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  1. Article ; Online: Comprehensive structure-function analysis of causative variants in retinal pigment epithelium specific 65 kDa protein associated Leber Congenital Amaurosis.

    Abduljaleel, Zainularifeen

    Non-coding RNA research

    2019  Volume 4, Issue 4, Page(s) 121–127

    Abstract: A recent study published to ... ...

    Abstract A recent study published to screen
    Language English
    Publishing date 2019-11-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2019.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation.

    Abduljaleel, Zainularifeen

    Non-coding RNA research

    2019  Volume 4, Issue 3, Page(s) 109–119

    Abstract: Oxidative damaged DNA base lesions are repaired through human 8-oxoguanine DNA glycosylase gene (hOGG1) mediated pathways. A recent report based on the meta-analysis has suggested that the DNA Repair Gene hOGG1 variant Ser326Cys [3p26.2; allele S/C in ... ...

    Abstract Oxidative damaged DNA base lesions are repaired through human 8-oxoguanine DNA glycosylase gene (hOGG1) mediated pathways. A recent report based on the meta-analysis has suggested that the DNA Repair Gene hOGG1 variant Ser326Cys [3p26.2; allele S/C in nucleotide position αHelix2 Ser⇒Cys326] was associated with Lung Cancer risk in Caucasian population will alter the level Zhong et al., 2012. To the best of our knowledge, there has not been any such comprehensive in-silico investigation that validates the functional and structural impact of non-synonymous Lung Cancer Risk Associated Protein Domain (LCRAPD) mutation Ser326Cys (rs1052133) by molecular dynamics (MD) simulation approach following prediction of hOGG1 protein before and after the mutation. Further to the native and mutant protein structures, the amino acid residue and its secondary structure were observed through a solvent accessibility model for protein stability confirmation at the point of mutation. Taken together, this study suggests that the protein functional and structural studies could be a reasonable approach for investigating the impact of nsSNPs in future studies. In addition, 4295 patients samples incorporate with the analysis that genomic data types from cBioPortal. In the result, 4295 cases (91.5%) had alterations in all genes but the frequency of alterations in our targeted hOGG1 gene was shown with and without case alteration in the ratio (Logrank Test P-Value: 0.670) Kaplan-Meier by the number of patients at risk of the survival function.
    Language English
    Publishing date 2019-10-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2019.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring the untapped pharmacological potential of imidazopyridazines.

    Malik, M Shaheer / Alshareef, Hossa F / Alfaidi, Khalid A / Ather, Hissana / Abduljaleel, Zainularifeen / Hussein, Essam M / Moussa, Ziad / Ahmed, Saleh A

    RSC advances

    2024  Volume 14, Issue 6, Page(s) 3972–3984

    Abstract: Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and ... ...

    Abstract Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra07280k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Peptides-based vaccine against SARS-

    Abduljaleel, Zainularifeen / Al-Allaf, Faisal A / Aziz, Syed A

    Bio-design and manufacturing

    2021  Volume 4, Issue 3, Page(s) 490–505

    Abstract: The World Health Organization has declared the rapidly spreading coronavirus to be a global pandemic. The FDA is yet to approve a vaccine for human novel coronavirus. Here, we developed a peptide-based vaccine and used high-throughput screening by ... ...

    Abstract The World Health Organization has declared the rapidly spreading coronavirus to be a global pandemic. The FDA is yet to approve a vaccine for human novel coronavirus. Here, we developed a peptide-based vaccine and used high-throughput screening by molecular dynamics simulation to identify T-cell- and
    Language English
    Publishing date 2021-02-03
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2927505-2
    ISSN 2522-8552 ; 2096-5524
    ISSN (online) 2522-8552
    ISSN 2096-5524
    DOI 10.1007/s42242-020-00114-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Design and optimization of 18-gene Ion AmpliSeq panel of Next-generation sequencing for gene mutation analysis causing pain insensitivity

    Mohammad Athar / Faisal Allaf / Zainularifeen Abduljaleel / Mohiuddin Taher / Abdellatif Bouazzaoui

    Journal of Umm Al-Qura University for Medical Science, Vol 8, Iss

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Umm Al-Qura University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entry.

