved in over 90% of cases involving the liver, spleen, RK, and LK. These findings indicate the efficacy of our 3D nnU-Net-based algorithm, developed using DECT images, which provides precise segmentation of the liver, spleen, and RK and LK in both non-contrast and post-contrast CT images, enabling reliable organ volumetry, albeit with relatively reduced performance for the pancreas.
    MeSH term(s) Deep Learning ; Tomography, X-Ray Computed/methods ; Abdomen/diagnostic imaging ; Liver/diagnostic imaging ; Algorithms
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55137-y
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  3. Article ; Online: Correction: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis.

    Hwang, Ee Taek / Yoon, Yeahwa / Kim, Ka Ram / Lee, Chan Hee / Jeon, Kyung Chan / Min, Ji Ho / Lee, Jae Won / Kim, Jangyong

    Biomaterials science

    2024  Volume 12, Issue 9, Page(s) 2445

    Abstract: Correction for 'Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis' by Ee Taek ... ...

    Abstract Correction for 'Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis' by Ee Taek Hwang
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d4bm90029d
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  4. Article ; Online: Utilizing fully-automated 3D organ segmentation for hepatic steatosis assessment with CT attenuation-based parameters.

    Yoo, Jeongin / Joo, Ijin / Jeon, Sun Kyung / Park, Junghoan / Yoon, Soon Ho

    European radiology

    2024  

    Abstract: Objectives: To investigate the clinical utility of fully-automated 3D organ segmentation in assessing hepatic steatosis on pre-contrast and post-contrast CT images using magnetic resonance spectroscopy (MRS)-proton density fat fraction (PDFF) as ... ...

    Abstract Objectives: To investigate the clinical utility of fully-automated 3D organ segmentation in assessing hepatic steatosis on pre-contrast and post-contrast CT images using magnetic resonance spectroscopy (MRS)-proton density fat fraction (PDFF) as reference standard.
    Materials and methods: This retrospective study analyzed 362 adult potential living liver donors with abdominal CT scans and MRS-PDFF. Using a deep learning-based tool, mean volumetric CT attenuation of the liver and spleen were measured on pre-contrast (liver(L)_pre and spleen(S)_pre) and post-contrast (L_post and S_post) images. Agreements between volumetric and manual region-of-interest (ROI)-based measurements were assessed using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Diagnostic performances of volumetric parameters (L_pre, liver-minus-spleen (L-S)_pre, L_post, and L-S_post) were evaluated for detecting MRS-PDFF ≥ 5% and ≥ 10% using receiver operating characteristic (ROC) curve analysis and compared with those of ROI-based parameters.
    Results: Among the 362 subjects, 105 and 35 had hepatic steatosis with MRS-PDFF ≥ 5% and ≥ 10%, respectively. Volumetric and ROI-based measurements revealed ICCs of 0.974, 0.825, 0.992, and 0.962, with mean differences of -4.2 HU, -3.4 HU, -1.2 HU, and -7.7 HU for L_pre, S_pre, L_post, and S_post, respectively. Volumetric L_pre, L-S_pre, L_post, and L-S_post yielded areas under the ROC curve of 0.813, 0.813, 0.734, and 0.817 for MRS-PDFF ≥ 5%; and 0.901, 0.915, 0.818, and 0.868 for MRS-PDFF ≥ 10%, comparable with those of ROI-based parameters (0.735-0.818; and 0.816-0.895, Ps = 0.228-0.911).
    Conclusion: Automated 3D segmentation of the liver and spleen in CT scans can provide volumetric CT attenuation-based parameters to detect and grade hepatic steatosis, applicable to pre-contrast and post-contrast images.
    Clinical relevance statement: Volumetric CT attenuation-based parameters of the liver and spleen, obtained through automated segmentation tools from pre-contrast or post-contrast CT scans, can efficiently detect and grade hepatic steatosis, making them applicable for large population data collection.
    Key points: • Automated organ segmentation enables the extraction of CT attenuation-based parameters for the target organ. • Volumetric liver and spleen CT attenuation-based parameters are highly accurate in hepatic steatosis assessment. • Automated CT measurements from pre- or post-contrast imaging show promise for hepatic steatosis screening in large cohorts.
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-024-10660-4
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  5. Article ; Online: A Case of Hodgkin Lymphoma Presenting Initially with Constrictive Pericarditis.

    Kim, Eric Eunshik / Jeon, Yoon Kyung / Koh, Jiwon

    International journal of surgical pathology

    2022  Volume 31, Issue 6, Page(s) 1115–1118

    MeSH term(s) Humans ; Pericarditis, Constrictive/diagnosis ; Pericarditis, Constrictive/etiology ; Hodgkin Disease/complications ; Hodgkin Disease/diagnosis
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969221118914
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  6. Article ; Online: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis.

    Hwang, Ee Taek / Yoon, Yeahwa / Kim, Ka Ram / Lee, Chan Hee / Jeon, Kyung Chan / Min, Ji Ho / Lee, Jae Won / Kim, Jangyong

    Biomaterials science

    2024  Volume 12, Issue 9, Page(s) 2434–2443

    Abstract: In this study, the formation of protein microspheres through lysosomal enzyme-assisted biomineralized crystallization was demonstrated. Spherical micro-sized hybrid ... ...

