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  1. Article ; Online: The Chemical Reactivity of Membrane Lipids.

    Duché, Genevieve / Sanderson, John M

    Chemical reviews

    2024  Volume 124, Issue 6, Page(s) 3284–3330

    Abstract: It is well-known that aqueous dispersions of phospholipids spontaneously assemble into bilayer structures. These structures have numerous applications across chemistry and materials science and form the fundamental structural unit of the biological ... ...

    Abstract It is well-known that aqueous dispersions of phospholipids spontaneously assemble into bilayer structures. These structures have numerous applications across chemistry and materials science and form the fundamental structural unit of the biological membrane. The particular environment of the lipid bilayer, with a water-poor low dielectric core surrounded by a more polar and better hydrated interfacial region, gives the membrane particular biophysical and physicochemical properties and presents a unique environment for chemical reactions to occur. Many different types of molecule spanning a range of sizes, from dissolved gases through small organics to proteins, are able to interact with membranes and promote chemical changes to lipids that subsequently affect the physicochemical properties of the bilayer. This Review describes the chemical reactivity exhibited by lipids in their membrane form, with an emphasis on conditions where the lipids are well hydrated in the form of bilayers. Key topics include the following: lytic reactions of glyceryl esters, including hydrolysis, aminolysis, and transesterification; oxidation reactions of alkenes in unsaturated fatty acids and sterols, including autoxidation and oxidation by singlet oxygen; reactivity of headgroups, particularly with reactive carbonyl species; and
    MeSH term(s) Membrane Lipids/chemistry ; Lipid Bilayers/chemistry ; Cell Membrane/metabolism ; Membranes/metabolism ; Phospholipids/metabolism ; Alkenes/metabolism
    Chemical Substances Membrane Lipids ; Lipid Bilayers ; Phospholipids ; Alkenes
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.3c00608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The association of lipids with amyloid fibrils.

    Sanderson, John M

    The Journal of biological chemistry

    2022  Volume 298, Issue 8, Page(s) 102108

    Abstract: Amyloid formation continues to be a widely studied area because of its association with numerous diseases, such as Alzheimer's and Parkinson's diseases. Despite a large body of work on protein aggregation and fibril formation, there are still significant ...

    Abstract Amyloid formation continues to be a widely studied area because of its association with numerous diseases, such as Alzheimer's and Parkinson's diseases. Despite a large body of work on protein aggregation and fibril formation, there are still significant gaps in our understanding of the factors that differentiate toxic amyloid formation in vivo from alternative misfolding pathways. In addition to proteins, amyloid fibrils are often associated in their cellular context with several types of molecule, including carbohydrates, polyanions, and lipids. This review focuses in particular on evidence for the presence of lipids in amyloid fibrils and the routes by which those lipids may become incorporated. Chemical analyses of fibril composition, combined with studies to probe the lipid distribution around fibrils, provide evidence that in some cases, lipids have a strong association with fibrils. In addition, amyloid fibrils formed in the presence of lipids have distinct morphologies and material properties. It is argued that lipids are an integral part of many amyloid deposits in vivo, where their presence has the potential to influence the nucleation, morphology, and mechanical properties of fibrils. The role of lipids in these structures is therefore worthy of further study.
    MeSH term(s) Amyloid/chemistry ; Amyloid beta-Peptides/chemistry ; Amyloidosis ; Humans ; Lipids/chemistry ; Protein Aggregates
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Lipids ; Protein Aggregates
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102108
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Far from Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences for Cell Biology.

    Sanderson, John M

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2020  Volume 42, Issue 3, Page(s) e1900147

    Abstract: In this article, it is hypothesized that a fundamental chemical reactivity exists between some non-lipid constituents of cellular membranes and ester-based lipids, the significance of which is not generally recognized. Many peptides and smaller organic ... ...

    Abstract In this article, it is hypothesized that a fundamental chemical reactivity exists between some non-lipid constituents of cellular membranes and ester-based lipids, the significance of which is not generally recognized. Many peptides and smaller organic molecules have now been shown to undergo lipidation reactions in model membranes in circumstances where direct reaction with the lipid is the only viable route for acyl transfer. Crucially, drugs like propranolol are lipidated in vivo with product profiles that are comparable to those produced in vitro. Some compounds have also been found to promote lipid hydrolysis. Drugs with high lytic activity in vivo tend to have higher toxicity in vitro. Deacylases and lipases are proposed as key enzymes that protect cells against the effects of intrinsic lipidation. The toxic effects of intrinsic lipidation are hypothesized to include a route by which nucleation can occur during the formation of amyloid fibrils.
    MeSH term(s) Acetyl-CoA Hydrolase/chemistry ; Acetyl-CoA Hydrolase/metabolism ; Acyl Coenzyme A/chemistry ; Acyl Coenzyme A/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Animals ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Humans ; Hydrolysis ; Lipase/chemistry ; Lipase/metabolism ; Liposomes/chemistry ; Liposomes/metabolism ; Membrane Lipids/chemistry ; Membrane Lipids/metabolism ; Parkinson Disease/metabolism ; Protein Aggregation, Pathological/metabolism ; Protein Binding ; Protein Conformation, beta-Strand ; Signal Transduction
    Chemical Substances Acyl Coenzyme A ; Amyloid beta-Peptides ; Liposomes ; Membrane Lipids ; Lipase (EC 3.1.1.3) ; Acetyl-CoA Hydrolase (EC 3.1.2.1)
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201900147
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Far from Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences for Cell Biology

