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  1. Article ; Online: Reply to Fumihiko Urabe, Takashi Yoshioka, and Takahiro Kimura's Letter to the Editor re: Felix Seelemeyer, David Pfister, Robert Pappesch, Sabine Merkelbach-Bruse, Pia Paffenholz and Axel Heidenreich. Evaluation of a miRNA-371a-3p Assay for Predicting Final Histopathology in Patients Undergoing Primary Nerve-sparing Retroperitoneal Lymphadenectomy for Stage IIA/B Seminoma or Nonseminoma. Eur Urol Oncol. In press. https://doi.org/10.1016/j.euo.2023.10.021.

    Seelemeyer, Felix / Pfister, David / Pappesch, Robert / Merkelbach-Bruse, Sabine / Paffenholz, Pia / Heidenreich, Axel

    European urology oncology

    2024  Volume 7, Issue 2, Page(s) 306

    MeSH term(s) Male ; Humans ; MicroRNAs ; Seminoma ; Lymph Node Excision ; Testicular Neoplasms
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Letter
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2024.01.001
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  2. Book ; Thesis: Vergleich des Resektatgewichts und des eingesetzten Implantatvolumens in Abhängigkeit der Brustdrüsendichte nach hautschonender Mastektomie der weiblichen Brust

    Bachmann, Bo Jan / Mallmann, Peter / Paffenholz, Pia Valerie

    2021  

    Institution Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe Köln
    Author's details vorgelegt von Bo Jan Bachmann ; 1. Gutachter: Universitätsprofessor Dr. med. P.K. Mallmann, 2. Gutachterin: Privatdozentin Dr. med. P. Paffenholz ; aus der Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der Universität zu Köln
    Subject code 610
    Language German
    Size 70 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    HBZ-ID HT021009037
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Optimierung der Diagnostik und Therapie fortgeschrittener und metastasierter testikulärer Keimzelltumore

    Paffenholz, Pia Valerie

    = Improvement of diagnostics and treatment options of advanced and metastatic testicular germ cell tumors

    2019  

    Title variant Improvement of diagnostics and treatment options of advanced and metastatic testicular germ cell tumors
    Institution Klinik und Poliklinik für Urologie
    Author's details vorgelegt von Dr. med. Pia Valerie Paffenholz ; aus der Klinik für Urologie, Uro-Onkologie, spezielle und roboter-assistierte Chirurgie der Universität zu Köln
    Subject code 610
    Language German ; English
    Size 1 Band verschiedene Seitenzählungen, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universität zu Köln, 2020
    Note Enthält Sonderabdrucke aus Zeitschriften in englischer Sprache
    HBZ-ID HT020433125
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Thesis: Vitrification of human spermatozoa

    Wang, Mengying / Rahimi, Gohar / Paffenholz, Pia Valerie

    effect of cooling methods and cryoprotectants on post-thaw quality, ultrastructural changes, and proteomic profile evaluations

    2021  

    Institution Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe Köln
    Author's details vorgelegt von Mengying Wang ; 1. Gutachterin: Professorin Dr. med. G. Rahimi, 2. Gutachterin: Privatdozentin Dr. med. P. Paffenholz ; aus der Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der Universität zu Köln
    Subject code 610
    Language English
    Size 110 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    HBZ-ID HT021296905
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Thrombembolie-Risikofaktoren und Prophylaxe.

    Paffenholz, Pia

    Aktuelle Urologie

    2023  Volume 55, Issue 1, Page(s) 44–49

    Abstract: Venous thromboembolism is an important complication in tumour patients as it occurs frequently in these patients and causes relevant morbidity. The risk of thromboembolic complications in tumour patients is 3-9 times higher than in non-tumour patients ... ...

