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  1. Book ; Online ; E-Book: Youth mental health

    Uhlhaas, Peter J. / Wood, Stephen J.

    a paradigm for prevention and early intervention

    (Strüngmann forum reports series)

    2020  

    Abstract: Experts discuss the potential of early intervention to transform outcomes for people with mental disorders. ...

    Author's details edited by Peter J. Uhlhaas and Stephen J. Wood
    Series title Strüngmann forum reports series
    Abstract Experts discuss the potential of early intervention to transform outcomes for people with mental disorders.
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xii, 329 Seiten), Illustrationen, Diagramme
    Publisher The MIT Press
    Publishing place Cambridge, Massachusetts
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021075379
    ISBN 978-0-262-04454-7 ; 9780262043977 ; 0-262-04454-4 ; 0262043971
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Das adoleszente Gehirn

    Uhlhaas, Peter J.

    2011  

    Author's details Peter J. Uhlhaas ... (Hrsg.)
    Keywords Erwachsenwerden ; Gehirn ; Entwicklung ; Hormon ; Neurotransmitter ; Neuropsychologie ; Entwicklungspsychologie ; Psychiatrie
    Subject Hormone ; Ursprung ; Entwicklungsstadium ; Seelenheilkunde ; Genetische Psychologie ; Psychogenese ; Transmitter ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse ; Adoleszenz ; Heranwachsen
    Language German
    Size 310 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT016473164
    ISBN 978-3-17-021013-4 ; 3-17-021013-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 4457 order for loan Magazin

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  3. Article ; Online: Characteristics and clinical correlates of risk symptoms in individuals at clinical high-risk for psychosis: A systematic review and meta-analysis.

    Cooper, Saskia M / Fusar-Poli, Paolo / Uhlhaas, Peter J

    Schizophrenia research

    2023  Volume 254, Page(s) 54–61

    Abstract: Emerging evidence suggests that the duration of risk symptoms (DUR) may have an impact on clinical outcomes in clinical high-risk for psychosis (CHRP) participants. To explore this hypothesis, we performed a meta-analysis on studies that examined DUR in ... ...

    Abstract Emerging evidence suggests that the duration of risk symptoms (DUR) may have an impact on clinical outcomes in clinical high-risk for psychosis (CHRP) participants. To explore this hypothesis, we performed a meta-analysis on studies that examined DUR in CHR-P individuals in relation to their clinical outcomes. This review was conducted in accordance with the PRISMA guidelines and the protocol was registered with PROSPERO on 16th April 2021 (ID no. CRD42021249443). Literature searches were conducted using PsycINFO and Web of Science in March and November 2021, for studies reporting on DUR in CHR-P populations, in relation to transition to psychosis or symptomatic, functional, or cognitive outcomes. The primary outcome was transition to psychosis, while the secondary outcomes were remission from CHR-P status and functioning at baseline. Thirteen independent studies relating to 2506 CHR-P individuals were included in the meta-analysis. The mean age was 19.88 years (SD = 1.61) and 1194 individuals (47.65 %) were females. The mean length of DUR was 23.61 months (SD = 13.18). There was no meta-analytic effect of DUR on transition to psychosis at 12-month follow-up (OR = 1.000, 95%CI = 0.999-1.000, k = 8, p = .98), while DUR was related to remission (Hedge's g = 0.236, 95%CI = 0.014-0.458, k = 4, p = .037). DUR was not related to baseline GAF scores (beta = -0.004, 95%CI = -0.025-0.017, k = 3, p = .71). The current findings suggest that DUR is not associated with transition to psychosis at 12 months, but may impact remission. However, the database was small and further research in this area is required.
    MeSH term(s) Female ; Humans ; Male ; Young Adult ; Databases, Factual ; Psychotic Disorders/psychology ; Adolescent
    Language English
    Publishing date 2023-02-15
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2023.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Current MEG Research in Psychiatry.

    Hirano, Yoji / Uhlhaas, Peter J

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 647085

    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.647085
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  5. Article ; Online: Current findings and perspectives on aberrant neural oscillations in schizophrenia.