    Sanderson, John M

    BioEssays. 2020 Mar., v. 42, no. 3

    2020  

    Abstract: In this article, it is hypothesized that a fundamental chemical reactivity exists between some non‐lipid constituents of cellular membranes and ester‐based lipids, the significance of which is not generally recognized. Many peptides and smaller organic ... ...

    Abstract In this article, it is hypothesized that a fundamental chemical reactivity exists between some non‐lipid constituents of cellular membranes and ester‐based lipids, the significance of which is not generally recognized. Many peptides and smaller organic molecules have now been shown to undergo lipidation reactions in model membranes in circumstances where direct reaction with the lipid is the only viable route for acyl transfer. Crucially, drugs like propranolol are lipidated in vivo with product profiles that are comparable to those produced in vitro. Some compounds have also been found to promote lipid hydrolysis. Drugs with high lytic activity in vivo tend to have higher toxicity in vitro. Deacylases and lipases are proposed as key enzymes that protect cells against the effects of intrinsic lipidation. The toxic effects of intrinsic lipidation are hypothesized to include a route by which nucleation can occur during the formation of amyloid fibrils.
    Keywords amyloid ; carboxylic ester hydrolases ; hydrolysis ; lipids ; peptides ; propranolol ; toxicity
    Language English
    Dates of publication 2020-03
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201900147
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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Environmental exposures and pulmonary function among adult residents of rural Appalachian Kentucky.

    Flunker, John C / Sanderson, Wayne T / Christian, W Jay / Mannino, David M / Browning, Steven R

    Journal of exposure science & environmental epidemiology

    2023  

    Abstract: Background: Estimated residential exposures of adults to roadway density and several metrics of resource extraction, including coal mining and oil and gas drilling, were hypothesized to contribute to the prevalence of respiratory disease in rural ... ...

    Abstract Background: Estimated residential exposures of adults to roadway density and several metrics of resource extraction, including coal mining and oil and gas drilling, were hypothesized to contribute to the prevalence of respiratory disease in rural Appalachia.
    Objective: Determine how small-area geographic variation in residential environmental exposures impacts measures of pulmonary function among adults in a community-based study.
    Methods: We examined associations between residential environmental respiratory exposures and pulmonary function among 827 adult participants of the "The Mountain Air Project", a community-based, cross-sectional study in Southeastern Kentucky during 2016-2018. Exposures characterized the density of roadways, oil/gas wells, or current/past surface and underground coal mining at the level of 14-digit hydrologic unit code (HUC), or valley "hollow" where participants resided. Each participant completed an in-person interview to obtain extensive background data on risk factors, health history, and occupational and environmental exposures, as well as a spirometry test administered by experienced study staff at their place of residence. Multivariable linear regression was used to model the adjusted association between each environmental exposure and percent predicted forced expiratory volume in one second (FEV
    Results: Adjusted regression models indicate persons living in HUCs with the highest level of roadway density experienced a reduction in both FEV
    Impact statement: Our work demonstrates the potential adverse impact of roadway-related exposures on the respiratory health of rural Appalachia residents. We employed a novel method of small-area exposure classification based on the hydrologic unit code (HUC), representing potential exposure levels per hollow occurring  in proximity to the residence, and controlled for individual-level risk factors for reduced respiratory health. We highlight an overlooked yet ubiquitous source of residential exposure from motor vehicles that may contribute to the regionally high prevalence of respiratory disease in rural Appalachia.
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-023-00584-4
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    Z 7529: Show issues

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  6. Article: Membrane-active peptides, IUPAB/EBSA symposium, Edinburgh.

    Sanderson, John M / Separovic, Frances

    Biophysical reviews

    2017  Volume 9, Issue 4, Page(s) 283–284

    Language English
    Publishing date 2017-08-24
    Publishing country Germany
    Document type Letter
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-017-0307-1
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  7. Article ; Online: Peptide lipidation in lysophospholipid micelles and lysophospholipid-enriched membranes.