    Title translation Venous thromboembolism: risk factors and prophylaxis.
    Abstract Venous thromboembolism is an important complication in tumour patients as it occurs frequently in these patients and causes relevant morbidity. The risk of thromboembolic complications in tumour patients is 3-9 times higher than in non-tumour patients and is the second most common cause of death in tumour patients. The risk of thrombosis depends on tumour-induced coagulopathy and on individual factors, type and stage of cancer, time since cancer diagnosis as well as type of systemic cancer therapy. Thromboprophylaxis in tumour patients is effective but can be associated with increased bleeding. Even though there are currently no dedicated recommendations for individual tumour entities, international guidelines recommend prophylactic measures in high-risk patients. A thrombosis risk of >8-10% can be considered an indication for thromboprophylaxis, which is indicated by a Khorana score ≥2, and should be calculated individually using nomograms. In particular, patients with a low risk of bleeding should receive thromboprophylaxis. Risk factors and symptoms of a thromboembolic event should also be intensively discussed with the patient and materials for patient information should be handed out.
    MeSH term(s) Humans ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/diagnosis ; Anticoagulants/adverse effects ; Thrombosis/complications ; Thrombosis/drug therapy ; Thrombosis/prevention & control ; Risk Factors ; Neoplasms/complications ; Neoplasms/chemically induced ; Neoplasms/drug therapy
    Chemical Substances Anticoagulants
    Language German
    Publishing date 2023-06-20
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-2099-8233
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  6. Article: Thrombembolie-Risikofaktoren und Prophylaxe

    Paffenholz, Pia

    Aktuelle Urologie

    2023  Volume 55, Issue 01, Page(s) 44–49

    Abstract: Venöse Thromboembolien stellen eine wichtige Komplikation bei Tumorpatienten, da sie bei diesen Patienten gehäuft auftreten und eine relevante Morbidität bedingen. Das Risiko für thromboembolische Komplikationen bei Tumorpatienten liegt 3–9-mal höher als ...

    Abstract Venöse Thromboembolien stellen eine wichtige Komplikation bei Tumorpatienten, da sie bei diesen Patienten gehäuft auftreten und eine relevante Morbidität bedingen. Das Risiko für thromboembolische Komplikationen bei Tumorpatienten liegt 3–9-mal höher als bei Nichttumorpatienten und stellt die zweithäufigste Todesursache bei Tumorpatienten dar. Das Thromboserisiko hängt neben der tumorinduzierten Koagulopathie von individuellen Faktoren, der Art und dem Stadium der Krebserkrankung, der Zeit seit der Krebsdiagnose sowie der Art einer systemischen Krebstherapie ab. Eine Thromboseprophylaxe bei Tumorpatienten ist wirksam, kann jedoch mit erhöhten Blutungen einhergehen. Auch wenn dezidierte Empfehlungen für einzelne Tumorentitäten aktuell nicht vorliegen, empfehlen internationale Leitlinien prophylaktische Maßnahmen bei Hochrisikopatienten. So kann ein Thromboserisiko von >8–10% als Indikation für eine Thromboseprophylaxe angesehen werden. Dieses Risiko wurde bei Patienten mit einem Khorana-Score von ≥2 erreicht und sollte individuell mithilfe der Nomogramme berechnet werden. Vor allem bei Patienten mit geringem Blutungsrisiko wird diese Empfehlung ausgesprochen. Während des Arztgesprächs sollten zudem Risikofaktoren und Symptome eines thromboembolischen Events thematisiert und Materialien zur Patientenaufklärung ausgehändigt werden.
    Keywords venöse thromboembolische Komplikationen ; urogenitale Tumore ; Thrombosprophylaxe ; venous thromboembolic events ; genitourinary cancer ; thromboembolic prophylaxis
    Language German
    Publishing date 2023-06-20
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-2099-8233
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  7. Article ; Online: Medikamentöse Tumortherapie des mHSPC: Double- oder Tripletherapie: wer, wann und wie?

    Paffenholz, Pia / Roesch, Marie Christine

    Aktuelle Urologie

    2023  Volume 55, Issue 2, Page(s) 116–122

    Abstract: At present, androgen deprivation therapy (ADT) as monotherapy for metastatic hormone-sensitive prostate cancer (mHSPC) should be an exception. The new standard of care is a doublet combination consisting of ADT + a new hormonal agent (NHA) or ADT + ... ...