    Abduljaleel, Zainularifeen / Shahzad, Naiyer / Aziz, Syed A / Malik, Shaheer M

    Molecular diversity

    2022  Volume 27, Issue 2, Page(s) 695–708

    Abstract: SARS, or severe acute respiratory syndrome, is caused by a novel coronavirus (COVID-19). This situation has compelled many pharmaceutical R&D companies and public health research sectors to focus their efforts on developing effective therapeutics. SARS- ... ...

    Abstract SARS, or severe acute respiratory syndrome, is caused by a novel coronavirus (COVID-19). This situation has compelled many pharmaceutical R&D companies and public health research sectors to focus their efforts on developing effective therapeutics. SARS-nCoV-2 was chosen as a protein spike to targeted monoclonal antibodies and therapeutics for prevention and treatment. Deep mutational scanning created a monoclonal antibody to characterize the effects of mutations in a variable antibody fragment based on its expression levels, specificity, stability, and affinity for specific antigenic conserved epitopes to the Spike-S-Receptor Binding Domain (RBD). Improved contacts between Fv light and heavy chains and the targeted antigens of RBD could result in a highly potent neutralizing antibody (NAbs) response as well as cross-protection against other SARS-nCoV-2 strains. It undergoes multipoint core mutations that combine enhancing mutations, resulting in increased binding affinity and significantly increased stability between RBD and antibody. In addition, we improved. Structures of variable fragment (Fv) complexed with the RBD of Spike protein were subjected to our established in-silico antibody-engineering platform to obtain enhanced binding affinity to SARS-nCoV-2 and develop ability profiling. We found that the size and three-dimensional shape of epitopes significantly impacted the activity of antibodies produced against the RBD of Spike protein. Overall, because of the conformational changes between RBD and hACE2, it prevents viral entry. As a result of this in-silico study, the designed antibody can be used as a promising therapeutic strategy to treat COVID-19.
    MeSH term(s) Humans ; COVID-19 ; Epitopes ; Severe acute respiratory syndrome-related coronavirus ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/metabolism ; Virus Internalization ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Antibodies, Viral/pharmacology ; Antibodies, Viral/metabolism ; SARS-CoV-2/metabolism ; Protein Binding
    Chemical Substances Epitopes ; Antibodies, Monoclonal ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral
    Language English
    Publishing date 2022-05-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-022-10449-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4946: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights.

    Athar, Mohammad / Toonsi, Mawaddah / Abduljaleel, Zainularifeen / Bouazzaoui, Abdellatif / Bogari, Neda M / Dannoun, Anas / Al-Allaf, Faisal A

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 7

    Abstract: Background: Familial Hypercholesterolemia (FH) is a hereditary condition that causes a rise in blood cholesterol throughout a person's life. FH can result in myocardial infarction and even sudden death if not treated. FH is thought to be caused mainly ... ...

    Abstract Background: Familial Hypercholesterolemia (FH) is a hereditary condition that causes a rise in blood cholesterol throughout a person's life. FH can result in myocardial infarction and even sudden death if not treated. FH is thought to be caused mainly by variants in the gene for the low-density lipoprotein receptor (LDLR). This study aimed to investigate the genetic variants in FH patients, verify their pathogenicity, and comprehend the relationships between genotype and phenotype. Also, review studies assessed the relationship between the LDLR null variants and the reaction to lipid-lowering therapy.
    Methods: The study utilised high-throughput next-generation sequencing for genetic screening of FH-associated genes and capillary sequencing for cascade screening. Furthermore, bioinformatic analysis was employed to describe the pathogenic effects of the revealed novel variant on the structural features of the corresponding RNA molecule.
    Results: We studied the clinical signs of hypercholesterolemia in a Saudi family with three generations of FH. We discovered a novel frameshift variant (c.666_670dup, p.(Asp224Alafs*43) in the LDLR and a known single nucleotide variant (c.9835A > G, p.(Ser3279Gly) in the APOB gene. It is thought that the LDLR variant causes a protein to be prematurely truncated, likely through nonsense-mediated protein decay. The LDLR variant is strongly predicted to be pathogenic in accordance with ACMG guidelines and co-segregated with the FH clinical characteristics of the family. This LDLR variant exhibited severe clinical FH phenotypes and was restricted to the LDLR protein's ligand-binding domain. According to computational functional characterization, this LDLR variant was predicted to change the free energy dynamics of the RNA molecule, thereby affecting its stability. This frameshift variant is thought to eliminate important functional domains in LDLR that are required for receptor recycling and LDL particle binding. We provide insight into how FH patients with a null variant in the LDLR gene respond to lipid-lowering therapy.
    Conclusions: The findings expand the range of FH variants and assist coronary artery disease preventive efforts by improving diagnosis, understanding the genotype-phenotype relationship, prognosis, and personalised therapy for patients with FH.
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13071542
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  8. Article ; Online: SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact.