    Hirano, Yoji / Uhlhaas, Peter J

    Psychiatry and clinical neurosciences

    2021  Volume 75, Issue 12, Page(s) 358–368

    Abstract: There is now consistent evidence that neural oscillation at low- and high-frequencies constitute an important aspect of the pathophysiology of schizophrenia. Specifically, impaired rhythmic activity may underlie the deficit to generate coherent cognition ...

    Abstract There is now consistent evidence that neural oscillation at low- and high-frequencies constitute an important aspect of the pathophysiology of schizophrenia. Specifically, impaired rhythmic activity may underlie the deficit to generate coherent cognition and behavior, leading to the characteristic symptoms of psychosis and cognitive deficits. Importantly, the generating mechanisms of neural oscillations are relatively well-understood and thus enable the targeted search for the underlying circuit impairments and novel treatment targets. In the following review, we will summarize and assess the evidence for aberrant rhythmic activity in schizophrenia through evaluating studies that have utilized Electro/Magnetoencephalography to examine neural oscillations during sensory and cognitive tasks as well as during resting-state measurements. These data will be linked to current evidence from post-mortem, neuroimaging, genetics, and animal models that have implicated deficits in GABAergic interneurons and glutamatergic neurotransmission in oscillatory deficits in schizophrenia. Finally, we will highlight methodological and analytical challenges as well as provide recommendations for future research.
    MeSH term(s) Animals ; Cognition Disorders/complications ; Cognition Disorders/physiopathology ; Electroencephalography ; Humans ; Magnetoencephalography ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Synaptic Transmission
    Language English
    Publishing date 2021-10-29
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Do NMDA-R antagonists re-create patterns of spontaneous gamma-band activity in schizophrenia? A systematic review and perspective.

    Bianciardi, Bianca / Uhlhaas, Peter J

    Neuroscience and biobehavioral reviews

    2021  Volume 124, Page(s) 308–323

    Abstract: NMDA-R hypofunctioninig is a core pathophysiological mechanism in schizophrenia. However, it is unclear whether the physiological changes observed following NMDA-R antagonist administration are consistent with gamma-band alterations in schizophrenia. ... ...

    Abstract NMDA-R hypofunctioninig is a core pathophysiological mechanism in schizophrenia. However, it is unclear whether the physiological changes observed following NMDA-R antagonist administration are consistent with gamma-band alterations in schizophrenia. This systematic review examined the effects of NMDA-R antagonists on the amplitude of spontaneous gamma-band activity and functional connectivity obtained from preclinical (n = 24) and human (n = 9) studies and compared these data to resting-state EEG/MEG-measurements in schizophrenia patients (n = 27). Overall, the majority of preclinical and human studies observed increased gamma-band power following acute administration of NMDA-R antagonists. However, the direction of gamma-band power alterations in schizophrenia were inconsistent, which involved upregulation (n = 10), decreases (n = 7), and no changes (n = 8) in spectral power. Five out of 6 preclinical studies observed increased connectivity, while in healthy controls receiving Ketamine and in schizophrenia patients the direction of connectivity results was also inconsistent. Accordingly, the effects of NMDA-R hypofunctioning on gamma-band oscillations are different than pathophysiological signatures observed in schizophrenia. The implications of these findings for current E/I balance models of schizophrenia are discussed.
    MeSH term(s) Excitatory Amino Acid Antagonists ; Gamma Rhythm ; Humans ; N-Methylaspartate ; Receptors, N-Methyl-D-Aspartate ; Schizophrenia/drug therapy
    Chemical Substances Excitatory Amino Acid Antagonists ; Receptors, N-Methyl-D-Aspartate ; N-Methylaspartate (6384-92-5)
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia.

    Metzner, Christoph / Dimulescu, Cristiana / Kamp, Fabian / Fromm, Sophie / Uhlhaas, Peter J / Obermayer, Klaus

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1352641

    Abstract: Introduction: We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and ... ...