    Title translation Systemic therapy for mHSPC: doublet or triplet therapy - who, when and how?
    Abstract At present, androgen deprivation therapy (ADT) as monotherapy for metastatic hormone-sensitive prostate cancer (mHSPC) should be an exception. The new standard of care is a doublet combination consisting of ADT + a new hormonal agent (NHA) or ADT + chemotherapy. Contemporary investigations even recommend a triplet therapy consisting of ADT + NHA + chemotherapy for selected mHSPC patients. The current evolution of mHSPC therapy demands a pretherapeutic classification of mHSPC: "low" vs. "high risk", "low" vs. "high volume" and synchronous vs. metachronous mHSPC. Additionally, attention should be paid to the drug specific side effects and especially whether the patient is fit for chemotherapy. This article gives a concise overview of the key clinical trials, current guideline recommendations and drug approvals for Germany.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/pathology ; Androgen Antagonists/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Germany
    Chemical Substances Androgen Antagonists
    Language German
    Publishing date 2023-08-22
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-2129-7206
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  8. Article ; Online: Indikation zur operativen oder radiologischen Sanierung einer Varikozele im Kindes- und Jugendalter.

    Paffenholz, Pia

    Der Urologe. Ausg. A

    2019  Volume 58, Issue 6, Page(s) 690–691

    Title translation Indications for surgical or radiological treatment of varicocele in children and adolescents.
    MeSH term(s) Adolescent ; Child ; Humans ; Male ; Radiotherapy ; Testis/pathology ; Urologic Surgical Procedures, Male/methods ; Varicocele/diagnosis ; Varicocele/etiology ; Varicocele/therapy
    Language German
    Publishing date 2019-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-019-0950-1
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  9. Article ; Online: Reply by Authors.

    Nestler, Tim / Paffenholz, Pia / Pfister, David / Schoch, Justine / Nini, Alessandro / Hiester, Andreas / Albers, Peter / Heidenreich, Axel

    The Journal of urology

    2024  Volume 211, Issue 3, Page(s) 435

    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000003812.02
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  10. Article ; Online: Cytoreductive radical prostatectomy: who benefits from the surgical approach?

    Heidenreich, Axel / Paffenholz, Pia / Pfister, David / Rieger, Constantin

    Current opinion in urology

    2023  Volume 33, Issue 2, Page(s) 168–171

    Abstract: Purpose of review: Local treatment in oligometastatic prostate cancer patients is associated with improved survival. Nevertheless, in term of surgery, cytoreductive radical prostatectomy has no level of evidence 1 and is an individual treatment approach. ...

    Abstract Purpose of review: Local treatment in oligometastatic prostate cancer patients is associated with improved survival. Nevertheless, in term of surgery, cytoreductive radical prostatectomy has no level of evidence 1 and is an individual treatment approach. We reviewed the recent literature to highlight parameters for selecting patients for a surgical approach.
    Recent findings: Retrospective data on oncologic outcome for cytoreductive prostatectomy are confirmed. We identified several parameters that help to select patients for surgery. Patients with a favorable prostate-specific antigen (PSA) decline after androgen deprivation therapy (ADT) have excellent oncologic long-term control. Circulating tumor cells (CTC's) are frequently analyzed in more advanced prostate cancer. In case of C-reactive protein (CRP) at least a longer interval to develop castration resistant prostate cancer (CRPC) is shown in case of low CTC count at time of surgery. Nutrition status analyzed as the hemoglobin, albumin, lymphocyte, and platelet (HALP)-score is of significant value in demonstrating an effect of CRP.
    Summary: From retrospective findings we have several clinical and basic science parameters to select patients for CRP. PSA at the time of surgery is the most frequently analyzed one, whereas CTC and HALP-score are promising tools to select patients that need to be validated.
    MeSH term(s) Male ; Humans ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/pathology ; Cytoreduction Surgical Procedures/adverse effects ; Retrospective Studies ; Androgen Antagonists/therapeutic use ; Prostatectomy/adverse effects
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; Androgen Antagonists
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1091792-5
    ISSN 1473-6586 ; 0963-0643
    ISSN (online) 1473-6586
    ISSN 0963-0643
    DOI 10.1097/MOU.0000000000001068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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