    Abduljaleel, Zainularifeen / Melebari, Sami / Athar, Mohammad / Dehlawi, Saied / Udhaya Kumar, S / Aziz, Syed A / Dannoun, Anas Ibrahim / Malik, Shaheer M / Thasleem, Jasheela / George Priya Doss, C

    Cellular signalling

    2023  Volume 109, Page(s) 110798

    Abstract: This study investigated the efficacy of existing vaccines against hospitalization and infection due to the Omicron variant of COVID-19, particularly for those who received two doses of Moderna or Pfizer vaccines and one dose of Johnson & Johnson vaccine ... ...

    Abstract This study investigated the efficacy of existing vaccines against hospitalization and infection due to the Omicron variant of COVID-19, particularly for those who received two doses of Moderna or Pfizer vaccines and one dose of Johnson & Johnson vaccine or who were vaccinated more than five months before. A total of 36 variants in Omicron's spike protein, targeted by all three vaccinations, have made antibodies less effective at neutralizing the virus. The genotyping of the SARS-CoV-2 viral sequence revealed clinically significant variants such as E484K in three genetic mutations (T95I, D614G, and del142-144). A woman showed two of these mutations, indicating a potential risk of infection after successful immunization, as recently reported by Hacisuleyman (2021). We examine the effects of mutations on domains (NID, RBM, and SD2) found at the interfaces of the spike domains Omicron B.1.1529, Delta/B.1.1529, Alpha/B.1.1.7, VUM B.1.526, B.1.575.2, and B.1.1214 (formerly VOI Iota). We tested the affinity of Omicron for ACE2 and found that the wild- and mutant-spike proteins were using atomistic molecular dynamics simulations. According to the binding free energies calculated during mutagenesis, the ACE2 bound Omicron spikes more strongly than the wild strain SARS-CoV-2. T95I, D614G, and E484K are three substitutions that significantly contribute to RBD, corresponding to ACE2 binding energies and a doubling of the electrostatic potential of Omicron spike proteins. The Omicron appears to bind to ACE2 with greater affinity, increasing its infectivity and transmissibility. The spike virus was designed to strengthen antibody immune evasion through binding while boosting receptor binding by enhancing IgG and IgM antibodies that stimulate human β-cell, as opposed to the wild strain, which has more vital stimulation of both antibodies.
    MeSH term(s) Female ; Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2/genetics ; Angiotensin-Converting Enzyme 2 ; Breakthrough Infections ; Spike Glycoprotein, Coronavirus/genetics ; Vaccines ; Immunoglobulin M
    Chemical Substances COVID-19 Vaccines ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Spike Glycoprotein, Coronavirus ; Vaccines ; Immunoglobulin M ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2023.110798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome.

    Abduljaleel, Zainularifeen / Athar, Mohammad / Al-Allaf, Faisal A / Al-Dehlawi, Saied / Vazquez, Jose R

    Non-coding RNA research

    2019  Volume 4, Issue 4, Page(s) 155–173

    Abstract: The human ... ...

    Abstract The human gene
    Language English
    Publishing date 2019-12-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2019.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New Imidazole-Based

    Malik, M Shaheer / Alsantali, Reem I / Jamal, Qazi Mohammad Sajid / Seddigi, Zaki S / Morad, Moataz / Alsharif, Meshari A / Hussein, Essam M / Jassas, Rabab S / Al-Rooqi, Munirah M / Abduljaleel, Zainularifeen / Babalgith, Ahmed O / Altass, Hatem M / Moussa, Ziad / Ahmed, Saleh A

    Frontiers in chemistry

    2022  Volume 9, Page(s) 808556

    Abstract: An efficient atom-economical synthetic protocol to access new imidazole- ... ...

    Abstract An efficient atom-economical synthetic protocol to access new imidazole-based
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2021.808556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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