    Ismail, Vian S / Britt, Hannah M / Mosely, Jackie A / Sanderson, John M

    Faraday discussions

    2021  Volume 232, Page(s) 282–294

    Abstract: Acyl transfer from lipids to membrane-associated peptides is a well-documented process, leading to the generation of a lipidated peptide and a lysolipid. In this article, we demonstrate that acyl transfer from lysophosphatidylcholines (lysoPCs) to the ... ...

    Abstract Acyl transfer from lipids to membrane-associated peptides is a well-documented process, leading to the generation of a lipidated peptide and a lysolipid. In this article, we demonstrate that acyl transfer from lysophosphatidylcholines (lysoPCs) to the peptide melittin also occurs, both in micelles of pure lysolipid and in lipid/lysolipid mixtures. In the case of bilayers containing lysolipids, acyl transfer from the lysolipid is marginally favoured over transfer from the lipid. In pure bilayers of saturated lipids, the introduction of even small amounts of lysolipid appears to significantly increase the reactivity towards lipidation.
    MeSH term(s) Lipid Bilayers ; Lysophospholipids ; Micelles ; Peptides
    Chemical Substances Lipid Bilayers ; Lysophospholipids ; Micelles ; Peptides
    Language English
    Publishing date 2021-12-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1364-5498
    ISSN (online) 1364-5498
    DOI 10.1039/d1fd00030f
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  8. Article ; Online: Illuminating Relationships Between the Pre- and Post-synapse.

    Sanderson, Thomas M / Georgiou, John / Collingridge, Graham L

    Frontiers in neural circuits

    2020  Volume 14, Page(s) 9

    Abstract: Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities. Imaging techniques, that enable physiology at ... ...

    Abstract Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities. Imaging techniques, that enable physiology at the resolution of individual synapses to be investigated, have allowed the presynaptic activity level of the synapse to be related to postsynaptic function. This approach has revealed that neuronal activity induces the pre- and post-synapse to be functionally correlated and that subsets of synapses are more susceptible to certain forms of synaptic plasticity. As presynaptic function is often examined in isolation from postsynaptic properties, the effect it has on the post-synapse is not fully understood. However, since postsynaptic receptors at excitatory synapses respond to release of glutamate, it follows that they may be differentially regulated depending on the frequency of its release. Therefore, examining postsynaptic properties in the context of presynaptic function may be a useful way to approach a broad range of questions on synaptic physiology. In this review, we focus on how optophysiology tools have been utilized to study relationships between the pre- and the post-synapse. Multiple imaging techniques have revealed correlations in synaptic properties from the submicron to the dendritic level. Optical tools together with advanced imaging techniques are ideally suited to illuminate this area further, due to the spatial resolution and control they allow.
    MeSH term(s) Animals ; Brain/metabolism ; Brain/ultrastructure ; Brain-Derived Neurotrophic Factor/metabolism ; Humans ; Neuronal Plasticity/physiology ; Presynaptic Terminals/metabolism ; Presynaptic Terminals/ultrastructure ; Receptors, AMPA/metabolism ; Synapses/metabolism ; Synapses/ultrastructure ; Synaptic Potentials/physiology ; Synaptic Transmission/physiology
    Chemical Substances Brain-Derived Neurotrophic Factor ; Receptors, AMPA
    Language English
    Publishing date 2020-04-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2452968-0
    ISSN 1662-5110 ; 1662-5110
    ISSN (online) 1662-5110
    ISSN 1662-5110
    DOI 10.3389/fncir.2020.00009
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  9. Article: Correction to: ICU-outcomes in CAR-T patients-A single centre experience.

    Materski, T / John, M / Pirani, T / Benjamin, R / Kuhnl, A / Potter, V / Sanderson, R / Metaxa, V

    Intensive care medicine experimental

    2021  Volume 9, Issue 1, Page(s) 9

    Language English
    Publishing date 2021-02-18
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-021-00370-2
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  10. Article ; Online: 17

    Rowlands, Lucy J / Marks, Adam / Sanderson, John M / Law, Robert V

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 92, Page(s) 14499–14502

    Abstract: Cholesterol is a crucial component of biological membranes and can interact with other membrane components through hydrogen bonding. NMR spectroscopy has been used previously to investigate this bonding, however this study represents the first 17O NMR ... ...

    Abstract Cholesterol is a crucial component of biological membranes and can interact with other membrane components through hydrogen bonding. NMR spectroscopy has been used previously to investigate this bonding, however this study represents the first 17O NMR spectroscopy study of isotopically enriched cholesterol. We demonstrate the 17O chemical shift is dependent on hydrogen bonding, providing a novel method for the study of cholesterol in bilayers.
    MeSH term(s) Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cholesterol/chemistry ; Hydrogen Bonding ; Lipid Bilayers/chemistry ; Magnetic Resonance Spectroscopy ; Oxygen Isotopes/chemistry ; Solvents/chemistry
    Chemical Substances Lipid Bilayers ; Oxygen Isotopes ; Oxygen-17 ; Solvents ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc05466f
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