    Abstract In this study, the formation of protein microspheres through lysosomal enzyme-assisted biomineralized crystallization was demonstrated. Spherical micro-sized hybrid CaCO
    MeSH term(s) Microspheres ; Melanins/chemistry ; Melanins/metabolism ; Calcium Carbonate/chemistry ; Calcium Carbonate/pharmacology ; Lysosomes/metabolism ; Animals ; Humans ; Hydrogen-Ion Concentration
    Chemical Substances Melanins ; Calcium Carbonate (H0G9379FGK)
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d4bm00106k
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  7. Article ; Online: An Integrated Radiologic-Pathologic Understanding of COVID-19 Pneumonia.

    Lee, Jong Hyuk / Koh, Jaemoon / Jeon, Yoon Kyung / Goo, Jin Mo / Yoon, Soon Ho

    Radiology

    2023  Volume 306, Issue 2, Page(s) e222600

    Abstract: This article reviews the radiologic and pathologic findings of the epithelial and endothelial injuries in COVID-19 pneumonia to help radiologists understand the fundamental nature of the disease. The radiologic and pathologic manifestations of COVID-19 ... ...

    Abstract This article reviews the radiologic and pathologic findings of the epithelial and endothelial injuries in COVID-19 pneumonia to help radiologists understand the fundamental nature of the disease. The radiologic and pathologic manifestations of COVID-19 pneumonia result from epithelial and endothelial injuries based on viral toxicity and immunopathologic effects. The pathologic features of mild and reversible COVID-19 pneumonia involve nonspecific pneumonia or an organizing pneumonia pattern, while the pathologic features of potentially fatal and irreversible COVID-19 pneumonia are characterized by diffuse alveolar damage followed by fibrosis or acute fibrinous organizing pneumonia. These pathologic responses of epithelial injuries observed in COVID-19 pneumonia are not specific to SARS-CoV-2 but rather constitute universal responses to viral pneumonia. Endothelial injury in COVID-19 pneumonia is a prominent feature compared with other types of viral pneumonia and encompasses various vascular abnormalities at different levels, including pulmonary thromboembolism, vascular engorgement, peripheral vascular reduction, a vascular tree-in-bud pattern, and lung perfusion abnormality. Chest CT with different imaging techniques (eg, CT quantification, dual-energy CT perfusion) can fully capture the various manifestations of epithelial and endothelial injuries. CT can thus aid in establishing prognosis and identifying patients at risk for deterioration.
    MeSH term(s) Humans ; COVID-19/pathology ; SARS-CoV-2 ; Pneumonia, Viral/pathology ; Pneumonia ; Lung Diseases/pathology ; Radiologists ; Lung/pathology
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.222600
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  8. Article ; Online: Author Correction: Enterococcus faecium and Pediococcus acidilactici deteriorate Enterobacteriaceae-induced depression and colitis in mice.

    Jang, Hyo-Min / Kim, Jeon-Kyung / Joo, Min-Kyung / Shin, Yoon-Jung / Lee, Kyung-Eon / Lee, Chang Kyun / Kim, Hyo-Jong / Kim, Dong-Hyun

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 12997

    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39969-8
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  9. Article ; Online: For the Universal Right to Access Quality End-of-Life Care in Korea: Broadening Our Perspective After the 2018 Life-Sustaining Treatment Decisions Act.

    Park, Hye Yoon / Kim, Min Sun / Yoo, Shin Hye / Lee, Jung / Song, In Gyu / Jeon, So Yeon / Choi, Eun Kyung

    Journal of Korean medical science

    2024  Volume 39, Issue 12, Page(s) e123

    MeSH term(s) Humans ; Terminal Care ; Hospice Care ; Korea ; Republic of Korea ; Decision Making ; Withholding Treatment
    Language English
    Publishing date 2024-04-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2024.39.e123
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  10. Article ; Online: Efficient polyhydroxybutyrate production using acetate by engineered Halomonas sp. JJY01 harboring acetyl-CoA acetyltransferase.

    Park, Jea-Kyung / Jeon, Jong-Min / Yang, Yung-Hun / Kim, Sang-Hyoun / Yoon, Jeong-Jun

    International journal of biological macromolecules

    2023  Volume 254, Issue Pt 1, Page(s) 127475

    Abstract: Polyhydroxybutyrate (PHB) is a well-known biodegradable bioplastic synthesized by microorganisms and can be produced from volatile fatty acids (VFAs). Among VFAs acetate can be utilized by Halomonas sp. YLGW01 for growth and PHB production. In this study, ...

    Abstract Polyhydroxybutyrate (PHB) is a well-known biodegradable bioplastic synthesized by microorganisms and can be produced from volatile fatty acids (VFAs). Among VFAs acetate can be utilized by Halomonas sp. YLGW01 for growth and PHB production. In this study, Halomonas sp. JJY01 was developed through introducing acetyl-CoA acetyltransferase (atoAD) with LacI
    MeSH term(s) Hydroxybutyrates/metabolism ; Halomonas/genetics ; Halomonas/metabolism ; Acetyl-CoA C-Acetyltransferase/metabolism ; Polyhydroxybutyrates ; Acetates/metabolism ; Polyesters/metabolism
    Chemical Substances Hydroxybutyrates ; Acetyl-CoA C-Acetyltransferase (EC 2.3.1.9) ; Polyhydroxybutyrates ; Acetates ; Polyesters
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127475
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