    Abstract Introduction: We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and computational modelling.
    Methods: The rs-fMRI measurements from patients with chronic ScZ (n=38) and matched healthy controls (n=43), were obtained through the public schizConnect repository. Computational models were constructed based on diffusion-weighted MRI scans and fit to the experimental rs-fMRI data.
    Results: We found decreased large-scale functional connectivity across sensory and association areas and for all functional subnetworks for the ScZ group. Additionally global synchrony was reduced in patients while metastability was unaltered. Perturbations of the computational model revealed that decreased global coupling and increased background noise levels both explained the experimentally found deficits better than local changes to the GABAergic or glutamatergic system.
    Discussion: The current study suggests that large-scale alterations in ScZ are more likely the result of global rather than local network changes.
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1352641
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  8. Article: Neural dynamics in mental disorders.

    Uhlhaas, Peter J

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2015  Volume 14, Issue 2, Page(s) 116–118

    Language English
    Publishing date 2015-06-02
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20203
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  9. Article ; Online: 40 Hz Steady-State Response in Human Auditory Cortex Is Shaped by GABAergic Neuronal Inhibition.

    Toso, Alessandro / Wermuth, Annika P / Arazi, Ayelet / Braun, Anke / Jong, Tineke Grent-'t / Uhlhaas, Peter J / Donner, Tobias H

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  

    Abstract: The 40 Hz auditory steady-state response (ASSR), an oscillatory brain response to periodically modulated auditory stimuli, is a promising, non-invasive physiological biomarker for schizophrenia and related neuropsychiatric disorders. The 40 Hz ASSR might ...

    Abstract The 40 Hz auditory steady-state response (ASSR), an oscillatory brain response to periodically modulated auditory stimuli, is a promising, non-invasive physiological biomarker for schizophrenia and related neuropsychiatric disorders. The 40 Hz ASSR might be amplified by synaptic interactions in cortical circuits, which are, in turn, disturbed in neuropsychiatric disorders. Here, we tested whether the 40 Hz ASSR in human auditory cortex depends on two key synaptic components of neuronal interactions within cortical circuits: excitation via N-methyl-aspartate glutamate (NMDA) receptors and inhibition via gamma-amino-butyric acid (GABA) receptors. We combined magnetoencephalography (MEG) recordings with placebo-controlled, low-dose pharmacological interventions in the same healthy human participants (13 males, 7 females). All participants exhibited a robust 40 Hz ASSR in auditory cortices, especially in the right hemisphere, under placebo. The GABA
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2029-23.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 40-Hz Auditory Steady-State Responses in Schizophrenia: Toward a Mechanistic Biomarker for Circuit Dysfunctions and Early Detection and Diagnosis.

    Grent-'t-Jong, Tineke / Brickwedde, Marion / Metzner, Christoph / Uhlhaas, Peter J

    Biological psychiatry

    2023  Volume 94, Issue 7, Page(s) 550–560

    Abstract: There is converging evidence that 40-Hz auditory steady-state responses (ASSRs) are robustly impaired in schizophrenia and could constitute a potential biomarker for characterizing circuit dysfunctions as well as enable early detection and diagnosis. ... ...

    Abstract There is converging evidence that 40-Hz auditory steady-state responses (ASSRs) are robustly impaired in schizophrenia and could constitute a potential biomarker for characterizing circuit dysfunctions as well as enable early detection and diagnosis. Here, we provide an overview of the mechanisms involved in 40-Hz ASSRs, drawing on computational, physiological, and pharmacological data with a focus on parameters modulating the balance between excitation and inhibition. We will then summarize findings from electro- and magnetoencephalographic studies in participants at clinical high risk for psychosis, patients with first-episode psychosis, and patients with schizophrenia to identify the pattern of deficits across illness stages, the relationship with clinical variables, and the prognostic potential. Finally, data on genetics and developmental modifications will be reviewed, highlighting the importance of late modifications of 40-Hz ASSRs during adolescence, which are closely related to the underlying changes in GABA (gamma-aminobutyric acid) interneurons. Together, our review suggests that 40-Hz ASSRs may constitute an informative electrophysiological approach to characterize circuit dysfunctions in psychosis that could be relevant for the development of mechanistic biomarkers.
    MeSH term(s) Adolescent ; Humans ; Schizophrenia/diagnosis ; Acoustic Stimulation ; Evoked Potentials, Auditory/physiology ; Psychotic Disorders/diagnosis ; Electroencephalography ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2023.03.026
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